Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils

Archives of Biochemistry and Biophysics

Volumn 523, Issue 2, 2012, Pages 144-150

  Yu, Wen Bo ^a,c   Jiang, Teng ^a   Lan, Dan Mei ^a   Lu, Jia Hong ^a   Yue, Zhen Yu ^b   Wang, Jian ^a   Zhou, Ping ^a,d  

^a FUDAN UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c NANJING MEDICAL UNIVERSITY   (China)

^d NONE   (China)

Author keywords

Aggregate morphologies; Alpha synuclein; Parkinson's disease; Protein conformation; Trehalose

Indexed keywords

ALPHA SYNUCLEIN; MUTANT PROTEIN; THIOFLAVINE; TREHALOSE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CIRCULAR DICHROISM; CONTROLLED STUDY; FIBER; FLUORESCENCE; HUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

EID: 84861899099     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2012.04.021     Document Type: Article

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