Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

Science Signaling

Volumn 4, Issue 167, 2011, Pages

  Wang, Yingfei ^a   Kim, No Soo ^a,c   Haince, Jean Francois ^b   Kang, Ho Chul ^a   David, Karen K ^a   Andrabi, Shaida A ^a   Poirier, Guy G ^b   Dawson, Valina L ^a   Dawson, Ted M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LAVAL UNIVERSITY   (Canada)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; ARGININE; BINDING PROTEIN; DNA; DNA DIRECTED DNA POLYMERASE BETA; FLAVINE ADENINE NUCLEOTIDE; LYSINE; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; POLY(ADENOSINE DIPHOSPHATE RIBOSE); NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ARTICLE; BINDING SITE; BIOENERGY; CELL DEATH; CELL SURVIVAL; ENZYME ACTIVATION; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DNA SEQUENCE; GEL MOBILITY SHIFT ASSAY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LENTIVIRINAE; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS INDUCING FACTOR; ARGININE; BASE SEQUENCE; CELL DEATH; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENETIC VECTORS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LENTIVIRUS; LYSINE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; SEQUENCE ANALYSIS, DNA; TRANSFECTION;

EID: 79953840957     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000902     Document Type: Article

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43. Funding: This work was supported by NIH grants DA00266, NINDS NS039148 and NS067525, the American Heart Association (AHA, 0825413E), and a Canadian Institutes Health Research grant (G.G.P.). G.G.P. holds a research chair in proteomics. T.M.D. is a Leonard and Madlyn Abramson professor in neurodegenerative diseases. Author contributions: The experiments were coordinated by G.G.P., V.L.D., and T.M.D. and conducted by Y.W., N.S.K., J.-F.H., H.C.K., K.K.D., and S.A.A. The study was conceived and scientifically directed by V.L.D. and T.M.D. The paper was written by Y.W., N.S.K., V.L.D., and T.M.D. All authors contributed to the final editing of the manuscript. Competing interests: We are planning to submit a report of invention and to patent the PAR binding to AIF.