Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death

Journal of Neuroscience

Volumn 26, Issue 1, 2006, Pages 41-50

  Martin, Lee J ^a   Pan, Yan ^a   Price, Ann C ^a   Sterling, Wanda ^a   Copeland, Neal G ^b   Jenkins, Nancy A ^b   Price, Donald L ^a   Lee, Michael K ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Axonopathy; DNA damage; Motor neuron disease; Neuronal apoptosis; Nitrative stress; Peroxynitrite; Synucleinopathy

Indexed keywords

ALPHA SYNUCLEIN; CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; MUTANT PROTEIN; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CELL INCLUSION; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; ELECTRON MICROSCOPY; ENZYME DEGRADATION; EOSINOPHIL; LEWY BODY; MITOCHONDRION; MOUSE; NEOCORTEX; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE FIBER DEGENERATION; NICK END LABELING; NITRATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD; SPINAL CORD MOTONEURON; SPINAL CORD VENTRAL HORN; TRANSGENIC MOUSE; WILD TYPE;

ALANINE; ALPHA-SYNUCLEIN; ANIMALS; BRAIN STEM; CELL DEATH; DNA DAMAGE; HUMANS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MUTATION; NEOCORTEX; NERVE DEGENERATION; PARKINSON DISEASE; THREONINE;

EID: 30644471051     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4308-05.2006     Document Type: Article

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