Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Nature Chemical Biology

Volumn 13, Issue 1, 2017, Pages 81-90

  Kagan, Valerian E ^a,b   Mao, Gaowei ^a,b   Qu, Feng ^a   Angeli, Jose Pedro Friedmann ^c   Doll, Sebastian ^c   Croix, Claudette St ^b   Dar, Haider Hussain ^a   Liu, Bing ^b   Tyurin, Vladimir A ^a   Ritov, Vladimir B ^a   Kapralov, Alexandr A ^a   Amoscato, Andrew A ^a   Jiang, Jianfei ^a   Anthonymuthu, Tamil ^b   Mohammadyani, Dariush ^a   Yang, Qin ^b   Proneth, Bettina ^c   Klein Seetharaman, Judith ^d   Watkins, Simon ^b   Bahar, Ivet ^b   Greenberger, Joel ^b   Mallampalli, Rama K ^b   Stockwell, Brent R ^e   Tyurina, Yulia Y ^a   Conrad, Marcus ^c   Baylr, Hülya ^a,b   more..

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE; 1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ACYL COENZYME A; ACYL COENZYME A SYNTHASE 4; ADRENIC ACID; ALPHA TOCOTRIENOL; ARACHIDONIC ACID; ARACHIDONOYL COENZYME A; CARDIOLIPIN; CYTOCHROME P450; LIPID HYDROPEROXIDE; LIPOXYGENASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; TOCOPHEROL; UNCLASSIFIED DRUG; ACSL4 PROTEIN, MOUSE; COENZYME A LIGASE; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOINFORMATICS; CELL DEATH; CONTROLLED STUDY; EMBRYO; ESTERIFICATION; FERROPTOSIS; LIPID PEROXIDATION; LIPIDOMICS; MOUSE; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXYGENATION; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE GENETICS; SYSTEMS BIOLOGY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; DEFICIENCY; DRUG EFFECTS; FEMALE; KNOCKOUT MOUSE; MALE; METABOLISM;

ANIMALS; ARACHIDONIC ACID; CELL DEATH; CELL LINE; COENZYME A LIGASES; FATTY ACIDS, UNSATURATED; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOLIPIDS;

EID: 84995452435     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2238     Document Type: Article

References (57)

1. Allocati, N., Masulli, M., Di Ilio, C., De Laurenzi, V. Die for the community: an overview of programmed cell death in bacteria. Cell Death Dis. 6, e1609 (2015).
2. Byrne, J.M., et al. Redox cycling of Fe(II) and Fe(III) in magnetite by Fe-metabolizing bacteria. Science 347, 1473-1476 (2015).
3. Dixon, S.J., Stockwell, B.R. The role of iron and reactive oxygen species in cell death. Nat. Chem. Biol. 10, 9-17 (2014).
4. Dixon, S.J., et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060-1072 (2012).
5. Yang, W.S., Stockwell, B.R. Ferroptosis: death by lipid peroxidation. Trends Cell Biol. 26, 165-176 (2016).
6. Yang, W.S., Stockwell, B.R. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem. Biol. 15, 234-245 (2008).
7. Imai, H., Nakagawa, Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic. Biol. Med. 34, 145-169 (2003).
8. Yamanaka, K., et al. A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells. RSC Advances 2, 7894-7900 (2012).
9. Drummen, G.P., van Liebergen, L.C., Op den Kamp, J.A., Post, J.A. C11-BODIPY581/591, an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology. Free Radic. Biol. Med. 33, 473-490 (2002).
10. Li, B., Pratt, D.A. Methods for determining the efficacy of radical-trapping antioxidants. Free Radic. Biol. Med. 82, 187-202 (2015).
11. Küch, E.M., et al. Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol. Biochim. Biophys. Acta 1841, 227-239 (2014).
12. Golej, D.L., et al. Long-chain acyl-CoA synthetase 4 modulates prostaglandin E release from human arterial smooth muscle cells. J. Lipid Res. 52, 782-793 (2011).
13. Doll, S., et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat. Chem. Biol. http://dx.doi.org/10.1038/nchembio.2239 (2016).
14. McIntyre, T.M., Prescott, S.M., Stafforini, D.M. The emerging roles of PAF acetylhydrolase. J. Lipid Res. 50 (Suppl.): S255-S259 (2009).
15. Soh, N., et al. Swallow-tailed perylene derivative: a new tool for fluorescent imaging of lipid hydroperoxides. Org. Biomol. Chem. 5, 3762-3768 (2007).
16. Dixon, S.J., et al. Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem. Biol. 10, 1604-1609 (2015).
17. Seiler, A., et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent-and AIF-mediated cell death. Cell Metab. 8, 237-248 (2008).
18. Friedmann Angeli, J.P., et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell Biol. 16, 1180-1191 (2014).
19. Askari, B., et al. Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-?-independent mechanism in human arterial smooth muscle cells and macrophages. Diabetes 56, 1143-1152 (2007).
20. O'Donnell, V.B., Murphy, R.C. New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions. Blood 120, 1985-1992 (2012).
21. Xiao, Y., Guengerich, F.P. Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids. J. Lipid Res. 53, 1610-1617 (2012).
22. Khanna, S., et al. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J. Biol. Chem. 278, 43508-43515 (2003).
23. Arai, H., Nagao, A., Terao, J., Suzuki, T., Takama, K. Effect of D-?-tocopherol analogues on lipoxygenase-dependent peroxidation of phospholipid-bile salt micelles. Lipids 30, 135-140 (1995).
24. Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A2. J. Biol. Chem. 269, 13057-13060 (1994).
25. van den Brink-van der Laan, E., Killian, J.A., de Kruijff, B. Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile. Biochim. Biophys. Acta 1666, 275-288 (2004).
26. Lee, A.G. How lipids affect the activities of integral membrane proteins. Biochim. Biophys. Acta 1666, 62-87 (2004).
27. Toppo, S., Flohé, L., Ursini, F., Vanin, S., Maiorino, M. Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme. Biochim. Biophys. Acta 1790, 1486-1500 (2009).
28. Uderhardt, S., et al. 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity 36, 834-846 (2012).
29. Orrenius, S., Zhivotovsky, B. Cardiolipin oxidation sets cytochrome c free. Nat. Chem. Biol. 1, 188-189 (2005).
30. Kagan, V.E., et al. Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nat. Chem. Biol. 1, 223-232 (2005).
31. Massey, K.A., Nicolaou, A. Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites. Biochem. Soc. Trans. 39, 1240-1246 (2011).
32. Kuhn, H., Banthiya, S., van Leyen, K. Mammalian lipoxygenases and their biological relevance. Biochim. Biophys. Acta 1851, 308-330 (2015).
33. Schroeder, F. Regulation of aminophospholipid asymmetry in murine fibroblast plasma membranes by choline and ethanolamine analogues. Biochim. Biophys. Acta 599, 254-270 (1980).
34. Sessions, A., Horwitz, A.F. Myoblast aminophospholipid asymmetry differs from that of fibroblasts. FEBS Lett. 134, 75-78 (1981).
35. Garreta, A., et al. Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa. FASEB J. 27, 4811-4821 (2013).
36. Suardiáz, R., et al. Understanding the mechanism of the hydrogen abstraction from arachidonic acid catalyzed by the human enzyme 15-lipoxygenase-2. A quantum mechanics/molecular mechanics free energy simulation. J. Chem. Theory Comput. 12, 2079-2090 (2016).
37. Noguchi, N., et al. The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants. Biol. Chem. 383, 619-626 (2002).
38. Carlson, B.A., et al. Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration. Redox Biol. 9, 22-31 (2016).
39. Chen, L., Hambright, W.S., Na, R., Ran, Q. Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis. J. Biol. Chem. 290, 28097-28106 (2015).
40. Matsushita, M., et al. T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J. Exp. Med. 212, 555-568 (2015).
41. Wortmann, M., et al. Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice. Circ. Res. 113, 408-417 (2013).
42. Sen, C.K., Khanna, S., Roy, S., Packer, L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60c-Src kinase activation and death of HT4 neuronal cells. J. Biol. Chem. 275, 13049-13055 (2000).
43. Yang, W.S., et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317-331 (2014).
44. Telmer, C.A., et al. Rapid, specific, no-wash, far-red fluorogen activation in subcellular compartments by targeted fluorogen activating proteins. ACS Chem. Biol. 10, 1239-1246 (2015).
45. Szent-Gyorgyi, C., et al. Fluorogen-activating single-chain antibodies for imaging cell surface proteins. Nat. Biotechnol. 26, 235-240 (2008).
46. Tardi, P.G., Mukherjee, J.J., Choy, P.C. The quantitation of long-chain acyl-CoA in mammalian tissue. Lipids 27, 65-67 (1992).
47. Minkler, P.E., Kerner, J., Ingalls, S.T., Hoppel, C.L. Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue. Anal. Biochem. 376, 275-276 (2008).
48. Sun, D., Cree, M.G., Wolfe, R.R. Quantification of the concentration and 13C tracer enrichment of long-chain fatty acyl-coenzyme A in muscle by liquid chromatography/mass spectrometry. Anal. Biochem. 349, 87-95 (2006).
49. Folch, J., Lees, M., Sloane Stanley, G.H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497-509 (1957).
50. Miller, T.M., et al. Rapid, simultaneous quantitation of mono and dioxygenated metabolites of arachidonic acid in human CSF and rat brain. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 3991-4000 (2009).
51. Tejero, J., et al. Peroxidase activation of cytoglobin by anionic phospholipids: mechanisms and consequences. Biochim. Biophys. Acta 1861, 391-401 (2016).
52. Kobe, M.J., Neau, D.B., Mitchell, C.E., Bartlett, S.G., Newcomer, M.E. The structure of human 15-lipoxygenase-2 with a substrate mimic. J. Biol. Chem. 289, 8562-8569 (2014).
53. Marrink, S.J., Risselada, H.J., Yefimov, S., Tieleman, D.P., de Vries, A.H. The MARTINI force field: coarse grained model for biomolecular simulations. J. Phys. Chem. B 111, 7812-7824 (2007).
54. Van Der Spoel, D., et al. GROMACS: fast, flexible, and free. J. Comput. Chem. 26, 1701-1718 (2005).
55. Yang, K., et al. Dynamic simulations on the arachidonic acid metabolic network. PLoS Comput. Biol. 3, e55 (2007).
56. Gupta, S., Maurya, M.R., Stephens, D.L., Dennis, E.A., Subramaniam, S. An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis. Biophys. J. 96, 4542-4551 (2009).
57. Hoops, S., et al. COPASI-a COmplex PAthway SImulator. Bioinformatics 22, 3067-3074 (2006).