Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

Journal of the American Chemical Society

Volumn 136, Issue 12, 2014, Pages 4551-4556

  Skouta, Rachid ^a   Dixon, Scott J ^a   Wang, Jianlin ^b   Dunn, Denise E ^c   Orman, Marina ^a   Shimada, Kenichi ^a   Rosenberg, Paul A ^b   Lo, Donald C ^c   Weinberg, Joel M ^d   Linkermann, Andreas ^e   Stockwell, Brent R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LIPIDS;

DISEASE PHENOTYPES; HUNTINGTON'S DISEASE; KIDNEY DYSFUNCTION; LIPID PEROXIDATION; LYSOSOMAL MEMBRANES; MECHANISTIC MODELING; PERIVENTRICULAR LEUKOMALACIA; REACTIVE OXYGEN SPECIES;

CELL DEATH;

CHONDROITIN SULFATE IRON; REACTIVE OXYGEN METABOLITE; CYCLOHEXYLAMINE DERIVATIVE; FERROSTATIN-1; MEMBRANE LIPID; PHENYLENEDIAMINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISEASE MODEL; HUNTINGTON CHOREA; KIDNEY DYSFUNCTION; LEUKOMALACIA; LIPID PEROXIDATION; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; NONHUMAN; OXIDATIVE STRESS; PERIVENTRICULAR LEUKOMALACIA; RAT; STRUCTURE ACTIVITY RELATION; UNITED STATES; DRUG EFFECTS; HUNTINGTON DISEASE; KIDNEY DISEASES; LEUKOMALACIA, PERIVENTRICULAR; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY;

CELL DEATH; CYCLOHEXYLAMINES; HUNTINGTON DISEASE; KIDNEY DISEASES; LEUKOMALACIA, PERIVENTRICULAR; LIPID PEROXIDATION; MEMBRANE LIPIDS; OXIDATION-REDUCTION; PHENYLENEDIAMINES;

EID: 84897059782     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja411006a     Document Type: Article

References (44)

1. Sena, L. A.; Chandel, N. S. Mol. Cell 2012, 48, 158
2. Kell, D. B. BMC Med. Genomics 2009, 2, 2
3. Xun, Z.; Xun, Z.; Rivera-Sánchez, S.; Ayala-Peña, S.; Lim, J.; Budworth, H.; Skoda, E. M.; Robbins, P. D.; Niedernhofer, L. J.; Wipf, P.; McMurray, C. T. Cell Rep. 2012, 2, 1137
4. Dixon, S. J.; Lemberg, K. M.; Lamprecht, M. R.; Skouta, R.; Zaitsev, E. M.; Gleason, C. E.; Patel, D. N.; Bauer, A. J.; Cantley, A. M.; Yang, W. S.; Morrison, B.; Stockwell, B. R. Cell 2012, 149, 1060
5. Skouta, R.; Hayano, M.; Shimada, K.; Stockwell, B. R. Bioorg. Med. Chem. Lett. 2012, 22, 5707
6. Yang, W. S.; Stockwell, B. R. Chem. Biol. 2008, 15, 234
7. Dolma, S.; Lessnick, S. L.; Hahn, W. C.; Stockwell, B. R. Cancer Cell 2003, 3, 285
8. Dixon, S. J.; Stockwell, B. R. Nat. Chem. Biol. 2014, 10, 9
9. Finley, J. W.; Kong, A. N.; Hintze, K. J.; Jeffery, E. H.; Ji, L. L.; Lei, X. G. J. Agric. Food. Chem. 2011, 59, 6837
10. Klemchuk, P. P. Ullmann's Encyclopedia of Industrial Chemistry; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2000.
11. Adeniyi, J. B.; Al-Malika, S.; Scott, G. J. Appl. Polym. Sci. 1986, 32, 6063
12. Lye, P. H.; Toh, H. K. J. Polym. Sci., Polym. Lett. Ed. 1984, 22, 327
13. Shelton, J. R. Rubber Rev. Rubber Chem. Technol. 1957, 30, 1270
14. Shelton, J. R.; Cox, W. L. Ind. Eng. Chem. 1953, 45, 392
15. Shelton, J. R.; Vincent, D. N. J. Am. Chem. Soc. 1963, 85, 2433
16. Ingold, K. U. Chem. Rev. 1961, 61, 563
17. Brownlie, I. T.; Ingold, K. U. Can. J. Chem. 1966, 44, 861
18. Adamic, K.; Ingold, K. U. Can. J. Chem. 1969, 47, 295
19. Behl, C. Prog. Neurobiol. 1999, 57, 301
20. Behl, C.; Moosmann, B. Free Radical Biol. Med. 2002, 33, 182
21. Gryn'ova, G.; Ingold, K. U.; Coote, M. L. J. Am. Chem. Soc. 2012, 134, 12979
22. Esteves, M. A.; Narender, N.; Marcelo-Curto, M. J.; Gigante, B. J. Nat. Prod. 2001, 64, 761
23. Scott, G. Bull. Chem. Soc. Jpn. 1988, 61, 165
24. Bannai, S. J. Biol. Chem. 1986, 261, 2256
25. Murphy, T. H.; Miyamoto, M.; Sastre, A.; Schnaar, R. L.; Coyle, J. T. Neuron 1989, 2, 1547
26. Johnson, W. M.; Wilson-Delfosse, A. L.; Mieyal, J. J. Nutrients 2012, 4, 1399
27. Lee, J.; Kosaras, B.; Del Signore, S. J.; Cormier, K.; McKee, A.; Ratan, R. R.; Kowall, N. W.; Ryu, H. Acta Neuropathol. 2011, 121, 487
28. Turmaine, M.; Raza, A.; Mahal, A.; Mangiarini, L.; Bates, G. P.; Davies, S. W. Proc. Natl. Acad. Sci. U. S. A. 2000, 97, 8093
29. Hoffstrom, B. G.; Kaplan, A.; Letso, R.; Schmid, R. S.; Turmel, G. J.; Lo, D. C.; Stockwell, B. R. Nat. Chem. Biol. 2010, 6, 900
30. Volpe, J. J.; Kinney, H. C.; Jensen, F. E.; Rosenberg, P. A. Int. J. Dev. Neurosci. 2011, 29, 565
31. Back, S. A.; Luo, N. L.; Mallinson, R. A.; O'Malley, J. P.; Wallen, L. D.; Frei, B.; Morrow, J. D.; Petito, C. K.; Roberts, C. T., Jr.; Murdoch, G. H.; Montine, T. J. Ann. Neurol. 2005, 58, 108
32. Inder, T.; Mocatta, T.; Darlow, B.; Spencer, C.; Volpe, J. J.; Winterbourn, C. Pediatr. Res. 2002, 52, 213
33. Brault, S.; Martinez-Bermudez, A. K.; Roberts, J., 2nd; Cui, Q. L.; Fragoso, G.; Hemdan, S.; Liu, H. N.; Gobeil, F., Jr.; Quiniou, C.; Kermorvant-Duchemin, E.; Lachance, C.; Almazan, G.; Varma, D. R.; Chemtob, S. Free Radical Biol. Med. 2004, 37, 358
34. Welin, A. K.; Svedin, P.; Lapatto, R.; Sultan, B.; Hagberg, H.; Gressens, P.; Kjellmer, I.; Mallard, C. Pediatr. Res. 2007, 61, 153
35. Sogabe, K.; Roeser, N. F.; Venkatachalam, M. A.; Weinberg, J. M. Kidney Int. 1996, 50, 845
36. Drummen, G. P.; Gadella, B. M.; Post, J. A.; Brouwers, J. F. Free Radical Biol. Med. 2004, 36, 1635
37. Soga, T.; Baran, R.; Suematsu, M.; Ueno, Y.; Ikeda, S.; Sakurakawa, T.; Kakazu, Y.; Ishikawa, T.; Robert, M.; Nishioka, T.; Tomita, M. J. Biol. Chem. 2006, 28, 16768
38. Loscalzo, J. Cell Metab. 2008, 8, 182
39. Do, T. Q.; Schultz, J. R.; Clarke, C. F. Proc. Natl. Acad. Sci. U. S. A. 1996, 93, 7534
40. Beaulieu, P. L.; Hache, B.; Von Moos, E. Synthesis 2003, 11, 1683
41. Abdel-Magid, A. F.; Carson, K. G.; Harris, B. D.; Maryanoff, C. A.; Shah, R. D. J. Org. Chem. 1996, 61, 3849
42. Lehuédé, J.; Fauconneau, B.; Barrier, L.; Ourakow, M.; Piriou, A.; Vierfond, J.-M. Eur. J. Med. Chem. 1999, 34, 991
43. Okawa, M.; Kinjo, J.; Nohara, T.; Ono, M. Biol. Pharm. Bul. 2001, 24, 1202
44. Huang, D.; Ou, B.; Prior, R. L. J. Agric. Food. Chem. 2005, 53, 1841