Glutathione: A key component of the cytoplasmic labile iron pool

BioMetals

Volumn 24, Issue 6, 2011, Pages 1179-1187

  Hider, Robert C ^a   Kong, Xiao L ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cytoplasmic labile iron pool; Glutathione; Iron

Indexed keywords

GLUTAREDOXIN; GLUTATHIONE; IRON; IRON SULFUR PROTEIN; LIGAND; MANGANESE;

ARTICLE; CELLS AND CELL COMPONENTS; CHEMICAL INTERACTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASMIC LABILE IRON POOL; OXIDATION REDUCTION STATE; POTENTIOMETRIC TITRATION;

ANIMALS; CYTOPLASM; GLUTATHIONE; HUMANS; IRON; LIGANDS; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PROTEIN CONFORMATION; SULFHYDRYL COMPOUNDS; SULFUR;

EID: 83555173402     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-011-9476-8     Document Type: Article

References (52)

1. A Albert 1952 Quantitative studies of the avidity of naturally occurring substances for trace metals. 2. Amino-acids having three ionizing groups J Chem Soc 50 690 697 1:CAS:528:DyaG38XivFygtA%3D%3D
2. L Alderighi P Gans A Ienco A Sabatini A Vacca 1999 Hyperquad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species Coord Chem Rev 184 311 318 10.1016/S0010-8545(98)00260-4 1:CAS:528:DyaK1MXis1Kitr8%3D
3. LA Ba M Doering T Burkholz C Jacob 2009 Metal trafficking: from maintaining the metal homeostasis to future drug design Metallomics 1 292 311 21305127 10.1039/b904533c 1:CAS:528:DC%2BC3cXlslWltbo%3D
4. W Breuer S Epsztejn ZI Cabantchik 1995 Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II) J Biol Chem 270 24209 24215 7592626 10.1074/jbc.270.33.19330 1:CAS:528: DyaK2MXovVSgtb4%3D
5. C Camaschella A Campanella L DeFalco L Boschetto R Merlini L Silvestri S Levi A Iolascon 2007 The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload Blood 110 1353 1358 17485548 10.1182/blood-2007-02-072520 1:CAS:528:DC%2BD2sXptFKlsL4%3D (Pubitemid 47281436)
6. Crichton R (2009) Iron metabolism, 3rd edn. Wiley, Chichester
7. LR Devireddy DO Hart DH Goetz MRA Green 2010 Mammalian siderophore synthesised by an enzyme with a bacterial homolog involved in enterobactin production Cell 141 1006 1017 20550936 10.1016/j.cell.2010.04.040 1:CAS:528:DC%2BC3cXnvValtL8%3D
8. DA Dickinson HJ Forman 2002 Cellular glutathione and thiols metabolism Biochem Pharmacol 64 1019 1026 12213601 10.1016/S0006-2952(02)01172-3 1:CAS:528:DC%2BD38Xms1ymsb4%3D (Pubitemid 35238033)
9. A Egyed P Saltman 1984 Iron is maintained as Fe(II) under aerobic conditions in erythroid cells Biol Trace Element Res 6 357 364 10.1007/BF02989243 1:CAS:528:DyaL2cXmtVyhs7c%3D
10. RS Eisenstein KP Blemings 1998 Iron regulatory proteins, iron responsive elements and iron homeostasis J Nutrit 128 2295 2298 9868172 1:CAS:528:DyaK1cXotVOhtb4%3D (Pubitemid 29012974)
11. J Fuhr D Rabenstein 1973 Nuclear magnetic resonance studies of the solution chemistry of metal complexes. IX Binding of cadmium, zinc, lead, and mercury by glutathione J Am Chem Soc 95 6944 6948 4784285 10.1021/ja00802a013 1:CAS:528:DyaE3sXlsFSjsb0%3D
12. J Furne A Saeed MD Levitt 2008 Whole tissue hydrogen sulphide concentrations are orders of magnitude lower than presently accepted levels Am J Physiol 295 R1479 R1485 1:CAS:528:DC%2BD1cXhsVWktbjF
13. MY Hamed J Silver MT Wilson 1983 Studies of the reactions of ferric iron with glutathione and some related thiols Inorg Chim Acta 78 1 11 10.1016/S0020-1693(00)86480-4 1:CAS:528:DyaL3sXps1Cmsw%3D%3D
14. Y Han J Qin X Chang Z Yang J Du 2006 Hydrogen sulfide and carbon monoxide are in synergy with each other in the pathogenesis of recurrent febrile seizures Cell Mol Neurobiol 26 101 107 16633905 10.1007/s10571-006-8848-z (Pubitemid 43987373)
15. DC Harris P Aisen 1973 Facilitation of Fe(II) autoxidation by Fe(III) complexing agents Biochim Biophys Acta 329 156 158 4206209 10.1016/0304-4165(73) 90019-6 1:CAS:528:DyaE2cXht12msrw%3D
16. L Helm AE Merbach 2005 Inorganic and bioin-organic solvent exchange mechanisms Chem Rev 105 1922 1959 10.1021/cr030726o (Pubitemid 40947946)
17. MW Hentze LC Kuhn 1996 Molecular control of vertebrate iron metabolism: in RNA-based regulatory circuits operated by iron, nitric oxide and oxidative stress Proc Natl Acad Sci USA 93 8175 8182 8710843 10.1073/pnas.93.16.8175 1:CAS:528:DyaK28XkvFylsb4%3D (Pubitemid 26269529)
18. RC Hider XL Kong 2010 Chemistry, biology of siderophores Nat Prod Rep 27 637 657 20376388 10.1039/b906679a 1:CAS:528:DC%2BC3cXls1Wrsb0%3D
19. A Jacobs 1977 Low molecular weight intracellular iron transport compounds Blood 50 433 439 328083 1:CAS:528:DyaE2sXltlWjtro%3D (Pubitemid 8180426)
20. T Kondo GL Dale E Beutler 1995 Thiol transport from human red blood cells Methods Enzymol 252 72 82 7476376 10.1016/0076-6879(95)52010-4 1:CAS:528:DyaK2MXptFOrtrk%3D
21. XL Kong T Zhou H Neubert Z Liu RC Hider 2009 3-Hydroxy-2-(5- hydroxypentyl)-4H-chromen-4-one: a bidentate or tridentate iron(III) ligand? J Med Chem 49 3028 3130 10.1021/jm050905t
22. EG Kovaleva JD Lipscomb 2008 Versatility of biological non-heme Fe(II) centres in oxygen activation reactions Nat Chem Biol 4 186 193 18277980 10.1038/nchembio.71 1:CAS:528:DC%2BD1cXitVGlu7c%3D (Pubitemid 351265327)
23. H Li DT Mapolelo NN Dingra SG Naik NS Lees BM Hoffman PJ Riggs-Gelasco BH Huynh MK Johnson CE Outten 2009 The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation Biochemistry 48 9569 9581 19715344 10.1021/bi901182w 1:CAS:528:DC%2BD1MXhtFaqs7nI
24. CH Lillig C Berndt A Holmgren 2008 Glutaredoxin systems Biochim Biophys Acta 1780 1304 1317 18621099 10.1016/j.bbagen.2008.06.003 1:CAS:528: DC%2BD1cXhtVarsbfL
25. C Loenarz CJ Schofield 2008 Expanding chemical biology of 2-oxoglutarate oxygenases Nat Chem Biol 4 152 156 18277970 10.1038/nchembio0308-152 1:CAS:528:DC%2BD1cXitVGksrY%3D (Pubitemid 351264133)
26. 2+ by voltammetric methods Environ Sci Technol 30 671 679 10.1021/es950417i 1:CAS:528:DyaK28XhtFWntw%3D%3D (Pubitemid 26042376)
27. Marschner H (1993) Mineral nutrition of higher plants, 2nd edn. Academic Press, London
28. Martell A, Hancock R (1996) Metal complexes in aqueous solutions. Plenum Press, New York
29. HB Martin JT Edsall 1959 The association of divalent cations with glutathione J Am Chem Soc 81 4044 10.1021/ja01524a057 1:CAS:528: DyaG1MXht1arsb8%3D
30. A Meister 1988 Glutathione metabolism and its selective modification J Biol Chem 263 17205 17208 3053703 1:CAS:528:DyaL1cXmtVKrs7g%3D (Pubitemid 19029311)
31. N Mesecke S Mittler E Eckers JM Herrmann M Deponte 2008 Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insight into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins Biochemistry 47 1452 1463 18171082 10.1021/bi7017865 1:CAS:528:DC%2BD1cXitFelug%3D%3D (Pubitemid 351198720)
32. JPG Miller DJ Perkins 1969 Model experiments for the study of iron transfer from transferrin to ferritin Eur J Biochem 10 146 151 4310277 10.1111/j.1432-1033.1969.tb00666.x 1:CAS:528:DyaF1MXkvVOqsbc%3D
33. CGD Morley A Bezkorovainy 1983 Identification of the iron chelate in hepatocyte cytosol IRCS Med Sci 11 1106 1107 1:CAS:528:DyaL2cXhsFChtrw%3D (Pubitemid 14202540)
34. TV O'Halloran 1993 Transition metals in control of gene expression Science 261 715 724 8342038 10.1126/science.8342038
35. A Ozer RK Bruick 2007 Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nat Chem Biol 3 144 153 17301803 10.1038/nchembio863 1:CAS:528:DC%2BD2sXhslWgsLo%3D
36. F Petrat H de Groot R Sustmann U Raven 2002 The chelatable iron pool in living cells: a methodically defined quantity Biol Chem 383 489 502 12033438 10.1515/BC.2002.051 1:CAS:528:DC%2BD38XksVajt7s%3D (Pubitemid 34506286)
37. W Qi JA Cowan 2011 Mechanism of glutaredoxin-ISU [2Fe-2S] cluster exchange Chem Commun 47 17 4989 4991 10.1039/c0cc05079b 1:CAS:528: DC%2BC3MXkslKitL8%3D
38. N Rouhier J Couturier MK Johnson JP Jacquot 2009 Glutaredoxins: roles in iron homeostasis Trends Biochem Sci 35 43 52 19811920 10.1016/j.tibs.2009.08.005
39. JC Savage DH Gould 1990 Determination of sulfide in brain tissue and rumen fluid by ion-interaction, reverse-phase, high performance, liquid chromatography J Chromatogr 526 540 545 2361993 10.1016/S0378-4347(00)82537-2 1:CAS:528:DyaK3cXitFehtLc%3D (Pubitemid 20111749)
40. AK Sharma LJ Pallesen RJ Spang WE Walden 2010 Cytosolic iron-sulfur cluster assembly (CIA) system: factors, mechanism, and relevance to cellular iron regulation J Biol Chem 285 26745 26751 20522543 10.1074/jbc.R110.122218 1:CAS:528:DC%2BC3cXhtVKhs77E
41. K Sipos H Lange Z Fekete P Ullmann R Lill G Kispal 2002 Maturation of cytosolic iron-sulfur proteins requires glutathione J Biol Chem 30 26944 26949 10.1074/jbc.M200677200 (Pubitemid 34951704)
42. S Soboll S Gründel J Harris V Kolb-Bachofen B Ketterer H Sies 1995 The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a non-aqueous technique of cell fractionation Biochem J 311 889 894 7487946 1:CAS:528:DyaK2MXptFagsrw%3D
43. Timberlake CF (1964) Iron-malate and iron-citrate complexes. J Chem Soc 5078-5085
44. WH Tong S Chen SG Lloyd DE Edmondson B-H Huynh J Stubbe 1996 Mechanism of assembly of the diferric cluster-tyrosyl radical cofactor of Escherichia coli ribonucleotide reductase from the diferrous form of the R2 subunit J Am Chem Soc 118 2107 2108 10.1021/ja952764y 1:CAS:528:DyaK28Xpt1aisQ%3D%3D (Pubitemid 26100229)
45. N Veiga J Torres D Mansell S Freeman S Domínguez CJ Barker A Díaz C Kremer 2009 "Chelatable iron pool": inositol 1,2,3-trisphosphate fulfils the conditions required to be a safe cellular iron ligand J Biol Inorg Chem 14 51 59 18762996 10.1007/s00775-008-0423-2 1:CAS:528:DC%2BD1cXhsVeqsrfJ
46. PD Vivancos T Wolff J Markovic FV Pallardó CH Foyer 2010 A nuclear glutathione cycle within the cell cycle Biochem J 431 169 178 10.1042/BJ20100409
47. KJ Waldron JC Rutherford D Ford NJ Robinson 2009 Metalloproteins and metal sensing Nature 460 823 830 19675642 10.1038/nature08300 1:CAS:528:DC%2BD1MXpvFCruro%3D
48. J Weaver S Pollack 1989 Low-Mr iron isolated from guinea pig reticulocytes as AMP-Fe and ATP-Fe complexes Biochem J 261 787 792 2803243 1:CAS:528:DyaL1MXkvFCnu74%3D (Pubitemid 19209517)
49. WW Wells Y Yang TL Deits ZR Gan 1993 Thioltransferases Adv Enzymol Relat Areas Mol Biol 66 149 201 8430514 1:CAS:528:DyaK2cXisF2ltw%3D%3D
50. 2S/sulfide concentration in vertebrate blood and its potential significance in ischemic pre conditioning and vascular signalling Am J Physiol 294 R1930 R1937 1:CAS:528:DC%2BD1cXnsVars74%3D
51. RJP Williams 1982 Free manganese(II) and iron(II) cations can act as intracellular cell controls FEBS Lett 140 3 10 7084455 10.1016/0014-5793(82) 80508-5 1:CAS:528:DyaL38XktF2iu7k%3D (Pubitemid 12123448)
52. H Ye SY Jeong MC Ghosh G Kovtunovych L Silvestri D Ortillo N Uchida J Tisdale C Camaschella TA Rouault 2010 Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts J Clin Invest 120 1749 1761 20364084 10.1172/JCI40372 1:CAS:528:DC%2BC3cXlslSiurw%3D