Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease

Journal of Neuroscience

Volumn 21, Issue 24, 2001, Pages 9519-9528

  Viswanath, Veena ^b   Wu, Yongqin ^a   Boonplueang, Rapee ^a,b   Chen, Sylvia ^a   Stevenson, Fang Feng ^a   Yantiri, Ferda ^b   Yang, Lichuan ^c   Flint Beal, M ^c   Andersen, Julie K ^a,b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c Medical College ^*  (United States)

Author keywords

Caspases; Mesencephalic cultures; MPTP; Parkinson's disease; PC12; Substantia nigra

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CASPASE 8; CASPASE 9; CASPASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0035894881     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-24-09519.2001     Document Type: Article

References (62)

1. Does neuronal loss in Parkinson's disease involve programmed cell death?
2. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
3. Homocysteic acid striatal lesions in rats spare somatostatin-neuropeptide Y neurons
4. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
5. Inhibition of ICE family proteases by baculovirus anti-apoptotic protein p35
6. Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: Protective role of Bcl-2
7. Targeted disruption of caspase genes in mice: What they tell us about the functions of individual caspases in apoptosis
8. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
9. P53- and CD95-associated apoptosis in neurodegenerative diseases
10. Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinium-induced toxicity of cultured fetal rat mesencephalic dopamine neurons
11. Crystal structure of baculovirus p35: Role of a novel reactive site loop in apoptotic caspase inhibition
12. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
13. The role of apoptosis in neurodegenerative disease
14. Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease
15. CD95 (APO-1/Fas) and Parkinson's disease
16. Caspase 3: A vulnerability factor and final effector in apoptotic cell death of dopaminergic neurons in Parkinson's disease
17. Caspase 8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis
18. Increase in Bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of mice
19. Expression of baculovirus P35 prevents cell death in Drosophila
20. Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination
21. Clinicopathological aspects of Parkinson's disease
22. Blocked negative selection of developing T-cells in mice expressing the baculovirus p35 caspase inhibitor
23. Cell death mechanisms in Parkinson's disease
24. Caspase-3-dependent cleavage of Bcl-2 promotes release of cyt c
25. Huntington aggregates may not predict neuronal death in Huntington's disease
26. Decreased apoptosis in the brain and premature lethality in CPP-32 deficient mice
27. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
28. Mechanisms mediating caspase activation in cell death
29. Apoptosis induction by caspase 8 is amplified through the mitochondrial release of cytochrome c
30. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
31. Cytochrome c and dATP-dependent formation of apaf-1/caspase 9 complex initiates an apoptotic protease cascade
32. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
33. Neuropharmacological aspects of apoptosis: Significance for neurodegenerative diseases
34. Mitochondrial dysfunction in Parkinson's disease
35. Histochemical detection of apoptosis in Parkinson's disease
36. Caspases: The proteases of the apoptotic pathway
37. Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
38. Etiology and pathogenesis of Parkinson's disease
39. Mechanisms of MPTP toxicity
40. Caspases: Intracellular signaling by proteolysis
41. Caspase 8 is required for cell death induced by expanding polyglutamine repeats
42. Mitochondria in the etiology and pathogenesis of Parkinson's disease
43. Ion channel activity of the BH3 only Bcl-2 family member, BID
44. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8 and -10 in a caspase-9-dependent manner
45. Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death
46. Caspases - Controlling intracellular signals by protease zymogen activation
47. Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans
48. Caspase 8 activation and BID cleavage contribute to MCF7 cellular execution in a caspase 3-dependent manner during staurosporin-mediated apoptosis
49. In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyri-dine-treated mice using terminal deoxynucleotidyl transferase labeling and acridine orange staining
50. A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease
51. Caspases: Enemies within
52. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
53. Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat
54. Transgenic mice neuronally expressing baculoviral p35 are resistant to diverse types of induced apoptosis including seizure-associated neurodegeneration
55. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction
56. Caspases and neurodegeneration: On the cutting edge of new therapeutic approaches
57. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
58. Suicidal tendencies: Apoptotic cell death by caspase family proteinases
59. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2
60. Caspase knockouts: Matters of life and death
61. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex
62. Modulation of control mechanisms of dopamine-induced apoptosis - A future approach to the treatment of Parkinson's disease?