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Volumn 41, Issue 12, 2009, Pages 1303-1307

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(22)  Satake, Wataru a,b   Nakabayashi, Yuko a,b   Mizuta, Ikuko a,b   Hirota, Yushi a,b   Ito, Chiyomi a,b   Kubo, Michiaki c   Kawaguchi, Takahisa c   Tsunoda, Tatsuhiko c   Watanabe, Masahiko d   Takeda, Atsushi e   Tomiyama, Hiroyuki f   Nakashima, Kenji g   Hasegawa, Kazuko h   Obata, Fumiya i   Yoshikawa, Takeo j   Kawakami, Hideshi k   Sakoda, Saburo b   Yamamoto, Mitsutoshi b   Hattori, Nobutaka f   Murata, Miho l   more..

c RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE RICH REPEAT KINASE 2;

EID: 70549084415     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.485     Document Type: Article
Times cited : (1107)

References (42)
  • 1
    • 0031013848 scopus 로고    scopus 로고
    • Prevalence of parkinsonism and Parkinson's disease in Europe: The EUROPARKINSON collaborative study
    • de Rijk, M.C. et al. Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON collaborative study. J. Neurol. Neurosurg. Psychiatry 62, 10-15 (1997).
    • (1997) J. Neurol. Neurosurg. Psychiatry , vol.62 , pp. 10-15
    • De Rijk, M.C.1
  • 2
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identifed in families with Parkinson's disease
    • Polymeropoulos, M.H. et al. Mutation in the α-synuclein gene identifed in families with Parkinson's disease. Science 276, 2045-2047 (1997).
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 3
    • 8844266996 scopus 로고    scopus 로고
    • Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
    • Paisán-Ruíz, C. et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595-600 (2004).
    • (2004) Neuron , vol.44 , pp. 595-600
    • Paisán-Ruíz, C.1
  • 4
    • 8844233579 scopus 로고    scopus 로고
    • Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
    • Zimprich, A. et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601-607 (2004).
    • (2004) Neuron , vol.44 , pp. 601-607
    • Zimprich, A.1
  • 5
    • 33645116252 scopus 로고    scopus 로고
    • Genetics of Parkinson disease: Paradigm shifts and future prospects
    • Farrer, M.J. Genetics of Parkinson disease: paradigm shifts and future prospects. Nat. Rev. Genet. 7, 306-318 (2006).
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 306-318
    • Farrer, M.J.1
  • 6
    • 37349004102 scopus 로고    scopus 로고
    • Parkinson's diseases
    • spec No. 2
    • Thomas, B. & Beal, M.F. Parkinson's disease. Hum. Mol. Genet. 16 spec No. 2, R183-R194 (2007).
    • (2007) Hum. Mol. Genet.V , vol.16
    • Thomas, B.1    Beal, M.F.2
  • 7
    • 0037379324 scopus 로고    scopus 로고
    • Genetic and environmental factors in the cause of Parkinson's disease
    • Warner, T.T. & Schapira, A.H. Genetic and environmental factors in the cause of Parkinson's disease. Ann. Neurol. 53(Suppl 3), S16-S23 (2003).
    • (2003) Ann. Neurol. , vol.53 , Issue.SUPPL 3
    • Warner, T.T.1    Schapira, A.H.2
  • 8
    • 4844222408 scopus 로고    scopus 로고
    • α-Synuclein promoter confers susceptibility to Parkinson's disease
    • Pals, P. et al. α-Synuclein promoter confers susceptibility to Parkinson's disease. Ann. Neurol. 56, 591-595 (2004).
    • (2004) Ann. Neurol. , vol.56 , pp. 591-595
    • Pals, P.1
  • 9
    • 33645111633 scopus 로고    scopus 로고
    • Multiple candidate gene analysis identifes α-synuclein as a susceptibility gene for sporadic Parkinson's disease
    • Mizuta, I. et al. Multiple candidate gene analysis identifes α-synuclein as a susceptibility gene for sporadic Parkinson's disease. Hum. Mol. Genet. 15, 1151-1158 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1151-1158
    • Mizuta, I.1
  • 10
    • 20144387092 scopus 로고    scopus 로고
    • Multiple regions of α-synuclein are associated with Parkinson's disease
    • Müller, J.C. et al. Multiple regions of α-synuclein are associated with Parkinson's disease. Ann. Neurol. 57, 535-541 (2005).
    • (2005) Ann. Neurol. , vol.57 , pp. 535-541
    • Müller, J.C.1
  • 11
    • 7444237665 scopus 로고    scopus 로고
    • Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews
    • Aharon-Peretz, J., Rosenbaum, H. & Gershoni-Baruch, R. Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews. N. Engl. J. Med. 351, 1972-1977 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1972-1977
    • Aharon-Peretz, J.1    Rosenbaum, H.2    Gershoni-Baruch, R.3
  • 12
    • 27244451809 scopus 로고    scopus 로고
    • High-resolution whole-genome association study of Parkinson disease
    • Maraganore, D.M. et al. High-resolution whole-genome association study of Parkinson disease. Am. J. Hum. Genet. 77, 685-693 (2005).
    • (2005) Am. J. Hum. Genet. , vol.77 , pp. 685-693
    • Maraganore, D.M.1
  • 13
    • 33749667345 scopus 로고    scopus 로고
    • Genome-wide genotyping in Parkinson's disease and neurologically normal controls: Frst stage analysis and public release of data
    • Fung, H.C. et al. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: frst stage analysis and public release of data. Lancet Neurol. 5, 911-916 (2006).
    • (2006) Lancet Neurol. , vol.5 , pp. 911-916
    • Fung, H.C.1
  • 14
    • 58149100151 scopus 로고    scopus 로고
    • Genomewide association study for susceptibility genes contributing to familial Parkinson disease
    • Pankratz, N. et al. Genomewide association study for susceptibility genes contributing to familial Parkinson disease. Hum. Genet. 124, 593-605 (2009).
    • (2009) Hum. Genet. , vol.124 , pp. 593-605
    • Pankratz, N.1
  • 15
    • 84969213492 scopus 로고    scopus 로고
    • Welcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Welcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
    • (2007) Nature , vol.447 , pp. 661-678
  • 16
    • 18444369013 scopus 로고    scopus 로고
    • The structure of haplotype blocks in the human genome
    • Gabriel, S.B. et al. The structure of haplotype blocks in the human genome. Science 296, 2225-2229 (2002).
    • (2002) Science , vol.296 , pp. 2225-2229
    • Gabriel, S.B.1
  • 17
    • 70549088602 scopus 로고    scopus 로고
    • Genome-wide association study reveals genetic risk underlying Parkinson's disease
    • advance online publication, doi:10.1038/ng.487 15 November
    • Simón-Sánchez, J. et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. advance online publication, doi:10.1038/ng.487 (15 November 2009).
    • (2009) Nat. Genet
    • Simón-Sánchez, J.1
  • 18
    • 47049100471 scopus 로고    scopus 로고
    • 2+ carrier
    • Kolisek, M. et al. SLC41A1 is a novel mammalian Mg2+ carrier. J. Biol. Chem. 283, 16235-16247 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 16235-16247
    • Kolisek, M.1
  • 19
    • 0021926745 scopus 로고
    • Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam
    • Garruto, R.M. et al. Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. Neurology 35, 193-198 (1985).
    • (1985) Neurology , vol.35 , pp. 193-198
    • Garruto, R.M.1
  • 20
    • 0030755246 scopus 로고    scopus 로고
    • Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily
    • Shimizu, F. et al. Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily. Cytogenet. Cell Genet. 77, 261-263 (1997).
    • (1997) Cytogenet. Cell Genet. , vol.77 , pp. 261-263
    • Shimizu, F.1
  • 21
    • 0035006828 scopus 로고    scopus 로고
    • Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo
    • Ostvold, A.C. et al. Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo. Eur. J. Biochem. 268, 2430-2440 (2001).
    • (2001) Eur. J. Biochem. , vol.268 , pp. 2430-2440
    • Ostvold, A.C.1
  • 22
    • 34548805282 scopus 로고    scopus 로고
    • A genome-wide association study of global gene expression
    • Dixon, A.L. et al. A genome-wide association study of global gene expression. Nat. Genet. 39, 1202-1207 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 1202-1207
    • Dixon, A.L.1
  • 23
    • 0036300516 scopus 로고    scopus 로고
    • Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities
    • Yamamoto-Katayama, S. et al. Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. J. Mol. Biol. 316, 711-723 (2002).
    • (2002) J. Mol. Biol. , vol.316 , pp. 711-723
    • Yamamoto-Katayama, S.1
  • 24
    • 0035033022 scopus 로고    scopus 로고
    • Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
    • Lee, H.C. et al. Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annu. Rev. Pharmacol. Toxicol. 41, 317-345 (2001).
    • (2001) Annu. Rev. Pharmacol. Toxicol. , vol.41 , pp. 317-345
    • Lee, H.C.1
  • 25
    • 0034118103 scopus 로고    scopus 로고
    • Coupled oscillator model of the dopaminergic neuron of the substantia nigra
    • Wilson, C.J. & Callaway, J.C. Coupled oscillator model of the dopaminergic neuron of the substantia nigra. J. Neurophysiol. 83, 3084-3100 (2000).
    • (2000) J. Neurophysiol. , vol.83 , pp. 3084-3100
    • Wilson, C.J.1    Callaway, J.C.2
  • 26
    • 34347359673 scopus 로고    scopus 로고
    • Rejuvenation' protects neurons in mouse models of Parkinson's disease
    • Chan, C.S. et al. 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature 447, 1081-1086 (2007).
    • (2007) Nature , vol.447 , pp. 1081-1086
    • Chan, C.S.1
  • 27
    • 34548657565 scopus 로고    scopus 로고
    • Calcium, ageing, and neuronal vulnerability in Parkinson's disease
    • Surmeier, D.J. Calcium, ageing, and neuronal vulnerability in Parkinson's disease. Lancet Neurol. 6, 933-938 (2007).
    • (2007) Lancet Neurol. , vol.6 , pp. 933-938
    • Surmeier, D.J.1
  • 28
    • 0242300619 scopus 로고    scopus 로고
    • α-Synuclein locus triplication causes Parkinson's disease
    • Singleton, A.B. et al. α-Synuclein locus triplication causes Parkinson's disease. Science 302, 841 (2003).
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1
  • 29
    • 0035881509 scopus 로고    scopus 로고
    • Identifcation of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain
    • Uldry, M. et al. Identifcation of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. EMBO J. 20, 4467-4477 (2001).
    • (2001) EMBO J. , vol.20 , pp. 4467-4477
    • Uldry, M.1
  • 30
    • 28744453588 scopus 로고    scopus 로고
    • Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease
    • Skipper, L. et al. Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease. Hum. Mol. Genet. 14, 3549-3556 (2005).
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 3549-3556
    • Skipper, L.1
  • 31
    • 28544447258 scopus 로고    scopus 로고
    • Common variants of LRRK2 are not associated with sporadic Parkinson's disease
    • Biskup, S. et al. Common variants of LRRK2 are not associated with sporadic Parkinson's disease. Ann. Neurol. 58, 905-908 (2005).
    • (2005) Ann. Neurol. , vol.58 , pp. 905-908
    • Biskup, S.1
  • 32
    • 33748993710 scopus 로고    scopus 로고
    • Kinase activity of mutant LRRK2 mediates neuronal toxicity
    • Smith, W.W. et al. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat. Neurosci. 9, 1231-1233 (2006).
    • (2006) Nat. Neurosci. , vol.9 , pp. 1231-1233
    • Smith, W.W.1
  • 33
    • 28044460070 scopus 로고    scopus 로고
    • Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
    • West, A.B. et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc. Natl. Acad. Sci. USA 102, 16842-16847 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 16842-16847
    • West, A.B.1
  • 34
    • 19944432921 scopus 로고    scopus 로고
    • A common LRRK2 mutation in idiopathic Parkinson's disease
    • Gilks, W.P. et al. A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet 365, 415-416 (2005).
    • (2005) Lancet , vol.365 , pp. 415-416
    • Gilks, W.P.1
  • 35
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
    • Hutton, M. et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393, 702-705 (1998).
    • (1998) Nature , vol.393 , pp. 702-705
    • Hutton, M.1
  • 36
    • 24644502474 scopus 로고    scopus 로고
    • Linkage disequilibrium fne mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration
    • Pittman, A.M. et al. Linkage disequilibrium fne mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J. Med. Genet. 42, 837-846 (2005).
    • (2005) J. Med. Genet. , vol.42 , pp. 837-846
    • Pittman, A.M.1
  • 37
    • 55949134996 scopus 로고    scopus 로고
    • Role of the tau gene region chromosome inversion in progressive supranuclear palsy, corticobasal degeneration, and related disorders
    • Webb, A. et al. Role of the tau gene region chromosome inversion in progressive supranuclear palsy, corticobasal degeneration, and related disorders. Arch. Neurol. 65, 1473-1478 (2008).
    • (2008) Arch. Neurol. , vol.65 , pp. 1473-1478
    • Webb, A.1
  • 38
    • 3042797560 scopus 로고    scopus 로고
    • Tau gene and Parkinson's disease: A case-control study and meta-analysis
    • Healy, D.G. et al. Tau gene and Parkinson's disease: a case-control study and meta-analysis. J. Neurol. Neurosurg. Psychiatry 75, 962-965 (2004).
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , pp. 962-965
    • Healy, D.G.1
  • 39
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1
  • 40
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International HapMap Consortium.
    • International HapMap Consortium. A haplotype map of the human genome. Nature 437, 1299-1320 (2005).
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 41
    • 31744435871 scopus 로고    scopus 로고
    • Joint analysis is more effcient than replication-based analysis for two-stage genome-wide association studies
    • Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more effcient than replication-based analysis for two-stage genome-wide association studies. Nat. Genet. 38, 209-213 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 209-213
    • Skol, A.D.1    Scott, L.J.2    Abecasis, G.R.3    Boehnke, M.4
  • 42
    • 13444269543 scopus 로고    scopus 로고
    • Analysis and visualization of LD and haplotype maps
    • Barrett, J.C., Fry, B., Maller, J. & Daly, M. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Haploview, D.M.4


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