Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells

Journal of Neurochemistry

Volumn 128, Issue 6, 2014, Pages 950-961

  Crabtree, Donna ^a   Dodson, Matthew ^a,b   Ouyang, Xiaosen ^a,b,c   Boyer Guittaut, Michaël ^a,b,d   Liang, Qiuli ^a,b,c   Ballestas, Mary E ^e   Fineberg, Naomi ^f   Zhang, Jianhua ^a,b,c  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

^d UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^e University of Alabama at Birmingham   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

autophagy; cathepsin D; lysosome; synuclein

Indexed keywords

ALPHA SYNUCLEIN; CASPASE; CATHEPSIN B; CATHEPSIN D; CHYMOTRYPSIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PEPSTATIN;

ARTICLE; AUTOPHAGY; CELL ACTIVITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; FLOW CYTOMETRY; IN VIVO STUDY; LYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS;

AUTOPHAGY; CATHEPSIN D; LYSOSOME; Α-SYNUCLEIN;

ALPHA-SYNUCLEIN; AUTOPHAGY; CASPASES; CATHEPSIN B; CATHEPSIN D; CELL LINE, TUMOR; GENE EXPRESSION; HUMANS; LENTIVIRUS; LYSOSOMES; NEUROBLASTOMA; NEURODEGENERATIVE DISEASES; NEURONS; PEPSTATINS; PROTEASE INHIBITORS;

EID: 84895920556     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12497     Document Type: Article

References (33)

1. Alvarez-Erviti L., Rodriguez-Oroz M. C., Cooper J. M., Caballero C., Ferrer I., Obeso J. A., and, Schapira A. H., (2010) Chaperone-mediated autophagy markers in Parkinson disease brains. Arch. Neurol. 67, 1464-1472.
2. Anglade P., Vyas S., Javoy-Agid F., Herrero M. T., Michel P. P., Marquez J., Mouatt-Prigent A., Ruberg M., Hirsch E. C., and, Agid Y., (1997) Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol. 12, 25-31.
3. Barrett A. J., Kembhavi A. A., Brown M. A., Kirschke H., Knight C. G., Tamai M., and, Hanada K., (1982) L-trans-Epoxysuccinyl-leucylamido(4-guanidino) butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201, 189-198.
4. Chartier-Harlin M. C., Kachergus J., Roumier C., et al,. (2004) Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364, 1167-1169.
5. Crews L., Spencer B., Desplats P., Patrick C., Paulino A., Rockenstein E., Hansen L., Adame A., Galasko D., and, Masliah E., (2010) Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One 5, e9313.
6. Cuervo A. M., Stefanis L., Fredenburg R., Lansbury P. T., and, Sulzer D., (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305, 1292-1295.
7. Cullen V., Lindfors M., Ng J., et al,. (2009) Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Mol. Brain 2, 5.
8. Dehay B., Bove J., Rodriguez-Muela N., Perier C., Recasens A., Boya P., and, Vila M., (2010) Pathogenic lysosomal depletion in Parkinson's disease. J. Neurosci. 30, 12535-12544.
9. Dodson M., Darley-Usmar V., and, Zhang J., (2013) Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling. Free Radic. Biol. Med. 63, 207-221.
10. Eskelinen E. L., (2006) Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol. Aspects Med. 27, 495-502.
11. Geisler S., Holmstrom K. M., Treis A., Skujat D., Weber S. S., Fiesel F. C., Kahle P. J., and, Springer W., (2010) The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy 6, 871-878.
12. Glondu M., Coopman P., Laurent-Matha V., Garcia M., Rochefort H., and, Liaudet-Coopman E., (2001) A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells. Oncogene 20, 6920-6929.
13. Ibanez P., Bonnet A. M., Debarges B., Lohmann E., Tison F., Pollak P., Agid Y., Durr A., and, Brice A., (2004) Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 364, 1169-1171.
14. Iwata A., Maruyama M., Akagi T., Hashikawa T., Kanazawa I., Tsuji S., and, Nukina N., (2003) Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Hum. Mol. Genet. 12, 2625-2635.
15. Koike M., Nakanishi H., Saftig P., et al,. (2000) Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J. Neurosci. 20, 6898-6906.
16. Lamark T., and, Johansen T., (2010) Autophagy: links with the proteasome. Curr. Opin. Cell Biol. 22, 192-198.
17. Lee J., Giordano S., and, Zhang J., (2012) Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem. J. 441, 523-540.
18. Mak S. K., McCormack A. L., Manning-Bog A. B., Cuervo A. M., and, Di Monte D. A., (2010) Lysosomal degradation of alpha-synuclein in vivo. J. Biol. Chem. 285, 13621-13629.
19. Martin I., Dawson V. L., and, Dawson T. M., (2011) Recent advances in the genetics of Parkinson's disease. Annu. Rev. Genomics Hum. Genet. 12, 301-325.
20. Mishizen-Eberz A. J., Guttmann R. P., Giasson B. I., Day G. A., III, Hodara R., Ischiropoulos H., Lee V. M., Trojanowski J. Q., and, Lynch D. R., (2003) Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. J. Neurochem. 86, 836-847.
21. Partanen S., Storch S., Loffler H. G., Hasilik A., Tyynela J., and, Braulke T., (2003) A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells. Biochem. J. 369, 55-62.
22. Qiao L., and, Zhang J., (2009) Inhibition of lysosomal functions reduces proteasomal activity. Neurosci. Lett. 456, 15-19.
23. Qiao L., Hamamichi S., Caldwell K. A., et al,. (2008) Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol. Brain 1, 17.
24. Schneider L., and, Zhang J., (2010) Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease. Mol. Neurodegener. 5, 14.
25. Singleton A. B., Farrer M., Johnson J., et al,. (2003) alpha-Synuclein locus triplication causes Parkinson's disease. Science 302, 841.
26. Tyynela J., Sohar I., Sleat D. E., Gin R. M., Donnelly R. J., Baumann M., Haltia M., and, Lobel P., (2000) A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration. EMBO J. 19, 2786-2792.
27. Vekrellis K., and, Stefanis L., (2012) Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies. Expert. Opin. Ther. Targets. 16, 421-432.
28. Vogiatzi T., Xilouri M., Vekrellis K., and, Stefanis L., (2008) Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem. 283, 23542-23556.
29. Webb J. L., Ravikumar B., Atkins J., Skepper J. N., and, Rubinsztein D. C., (2003) Alpha-Synuclein is degraded by both autophagy and the proteasome. J. Biol. Chem. 278, 25009-25013.
30. Winslow A. R., Chen C. W., Corrochano S., et al,. (2010) alpha-Synuclein impairs macroautophagy: implications for Parkinson's disease. J. Cell Biol. 190, 1023-1037.
31. Yamamoto A., Tagawa Y., Yoshimori T., Moriyama Y., Masaki R., and, Tashiro Y., (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct. Funct. 23, 33-42.
32. Yang Z., and, Klionsky D. J., (2010) Eaten alive: a history of macroautophagy. Nat. Cell Biol. 12, 814-822.
33. Zhang J., (2013) Autophagy and mitophagy in cellular damage control. Redox Biol. 1, 19-23.