-
1
-
-
0034643838
-
Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group
-
de Rijk MC, Launer LJ, Berger K, Breteler MM, Dartigues JF, et al. (2000) Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54: S21-23.
-
(2000)
Neurology
, vol.54
-
-
de Rijk, M.C.1
Launer, L.J.2
Berger, K.3
Breteler, M.M.4
Dartigues, J.F.5
-
2
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, et al. (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24: 197-211.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rub, U.3
de Vos, R.A.4
Jansen Steur, E.N.5
-
3
-
-
27344438938
-
Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
-
Croisier E, Moran LB, Dexter DT, Pearce RK, Graeber MB, (2005) Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. J Neuroinflammation 2: 14.
-
(2005)
J Neuroinflammation
, vol.2
, pp. 14
-
-
Croisier, E.1
Moran, L.B.2
Dexter, D.T.3
Pearce, R.K.4
Graeber, M.B.5
-
4
-
-
0032568534
-
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
-
Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M, (1998) alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A 95: 6469-6473.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
5
-
-
23344453013
-
Genetics of Parkinson's disease
-
Gasser T, (2005) Genetics of Parkinson's disease. Curr Opin Neurol 18: 363-369.
-
(2005)
Curr Opin Neurol
, vol.18
, pp. 363-369
-
-
Gasser, T.1
-
6
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, et al. (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18: 106-108.
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
-
7
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
-
8
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, et al. (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55: 164-173.
-
(2004)
Ann Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
-
9
-
-
33746377894
-
Protein misfolding, functional amyloid, and human disease
-
Chiti F, Dobson CM, (2006) Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem 75: 333-366.
-
(2006)
Annu Rev Biochem
, vol.75
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
10
-
-
0034674376
-
Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects
-
Borghi R, Marchese R, Negro A, Marinelli L, Forloni G, et al. (2000) Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects. Neurosci Lett 287: 65-67.
-
(2000)
Neurosci Lett
, vol.287
, pp. 65-67
-
-
Borghi, R.1
Marchese, R.2
Negro, A.3
Marinelli, L.4
Forloni, G.5
-
11
-
-
85109083933
-
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
-
El-Agnaf OM, Salem SA, Paleologou KE, Cooper LJ, Fullwood NJ, et al. (2003) Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J 17: 1945-1947.
-
(2003)
FASEB J
, vol.17
, pp. 1945-1947
-
-
El-Agnaf, O.M.1
Salem, S.A.2
Paleologou, K.E.3
Cooper, L.J.4
Fullwood, N.J.5
-
12
-
-
33645833848
-
Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
-
El-Agnaf OM, Salem SA, Paleologou KE, Curran MD, Gibson MJ, et al. (2006) Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J 20: 419-425.
-
(2006)
FASEB J
, vol.20
, pp. 419-425
-
-
El-Agnaf, O.M.1
Salem, S.A.2
Paleologou, K.E.3
Curran, M.D.4
Gibson, M.J.5
-
13
-
-
33748325848
-
Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease
-
Tokuda T, Salem SA, Allsop D, Mizuno T, Nakagawa M, et al. (2006) Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. Biochem Biophys Res Commun 349: 162-166.
-
(2006)
Biochem Biophys Res Commun
, vol.349
, pp. 162-166
-
-
Tokuda, T.1
Salem, S.A.2
Allsop, D.3
Mizuno, T.4
Nakagawa, M.5
-
14
-
-
33748932543
-
The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy
-
Lee PH, Lee G, Park HJ, Bang OY, Joo IS, et al. (2006) The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy. J Neural Transm 113: 1435-1439.
-
(2006)
J Neural Transm
, vol.113
, pp. 1435-1439
-
-
Lee, P.H.1
Lee, G.2
Park, H.J.3
Bang, O.Y.4
Joo, I.S.5
-
15
-
-
40749094842
-
Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease
-
Lee SJ, (2008) Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease. J Mol Neurosci 34: 17-22.
-
(2008)
J Mol Neurosci
, vol.34
, pp. 17-22
-
-
Lee, S.J.1
-
16
-
-
84858677969
-
alpha-Synuclein Alters Toll-Like Receptor Expression
-
Beraud D, Twomey M, Bloom B, Mittereder A, Ton V, et al. (2011) alpha-Synuclein Alters Toll-Like Receptor Expression. Front Neurosci 5: 80.
-
(2011)
Front Neurosci
, vol.5
, pp. 80
-
-
Beraud, D.1
Twomey, M.2
Bloom, B.3
Mittereder, A.4
Ton, V.5
-
17
-
-
55249087467
-
Immunological features of alpha-synuclein in Parkinson's disease
-
Roodveldt C, Christodoulou J, Dobson CM, (2008) Immunological features of alpha-synuclein in Parkinson's disease. J Cell Mol Med 12: 1820-1829.
-
(2008)
J Cell Mol Med
, vol.12
, pp. 1820-1829
-
-
Roodveldt, C.1
Christodoulou, J.2
Dobson, C.M.3
-
18
-
-
20144389524
-
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
-
Zhang W, Wang T, Pei Z, Miller DS, Wu X, et al. (2005) Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 19: 533-542.
-
(2005)
FASEB J
, vol.19
, pp. 533-542
-
-
Zhang, W.1
Wang, T.2
Pei, Z.3
Miller, D.S.4
Wu, X.5
-
19
-
-
43449090378
-
Nitrated alpha-synuclein and microglial neuroregulatory activities
-
Reynolds AD, Kadiu I, Garg SK, Glanzer JG, Nordgren T, et al. (2008) Nitrated alpha-synuclein and microglial neuroregulatory activities. J Neuroimmune Pharmacol 3: 59-74.
-
(2008)
J Neuroimmune Pharmacol
, vol.3
, pp. 59-74
-
-
Reynolds, A.D.1
Kadiu, I.2
Garg, S.K.3
Glanzer, J.G.4
Nordgren, T.5
-
20
-
-
77956194977
-
Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1
-
Lee EJ, Woo MS, Moon PG, Baek MC, Choi IY, et al. (2010) Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1. J Immunol 185: 615-623.
-
(2010)
J Immunol
, vol.185
, pp. 615-623
-
-
Lee, E.J.1
Woo, M.S.2
Moon, P.G.3
Baek, M.C.4
Choi, I.Y.5
-
21
-
-
79951811787
-
alpha-Synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: the effect of therapeutic hypothermia
-
Su E, Bell MJ, Wisniewski SR, Adelson PD, Janesko-Feldman KL,et al. alpha-Synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: the effect of therapeutic hypothermia. Dev Neurosci 32: 385-395.
-
Dev Neurosci
, vol.32
, pp. 385-395
-
-
Su, E.1
Bell, M.J.2
Wisniewski, S.R.3
Adelson, P.D.4
Janesko-Feldman, K.L.5
-
22
-
-
70349917814
-
Mutant alpha-synuclein overexpression mediates early proinflammatory activity
-
Su X, Federoff HJ, Maguire-Zeiss KA, (2009) Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox Res 16: 238-254.
-
(2009)
Neurotox Res
, vol.16
, pp. 238-254
-
-
Su, X.1
Federoff, H.J.2
Maguire-Zeiss, K.A.3
-
23
-
-
58149380755
-
Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease
-
Theodore S, Cao S, McLean PJ, Standaert DG, (2008) Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease. J Neuropathol Exp Neurol 67: 1149-1158.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 1149-1158
-
-
Theodore, S.1
Cao, S.2
McLean, P.J.3
Standaert, D.G.4
-
24
-
-
79952172294
-
Inflammatory mechanisms of neurodegeneration in toxin-based models of Parkinson's disease
-
Litteljohn D, Mangano E, Clarke M, Bobyn J, Moloney K, et al. (2010) Inflammatory mechanisms of neurodegeneration in toxin-based models of Parkinson's disease. Parkinsons Dis 2011: 713517.
-
(2010)
Parkinsons Dis
, vol.2011
, pp. 713517
-
-
Litteljohn, D.1
Mangano, E.2
Clarke, M.3
Bobyn, J.4
Moloney, K.5
-
25
-
-
33748973074
-
Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra
-
Ferrari CC, Pott Godoy MC, Tarelli R, Chertoff M, Depino AM, et al. (2006) Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiol Dis 24: 183-193.
-
(2006)
Neurobiol Dis
, vol.24
, pp. 183-193
-
-
Ferrari, C.C.1
Pott Godoy, M.C.2
Tarelli, R.3
Chertoff, M.4
Depino, A.M.5
-
26
-
-
84858652204
-
Misfolded alpha-synuclein and Toll-like receptors: therapeutic targets for Parkinson's disease
-
Beraud D, Maguire-Zeiss KA, (2012) Misfolded alpha-synuclein and Toll-like receptors: therapeutic targets for Parkinson's disease. Parkinsonism Relat Disord 18 (Suppl 1):: S17-20.
-
(2012)
Parkinsonism Relat Disord
, vol.18
, Issue.SUPPL. 1
-
-
Beraud, D.1
Maguire-Zeiss, K.A.2
-
27
-
-
77749304035
-
IL-1: discoveries, controversies and future directions
-
Dinarello CA, (2010) IL-1: discoveries, controversies and future directions. Eur J Immunol 40: 599-606.
-
(2010)
Eur J Immunol
, vol.40
, pp. 599-606
-
-
Dinarello, C.A.1
-
28
-
-
0026517239
-
Molecular cloning of the interleukin-1 beta converting enzyme
-
Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, et al. (1992) Molecular cloning of the interleukin-1 beta converting enzyme. Science 256: 97-100.
-
(1992)
Science
, vol.256
, pp. 97-100
-
-
Cerretti, D.P.1
Kozlosky, C.J.2
Mosley, B.3
Nelson, N.4
Van Ness, K.5
-
29
-
-
39749084641
-
Active caspase-1 is a regulator of unconventional protein secretion
-
Keller M, Ruegg A, Werner S, Beer HD, (2008) Active caspase-1 is a regulator of unconventional protein secretion. Cell 132: 818-831.
-
(2008)
Cell
, vol.132
, pp. 818-831
-
-
Keller, M.1
Ruegg, A.2
Werner, S.3
Beer, H.D.4
-
30
-
-
0036671894
-
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
-
Martinon F, Burns K, Tschopp J, (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10: 417-426.
-
(2002)
Mol Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
31
-
-
84855989829
-
Inflammasomes in health and disease
-
Strowig T, Henao-Mejia J, Elinav E, Flavell R, (2012) Inflammasomes in health and disease. Nature 481: 278-286.
-
(2012)
Nature
, vol.481
, pp. 278-286
-
-
Strowig, T.1
Henao-Mejia, J.2
Elinav, E.3
Flavell, R.4
-
32
-
-
77950362382
-
The inflammasomes
-
Schroder K, Tschopp J, (2010) The inflammasomes. Cell 140: 821-832.
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
33
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-232.
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
McBride, J.4
O'Rourke, K.5
-
34
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, et al. (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320: 674-677.
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
Petrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
-
35
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J, (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241.
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
36
-
-
84870705290
-
NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1beta and neuronal toxicity
-
Hafner-Bratkovic I, Bencina M, Fitzgerald KA, Golenbock D, Jerala R (2012) NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1beta and neuronal toxicity. Cell Mol Life Sci.
-
(2012)
Cell Mol Life Sci
-
-
Hafner-Bratkovic, I.1
Bencina, M.2
Fitzgerald, K.A.3
Golenbock, D.4
Jerala, R.5
-
37
-
-
34548027736
-
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
-
Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, et al. (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14: 1583-1589.
-
(2007)
Cell Death Differ
, vol.14
, pp. 1583-1589
-
-
Petrilli, V.1
Papin, S.2
Dostert, C.3
Mayor, A.4
Martinon, F.5
-
38
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, et al. (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9: 847-856.
-
(2008)
Nat Immunol
, vol.9
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
-
39
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J, (2010) Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 11: 136-140.
-
(2010)
Nat Immunol
, vol.11
, pp. 136-140
-
-
Zhou, R.1
Tardivel, A.2
Thorens, B.3
Choi, I.4
Tschopp, J.5
-
40
-
-
0037438154
-
Expression of recombinant proteins in a lipid A mutant of Escherichia coli BL21 with a strongly reduced capacity to induce dendritic cell activation and maturation
-
Cognet I, de Coignac AB, Magistrelli G, Jeannin P, Aubry JP, et al. (2003) Expression of recombinant proteins in a lipid A mutant of Escherichia coli BL21 with a strongly reduced capacity to induce dendritic cell activation and maturation. J Immunol Methods 272: 199-210.
-
(2003)
J Immunol Methods
, vol.272
, pp. 199-210
-
-
Cognet, I.1
de Coignac, A.B.2
Magistrelli, G.3
Jeannin, P.4
Aubry, J.P.5
-
41
-
-
20444412385
-
A new method for purification of recombinant human alpha-synuclein in Escherichia coli
-
Huang C, Ren G, Zhou H, Wang CC, (2005) A new method for purification of recombinant human alpha-synuclein in Escherichia coli. Protein Expr Purif 42: 173-177.
-
(2005)
Protein Expr Purif
, vol.42
, pp. 173-177
-
-
Huang, C.1
Ren, G.2
Zhou, H.3
Wang, C.C.4
-
42
-
-
34147151003
-
Translocation of alpha-synuclein expressed in Escherichia coli
-
Ren G, Wang X, Hao S, Hu H, Wang CC, (2007) Translocation of alpha-synuclein expressed in Escherichia coli. J Bacteriol 189: 2777-2786.
-
(2007)
J Bacteriol
, vol.189
, pp. 2777-2786
-
-
Ren, G.1
Wang, X.2
Hao, S.3
Hu, H.4
Wang, C.C.5
-
43
-
-
33646157959
-
A statistical-mechanical theory of fibril formation in dilute protein solutions
-
van Gestel J, de Leeuw SW, (2006) A statistical-mechanical theory of fibril formation in dilute protein solutions. Biophys J 90: 3134-3145.
-
(2006)
Biophys J
, vol.90
, pp. 3134-3145
-
-
van Gestel, J.1
de Leeuw, S.W.2
-
44
-
-
58149277410
-
Concentration dependence of alpha-synuclein fibril length assessed by quantitative atomic force microscopy and statistical-mechanical theory
-
van Raaij ME, van Gestel J, Segers-Nolten IM, de Leeuw SW, Subramaniam V, (2008) Concentration dependence of alpha-synuclein fibril length assessed by quantitative atomic force microscopy and statistical-mechanical theory. Biophys J 95: 4871-4878.
-
(2008)
Biophys J
, vol.95
, pp. 4871-4878
-
-
van Raaij, M.E.1
van Gestel, J.2
Segers-Nolten, I.M.3
de Leeuw, S.W.4
Subramaniam, V.5
-
45
-
-
0027502784
-
Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution
-
LeVine H, 3rd (1993) Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci 2: 404-410.
-
(1993)
Protein Sci
, vol.2
, pp. 404-410
-
-
LeVine 3rd, H.1
-
46
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
47
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
-
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, et al. (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9: 857-865.
-
(2008)
Nat Immunol
, vol.9
, pp. 857-865
-
-
Halle, A.1
Hornung, V.2
Petzold, G.C.3
Stewart, C.R.4
Monks, B.G.5
-
48
-
-
84856368969
-
Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation
-
Mankan AK, Kubarenko A, Hornung V, (2012) Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation. Clin Exp Immunol 167: 369-381.
-
(2012)
Clin Exp Immunol
, vol.167
, pp. 369-381
-
-
Mankan, A.K.1
Kubarenko, A.2
Hornung, V.3
-
49
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes
-
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, et al. (2010) Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat Immunol 11: 897-904.
-
(2010)
Nat Immunol
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
Dunne, A.2
Subramanian, S.L.3
Hull, R.L.4
Tannahill, G.M.5
-
50
-
-
0028364479
-
Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells
-
Palokangas H, Metsikko K, Vaananen K, (1994) Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells. J Biol Chem 269: 17577-17585.
-
(1994)
J Biol Chem
, vol.269
, pp. 17577-17585
-
-
Palokangas, H.1
Metsikko, K.2
Vaananen, K.3
-
51
-
-
77957554717
-
Molecular mechanism of NLRP3 inflammasome activation
-
Jin C, Flavell RA, (2010) Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol 30: 628-631.
-
(2010)
J Clin Immunol
, vol.30
, pp. 628-631
-
-
Jin, C.1
Flavell, R.A.2
-
52
-
-
77953105116
-
Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
-
Tassi S, Carta S, Delfino L, Caorsi R, Martini A, et al. (2010) Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion. Proc Natl Acad Sci U S A 107: 9789-9794.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 9789-9794
-
-
Tassi, S.1
Carta, S.2
Delfino, L.3
Caorsi, R.4
Martini, A.5
-
53
-
-
84873149761
-
Microglial Activation and Antioxidant Responses Induced by the Parkinson's Disease Protein alpha-Synuclein
-
Beraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA,et al. Microglial Activation and Antioxidant Responses Induced by the Parkinson's Disease Protein alpha-Synuclein. J Neuroimmune Pharmacol.
-
J Neuroimmune Pharmacol
-
-
Beraud, D.1
Hathaway, H.A.2
Trecki, J.3
Chasovskikh, S.4
Johnson, D.A.5
-
54
-
-
0032133278
-
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
-
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, et al. (1998) MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 2: 253-258.
-
(1998)
Mol Cell
, vol.2
, pp. 253-258
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Kopp, E.3
Stadlen, A.4
Chen, C.5
-
55
-
-
77956977811
-
Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease
-
Maguire-Zeiss KA, Federoff HJ, (2010) Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. J Neural Transm 117: 1019-1025.
-
(2010)
J Neural Transm
, vol.117
, pp. 1019-1025
-
-
Maguire-Zeiss, K.A.1
Federoff, H.J.2
-
56
-
-
79951948479
-
Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
-
Alvarez-Erviti L, Couch Y, Richardson J, Cooper JM, Wood MJ, (2011) Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line. Neurosci Res 69: 337-342.
-
(2011)
Neurosci Res
, vol.69
, pp. 337-342
-
-
Alvarez-Erviti, L.1
Couch, Y.2
Richardson, J.3
Cooper, J.M.4
Wood, M.J.5
-
57
-
-
0023789193
-
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
-
McGeer PL, Itagaki S, Boyes BE, McGeer EG, (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38: 1285-1291.
-
(1988)
Neurology
, vol.38
, pp. 1285-1291
-
-
McGeer, P.L.1
Itagaki, S.2
Boyes, B.E.3
McGeer, E.G.4
-
58
-
-
30744472146
-
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
-
Gerhard A, Pavese N, Hotton G, Turkheimer F, Es M, et al. (2006) In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 21: 404-412.
-
(2006)
Neurobiol Dis
, vol.21
, pp. 404-412
-
-
Gerhard, A.1
Pavese, N.2
Hotton, G.3
Turkheimer, F.4
Es, M.5
-
59
-
-
33845768784
-
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
-
Block ML, Zecca L, Hong JS, (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8: 57-69.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 57-69
-
-
Block, M.L.1
Zecca, L.2
Hong, J.S.3
-
60
-
-
34447500591
-
Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein
-
Bisaglia M, Mammi S, Bubacco L, (2007) Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein. J Biol Chem 282: 15597-15605.
-
(2007)
J Biol Chem
, vol.282
, pp. 15597-15605
-
-
Bisaglia, M.1
Mammi, S.2
Bubacco, L.3
-
61
-
-
33749258893
-
Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice
-
Djukic M, Mildner A, Schmidt H, Czesnik D, Bruck W, et al. (2006) Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice. Brain 129: 2394-2403.
-
(2006)
Brain
, vol.129
, pp. 2394-2403
-
-
Djukic, M.1
Mildner, A.2
Schmidt, H.3
Czesnik, D.4
Bruck, W.5
-
62
-
-
53349153299
-
Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis
-
Getts DR, Terry RL, Getts MT, Muller M, Rana S, et al. (2008) Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. J Exp Med 205: 2319-2337.
-
(2008)
J Exp Med
, vol.205
, pp. 2319-2337
-
-
Getts, D.R.1
Terry, R.L.2
Getts, M.T.3
Muller, M.4
Rana, S.5
-
63
-
-
77954005130
-
Endogenous ligands of TLR2 and TLR4: agonists or assistants
-
Erridge C, (2010) Endogenous ligands of TLR2 and TLR4: agonists or assistants? J Leukoc Biol 87: 989-999.
-
(2010)
J Leukoc Biol
, vol.87
, pp. 989-999
-
-
Erridge, C.1
-
64
-
-
80051672851
-
Structured regions of alpha-synuclein fibrils include the early-onset Parkinson's disease mutation sites
-
Comellas G, Lemkau LR, Nieuwkoop AJ, Kloepper KD, Ladror DT, et al. (2011) Structured regions of alpha-synuclein fibrils include the early-onset Parkinson's disease mutation sites. J Mol Biol 411: 881-895.
-
(2011)
J Mol Biol
, vol.411
, pp. 881-895
-
-
Comellas, G.1
Lemkau, L.R.2
Nieuwkoop, A.J.3
Kloepper, K.D.4
Ladror, D.T.5
-
65
-
-
77955356552
-
Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
-
Rajamaki K, Lappalainen J, Oorni K, Valimaki E, Matikainen S, et al. (2010) Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One 5: e11765.
-
(2010)
PLoS One
, vol.5
-
-
Rajamaki, K.1
Lappalainen, J.2
Oorni, K.3
Valimaki, E.4
Matikainen, S.5
-
66
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li JY, Englund E, Holton JL, Soulet D, Hagell P, et al. (2008) Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 14: 501-503.
-
(2008)
Nat Med
, vol.14
, pp. 501-503
-
-
Li, J.Y.1
Englund, E.2
Holton, J.L.3
Soulet, D.4
Hagell, P.5
|