Evidence for generation of oxidative stress in brain by MPTP: In vitro and in vivo studies in mice

Brain Research

Volumn 749, Issue 1, 1997, Pages 44-52

  Sriram, Krishnan ^a   Pai, Karnire S ^a   Boyd, Michael R ^b   Ravindranath, Vijayalakshmi ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Brain; Brain slice; Complex I; Glutathione; MPTP; Neurotoxicity; Oxidative stress; Reactive oxygen species

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; LACTATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; CORPUS STRIATUM; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL;

ANIMALS; BRAIN CHEMISTRY; DOPAMINE AGENTS; ELECTRON TRANSPORT COMPLEX I; L-LACTATE DEHYDROGENASE; MALE; MALONDIALDEHYDE; MICE; MPTP POISONING; NADH, NADPH OXIDOREDUCTASES; OXIDATIVE STRESS;

EID: 0031036391     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01271-1     Document Type: Article

References (34)

1. Adams, J.D., Klaidman, L.K. and Odunze, I.N., Oxidative effects of MPTP in the midbrain, Res. Commun. Subst. Abuse, 10 (1989) 169-180.
2. Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye binding. Anal. Biochem., 12 (1976) 248-254.
3. Cleeter, M.W.J., Cooper, J.M. and Schapira, A.H.V., Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenyl pyridinium: Evidence for free radical involvement, J. Neurochem., 58 (1992) 786-789.
4. Dupuis, A., Skehel, J.M. and Walker, J.E., NADH ubiquinone oxidoreductase from bovine mitochondria, Biochem. J., 277 (1991) 11-15.
5. + and analogues. Evidence against a redox cycling mechanism in MPTP neurotoxicity., Biochem. Biophys. Res. Commun., 147 (1987) 1095-1104.
6. 3H-DOPA in various regions of the rat brain, J. Neurochem., 13 (1966) 655-669.
7. +) induces NADH dependent Superoxide formation and enhances NADH dependent lipid peroxidation in bovine heart submitochondrial particles., Biochem. Biophys. Res. Commun., 170 (1990) 1049-1055.
8. Johannessen, J.N., Adams, J.D., Schuller, H.M., Bacon, J.P. and Markey, S.P., 1-Methyl-4-phenylpyridine induces oxidative stress in the rodent, Life Sci., 38 (1986) 743-749.
9. + and paraquat on mitochondrial potential and oxidative stress, Life Sci., 44 (1989) 1277-1284.
10. Lauterburg, B.H., Corcoran, G.B., Mitchell, J.R., Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats, in vivo, J. Clin. Invest., 71 (1983) 980-991.
11. Lebel, C.P., Ali, S.F., McKee, M. and Bondy, S.C., Organometal induced increases in oxygen reactive species: the potential of 2′,7′-dichlorofluorescein diacetate as an index of neurotoxic damage, Toxicol. Appl. Pharmacol., 104 (1990) 17-24.
12. Meister, A. and Anderson, M.E., Glutathione, Annu. Rev. Biochem., 52 (1983) 711-760.
13. Odunze, I.N., Klaidman, L.K. and Adams, J.D., MPTP toxicity in the mouse brain and vitamin E, Neurosci. Lett., 108 (1990) 346-349.
14. 3H]-glutathione binding sites in synaptic membranes from the brain, Neurosci. Res., 4 (1987) 486-96.
15. Ohkawa, H., Ohishi, N. and Yagi, K., Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal. Biochem., 95 (1979) 351-358.
16. Pai, K.S., Shankar, S.K. and Ravindranath, V., A simple and inexpensive slicer for preparation of brain slices, J. Neurosci. Methods, 37 (1991) 209-214.
17. Pai, K.S. and Ravindranath, V., Protection and potentiation of MPTP-induced toxicity by cytochrome P450 inhibitors and inducer in vitro studies with brain slices, Brain Res., 555 (1991) 239-244.
18. Perry, T.L., Yong, V.W., Clavier, R.M., Jones, K., Wright, J.M., Foulks, J.G. and Wall, R.A., Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse, Neurosci. Lett., 60, (1985) 109-114.
19. Perry, T.L., Yong, V.W., Jones, K. and Wright, J.M. Manipulation of glutathione content fails to alter dopaminergic nigrostriatal neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse, Neurosci. Lett., 70 (1986) 261-265.
20. Przedborski, S., Kostic, V., Jackson-Lewis, V., Naini, A.B., Siminetti, S., Fahn, S., Carlson, E., Epstein, C.J. and Cadet, J.L., Transgenic mice with increased copper/zinc-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity, J. Neurosci., 12 (1992) 1658-67.
21. Przedborski, S., Jackson-Lewis, V., Yokoyama, R., Shibata, T., Dawson, V.L. and Dawson, T.M., Role of nitric oxide in 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity, Proc. Natl. Acad. Sci. USA, 93 (1996) 4565-4571.
22. Ramsay, R.R., Salach, J.I., Dadgar, J. and Singer, T.P., Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism, Biochem. Biophys. Res. Commun., 135 (1986) 269-275.
23. Ravindranath, V. and Reed, D.J., Glutathione depletion and formation of glutathione-protein mixed disulfide following exposure of brain mitochondria to oxidative stress, Biochem. Biophys. Res. Commun., 169 (1990) 1075-1079.
24. Reed, D.J., Babson, J.R., Beatty, P.W., Brodie, A.E., Ellis, W.W. and Potter, D.W., High performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide and related thiols and disulfides, Anal. Biochem., 106 (1980) 55-62.
25. Shivakumar, B.R. and Ravindranath, V., Oxidative stress induced by administration of the neuroleptic drug haloperidol is attenuated by higher doses of haloperidol. Brain Res., 595 (1992) 256-262.
26. Shivakumar, B.R., Sastry, V.R., Kolluri and Ravindranath, V., Glutathione and protein thiol homeostasis in brain during reperfusion following cerebral ischemia, J. Pharmacol. Exp. Ther., 274 (1995) 1167-1173.
27. Shults, C.W., Nasirian, F., Ward, D.M., Nakano, K., Pay, M., Hill, L.R. and Haas, R.H., Carbidopa/levodopa and selegiline do not affect platelet mitochondrial function in early parkinsonism, Neurology, 45 (1995) 344-348 .
28. +): reductive activation by NADPH cytochrome P450 reductase, Biochem. Biophys. Res. Commun., 135 (1986) 583-588.
29. Sriram, K., Pai, K.S. and Ravindranath, V., Protection and potentiation of 1-methyl-4-phenyl pyridinium-induced toxicity by cytochrome P-450 inhibitors and inducer may be due to altered uptake of the toxin, J. Neurochem., 64 (1995) 1203-1208.
30. Tietze, F., Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues, Anal. Biochem., 27 (1969) 502-522.
31. Tipton, K.F. and Singer, T.P., Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds, J. Neurochem., 61 (1993) 1191-1206.
32. Turrens, J.F. and Boveris, A., Generation of Superoxide anion by the NADH dehydrogenase of bovine heart mitochondria, Biochem. J., 191 (1980) 421-427.
33. Wiener, H.L., Hashim, A., Lajtha, A. and Sershen, H., (-)-2-oxo-4-thiazolidine carboxylic acid attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced neurotoxicity. Res. Commun. Subst. Abuse, 9 (1988) 53-60.
34. Zhang, Y., Marcillat, O., Giulivi, G., Ernster, L. and Davies, K.J.A.; The oxidative inactivation of mitochondrial electron transport chain components and ATPase, J. Biol. Chem., 265 (1990) 16630-16636.