A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo

Neurobiology of Disease

Volumn 17, Issue 2, 2004, Pages 250-259

  Yang, Lichuan ^a   Sugama, Shuei ^b   Mischak, Ronald P ^c   Kiaei, Mahmoud ^a   Bizat, Nicolas ^d   Brouillet, Emmanuel ^d   Joh, Tong H ^b   Beal, M Flint ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^c Enzyme Systems Products   (United States)

^d DIF   (France)

Author keywords

ALS; Calpain; Caspase inhibitor; Huntington's disease; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3 NITROPROPIONIC ACID; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; DOPAMINE; MALONIC ACID; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DEGENERATIVE DISEASE; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; DRUG EFFECT; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG POTENCY; DRUG STABILITY; MALE; MESENCEPHALON; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; WESTERN BLOTTING;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BRAIN; CALPAIN; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; CORPUS STRIATUM; DOPAMINE AGENTS; ENZYME INHIBITORS; MALE; MALONATES; MESENCEPHALON; MICE; NEUROTOXINS; NITRO COMPOUNDS; PROPIONIC ACIDS; QUINOLINES; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY;

EID: 5144225191     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2004.07.021     Document Type: Article

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