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Volumn 16, Issue 9, 2012, Pages 855-868

Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CYCLOPHILIN D; FREE RADICAL;

EID: 84863229879     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2010.3849     Document Type: Article
Times cited : (47)

References (59)
  • 1
    • 77956223101 scopus 로고    scopus 로고
    • Calcium and mitochondrial reactive oxygen species generation: How to read the facts
    • Adam-Vizi V and Starkov AA. Calcium and mitochondrial reactive oxygen species generation: How to read the facts. J Alzheimers Dis 20: S413-426, 2010.
    • (2010) J Alzheimers Dis , vol.20
    • Adam-Vizi, V.1    Starkov, A.A.2
  • 2
    • 0026699090 scopus 로고
    • MPP+ redox cycling: A new mechanism involving hydride transfer
    • Adams JD, Klaidman LK, and Cadenas E. MPP+ redox cycling: A new mechanism involving hydride transfer. Ann NY Acad Sci 648: 239-240, 1992.
    • (1992) Ann NY Acad Sci , vol.648 , pp. 239-240
    • Adams, J.D.1    Klaidman, L.K.2    Cadenas, E.3
  • 3
    • 25444469412 scopus 로고    scopus 로고
    • Mitochondrial metabolism of reactive oxygen species
    • DOI 10.1007/s10541-005-0102-7
    • Andreyev AY, Kushnareva YE, and Starkov AA. Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc) 70: 200-214, 2005. (Pubitemid 40512329)
    • (2005) Biochemistry (Moscow) , vol.70 , Issue.2 , pp. 200-214
    • Andreyev, A.Yu.1    Kushnareva, Yu.E.2    Starkov, A.A.3
  • 5
    • 68649108355 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis
    • Banerjee R, Starkov AA, Beal MF, and Thomas B. Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochim Biophys Acta 1792: 651-663, 2009.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 651-663
    • Banerjee, R.1    Starkov, A.A.2    Beal, M.F.3    Thomas, B.4
  • 6
    • 21244446551 scopus 로고    scopus 로고
    • Properties of the permeability transition pore in mitochondria devoid of cyclophilin D
    • DOI 10.1074/jbc.C500089200
    • Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, and Bernardi P. Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem 280: 18558-18561, 2005. (Pubitemid 41379552)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.19 , pp. 18558-18561
    • Basso, E.1    Fante, L.2    Fowlkes, J.3    Petronilli, V.4    Forte, M.A.5    Bernardi, P.6
  • 7
    • 55549126837 scopus 로고    scopus 로고
    • Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation
    • Basso E, Petronilli V, Forte MA, and Bernardi P. Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J Biol Chem 283: 26307-26311, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 26307-26311
    • Basso, E.1    Petronilli, V.2    Forte, M.A.3    Bernardi, P.4
  • 8
    • 0032827410 scopus 로고    scopus 로고
    • Mitochondrial transport of cations: Channels, exchangers, and permeability transition
    • Bernardi P. Mitochondrial transport of cations: Channels, exchangers, and permeability transition. Physiol Rev 79: 1127-1155, 1999. (Pubitemid 29473313)
    • (1999) Physiological Reviews , vol.79 , Issue.4 , pp. 1127-1155
    • Bernardi, P.1
  • 9
    • 33750292972 scopus 로고    scopus 로고
    • Cell death in the nervous system
    • DOI 10.1038/nature05293, PII NATURE05293
    • Bredesen DE, Rao RV, and Mehlen P. Cell death in the nervous system. Nature 443: 796-802, 2006. (Pubitemid 44622684)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 796-802
    • Bredesen, D.E.1    Rao, R.V.2    Mehlen, P.3
  • 11
    • 79952837890 scopus 로고    scopus 로고
    • Modulation of F(0) F(1)-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels
    • Chinopoulos C, Konrad C, Kiss G, Metelkin E, Torocsik B, Zhang SF, and Starkov AA. Modulation of F(0) F(1)-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels. FEBS J 278: 1112-1125, 2011.
    • (2011) FEBS J , vol.278 , pp. 1112-1125
    • Chinopoulos, C.1    Konrad, C.2    Kiss, G.3    Metelkin, E.4    Torocsik, B.5    Zhang, S.F.6    Starkov, A.A.7
  • 12
    • 0037891050 scopus 로고    scopus 로고
    • Cyclosporin A-insensitive permeability transition in brain mitochondria. Inhibition by 2-aminoethoxydiphenyl borate
    • DOI 10.1074/jbc.M303808200
    • Chinopoulos C, Starkov AA, and Fiskum G. Cyclosporin Ainsensitive permeability transition in brain mitochondria: Inhibition by 2-aminoethoxydiphenyl borate. J Biol Chem 278: 27382-27389, 2003. (Pubitemid 36899919)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.30 , pp. 27382-27389
    • Chinopoulos, C.1    Starkov, A.A.2    Fiskum, G.3
  • 13
    • 27744532382 scopus 로고    scopus 로고
    • Promethazine protects against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity
    • DOI 10.1016/j.nbd.2005.05.022, PII S0969996105001397
    • Cleren C, Starkov AA, Calingasan NY, Lorenzo BJ, Chen J, and Beal MF. Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Neurobiol Dis 20: 701-708, 2005. (Pubitemid 41619346)
    • (2005) Neurobiology of Disease , vol.20 , Issue.3 , pp. 701-708
    • Cleren, C.1    Starkov, A.A.2    Calingasan, N.Y.3    Lorenzo, B.J.4    Chen, J.5    Beal, M.F.6
  • 15
    • 33645102302 scopus 로고    scopus 로고
    • Neural mitochondrial Ca2 + capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice
    • Damiano M, Starkov AA, Petri S, Kipiani K, Kiaei M, Mattiazzi M, Flint Beal M, and Manfredi G. Neural mitochondrial Ca2 + capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice. J Neurochem 96: 1349-1361, 2006.
    • (2006) J Neurochem , vol.96 , pp. 1349-1361
    • Damiano, M.1    Starkov, A.A.2    Petri, S.3    Kipiani, K.4    Kiaei, M.5    Mattiazzi, M.6    Flint Beal, M.7    Manfredi, G.8
  • 16
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • DOI 10.1016/S0896-6273(03)00568-3
    • Dauer W and Przedborski S. Parkinson's disease: Mechanisms and models. Neuron 39: 889-909, 2003. (Pubitemid 37130207)
    • (2003) Neuron , vol.39 , Issue.6 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 17
    • 77953666105 scopus 로고    scopus 로고
    • Genetic animal models of Parkinson's disease
    • Dawson TM, Ko HS, and Dawson VL. Genetic animal models of Parkinson's disease. Neuron 66: 646-661, 2010.
    • (2010) Neuron , vol.66 , pp. 646-661
    • Dawson, T.M.1    Ko, H.S.2    Dawson, V.L.3
  • 18
    • 0034006478 scopus 로고    scopus 로고
    • Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
    • Dehmer T, Lindenau J, Haid S, Dichgans J, and Schulz JB. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem 74: 2213-2216, 2000. (Pubitemid 30217680)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.5 , pp. 2213-2216
    • Dehmer, T.1    Lindenau, J.2    Haid, S.3    Dichgans, J.4    Schulz, J.B.5
  • 20
    • 79952901937 scopus 로고    scopus 로고
    • Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model
    • Du H, Guo L, Zhang W, Rydzewska M, and Yan S. Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model. Neurobiol Aging 32: 398-406, 2011.
    • (2011) Neurobiol Aging , vol.32 , pp. 398-406
    • Du, H.1    Guo, L.2    Zhang, W.3    Rydzewska, M.4    Yan, S.5
  • 22
    • 0032984198 scopus 로고    scopus 로고
    • Possible mechanism for the decrease of mitochondrial aspartate aminotransferase activity in ischemic and hypoxic rat retinas
    • DOI 10.1016/S0167-4889(99)00062-2, PII S0167488999000622
    • Endo S, Ishiguro S, and Tamai M. Possible mechanism for the decrease of mitochondrial aspartate aminotransferase activity in ischemic and hypoxic rat retinas. Biochim Biophys Acta 1450: 385-396, 1999. (Pubitemid 29295488)
    • (1999) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1450 , Issue.3 , pp. 385-396
    • Endo, S.1    Ishiguro, S.-I.2    Tamai, M.3
  • 24
    • 1442275733 scopus 로고    scopus 로고
    • Caspase-11 Mediates Inflammatory Dopaminergic Cell Death in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson's Disease
    • DOI 10.1523/JNEUROSCI.3309-03.2004
    • Furuya T, Hayakawa H, Yamada M, Yoshimi K, Hisahara S, Miura M, Mizuno Y, and Mochizuki H. Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci 24: 1865-1872, 2004. (Pubitemid 38292797)
    • (2004) Journal of Neuroscience , vol.24 , Issue.8 , pp. 1865-1872
    • Furuya, T.1    Hayakawa, H.2    Yamada, M.3    Yoshimi, K.4    Hisahara, S.5    Miura, M.6    Mizuno, Y.7    Mochizuki, H.8
  • 26
    • 0038421272 scopus 로고    scopus 로고
    • Imaging the permeability pore transition in single mitochondria
    • Huser J, Rechenmacher CE, and Blatter LA. Imaging the permeability pore transition in single mitochondria. Biophys J 74: 2129-2137, 1998. (Pubitemid 28157948)
    • (1998) Biophysical Journal , vol.74 , Issue.4 , pp. 2129-2137
    • Huser, J.1    Rechenmacher, C.E.2    Blatter, L.A.3
  • 27
    • 0028784523 scopus 로고
    • Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1 2 3,6-tetrahydropyridine
    • Jackson-Lewis V, Jakowec M, Burke RE, and Przedborski S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 4: 257-269, 1995.
    • (1995) Neurodegeneration , vol.4 , pp. 257-269
    • Jackson-Lewis, V.1    Jakowec, M.2    Burke, R.E.3    Przedborski, S.4
  • 28
    • 34347259269 scopus 로고    scopus 로고
    • Protocol for the MPTP mouse model of Parkinson's disease
    • DOI 10.1038/nprot.2006.342, PII NPROT.2006.342
    • Jackson-Lewis V and Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc 2: 141-151, 2007. (Pubitemid 47044700)
    • (2007) Nature Protocols , vol.2 , Issue.1 , pp. 141-151
    • Jackson-Lewis, V.1    Przedborski, S.2
  • 29
    • 0027260872 scopus 로고
    • +: Evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase
    • DOI 10.1016/0891-5849(93)90056-Z
    • Klaidman LK, Adams JD, Jr., Leung AC, Kim SS, and Cadenas E. Redox cycling of MPP+ : Evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase. Free Radic Biol Med 15: 169-179, 1993. (Pubitemid 23218819)
    • (1993) Free Radical Biology and Medicine , vol.15 , Issue.2 , pp. 169-179
    • Klaidman, L.K.1    Adams Jr., J.D.2    Leung, A.C.3    Kim, S.S.4    Cadenas, E.5
  • 31
    • 0344528794 scopus 로고    scopus 로고
    • The inflammatory reaction following 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine intoxication in mouse
    • DOI 10.1006/exnr.1998.6993
    • Kurkowska-Jastrzebska I, Wronska A, Kohutnicka M, Czlonkowski A, and Czlonkowska A. The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse. Exp Neurol 156: 50-61, 1999. (Pubitemid 29152982)
    • (1999) Experimental Neurology , vol.156 , Issue.1 , pp. 50-61
    • Kurkowska-Jastrzebska, I.1    Wronska, A.2    Kohutnicka, M.S.3    Czlonkowski, A.4    Czlonkowska, A.5
  • 32
    • 0021324639 scopus 로고
    • The activities of some energy-metabolising enzymes in nonsynaptic (free) and synaptic mitochondria derived from selected brain regions
    • Leong SF, Lai JC, Lim L, and Clark JB. The activities of some energy-metabolising enzymes in nonsynaptic (free) and synaptic mitochondria derived from selected brain regions. J Neurochem 42: 1306-1312, 1984. (Pubitemid 14137613)
    • (1984) Journal of Neurochemistry , vol.42 , Issue.5 , pp. 1306-1312
    • Leong, S.F.1    Lai, J.C.K.2    Lim, L.3    Clark, J.B.4
  • 34
    • 67649811029 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice
    • Martin LJ, Gertz B, Pan Y, Price AC, Molkentin JD, and Chang Q. The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice. Exp Neurol 218: 333-346, 2009.
    • (2009) Exp Neurol , vol.218 , pp. 333-346
    • Martin, L.J.1    Gertz, B.2    Pan, Y.3    Price, A.C.4    Molkentin, J.D.5    Chang, Q.6
  • 35
    • 15844407874 scopus 로고    scopus 로고
    • Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
    • DOI 10.1038/nature03317
    • Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, and Tsujimoto Y. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434: 652-658, 2005. (Pubitemid 40488558)
    • (2005) Nature , vol.434 , Issue.7033 , pp. 652-658
    • Nakagawa, T.1    Shimizu, S.2    Watanabe, T.3    Yamaguchi, O.4    Otsu, K.5    Yamagata, H.6    Inohara, H.7    Kubo, T.8    Tsujimoto, Y.9
  • 36
    • 44049086945 scopus 로고    scopus 로고
    • Histochemical methods for the detection of apoptosis in the nervous system
    • Oo TF and Burke RE. Histochemical methods for the detection of apoptosis in the nervous system. Curr Protoc Neurosci Chapter 1: Unit 1 15, 2007.
    • (2007) Curr Protoc Neurosci Chapter 1: Unit , vol.1 , pp. 15
    • Oo, T.F.1    Burke, R.E.2
  • 38
    • 0035853721 scopus 로고    scopus 로고
    • The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ
    • Petronilli V, Penzo D, Scorrano L, Bernardi P, and Di Lisa F. The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J Biol Chem 276: 12030-12034, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 12030-12034
    • Petronilli, V.1    Penzo, D.2    Scorrano, L.3    Bernardi, P.4    Di Lisa, F.5
  • 40
    • 10244222286 scopus 로고    scopus 로고
    • MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    • DOI 10.1023/B:JOBB.0000041771.66775.d5
    • Przedborski S, Tieu K, Perier C, and Vila M. MPTP as a mitochondrial neurotoxic model of Parkinson's disease. J Bioenerg Biomembr 36: 375-379, 2004. (Pubitemid 39619844)
    • (2004) Journal of Bioenergetics and Biomembranes , vol.36 , Issue.SPEC. ISS. , pp. 375-379
    • Przedborski, S.1    Tieu, K.2    Perier, C.3    Vila, M.4
  • 41
    • 0037713489 scopus 로고    scopus 로고
    • The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: A tool to explore the pathogenesis of Parkinson's disease
    • Przedborski S and Vila M. The 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model: A tool to explore the pathogenesis of Parkinson's disease. Ann NY Acad Sci 991: 189-198, 2003. (Pubitemid 36793814)
    • (2003) Annals of the New York Academy of Sciences , vol.991 , pp. 189-198
    • Przedborski, S.1    Vila, M.2
  • 42
    • 36249032567 scopus 로고    scopus 로고
    • Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease
    • DOI 10.1189/jlb.0507296
    • Reynolds AD, Banerjee R, Liu J, Gendelman HE, and Mosley RL. Neuroprotective activities of CD4+ CD25 + regulatory T cells in an animal model of Parkinson's disease. J Leukoc Biol 82: 1083-1094, 2007. (Pubitemid 350133504)
    • (2007) Journal of Leukocyte Biology , vol.82 , Issue.5 , pp. 1083-1094
    • Reynolds, A.D.1    Banerjee, R.2    Liu, J.3    Gendelman, H.E.4    Mosley, R.L.5
  • 43
    • 0014216603 scopus 로고
    • Mechanism of aconitase action.I. the hydrogen transfer reaction
    • Rose IA and O'Connell EL. Mechanism of aconitase action. I. The hydrogen transfer reaction. J Biol Chem242: 1870-1879, 1967.
    • (1967) J Biol Chem , vol.242 , pp. 1870-1879
    • Rose, I.A.1    O'Connell, E.L.2
  • 46
    • 0025471534 scopus 로고
    • Rapid isolation of metabolically active mitochondria from rat brain and subregions using percoll density gradient centrifugation
    • Sims NR. Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation. J Neurochem 55: 698-707, 1990. (Pubitemid 120021648)
    • (1990) Journal of Neurochemistry , vol.55 , Issue.2 , pp. 698-707
    • Sims, N.R.1
  • 47
    • 79952023305 scopus 로고    scopus 로고
    • Measurement of mitochondrial ROS production
    • Starkov AA. Measurement of mitochondrial ROS production. Methods Mol Biol 648: 245-255, 2010.
    • (2010) Methods Mol Biol , vol.648 , pp. 245-255
    • Starkov, A.A.1
  • 48
    • 0036788941 scopus 로고    scopus 로고
    • Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax
    • Starkov AA, Polster BM, and Fiskum G. Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J Neurochem 83: 220-228, 2002.
    • (2002) J Neurochem , vol.83 , pp. 220-228
    • Starkov, A.A.1    Polster, B.M.2    Fiskum, G.3
  • 49
    • 77549084979 scopus 로고    scopus 로고
    • Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease
    • Surmeier DJ, Guzman JN, and Sanchez-Padilla J. Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease. Cell Calcium 47: 175-182, 2010.
    • (2010) Cell Calcium , vol.47 , pp. 175-182
    • Surmeier, D.J.1    Guzman, J.N.2    Sanchez-Padilla, J.3
  • 50
    • 0026654844 scopus 로고
    • Selective inhibition of complex i by N-methylisoquinolinium ion and N-methyl-1,2 3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain
    • Suzuki K, Mizuno Y, Yamauchi Y, Nagatsu T, and Mitsuo Y. Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4- tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain. J Neurol Sci 109: 219-223, 1992.
    • (1992) J Neurol Sci , vol.109 , pp. 219-223
    • Suzuki, K.1    Mizuno, Y.2    Yamauchi, Y.3    Nagatsu, T.4    Mitsuo, Y.5
  • 51
    • 0030004759 scopus 로고    scopus 로고
    • Involvement of cyclophilin D in the activation of a mitochondrial pore by Ca2 + and oxidant stress
    • Tanveer A, Virji S, Andreeva L, Totty NF, Hsuan JJ, Ward JM, and Crompton M. Involvement of cyclophilin D in the activation of a mitochondrial pore by Ca2 + and oxidant stress. Eur J Biochem 238: 166-172, 1996.
    • (1996) Eur J Biochem , vol.238 , pp. 166-172
    • Tanveer, A.1    Virji, S.2    Andreeva, L.3    Totty, N.F.4    Hsuan, J.J.5    Ward, J.M.6    Crompton, M.7
  • 52
    • 0030888286 scopus 로고    scopus 로고
    • In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining
    • Tatton NA and Kish SJ. In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77: 1037-1048, 1997.
    • (1997) Neuroscience , vol.77 , pp. 1037-1048
    • Tatton, N.A.1    Kish, S.J.2
  • 53
    • 68949197599 scopus 로고    scopus 로고
    • Parkinson's disease: From molecular pathways in disease to therapeutic approaches
    • Thomas B. Parkinson's disease: From molecular pathways in disease to therapeutic approaches. Antioxid Redox Signal 11: 2077-2082, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2077-2082
    • Thomas, B.1
  • 56
    • 3342900223 scopus 로고    scopus 로고
    • 2+-dependent proteases in ischemic neuronal death. A conserved 'calpain-cathepsin cascade' from nematodes to primates
    • DOI 10.1016/j.ceca.2004.03.001, PII S0143416004000661
    • Yamashima T. Ca2 +-dependent proteases in ischemic neuronal death: A conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell Calcium 36: 285-293, 2004. (Pubitemid 38992354)
    • (2004) Cell Calcium , vol.36 , Issue.3-4 , pp. 285-293
    • Yamashima, T.1
  • 59
    • 0029116916 scopus 로고
    • The mitochondrial permeability transition
    • Zoratti M and Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta 1241: 139-176, 1995.
    • (1995) Biochim Biophys Acta , vol.1241 , pp. 139-176
    • Zoratti, M.1    Szabo, I.2


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