Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

Cell Death and Differentiation

Volumn 12, Issue 10, 2005, Pages 1329-1343

  Almeida, R D ^a   Manadas, B J ^a   Melo, C V ^a   Gomes, J R ^a   Mendes, C S ^a   Graos M M ^a   Carvalho, R F ^a   Carvalho, A P ^a   Duarte, C B ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Akt (PKB); Apoptosis; Bcl 2; BDNF; Extracecullar signal regulated kinase (ERK); Glutamate; Hippocampal neurons; Phosphatidylinositol 3 kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANISOMYCIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT; NEUROTROPHIN; NEUROTROPHIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; RAS PROTEIN; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; EXCITOTOXICITY; HIPPOCAMPUS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CASPASES; CELL SURVIVAL; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTAMIC ACID; HIPPOCAMPUS; MAP KINASE SIGNALING SYSTEM; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RAS PROTEINS; RATS; RATS, WISTAR; TRANSFECTION;

EID: 27144508812     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401662     Document Type: Review

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