Aggregated α-synuclein activates microglia: A process leading to disease progression in Parkinson's disease

FASEB Journal

Volumn 19, Issue 6, 2005, Pages 533-542

  Zhang, Wei ^a,b   Wang, Tongguang ^a   Pei, Zhong ^a   Miller, David S ^a   Wu, Xuefei ^f   Block, Michelle L ^a   Wilson, Belinda ^a   Zhang, Wanqin ^c   Zhou, Yong ^d   Hong, Jau Shyong ^a   Zhang, Jing ^d,e  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b Department of General Surgery   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f NONE

Author keywords

Aging; Inflammation; Innate immunity; Microglia; Oxidative stress; Phagocytosis; Protein aggregation

Indexed keywords

ALPHA SYNUCLEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; DOPAMINERGIC NERVE CELL; EMBRYO; ENZYME ACTIVATION; INFLAMMATION; INNATE IMMUNITY; LEWY BODY; MESENCEPHALON; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE DEGENERATION; NERVE INJURY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT; SUBSTANTIA NIGRA;

ALPHA-SYNUCLEIN; ANIMALS; ASTROCYTES; BRAIN; CELLS, CULTURED; DINOPROSTONE; DOPAMINE; EMBRYO; ENZYME ACTIVATION; GAMMA-AMINOBUTYRIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; MESENCEPHALON; MICE; MICE, KNOCKOUT; MICROGLIA; NADPH OXIDASE; NERVE DEGENERATION; NEUROGLIA; NEURONS; NITRIC OXIDE; NITRITES; OXIDATIVE STRESS; PARKINSON DISEASE; PHAGOCYTOSIS; POLYMERS; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; SUBSTANTIA NIGRA; TRITIUM; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE 3-MONOOXYGENASE;

EID: 20144389524     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.04-2751com     Document Type: Article

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