메뉴 건너뛰기




Volumn 11, Issue 6, 2016, Pages

N-Acetyl cysteine may support dopamine neurons in Parkinson's disease: Preliminary clinical and cell line data

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; DOPAMINE; DOPAMINE TRANSPORTER; ROTENONE; ANTIOXIDANT; NEUROPROTECTIVE AGENT; NEUROTOXIN;

EID: 84976384948     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0157602     Document Type: Article
Times cited : (109)

References (61)
  • 1
    • 85160144125 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease: An overview
    • Ebadi MPR, editor Boca Raton, FL: CRC Press
    • Korell M, Tanner CM. Epidemiology of Parkinson's disease: An overview In: Ebadi MPR, editor. Parkinson's Disease. Boca Raton, FL: CRC Press. 2005, pp 39-50.
    • (2005) Parkinson's Disease , pp. 39-50
    • Korell, M.1    Tanner, C.M.2
  • 2
    • 84937786477 scopus 로고    scopus 로고
    • Psychological benefits of nonpharmacological methods aimed for improving balance in Parkinson's disease: A systematic review
    • PMID: 26236107
    • Šumec R, Filip P, Sheardová K, Bareš M. Psychological benefits of nonpharmacological methods aimed for improving balance in Parkinson's disease: A systematic review. Behav Neurol. 2015; 2015:620674. doi: 10.1155/2015/620674 PMID: 26236107
    • (2015) Behav Neurol , vol.2015 , pp. 620674
    • Šumec, R.1    Filip, P.2    Sheardová, K.3    Bareš, M.4
  • 3
    • 84887926609 scopus 로고    scopus 로고
    • Exercise: Is it a neuroprotective and if so, how does it work?
    • PMID: 24262162
    • Zigmond MJ, Smeyne RJ. Exercise: is it a neuroprotective and if so, how does it work? Parkinsonism Relat Disord. 2014; 20 Suppl 1:S123-127. doi: 10.1016/S1353-8020(13)70030-0 PMID: 24262162
    • (2014) Parkinsonism Relat Disord , vol.20 , pp. S123-S127
    • Zigmond, M.J.1    Smeyne, R.J.2
  • 4
    • 33646773864 scopus 로고    scopus 로고
    • Antioxidants, supplements, and Parkinson's disease
    • PMID: 16622156
    • Weber CA, Ernst ME. Antioxidants, supplements, and Parkinson's disease. Ann Pharmacother. 2006; 40:935-938. PMID: 16622156
    • (2006) Ann Pharmacother , vol.40 , pp. 935-938
    • Weber, C.A.1    Ernst, M.E.2
  • 5
    • 84863314750 scopus 로고    scopus 로고
    • Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease
    • PMID: 22747840
    • Chao J, Leung Y, Wang M, Chang RC. Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease. Nutr Rev. 2012; 70(7):373-386. doi: 10.1111/j.1753-4887.2012.00484.x PMID: 22747840
    • (2012) Nutr Rev , vol.70 , Issue.7 , pp. 373-386
    • Chao, J.1    Leung, Y.2    Wang, M.3    Chang, R.C.4
  • 6
    • 0022428152 scopus 로고
    • Oxidative stress: Damage to intact cells and organs
    • PMID: 2869521
    • Sies H, Cadenas E. Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci. 1985; 311:617-631. PMID: 2869521
    • (1985) Philos Trans R Soc Lond B Biol Sci , vol.311 , pp. 617-631
    • Sies, H.1    Cadenas, E.2
  • 7
    • 49349106093 scopus 로고    scopus 로고
    • Redox imbalance in Parkinson's disease
    • PMID: 18358848
    • Chinta SJ, Andersen JK. Redox imbalance in Parkinson's disease. Biochimica et Biophysica Acta. 2008; 1780: 1362-1367. doi: 10.1016/j.bbagen.2008.02.005 PMID: 18358848
    • (2008) Biochimica et Biophysica Acta , vol.1780 , pp. 1362-1367
    • Chinta, S.J.1    Andersen, J.K.2
  • 8
    • 0023835113 scopus 로고
    • Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine
    • PMID: 3360052
    • Olsson B, Johansson M, Gabrielsson J, Bolme P. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol. 1988; 34:77-82. PMID: 3360052
    • (1988) Eur J Clin Pharmacol , vol.34 , pp. 77-82
    • Olsson, B.1    Johansson, M.2    Gabrielsson, J.3    Bolme, P.4
  • 9
    • 0022869818 scopus 로고
    • Pharmacokinetics of N-acetylcysteine in man
    • PMID: 3803419
    • Borgström L, Kågedal B, Paulsen O. Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol. 1986; 31:217-222. PMID: 3803419
    • (1986) Eur J Clin Pharmacol , vol.31 , pp. 217-222
    • Borgström, L.1    Kågedal, B.2    Paulsen, O.3
  • 10
    • 84880828603 scopus 로고    scopus 로고
    • N-acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases
    • PMID: 23860343
    • Holmay MJ, Terpstra M, Coles LD, Mishra U, Ahlskog M, Öz G, et al. N-acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases. Clin Neuropharmacol. 2013; 36(4):103-106. doi: 10.1097/WNF.0b013e31829ae713 PMID: 23860343
    • (2013) Clin Neuropharmacol , vol.36 , Issue.4 , pp. 103-106
    • Holmay, M.J.1    Terpstra, M.2    Coles, L.D.3    Mishra, U.4    Ahlskog, M.5    Öz, G.6
  • 11
    • 0033899208 scopus 로고    scopus 로고
    • Glutathione, oxidative stress and neurodegeneration
    • PMID: 10931172
    • Schulz JB, Lindenau J, Seyfried J, Dichgans J. Glutathione, oxidative stress and neurodegeneration. Eur J Biochem. 2000; 267(16):4904-4911. PMID: 10931172
    • (2000) Eur J Biochem , vol.267 , Issue.16 , pp. 4904-4911
    • Schulz, J.B.1    Lindenau, J.2    Seyfried, J.3    Dichgans, J.4
  • 12
    • 84875262810 scopus 로고    scopus 로고
    • BMP and TGF-β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells
    • PMID: 23352789
    • Cai J, Schleidt S, Pelta-Heller J, Hutchings D, Cannarsa G, Iacovitti L. BMP and TGF-β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells. Dev Biol. 2013; 376:62-73. doi: 10.1016/j.ydbio.2013.01.012 PMID: 23352789
    • (2013) Dev Biol , vol.376 , pp. 62-73
    • Cai, J.1    Schleidt, S.2    Pelta-Heller, J.3    Hutchings, D.4    Cannarsa, G.5    Iacovitti, L.6
  • 13
    • 0030884246 scopus 로고    scopus 로고
    • The dopamine transporter: A crucial component regulating dopamine transmission
    • PMID: 9380041
    • Jaber M. Jones S. Giros B. Caron MG. The dopamine transporter: a crucial component regulating dopamine transmission. Movement Dis. 1997; 12:629-633. PMID: 9380041
    • (1997) Movement Dis , vol.12 , pp. 629-633
    • Jaber, M.1    Jones, S.2    Giros, B.3    Caron, M.G.4
  • 14
    • 0030071106 scopus 로고    scopus 로고
    • Hyperlocomotion and indifference to cocaine and methamphetamine in mice lacking the dopamine transporter
    • Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. Hyperlocomotion and indifference to cocaine and methamphetamine in mice lacking the dopamine transporter. Nature. 1996; 379:606-612.
    • (1996) Nature , vol.379 , pp. 606-612
    • Giros, B.1    Jaber, M.2    Jones, S.R.3    Wightman, R.M.4    Caron, M.G.5
  • 15
    • 0027296568 scopus 로고
    • Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked decline in mild Parkinson's disease
    • PMID: 8363363
    • Frost JJ, Rosier AJ, Reich SG, Smith JS, Ehlers MD, Snyder SH, Ravert HT, Dannals RF. Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked decline in mild Parkinson's disease. Ann Neurol. 1993; 34:423-431. PMID: 8363363
    • (1993) Ann Neurol , vol.34 , pp. 423-431
    • Frost, J.J.1    Rosier, A.J.2    Reich, S.G.3    Smith, J.S.4    Ehlers, M.D.5    Snyder, S.H.6    Ravert, H.T.7    Dannals, R.F.8
  • 16
    • 0021893325 scopus 로고
    • Sodium dependent [3H] cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinson's disease
    • Shoemaker H, Pimoule C, Arbilla S, Scatton B, Javoy-Agid F, Langer SZ. Sodium dependent [3H] cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinson's disease. Naunyn-Schmiedeberg's Arch Pharmacol. 1985; 239:227-235.
    • (1985) Naunyn-Schmiedeberg's Arch Pharmacol , vol.239 , pp. 227-235
    • Shoemaker, H.1    Pimoule, C.2    Arbilla, S.3    Scatton, B.4    Javoy-Agid, F.5    Langer, S.Z.6
  • 17
    • 0027131948 scopus 로고
    • Single-photon emissioncomputed tomography imaging demonstrates loss of striatal dopamine transporters in Parkinson disease
    • PMID: 8265656
    • Innis RB, Seibyl JP, Scanley BE, Laruelle M, Abi-Dargham A, Wallace E, et al. Single-photon emissioncomputed tomography imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. Proc Natl Acad Sci USA. 1993; 90:11965-11969. PMID: 8265656
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11965-11969
    • Innis, R.B.1    Seibyl, J.P.2    Scanley, B.E.3    Laruelle, M.4    Abi-Dargham, A.5    Wallace, E.6
  • 18
    • 0031684335 scopus 로고    scopus 로고
    • Iodine-123-beta-CIT and iodine-123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson's patients
    • PMID: 9744331
    • Seibyl JP, Marek K, Sheff K, Zoghbi S, Baldwin RM, Charney DS, et al. Iodine-123-beta-CIT and iodine-123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson's patients. J Nucl Med. 1998; 39:1500-1508. PMID: 9744331
    • (1998) J Nucl Med , vol.39 , pp. 1500-1508
    • Seibyl, J.P.1    Marek, K.2    Sheff, K.3    Zoghbi, S.4    Baldwin, R.M.5    Charney, D.S.6
  • 19
    • 60549112829 scopus 로고    scopus 로고
    • Direct comparison of FP-CIT SPECT and F-DOPA PET in patients with Parkinson's disease and healthy controls
    • PMID: 19037637
    • Eshuis SA, Jager PL, Maguire RP, Jonkman S, Dierckx RA, Leenders KL. Direct comparison of FP-CIT SPECT and F-DOPA PET in patients with Parkinson's disease and healthy controls. Eur J Nucl Med Mol Imaging. 2009; 36:454-462. doi: 10.1007/s00259-008-0989-5 PMID: 19037637
    • (2009) Eur J Nucl Med Mol Imaging , vol.36 , pp. 454-462
    • Eshuis, S.A.1    Jager, P.L.2    Maguire, R.P.3    Jonkman, S.4    Dierckx, R.A.5    Leenders, K.L.6
  • 20
    • 0030614902 scopus 로고    scopus 로고
    • [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease
    • PMID: 9048712
    • Booij J, Tissingh G, Boer GJ, Speelman JD, Stoof JC, Janssen AG, et al. [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease. J Neurol Neurosurg Psychiatry. 1997; 62:133-140. PMID: 9048712
    • (1997) J Neurol Neurosurg Psychiatry , vol.62 , pp. 133-140
    • Booij, J.1    Tissingh, G.2    Boer, G.J.3    Speelman, J.D.4    Stoof, J.C.5    Janssen, A.G.6
  • 21
    • 33847662099 scopus 로고    scopus 로고
    • 18F-FP-CIT PET imaging and SPM analysis of dopamine transporters in Parkinson's disease in various Hoehn & Yahr stages
    • PMID: 17334953
    • Wang J, Zuo CT, Jiang YP, Guan YH, Chen ZP, Xiang JD, et al. 18F-FP-CIT PET imaging and SPM analysis of dopamine transporters in Parkinson's disease in various Hoehn & Yahr stages. J Neurol. 2007; 254:185-190. PMID: 17334953
    • (2007) J Neurol , vol.254 , pp. 185-190
    • Wang, J.1    Zuo, C.T.2    Jiang, Y.P.3    Guan, Y.H.4    Chen, Z.P.5    Xiang, J.D.6
  • 22
    • 84355166561 scopus 로고    scopus 로고
    • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
    • PMID: 22056989
    • Kriks S, Shim J-W, Piao J, Ganat YM, Wakeman DR, Xie Z, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 2011; 480 (7378):547-551. doi: 10.1038/nature10648 PMID: 22056989
    • (2011) Nature , vol.480 , Issue.7378 , pp. 547-551
    • Kriks, S.1    Shim, J.-W.2    Piao, J.3    Ganat, Y.M.4    Wakeman, D.R.5    Xie, Z.6
  • 23
    • 0642279489 scopus 로고    scopus 로고
    • Greater availability of brain dopamine transporters in major depression shown by [(99m)Tc]TRODAT-1 SPECT imaging
    • Brunswick DJ, Amsterdam JD, Mozley PD, Newberg AB. Greater availability of brain dopamine transporters in major depression shown by [(99m)Tc]TRODAT-1 SPECT imaging. Amer J Psych. 2003; 160:1836-1841.
    • (2003) Amer J Psych , vol.160 , pp. 1836-1841
    • Brunswick, D.J.1    Amsterdam, J.D.2    Mozley, P.D.3    Newberg, A.B.4
  • 24
    • 84930687286 scopus 로고    scopus 로고
    • Extrastriatal binding of [(123)I]FP-CIT in the thalamus and pons: Gender and age dependencies assessed in a European multicentre database of healthy controls
    • PMID: 24806112
    • Koch W, Unterrainer M, Xiong G, Bartenstein P, Diemling M, Varrone A, et al. Extrastriatal binding of [(123)I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls. Eur J Nucl Med Mol Imaging. 2014; 41:1938-1946. doi: 10.1007/ s00259-014-2785-8 PMID: 24806112
    • (2014) Eur J Nucl Med Mol Imaging , vol.41 , pp. 1938-1946
    • Koch, W.1    Unterrainer, M.2    Xiong, G.3    Bartenstein, P.4    Diemling, M.5    Varrone, A.6
  • 26
    • 0022428152 scopus 로고
    • Oxidative stress: Damage to intact cells and organs
    • PMID: 2869521
    • Sies H, Cadenas E. Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci. 1985; 311:617-631. PMID: 2869521
    • (1985) Philos Trans R Soc Lond B Biol Sci , vol.311 , pp. 617-631
    • Sies, H.1    Cadenas, E.2
  • 27
    • 0024448235 scopus 로고
    • Striatal dopamine deficiency in Parkinson's disease: Role of aging
    • PMID: 2817829
    • Scherman D, Desnos C, Darchen F, Pollak P, Javoy-Agid F, Agid Y. Striatal dopamine deficiency in Parkinson's disease: role of aging. Ann Neurol. 1989; 26: 551-557. PMID: 2817829
    • (1989) Ann Neurol , vol.26 , pp. 551-557
    • Scherman, D.1    Desnos, C.2    Darchen, F.3    Pollak, P.4    Javoy-Agid, F.5    Agid, Y.6
  • 28
    • 0029751104 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of Parkinson's disease
    • PMID: 8959985
    • Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology. 1996; 47:S161-S170. PMID: 8959985
    • (1996) Neurology , vol.47 , pp. S161-S170
    • Jenner, P.1    Olanow, C.W.2
  • 29
    • 0027329923 scopus 로고
    • Presymptomatic detection of Parkinson's disease
    • Jenner P. Presymptomatic detection of Parkinson's disease. J Neural Transm Suppl. 1993; 40: 23-36.
    • (1993) J Neural Transm Suppl , vol.40 , pp. 23-36
    • Jenner, P.1
  • 30
    • 0029751104 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of Parkinson's disease
    • PMID: 8959985
    • Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology. 1996; 47:S161-S170. PMID: 8959985
    • (1996) Neurology , vol.47 , pp. S161-S170
    • Jenner, P.1    Olanow, C.W.2
  • 31
    • 0034007822 scopus 로고    scopus 로고
    • Pathoanatomy of Parkinson's disease
    • PMID: 10991663
    • Braak H, Braak E. Pathoanatomy of Parkinson's disease. J Neurol. 2000; 247 (Suppl 2): II3-10. PMID: 10991663
    • (2000) J Neurol , vol.247 , pp. II3-II10
    • Braak, H.1    Braak, E.2
  • 32
    • 0035887860 scopus 로고    scopus 로고
    • Induction of alpha-synuclein aggregation by intracellular nitrative insult
    • PMID: 11588178
    • Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, et al. Induction of alpha-synuclein aggregation by intracellular nitrative insult. J Neurosci. 2001; 21:8053-8061. PMID: 11588178
    • (2001) J Neurosci , vol.21 , pp. 8053-8061
    • Paxinou, E.1    Chen, Q.2    Weisse, M.3    Giasson, B.I.4    Norris, E.H.5    Rueter, S.M.6
  • 33
    • 0037237927 scopus 로고    scopus 로고
    • Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
    • Ischiropoulos H, Beckman JS. Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest. 2003; 11:163-169.
    • (2003) J Clin Invest , vol.11 , pp. 163-169
    • Ischiropoulos, H.1    Beckman, J.S.2
  • 34
    • 0035941201 scopus 로고    scopus 로고
    • Metal-triggered structural transformations, aggregation, and fibrillation of human α-synuclein
    • Uversky VN, Li J, Fink AL. Metal-triggered structural transformations, aggregation, and fibrillation of human α-synuclein. J Biol Chem. 2001; 23:44284-44296.
    • (2001) J Biol Chem , vol.23 , pp. 44284-44296
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 35
    • 0033577159 scopus 로고    scopus 로고
    • Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro
    • PMID: 10208537
    • Hashimoto M, Hsu LJ, Xia Y, Takeda A, Sisk A, Sundsmo M, Masliah E. Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro. Neuroreport. 1999; 10:717-721. PMID: 10208537
    • (1999) Neuroreport , vol.10 , pp. 717-721
    • Hashimoto, M.1    Hsu, L.J.2    Xia, Y.3    Takeda, A.4    Sisk, A.5    Sundsmo, M.6    Masliah, E.7
  • 36
    • 33845746706 scopus 로고    scopus 로고
    • Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: Relevance for the pathogenesis of Parkinson's disease
    • PMID: 17241161
    • Thomas MP, Chartrand K, Reynolds A, Vitvitsky V, Banerjee R, Gendelman HE. Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease. J Neurochem. 2007; 100:503-519. PMID: 17241161
    • (2007) J Neurochem , vol.100 , pp. 503-519
    • Thomas, M.P.1    Chartrand, K.2    Reynolds, A.3    Vitvitsky, V.4    Banerjee, R.5    Gendelman, H.E.6
  • 37
    • 0030249286 scopus 로고    scopus 로고
    • Prevention of dopamine-induced cell death by thiol antioxidants: Possible implications for treatment of Parkinson's disease
    • Sep PMID: 8797665
    • Offen D, Ziv I, Sternin H, Melamed E, Hochman A. Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease. Exp Neurol. 1996 Sep; 141 (1):32-9. PMID: 8797665
    • (1996) Exp Neurol , vol.141 , Issue.1 , pp. 32-39
    • Offen, D.1    Ziv, I.2    Sternin, H.3    Melamed, E.4    Hochman, A.5
  • 38
    • 84886791649 scopus 로고    scopus 로고
    • N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner
    • PMID: 24096134
    • Jiang Y, Rumble JL, Gleixner AM, Unnithan AS, Pulugulla SH, Posimo JM, et al. N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner. Neuroscience. 2013; 255:19-32. doi: 10.1016/j.neuroscience.2013.09.049 PMID: 24096134
    • (2013) Neuroscience , vol.255 , pp. 19-32
    • Jiang, Y.1    Rumble, J.L.2    Gleixner, A.M.3    Unnithan, A.S.4    Pulugulla, S.H.5    Posimo, J.M.6
  • 39
    • 84891407440 scopus 로고    scopus 로고
    • N-Acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress
    • PMID: 24361774
    • Unnithan AS, Jiang Y, Rumble JL, Pulugulla SH, Posimo JM, Gleixner AM, et al. N-Acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress. Neurosci Lett. 2014; 560:71-76. doi: 10.1016/j.neulet.2013.12.023 PMID: 24361774
    • (2014) Neurosci Lett. , vol.560 , pp. 71-76
    • Unnithan, A.S.1    Jiang, Y.2    Rumble, J.L.3    Pulugulla, S.H.4    Posimo, J.M.5    Gleixner, A.M.6
  • 40
    • 0028246870 scopus 로고
    • Macromolecular synthesis inhibitors prevent oxidative stressinduced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione
    • Ratan RR, Murphy TH, Baraban JM. Macromolecular synthesis inhibitors prevent oxidative stressinduced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. J Neurosci. 1994; 17:4385-4392.
    • (1994) J Neurosci , vol.17 , pp. 4385-4392
    • Ratan, R.R.1    Murphy, T.H.2    Baraban, J.M.3
  • 41
    • 77957860419 scopus 로고    scopus 로고
    • Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in α-synuclein over-expressing mice
    • PMID: 20808797
    • Clark J, Clore EL, Zheng K, Adame A, Masliah E, Simon DK. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in α-synuclein over-expressing mice. PLoS One. 2010; 5(8):e12333. doi: 10. 1371/journal.pone.0012333 PMID: 20808797
    • (2010) PLoS One , vol.5 , Issue.8 , pp. e12333
    • Clark, J.1    Clore, E.L.2    Zheng, K.3    Adame, A.4    Masliah, E.5    Simon, D.K.6
  • 42
    • 59249099095 scopus 로고    scopus 로고
    • Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice
    • PMID: 19027004
    • Aoki E, Yano R, Yokoyama H, Kato H, Araki T. Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice. Exp Mol Pathol. 2009; 86: 57-64. doi: 10.1016/j.yexmp.2008.10.004 PMID: 19027004
    • (2009) Exp Mol Pathol. , vol.86 , pp. 57-64
    • Aoki, E.1    Yano, R.2    Yokoyama, H.3    Kato, H.4    Araki, T.5
  • 43
    • 77949478474 scopus 로고    scopus 로고
    • Phosphorylation of parkin by Parkinson disease linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
    • PMID: 19880420
    • Sha D, Chin LS, Li L. Phosphorylation of parkin by Parkinson disease linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet. 2010; 19:352-363. doi: 10.1093/ hmg/ddp501 PMID: 19880420
    • (2010) Hum Mol Genet , vol.19 , pp. 352-363
    • Sha, D.1    Chin, L.S.2    Li, L.3
  • 44
    • 46649104269 scopus 로고    scopus 로고
    • Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: Implications in the neuroprotective therapy of Parkinson's disease
    • PMID: 18569015
    • Bagh MB, Maiti AK, Jana S, Banerjee K, Roy A, Chakrabarti S. Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: implications in the neuroprotective therapy of Parkinson's disease. Free Radic Res. 2008; 42: 574-581. doi: 10.1080/10715760802158430 PMID: 18569015
    • (2008) Free Radic Res. , vol.42 , pp. 574-581
    • Bagh, M.B.1    Maiti, A.K.2    Jana, S.3    Banerjee, K.4    Roy, A.5    Chakrabarti, S.6
  • 45
    • 84867786709 scopus 로고    scopus 로고
    • N-acetyl cysteine protects against methamphetamine-induced dopaminergic neurodegeneration via modulation of redox status and autophagy in dopaminergic cells
    • PMID: 23056996
    • Chandramani Shivalingappa P, Jin H, Anantharam V, Kanthasamy A, Kanthasamy A. N-acetyl cysteine protects against methamphetamine-induced dopaminergic neurodegeneration via modulation of redox status and autophagy in dopaminergic cells. Parkinsons Dis. 2012:424285. doi: 10.1155/2012/424285 PMID: 23056996
    • (2012) Parkinsons Dis , pp. 424285
    • Chandramani Shivalingappa, P.1    Jin, H.2    Anantharam, V.3    Kanthasamy, A.4    Kanthasamy, A.5
  • 46
    • 0342378119 scopus 로고    scopus 로고
    • N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria
    • PMID: 9262186
    • Martínez-Banaclocha M, Hernández AI, Martínez N, Ferrándiz ML. N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria. Brain Res. 1997; 762: 256-258. PMID: 9262186
    • (1997) Brain Res , vol.762 , pp. 256-258
    • Martínez-Banaclocha, M.1    Hernández, A.I.2    Martínez, N.3    Ferrándiz, M.L.4
  • 47
    • 0020675384 scopus 로고
    • Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats
    • PMID: 6832291
    • Vina J, Romero FJ, Saez GT, Pallardó FV. Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats. Experientia. 1983; 39: 164-165. PMID: 6832291
    • (1983) Experientia , vol.39 , pp. 164-165
    • Vina, J.1    Romero, F.J.2    Saez, G.T.3    Pallardó, F.V.4
  • 48
    • 0033525423 scopus 로고    scopus 로고
    • Hypothesis: Can N-acetylcysteine be beneficial in Parkinson's disease?
    • PMID: 10227580
    • Martínez-Banaclocha M, Martínez N, Hernández, Ferrándiz ML. Hypothesis: can N-acetylcysteine be beneficial in Parkinson's disease? Life Sci. 1999; 64:1253-1257. PMID: 10227580
    • (1999) Life Sci , vol.64 , pp. 1253-1257
    • Martínez-Banaclocha, M.1    MartínezN, H.2    Ferrándiz, M.L.3
  • 49
    • 0034678112 scopus 로고    scopus 로고
    • N-acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice. Implications for treatment of Parkinson's disease
    • PMID: 10720628
    • Martínez-Banaclocha M. N-acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice. Implications for treatment of Parkinson's disease. Brain Res. 2000; 859: 173-175. PMID: 10720628
    • (2000) Brain Res , vol.859 , pp. 173-175
    • Martínez-Banaclocha, M.1
  • 50
    • 0022400573 scopus 로고
    • Partial protection from the dopaminergic neurotoxin Nmethyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse
    • PMID: 3877260
    • Perry TL, Yong VW, Clavier RM, Jones K, Wright JM, Foulks JG, et al. Partial protection from the dopaminergic neurotoxin Nmethyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse. Neurosci Lett. 1985; 60: 109-114. PMID: 3877260
    • (1985) Neurosci Lett. , vol.60 , pp. 109-114
    • Perry, T.L.1    Yong, V.W.2    Clavier, R.M.3    Jones, K.4    Wright, J.M.5    Foulks, J.G.6
  • 51
    • 34249036126 scopus 로고    scopus 로고
    • Attenuation of 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine induced nigro-striatal toxicity in mice by N-acetyl cysteine
    • PMID: 17519111
    • Sharma A, Kaur P, Kumar V, Gill KD. Attenuation of 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine induced nigro-striatal toxicity in mice by N-acetyl cysteine. Cell Mol Biol. 2007; 53: 48-55. PMID: 17519111
    • (2007) Cell Mol Biol. , vol.53 , pp. 48-55
    • Sharma, A.1    Kaur, P.2    Kumar, V.3    Gill, K.D.4
  • 52
    • 0036827988 scopus 로고    scopus 로고
    • Antioxidants inhibit the human cortical neuron apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42
    • PMID: 12592670
    • Medina S, Martínez-Banaclocha M, Hernanz A. Antioxidants inhibit the human cortical neuron apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42. Free Radic Res. 2002; 36: 1179-1184. PMID: 12592670
    • (2002) Free Radic Res , vol.36 , pp. 1179-1184
    • Medina, S.1    Martínez-Banaclocha, M.2    Hernanz, A.3
  • 53
    • 67651148277 scopus 로고    scopus 로고
    • Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease
    • PMID: 19230029
    • Hauser RA, Lyons KE, McClain T, Carter S, Perlmutter D. Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease. Mov Disord. 2009; 24:979-983. doi: 10.1002/mds. 22401 PMID: 19230029
    • (2009) Mov Disord , vol.24 , pp. 979-983
    • Hauser, R.A.1    Lyons, K.E.2    McClain, T.3    Carter, S.4    Perlmutter, D.5
  • 54
    • 84863882525 scopus 로고    scopus 로고
    • Low brain serotonin transporter binding in major depressive disorder
    • PMID: 22698760
    • Newberg AB, Amsterdam JD, Wintering N, Shults J. Low brain serotonin transporter binding in major depressive disorder. Psychiatry Res. 2012; 202:161-167. doi: 10.1016/j.pscychresns.2011.12.015 PMID: 22698760
    • (2012) Psychiatry Res , vol.202 , pp. 161-167
    • Newberg, A.B.1    Amsterdam, J.D.2    Wintering, N.3    Shults, J.4
  • 55
    • 47249151745 scopus 로고    scopus 로고
    • Midbrain serotonin and striatum dopamine transporter binding in double depression: A one-year follow-up study
    • PMID: 18588943
    • Lehto SM, Tolmunen T, Kuikka J, Valkonen-Korhonen M, Joensuu M, Saarinen PI, et al. Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. Neurosci Lett. 2008; 441:291-295. doi: 10.1016/j.neulet.2008.06.042 PMID: 18588943
    • (2008) Neurosci Lett. , vol.441 , pp. 291-295
    • Lehto, S.M.1    Tolmunen, T.2    Kuikka, J.3    Valkonen-Korhonen, M.4    Joensuu, M.5    Saarinen, P.I.6
  • 56
    • 44449093495 scopus 로고    scopus 로고
    • Placebo response in Parkinson's disease: Comparisons among 11 trials covering medical and surgical interventions
    • PMID: 18228568
    • Goetz CG, Wuu J, McDermott MP, Adler CH, Fahn S, Freed CR, et al. Placebo response in Parkinson's disease: comparisons among 11 trials covering medical and surgical interventions. Mov Disord. 2008; 23(5):690-9. doi: 10.1002/mds.21894 PMID: 18228568
    • (2008) Mov Disord , vol.23 , Issue.5 , pp. 690-699
    • Goetz, C.G.1    Wuu, J.2    McDermott, M.P.3    Adler, C.H.4    Fahn, S.5    Freed, C.R.6
  • 57
    • 50049101180 scopus 로고    scopus 로고
    • Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    • PMID: 18446306
    • Hesse S, Strecker K, Winkler D, Luthardt J, Scherfler C, Reupert A, et al. Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up. J Neurol. 2008; 255:1059-1066. doi: 10.1007/s00415-008-0849-z PMID: 18446306
    • (2008) J Neurol , vol.255 , pp. 1059-1066
    • Hesse, S.1    Strecker, K.2    Winkler, D.3    Luthardt, J.4    Scherfler, C.5    Reupert, A.6
  • 58
    • 0037012478 scopus 로고    scopus 로고
    • Dopamine transporter brain imaging to assess the effects of pramipexole vs. Levodopa on Parkinson disease progression
    • PMID: 11926889
    • Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs. levodopa on Parkinson disease progression. JAMA. 2002; 287:1653-1661. PMID: 11926889
    • (2002) JAMA , vol.287 , pp. 1653-1661
  • 59
    • 0037785449 scopus 로고    scopus 로고
    • Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study
    • PMID: 12838524
    • Whone AL, Watts RL, Stoessl AJ, Davis M, Reske S, Nahmias C, et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Ann Neurol. 2003; 54:93-101. PMID: 12838524
    • (2003) Ann Neurol , vol.54 , pp. 93-101
    • Whone, A.L.1    Watts, R.L.2    Stoessl, A.J.3    Davis, M.4    Reske, S.5    Nahmias, C.6
  • 60
    • 0037125376 scopus 로고    scopus 로고
    • Brain imaging to assess the effects of dopamine agonists on progression of Parkinson disease
    • Ahlskog JE, Maraganore DM, Uitti RJ, Uhl GR. Brain imaging to assess the effects of dopamine agonists on progression of Parkinson disease. JAMA. 2002; 288(3):311.
    • (2002) JAMA , vol.288 , Issue.3 , pp. 311
    • Ahlskog, J.E.1    Maraganore, D.M.2    Uitti, R.J.3    Uhl, G.R.4
  • 61
    • 79954993735 scopus 로고    scopus 로고
    • The role and interpretation of pilot studies in clinical research
    • Leon AC, Davis LL, Kraemer HC. The role and interpretation of pilot studies in clinical research. J Psych Res. 2011; 45(5), 626-629.
    • (2011) J Psych Res , vol.45 , Issue.5 , pp. 626-629
    • Leon, A.C.1    Davis, L.L.2    Kraemer, H.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.