메뉴 건너뛰기




Volumn 42, Issue , 2016, Pages 76-92

Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes

Author keywords

Gliptins; GLP 1; Metformin; Neuroprotection; Sulfonylureas; Thiazolidinediones

Indexed keywords

ALOGLIPTIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EXENDIN 4; GHRELIN; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; LINAGLIPTIN; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; PIOGLITAZONE; PLACEBO; REPAGLINIDE; ROSIGLITAZONE; SAXAGLIPTIN; SIRTUIN 1; SITAGLIPTIN; TOLBUTAMIDE; VILDAGLIPTIN; ANTIDIABETIC AGENT;

EID: 84981743851     PISSN: 00913022     EISSN: 10956808     Source Type: Journal    
DOI: 10.1016/j.yfrne.2016.07.002     Document Type: Review
Times cited : (47)

References (244)
  • 1
    • 84955286350 scopus 로고    scopus 로고
    • The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent
    • Aarse, J., Herlitze, S., Manahan-Vaughan, D., The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent. Hippocampus 26 (2015), 739–751.
    • (2015) Hippocampus , vol.26 , pp. 739-751
    • Aarse, J.1    Herlitze, S.2    Manahan-Vaughan, D.3
  • 2
    • 69549138878 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimer's disease
    • Abbas, T., Faivre, E., Holscher, C., Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimer's disease. Behav. Brain Res. 205 (2009), 265–271.
    • (2009) Behav. Brain Res. , vol.205 , pp. 265-271
    • Abbas, T.1    Faivre, E.2    Holscher, C.3
  • 5
    • 84951266035 scopus 로고    scopus 로고
    • Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
    • Allard, J.S., Perez, E.J., Fukui, K., Carpenter, P., Ingram, D.K., Cabo, R., Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice. Behav. Brain Res. 301 (2015), 1–9.
    • (2015) Behav. Brain Res. , vol.301 , pp. 1-9
    • Allard, J.S.1    Perez, E.J.2    Fukui, K.3    Carpenter, P.4    Ingram, D.K.5    Cabo, R.6
  • 6
    • 84951266035 scopus 로고    scopus 로고
    • Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
    • Allard, J.S., Perez, E.J., Fukui, K., Carpenter, P., Ingram, D.K., Cabo, R., Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice. Behav. Brain Res. 301 (2016), 1–9.
    • (2016) Behav. Brain Res. , vol.301 , pp. 1-9
    • Allard, J.S.1    Perez, E.J.2    Fukui, K.3    Carpenter, P.4    Ingram, D.K.5    Cabo, R.6
  • 7
    • 84896363955 scopus 로고    scopus 로고
    • Metformin eased cognitive impairment induced by chronic L-methionine administration: potential role of oxidative stress
    • Alzoubi, K.H., Khabour, O.F., Al-Azzam, S.I., Tashtoush, M.H., Mhaidat, N.M., Metformin eased cognitive impairment induced by chronic L-methionine administration: potential role of oxidative stress. Curr. Neuropharmacol. 12 (2014), 186–192.
    • (2014) Curr. Neuropharmacol. , vol.12 , pp. 186-192
    • Alzoubi, K.H.1    Khabour, O.F.2    Al-Azzam, S.I.3    Tashtoush, M.H.4    Mhaidat, N.M.5
  • 8
    • 84871995815 scopus 로고    scopus 로고
    • Standards of medical care in diabetes–2013
    • American Diabetes, A., Standards of medical care in diabetes–2013. Diabetes Care 36:Suppl. 1 (2013), S11–S66.
    • (2013) Diabetes Care , vol.36 , pp. S11-S66
    • American Diabetes, A.1
  • 10
    • 84891275812 scopus 로고    scopus 로고
    • Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1
    • Arunachalam, G., Samuel, S.M., Marei, I., Ding, H., Triggle, C.R., Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. Br. J. Pharmacol. 171 (2014), 523–535.
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 523-535
    • Arunachalam, G.1    Samuel, S.M.2    Marei, I.3    Ding, H.4    Triggle, C.R.5
  • 11
    • 2442424380 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
    • Arvanitakis, Z., Wilson, R.S., Bienias, J.L., Evans, D.A., Bennett, D.A., Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch. Neurol. 61 (2004), 661–666.
    • (2004) Arch. Neurol. , vol.61 , pp. 661-666
    • Arvanitakis, Z.1    Wilson, R.S.2    Bienias, J.L.3    Evans, D.A.4    Bennett, D.A.5
  • 15
    • 34249048643 scopus 로고    scopus 로고
    • Intrahippocampal insulin improves memory in a passive-avoidance task in male wistar rats
    • Babri, S., Badie, H.G., Khamenei, S., Seyedlar, M.O., Intrahippocampal insulin improves memory in a passive-avoidance task in male wistar rats. Brain Cogn. 64 (2007), 86–91.
    • (2007) Brain Cogn. , vol.64 , pp. 86-91
    • Babri, S.1    Badie, H.G.2    Khamenei, S.3    Seyedlar, M.O.4
  • 16
    • 38849187108 scopus 로고    scopus 로고
    • Higher total ghrelin levels are associated with higher insulin-mediated glucose disposal in non-diabetic maintenance hemodialysis patients
    • Barazzoni, R., Zanetti, M., Stulle, M., Mucci, M.P., Pirulli, A., Dore, F., Panzetta, G., Vasile, A., Biolo, G., Guarnieri, G., Higher total ghrelin levels are associated with higher insulin-mediated glucose disposal in non-diabetic maintenance hemodialysis patients. Clin. Nutr. 27 (2008), 142–149.
    • (2008) Clin. Nutr. , vol.27 , pp. 142-149
    • Barazzoni, R.1    Zanetti, M.2    Stulle, M.3    Mucci, M.P.4    Pirulli, A.5    Dore, F.6    Panzetta, G.7    Vasile, A.8    Biolo, G.9    Guarnieri, G.10
  • 17
    • 0035980149 scopus 로고    scopus 로고
    • Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3
    • Barber, A.J., Nakamura, M., Wolpert, E.B., Reiter, C.E., Seigel, G.M., Antonetti, D.A., Gardner, T.W., Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J. Biol. Chem. 276 (2001), 32814–32821.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32814-32821
    • Barber, A.J.1    Nakamura, M.2    Wolpert, E.B.3    Reiter, C.E.4    Seigel, G.M.5    Antonetti, D.A.6    Gardner, T.W.7
  • 18
    • 0033851246 scopus 로고    scopus 로고
    • Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin
    • Bauman, W.A., Shaw, S., Jayatilleke, E., Spungen, A.M., Herbert, V., Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 23 (2000), 1227–1231.
    • (2000) Diabetes Care , vol.23 , pp. 1227-1231
    • Bauman, W.A.1    Shaw, S.2    Jayatilleke, E.3    Spungen, A.M.4    Herbert, V.5
  • 19
    • 0027361094 scopus 로고
    • Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain
    • Baura, G.D., Foster, D.M., Porte, D. Jr., Kahn, S.E., Bergman, R.N., Cobelli, C., Schwartz, M.W., Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J. Clin. Investig. 92 (1993), 1824–1830.
    • (1993) J. Clin. Investig. , vol.92 , pp. 1824-1830
    • Baura, G.D.1    Foster, D.M.2    Porte, D.3    Kahn, S.E.4    Bergman, R.N.5    Cobelli, C.6    Schwartz, M.W.7
  • 21
    • 42049089751 scopus 로고    scopus 로고
    • Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin
    • Benedict, C., Kern, W., Schultes, B., Born, J., Hallschmid, M., Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J. Clin. Endocrinol. Metab. 93 (2008), 1339–1344.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 1339-1344
    • Benedict, C.1    Kern, W.2    Schultes, B.3    Born, J.4    Hallschmid, M.5
  • 24
    • 84944714835 scopus 로고    scopus 로고
    • Hippocampal insulin resistance and cognitive dysfunction
    • Biessels, G.J., Reagan, L.P., Hippocampal insulin resistance and cognitive dysfunction. Nat. Rev. Neurosci. 16 (2015), 660–671.
    • (2015) Nat. Rev. Neurosci. , vol.16 , pp. 660-671
    • Biessels, G.J.1    Reagan, L.P.2
  • 27
    • 84938717912 scopus 로고    scopus 로고
    • Glitazone treatment and incidence of Parkinson's disease among people with diabetes: a retrospective cohort study
    • Brauer, R., Bhaskaran, K., Chaturvedi, N., Dexter, D.T., Smeeth, L., Douglas, I., Glitazone treatment and incidence of Parkinson's disease among people with diabetes: a retrospective cohort study. PLoS Med., 12, 2015, e1001854.
    • (2015) PLoS Med. , vol.12 , pp. e1001854
    • Brauer, R.1    Bhaskaran, K.2    Chaturvedi, N.3    Dexter, D.T.4    Smeeth, L.5    Douglas, I.6
  • 29
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee, M., Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001), 813–820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 30
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: a unifying mechanism
    • Brownlee, M., The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54 (2005), 1615–1625.
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 33
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse, J.B., Rosenstock, J., Sesti, G., Schmidt, W.E., Montanya, E., Brett, J.H., Zychma, M., Blonde, L., Group, L.-S., Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 374 (2009), 39–47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6    Zychma, M.7    Blonde, L.8    Group, L.-S.9
  • 34
    • 84896707708 scopus 로고    scopus 로고
    • An examination of early neural and cognitive alterations in hippocampal-spatial function of ghrelin receptor-deficient rats
    • Cahill, S.P., Hatchard, T., Abizaid, A., Holahan, M.R., An examination of early neural and cognitive alterations in hippocampal-spatial function of ghrelin receptor-deficient rats. Behav. Brain Res. 264 (2014), 105–115.
    • (2014) Behav. Brain Res. , vol.264 , pp. 105-115
    • Cahill, S.P.1    Hatchard, T.2    Abizaid, A.3    Holahan, M.R.4
  • 35
    • 84904134776 scopus 로고    scopus 로고
    • Lixisenatide rescues spatial memory and synaptic plasticity from amyloid beta protein-induced impairments in rats
    • Cai, H.Y., Holscher, C., Yue, X.H., Zhang, S.X., Wang, X.H., Qiao, F., Yang, W., Qi, J.S., Lixisenatide rescues spatial memory and synaptic plasticity from amyloid beta protein-induced impairments in rats. Neuroscience 277 (2014), 6–13.
    • (2014) Neuroscience , vol.277 , pp. 6-13
    • Cai, H.Y.1    Holscher, C.2    Yue, X.H.3    Zhang, S.X.4    Wang, X.H.5    Qiao, F.6    Yang, W.7    Qi, J.S.8
  • 39
    • 84881311117 scopus 로고    scopus 로고
    • UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats
    • Cardoso, S., Santos, M.S., Moreno, A., Moreira, P.I., UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats. J. Bioenerg. Biomembr. 45 (2013), 397–407.
    • (2013) J. Bioenerg. Biomembr. , vol.45 , pp. 397-407
    • Cardoso, S.1    Santos, M.S.2    Moreno, A.3    Moreira, P.I.4
  • 42
    • 77949493599 scopus 로고    scopus 로고
    • Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
    • Caton, P.W., Nayuni, N.K., Kieswich, J., Khan, N.Q., Yaqoob, M.M., Corder, R., Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J. Endocrinol. 205 (2010), 97–106.
    • (2010) J. Endocrinol. , vol.205 , pp. 97-106
    • Caton, P.W.1    Nayuni, N.K.2    Kieswich, J.3    Khan, N.Q.4    Yaqoob, M.M.5    Corder, R.6
  • 46
    • 78651424438 scopus 로고    scopus 로고
    • Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats
    • Chen, L., Xing, T., Wang, M., Miao, Y., Tang, M., Chen, J., Li, G., Ruan, D.Y., Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats. Eur. J. Neurosci. 33 (2011), 266–275.
    • (2011) Eur. J. Neurosci. , vol.33 , pp. 266-275
    • Chen, L.1    Xing, T.2    Wang, M.3    Miao, Y.4    Tang, M.5    Chen, J.6    Li, G.7    Ruan, D.Y.8
  • 47
    • 84868121739 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and neurodegenerative disorders
    • Chen, Y.C., Wu, J.S., Tsai, H.D., Huang, C.Y., Chen, J.J., Sun, G.Y., Lin, T.N., Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and neurodegenerative disorders. Mol. Neurobiol. 46 (2012), 114–124.
    • (2012) Mol. Neurobiol. , vol.46 , pp. 114-124
    • Chen, Y.C.1    Wu, J.S.2    Tsai, H.D.3    Huang, C.Y.4    Chen, J.J.5    Sun, G.Y.6    Lin, T.N.7
  • 50
    • 84861450111 scopus 로고    scopus 로고
    • Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies
    • Cheng, G., Huang, C., Deng, H., Wang, H., Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Internal Med. J. 42 (2012), 484–491.
    • (2012) Internal Med. J. , vol.42 , pp. 484-491
    • Cheng, G.1    Huang, C.2    Deng, H.3    Wang, H.4
  • 51
    • 79951529849 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders
    • Chong, Z.Z., Shang, Y.C., Zhang, L., Wang, S., Maiese, K., Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders. Oxid. Med. Cell. Long. 3 (2010), 374–391.
    • (2010) Oxid. Med. Cell. Long. , vol.3 , pp. 374-391
    • Chong, Z.Z.1    Shang, Y.C.2    Zhang, L.3    Wang, S.4    Maiese, K.5
  • 54
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
    • Combs, C.K., Johnson, D.E., Karlo, J.C., Cannady, S.B., Landreth, G.E., Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J. Neurosci. 20 (2000), 558–567.
    • (2000) J. Neurosci. , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 55
    • 84942860454 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson's disease patients with mild cognitive impairment
    • Costa, A., Peppe, A., Carlesimo, G.A., Zabberoni, S., Scalici, F., Caltagirone, C., Angelucci, F., Brain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson's disease patients with mild cognitive impairment. Front. Behav. Neurosci., 9, 2015, 253.
    • (2015) Front. Behav. Neurosci. , vol.9 , pp. 253
    • Costa, A.1    Peppe, A.2    Carlesimo, G.A.3    Zabberoni, S.4    Scalici, F.5    Caltagirone, C.6    Angelucci, F.7
  • 56
    • 84959189375 scopus 로고    scopus 로고
    • The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders
    • Costales, J., Kolevzon, A., The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders. Neurosci. Biobehav. Rev. 63 (2016), 207–222.
    • (2016) Neurosci. Biobehav. Rev. , vol.63 , pp. 207-222
    • Costales, J.1    Kolevzon, A.2
  • 59
    • 84887105869 scopus 로고    scopus 로고
    • Glucose levels and risk of dementia
    • Crane, P.K., Walker, R., Larson, E.B., Glucose levels and risk of dementia. N. Engl. J. Med. 369 (2013), 1863–1864.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1863-1864
    • Crane, P.K.1    Walker, R.2    Larson, E.B.3
  • 61
    • 0036551775 scopus 로고    scopus 로고
    • Mutant mouse models of insulin-like growth factor actions in the central nervous system
    • D'Ercole, A.J., Ye, P., O'Kusky, J.R., Mutant mouse models of insulin-like growth factor actions in the central nervous system. Neuropeptides 36 (2002), 209–220.
    • (2002) Neuropeptides , vol.36 , pp. 209-220
    • D'Ercole, A.J.1    Ye, P.2    O'Kusky, J.R.3
  • 64
    • 70349744089 scopus 로고    scopus 로고
    • Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis
    • de la Monte, S.M., Longato, L., Tong, M., Wands, J.R., Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis. Curr. Opin. Investig. Drugs 10 (2009), 1049–1060.
    • (2009) Curr. Opin. Investig. Drugs , vol.10 , pp. 1049-1060
    • de la Monte, S.M.1    Longato, L.2    Tong, M.3    Wands, J.R.4
  • 66
    • 73749086345 scopus 로고    scopus 로고
    • The role of mitochondrial uncoupling proteins in lifespan
    • Dietrich, M.O., Horvath, T.L., The role of mitochondrial uncoupling proteins in lifespan. Pflugers Arch. 459 (2010), 269–275.
    • (2010) Pflugers Arch. , vol.459 , pp. 269-275
    • Dietrich, M.O.1    Horvath, T.L.2
  • 67
    • 84898873423 scopus 로고    scopus 로고
    • Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi
    • Du, L.L., Xie, J.Z., Cheng, X.S., Li, X.H., Kong, F.L., Jiang, X., Ma, Z.W., Wang, J.Z., Chen, C., Zhou, X.W., Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age 36 (2014), 613–623.
    • (2014) Age , vol.36 , pp. 613-623
    • Du, L.L.1    Xie, J.Z.2    Cheng, X.S.3    Li, X.H.4    Kong, F.L.5    Jiang, X.6    Ma, Z.W.7    Wang, J.Z.8    Chen, C.9    Zhou, X.W.10
  • 68
    • 33750882488 scopus 로고    scopus 로고
    • Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress
    • Duarte, A.I., Proenca, T., Oliveira, C.R., Santos, M.S., Rego, A.C., Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress. Diabetes 55 (2006), 2863–2870.
    • (2006) Diabetes , vol.55 , pp. 2863-2870
    • Duarte, A.I.1    Proenca, T.2    Oliveira, C.R.3    Santos, M.S.4    Rego, A.C.5
  • 69
    • 43549087343 scopus 로고    scopus 로고
    • Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3beta signaling pathways and changes in protein expression
    • Duarte, A.I., Santos, P., Oliveira, C.R., Santos, M.S., Rego, A.C., Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3beta signaling pathways and changes in protein expression. Biochim. Biophys. Acta 1783 (2008), 994–1002.
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 994-1002
    • Duarte, A.I.1    Santos, P.2    Oliveira, C.R.3    Santos, M.S.4    Rego, A.C.5
  • 72
    • 84949035544 scopus 로고    scopus 로고
    • Favorable effects of vildagliptin on metabolic and cognitive dysfunctions in streptozotocin-induced diabetic rats
    • El Batsh, M.M., El Batch, M.M., Shafik, N.M., Younos, I.H., Favorable effects of vildagliptin on metabolic and cognitive dysfunctions in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 769 (2015), 297–305.
    • (2015) Eur. J. Pharmacol. , vol.769 , pp. 297-305
    • El Batsh, M.M.1    El Batch, M.M.2    Shafik, N.M.3    Younos, I.H.4
  • 76
    • 84925229161 scopus 로고    scopus 로고
    • Glycaemic control: a balancing act or a different approach?
    • Fava, S., Glycaemic control: a balancing act or a different approach?. Curr. Diabetes Rev. 10 (2014), 124–130.
    • (2014) Curr. Diabetes Rev. , vol.10 , pp. 124-130
    • Fava, S.1
  • 81
    • 84924732903 scopus 로고    scopus 로고
    • Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline
    • Gault, V.A., Lennox, R., Flatt, P.R., Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline. Diabetes Obes. Metab. 17 (2015), 403–413.
    • (2015) Diabetes Obes. Metab. , vol.17 , pp. 403-413
    • Gault, V.A.1    Lennox, R.2    Flatt, P.R.3
  • 84
    • 82755176046 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • Gengler, S., McClean, P.L., McCurtin, R., Gault, V.A., Holscher, C., Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol. Aging 33 (2012), 265–276.
    • (2012) Neurobiol. Aging , vol.33 , pp. 265-276
    • Gengler, S.1    McClean, P.L.2    McCurtin, R.3    Gault, V.A.4    Holscher, C.5
  • 85
    • 0345305844 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons
    • Gilman, C.P., Perry, T., Furukawa, K., Grieg, N.H., Egan, J.M., Mattson, M.P., Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons. J. Neurochem. 87 (2003), 1137–1144.
    • (2003) J. Neurochem. , vol.87 , pp. 1137-1144
    • Gilman, C.P.1    Perry, T.2    Furukawa, K.3    Grieg, N.H.4    Egan, J.M.5    Mattson, M.P.6
  • 86
    • 77953058601 scopus 로고    scopus 로고
    • Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus
    • Glasper, E.R., Llorens-Martin, M.V., Leuner, B., Gould, E., Trejo, J.L., Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus. Hippocampus 20 (2010), 706–712.
    • (2010) Hippocampus , vol.20 , pp. 706-712
    • Glasper, E.R.1    Llorens-Martin, M.V.2    Leuner, B.3    Gould, E.4    Trejo, J.L.5
  • 89
    • 79952439187 scopus 로고    scopus 로고
    • Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes
    • Gupta, A., Bisht, B., Dey, C.S., Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes. Neuropharmacology 60 (2011), 910–920.
    • (2011) Neuropharmacology , vol.60 , pp. 910-920
    • Gupta, A.1    Bisht, B.2    Dey, C.S.3
  • 91
    • 69549128161 scopus 로고    scopus 로고
    • Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system
    • Hamilton, A., Holscher, C., Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. NeuroReport 20 (2009), 1161–1166.
    • (2009) NeuroReport , vol.20 , pp. 1161-1166
    • Hamilton, A.1    Holscher, C.2
  • 92
    • 79751479118 scopus 로고    scopus 로고
    • Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain
    • Hamilton, A., Patterson, S., Porter, D., Gault, V.A., Holscher, C., Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J. Neurosci. Res. 89 (2011), 481–489.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 481-489
    • Hamilton, A.1    Patterson, S.2    Porter, D.3    Gault, V.A.4    Holscher, C.5
  • 93
    • 84962229876 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy
    • Hansen, H.H., Barkholt, P., Fabricius, K., Jelsing, J., Terwel, D., Pyke, C., Knudsen, L.B., Vrang, N., The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy. Brain Res. 1634 (2016), 158–170.
    • (2016) Brain Res. , vol.1634 , pp. 158-170
    • Hansen, H.H.1    Barkholt, P.2    Fabricius, K.3    Jelsing, J.4    Terwel, D.5    Pyke, C.6    Knudsen, L.B.7    Vrang, N.8
  • 94
    • 84936990507 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease
    • Hansen, H.H., Fabricius, K., Barkholt, P., Niehoff, M.L., Morley, J.E., Jelsing, J., Pyke, C., Knudsen, L.B., Farr, S.A., Vrang, N., The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease. J. Alzheimer's Disease: JAD 46 (2015), 877–888.
    • (2015) J. Alzheimer's Disease: JAD , vol.46 , pp. 877-888
    • Hansen, H.H.1    Fabricius, K.2    Barkholt, P.3    Niehoff, M.L.4    Morley, J.E.5    Jelsing, J.6    Pyke, C.7    Knudsen, L.B.8    Farr, S.A.9    Vrang, N.10
  • 95
    • 45549108268 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
    • Harkavyi, A., Abuirmeileh, A., Lever, R., Kingsbury, A.E., Biggs, C.S., Whitton, P.S., Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease. J. Neuroinflam., 5, 2008, 19.
    • (2008) J. Neuroinflam. , vol.5 , pp. 19
    • Harkavyi, A.1    Abuirmeileh, A.2    Lever, R.3    Kingsbury, A.E.4    Biggs, C.S.5    Whitton, P.S.6
  • 96
    • 77954089784 scopus 로고    scopus 로고
    • Evidence for abnormal glucose uptake or metabolism in thalamus during acute hyperglycaemia in type 1 diabetes – a 1H MRS study
    • Heikkila, O., Lundbom, N., Timonen, M., Groop, P.H., Heikkinen, S., Makimattila, S., Evidence for abnormal glucose uptake or metabolism in thalamus during acute hyperglycaemia in type 1 diabetes – a 1H MRS study. Metab. Brain Dis. 25 (2010), 227–234.
    • (2010) Metab. Brain Dis. , vol.25 , pp. 227-234
    • Heikkila, O.1    Lundbom, N.2    Timonen, M.3    Groop, P.H.4    Heikkinen, S.5    Makimattila, S.6
  • 98
    • 78650873814 scopus 로고    scopus 로고
    • CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis
    • Herold, S., Jagasia, R., Merz, K., Wassmer, K., Lie, D.C., CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis. Mol. Cell. Neurosci. 46 (2011), 79–88.
    • (2011) Mol. Cell. Neurosci. , vol.46 , pp. 79-88
    • Herold, S.1    Jagasia, R.2    Merz, K.3    Wassmer, K.4    Lie, D.C.5
  • 99
    • 84863091207 scopus 로고    scopus 로고
    • Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
    • Heyward, F.D., Walton, R.G., Carle, M.S., Coleman, M.A., Garvey, W.T., Sweatt, J.D., Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiol. Learn. Mem. 98 (2012), 25–32.
    • (2012) Neurobiol. Learn. Mem. , vol.98 , pp. 25-32
    • Heyward, F.D.1    Walton, R.G.2    Carle, M.S.3    Coleman, M.A.4    Garvey, W.T.5    Sweatt, J.D.6
  • 100
    • 78649385516 scopus 로고    scopus 로고
    • The role of GLP-1 in neuronal activity and neurodegeneration
    • Holscher, C., The role of GLP-1 in neuronal activity and neurodegeneration. Vitam. Horm. 84 (2010), 331–354.
    • (2010) Vitam. Horm. , vol.84 , pp. 331-354
    • Holscher, C.1
  • 101
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst, J.J., The physiology of glucagon-like peptide 1. Physiol. Rev. 87 (2007), 1409–1439.
    • (2007) Physiol. Rev. , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 102
    • 79956277464 scopus 로고    scopus 로고
    • Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
    • Hsu, C.C., Wahlqvist, M.L., Lee, M.S., Tsai, H.N., Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin. J. Alzheimer's Disease: JAD 24 (2011), 485–493.
    • (2011) J. Alzheimer's Disease: JAD , vol.24 , pp. 485-493
    • Hsu, C.C.1    Wahlqvist, M.L.2    Lee, M.S.3    Tsai, H.N.4
  • 103
    • 84959330675 scopus 로고    scopus 로고
    • The effect of constitutive over-expression of insulin-like growth factor 1 on the cognitive function in aged mice
    • Hu, A., Yuan, H., Wu, L., Chen, R., Chen, Q., Zhang, T., Wang, Z., Liu, P., Zhu, X., The effect of constitutive over-expression of insulin-like growth factor 1 on the cognitive function in aged mice. Brain Res. 1631 (2016), 204–213.
    • (2016) Brain Res. , vol.1631 , pp. 204-213
    • Hu, A.1    Yuan, H.2    Wu, L.3    Chen, R.4    Chen, Q.5    Zhang, T.6    Wang, Z.7    Liu, P.8    Zhu, X.9
  • 105
    • 84955190089 scopus 로고    scopus 로고
    • Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline
    • Huffman, D.M., Farias Quipildor, G., Mao, K., Zhang, X., Wan, J., Apontes, P., Cohen, P., Barzilai, N., Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Aging Cell 15 (2016), 181–186.
    • (2016) Aging Cell , vol.15 , pp. 181-186
    • Huffman, D.M.1    Farias Quipildor, G.2    Mao, K.3    Zhang, X.4    Wan, J.5    Apontes, P.6    Cohen, P.7    Barzilai, N.8
  • 106
    • 77953534823 scopus 로고    scopus 로고
    • Metformin normalizes type 2 diabetes-induced decrease in cell proliferation and neuroblast differentiation in the rat dentate gyrus
    • Hwang, I.K., Kim, I.Y., Joo, E.J., Shin, J.H., Choi, J.W., Won, M.H., Yoon, Y.S., Seong, J.K., Metformin normalizes type 2 diabetes-induced decrease in cell proliferation and neuroblast differentiation in the rat dentate gyrus. Neurochem. Res. 35 (2010), 645–650.
    • (2010) Neurochem. Res. , vol.35 , pp. 645-650
    • Hwang, I.K.1    Kim, I.Y.2    Joo, E.J.3    Shin, J.H.4    Choi, J.W.5    Won, M.H.6    Yoon, Y.S.7    Seong, J.K.8
  • 107
    • 84861233877 scopus 로고    scopus 로고
    • Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study
    • Imfeld, P., Bodmer, M., Jick, S.S., Meier, C.R., Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study. J. Am. Geriatr. Soc. 60 (2012), 916–921.
    • (2012) J. Am. Geriatr. Soc. , vol.60 , pp. 916-921
    • Imfeld, P.1    Bodmer, M.2    Jick, S.S.3    Meier, C.R.4
  • 109
    • 13644271368 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
    • Inestrosa, N.C., Godoy, J.A., Quintanilla, R.A., Koenig, C.S., Bronfman, M., Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling. Exp. Cell Res. 304 (2005), 91–104.
    • (2005) Exp. Cell Res. , vol.304 , pp. 91-104
    • Inestrosa, N.C.1    Godoy, J.A.2    Quintanilla, R.A.3    Koenig, C.S.4    Bronfman, M.5
  • 111
    • 84937520622 scopus 로고    scopus 로고
    • Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial
    • Investigators, N.E.T.i.P.D.F.-Z., Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial. Lancet Neurol. 14 (2015), 795–803.
    • (2015) Lancet Neurol. , vol.14 , pp. 795-803
    • Investigators, N.E.T.I.P.D.F.-Z.1
  • 113
    • 78649745810 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test
    • Isacson, R., Nielsen, E., Dannaeus, K., Bertilsson, G., Patrone, C., Zachrisson, O., Wikstrom, L., The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test. Eur. J. Pharmacol. 650 (2011), 249–255.
    • (2011) Eur. J. Pharmacol. , vol.650 , pp. 249-255
    • Isacson, R.1    Nielsen, E.2    Dannaeus, K.3    Bertilsson, G.4    Patrone, C.5    Zachrisson, O.6    Wikstrom, L.7
  • 114
    • 84895067918 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents
    • Iwai, T., Sawabe, T., Tanimitsu, K., Suzuki, M., Sasaki-Hamada, S., Oka, J., Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents. J. Neurosci. Res. 92 (2014), 446–454.
    • (2014) J. Neurosci. Res. , vol.92 , pp. 446-454
    • Iwai, T.1    Sawabe, T.2    Tanimitsu, K.3    Suzuki, M.4    Sasaki-Hamada, S.5    Oka, J.6
  • 115
    • 84962236691 scopus 로고    scopus 로고
    • A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF
    • Ji, C., Xue, G.F., Lijun, C., Feng, P., Li, D., Li, L., Li, G., Holscher, C., A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF. Brain Res. 1634 (2016), 1–11.
    • (2016) Brain Res. , vol.1634 , pp. 1-11
    • Ji, C.1    Xue, G.F.2    Lijun, C.3    Feng, P.4    Li, D.5    Li, L.6    Li, G.7    Holscher, C.8
  • 116
    • 84864753094 scopus 로고    scopus 로고
    • PPARgamma agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus
    • Jiang, L.Y., Tang, S.S., Wang, X.Y., Liu, L.P., Long, Y., Hu, M., Liao, M.X., Ding, Q.L., Hu, W., Li, J.C., Hong, H., PPARgamma agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus. CNS Neurosci. Ther. 18 (2012), 659–666.
    • (2012) CNS Neurosci. Ther. , vol.18 , pp. 659-666
    • Jiang, L.Y.1    Tang, S.S.2    Wang, X.Y.3    Liu, L.P.4    Long, Y.5    Hu, M.6    Liao, M.X.7    Ding, Q.L.8    Hu, W.9    Li, J.C.10    Hong, H.11
  • 119
    • 84973861976 scopus 로고    scopus 로고
    • Sex and gender differences in risk, pathophysiology and complications of Type 2 diabetes mellitus
    • Kautzky-Willer, A., Harreiter, J., Pacini, G., Sex and gender differences in risk, pathophysiology and complications of Type 2 diabetes mellitus. Endocr. Rev. 37 (2016), 278–316.
    • (2016) Endocr. Rev. , vol.37 , pp. 278-316
    • Kautzky-Willer, A.1    Harreiter, J.2    Pacini, G.3
  • 120
    • 84875395645 scopus 로고    scopus 로고
    • Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone
    • Khanfar, M.A., AbuKhader, M.M., Alqtaishat, S., Taha, M.O., Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone. J. Mol. Graph. Model. 42 (2013), 39–49.
    • (2013) J. Mol. Graph. Model. , vol.42 , pp. 39-49
    • Khanfar, M.A.1    AbuKhader, M.M.2    Alqtaishat, S.3    Taha, M.O.4
  • 121
    • 85047286752 scopus 로고    scopus 로고
    • Diabetes mellitus: the epidemic of the century
    • Kharroubi, A.T., Darwish, H.M., Diabetes mellitus: the epidemic of the century. World J. Diabetes 6 (2015), 850–867.
    • (2015) World J. Diabetes , vol.6 , pp. 850-867
    • Kharroubi, A.T.1    Darwish, H.M.2
  • 122
    • 84901480460 scopus 로고    scopus 로고
    • Functional roles of CREB as a positive regulator in the formation and enhancement of memory
    • Kida, S., Serita, T., Functional roles of CREB as a positive regulator in the formation and enhancement of memory. Brain Res. Bull. 105 (2014), 17–24.
    • (2014) Brain Res. Bull. , vol.105 , pp. 17-24
    • Kida, S.1    Serita, T.2
  • 123
    • 84903173931 scopus 로고    scopus 로고
    • Insulin action in brain regulates systemic metabolism and brain function
    • Kleinridders, A., Ferris, H.A., Cai, W., Kahn, C.R., Insulin action in brain regulates systemic metabolism and brain function. Diabetes 63 (2014), 2232–2243.
    • (2014) Diabetes , vol.63 , pp. 2232-2243
    • Kleinridders, A.1    Ferris, H.A.2    Cai, W.3    Kahn, C.R.4
  • 127
    • 84920059626 scopus 로고    scopus 로고
    • GLP-1 and exendin-4 transiently enhance GABAA receptor-mediated synaptic and tonic currents in rat hippocampal CA3 pyramidal neurons
    • Korol, S.V., Jin, Z., Babateen, O., Birnir, B., GLP-1 and exendin-4 transiently enhance GABAA receptor-mediated synaptic and tonic currents in rat hippocampal CA3 pyramidal neurons. Diabetes 64 (2015), 79–89.
    • (2015) Diabetes , vol.64 , pp. 79-89
    • Korol, S.V.1    Jin, Z.2    Babateen, O.3    Birnir, B.4
  • 128
    • 84888008405 scopus 로고    scopus 로고
    • Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease
    • Kosaraju, J., Murthy, V., Khatwal, R.B., Dubala, A., Chinni, S., Muthureddy Nataraj, S.K., Basavan, D., Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease. J. Pharm. Pharmacol. 65 (2013), 1773–1784.
    • (2013) J. Pharm. Pharmacol. , vol.65 , pp. 1773-1784
    • Kosaraju, J.1    Murthy, V.2    Khatwal, R.B.3    Dubala, A.4    Chinni, S.5    Muthureddy Nataraj, S.K.6    Basavan, D.7
  • 129
    • 34147102288 scopus 로고    scopus 로고
    • Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease
    • Landreth, G., Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease. Curr. Alzheimer Res. 4 (2007), 159–164.
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 159-164
    • Landreth, G.1
  • 130
    • 84941585404 scopus 로고    scopus 로고
    • Regulation of hippocampal synaptic plasticity by BDNF
    • Leal, G., Afonso, P.M., Salazar, I.L., Duarte, C.B., Regulation of hippocampal synaptic plasticity by BDNF. Brain Res. 1621 (2015), 82–101.
    • (2015) Brain Res. , vol.1621 , pp. 82-101
    • Leal, G.1    Afonso, P.M.2    Salazar, I.L.3    Duarte, C.B.4
  • 132
    • 84907190290 scopus 로고    scopus 로고
    • Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice
    • Lennox, R., Flatt, P.R., Gault, V.A., Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice. Peptides 61 (2014), 38–47.
    • (2014) Peptides , vol.61 , pp. 38-47
    • Lennox, R.1    Flatt, P.R.2    Gault, V.A.3
  • 133
    • 84875613609 scopus 로고    scopus 로고
    • (Val(8))GLP-1-Glu-PAL: a GLP-1 agonist that improves hippocampal neurogenesis, glucose homeostasis, and beta-cell function in high-fat-fed mice
    • Lennox, R., Porter, D.W., Flatt, P.R., Gault, V.A., (Val(8))GLP-1-Glu-PAL: a GLP-1 agonist that improves hippocampal neurogenesis, glucose homeostasis, and beta-cell function in high-fat-fed mice. ChemMedChem 8 (2013), 595–602.
    • (2013) ChemMedChem , vol.8 , pp. 595-602
    • Lennox, R.1    Porter, D.W.2    Flatt, P.R.3    Gault, V.A.4
  • 134
    • 84907022517 scopus 로고    scopus 로고
    • Adherence to therapy and adverse drug reactions: is there a link?
    • Leporini, C., De Sarro, G., Russo, E., Adherence to therapy and adverse drug reactions: is there a link?. Exp. Opin. Drug Safety 13:Suppl. 1 (2014), S41–S55.
    • (2014) Exp. Opin. Drug Safety , vol.13 , pp. S41-S55
    • Leporini, C.1    De Sarro, G.2    Russo, E.3
  • 135
    • 84878777634 scopus 로고    scopus 로고
    • Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory
    • Li, E., Chung, H., Kim, Y., Kim, D.H., Ryu, J.H., Sato, T., Kojima, M., Park, S., Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory. Endocr. J. 60 (2013), 781–789.
    • (2013) Endocr. J. , vol.60 , pp. 781-789
    • Li, E.1    Chung, H.2    Kim, Y.3    Kim, D.H.4    Ryu, J.H.5    Sato, T.6    Kojima, M.7    Park, S.8
  • 136
    • 84942193062 scopus 로고    scopus 로고
    • Liraglutide promotes cortical neurite outgrowth via the MEK-ERK pathway
    • Li, M., Li, S., Li, Y., Liraglutide promotes cortical neurite outgrowth via the MEK-ERK pathway. Cell. Mol. Neurobiol. 35 (2015), 987–993.
    • (2015) Cell. Mol. Neurobiol. , vol.35 , pp. 987-993
    • Li, M.1    Li, S.2    Li, Y.3
  • 137
    • 84979221681 scopus 로고    scopus 로고
    • An update on type 2 diabetes mellitus as a risk factor for dementia
    • Li, W., Huang, E., An update on type 2 diabetes mellitus as a risk factor for dementia. J. Alzheimer's Disease: JAD 53 (2016), 393–402.
    • (2016) J. Alzheimer's Disease: JAD , vol.53 , pp. 393-402
    • Li, W.1    Huang, E.2
  • 138
    • 0035965708 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
    • Lichtenwalner, R.J., Forbes, M.E., Bennett, S.A., Lynch, C.D., Sonntag, W.E., Riddle, D.R., Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 107 (2001), 603–613.
    • (2001) Neuroscience , vol.107 , pp. 603-613
    • Lichtenwalner, R.J.1    Forbes, M.E.2    Bennett, S.A.3    Lynch, C.D.4    Sonntag, W.E.5    Riddle, D.R.6
  • 139
    • 84877310015 scopus 로고    scopus 로고
    • Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain beta-amyloid through PPARgamma activation
    • Liu, L.P., Yan, T.H., Jiang, L.Y., Hu, W., Hu, M., Wang, C., Zhang, Q., Long, Y., Wang, J.Q., Li, Y.Q., Hu, M., Hong, H., Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain beta-amyloid through PPARgamma activation. Acta Pharmacol. Sin. 34 (2013), 455–463.
    • (2013) Acta Pharmacol. Sin. , vol.34 , pp. 455-463
    • Liu, L.P.1    Yan, T.H.2    Jiang, L.Y.3    Hu, W.4    Hu, M.5    Wang, C.6    Zhang, Q.7    Long, Y.8    Wang, J.Q.9    Li, Y.Q.10    Hu, M.11    Hong, H.12
  • 140
    • 84875872441 scopus 로고    scopus 로고
    • Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells
    • Liu, Y., Yao, Z., Zhang, L., Zhu, H., Deng, W., Qin, C., Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells. Neuroscience 238 (2013), 371–380.
    • (2013) Neuroscience , vol.238 , pp. 371-380
    • Liu, Y.1    Yao, Z.2    Zhang, L.3    Zhu, H.4    Deng, W.5    Qin, C.6
  • 141
    • 0037007124 scopus 로고    scopus 로고
    • The insulin signalling pathway
    • Lizcano, J.M., Alessi, D.R., The insulin signalling pathway. Curr. Biol.: CB 12 (2002), R236–R238.
    • (2002) Curr. Biol.: CB , vol.12 , pp. R236-R238
    • Lizcano, J.M.1    Alessi, D.R.2
  • 143
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze, B.E., Ginty, D.D., Function and regulation of CREB family transcription factors in the nervous system. Neuron 35 (2002), 605–623.
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 144
    • 84900530338 scopus 로고    scopus 로고
    • BDNF and synaptic plasticity, cognitive function, and dysfunction
    • Lu, B., Nagappan, G., Lu, Y., BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb. Exp. Pharmacol. 220 (2014), 223–250.
    • (2014) Handb. Exp. Pharmacol. , vol.220 , pp. 223-250
    • Lu, B.1    Nagappan, G.2    Lu, Y.3
  • 145
    • 84871958330 scopus 로고    scopus 로고
    • Sex differences in the impact of diabetes on the risk of geriatric conditions
    • Lu, F.P., Chan, D.C., Kuo, H.K., Wu, S.C., Sex differences in the impact of diabetes on the risk of geriatric conditions. Geriatr. Gerontol. Int. 13 (2013), 116–122.
    • (2013) Geriatr. Gerontol. Int. , vol.13 , pp. 116-122
    • Lu, F.P.1    Chan, D.C.2    Kuo, H.K.3    Wu, S.C.4
  • 147
    • 0242330837 scopus 로고    scopus 로고
    • Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats
    • Lupien, S.B., Bluhm, E.J., Ishii, D.N., Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats. J. Neurosci. Res. 74 (2003), 512–523.
    • (2003) J. Neurosci. Res. , vol.74 , pp. 512-523
    • Lupien, S.B.1    Bluhm, E.J.2    Ishii, D.N.3
  • 148
    • 84943580301 scopus 로고    scopus 로고
    • Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice
    • Ma, D.L., Chen, F.Q., Xu, W.J., Yue, W.Z., Yuan, G., Yang, Y., Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. J. Neurochem. 135 (2015), 301–308.
    • (2015) J. Neurochem. , vol.135 , pp. 301-308
    • Ma, D.L.1    Chen, F.Q.2    Xu, W.J.3    Yue, W.Z.4    Yuan, G.5    Yang, Y.6
  • 149
    • 84938683644 scopus 로고    scopus 로고
    • Rosiglitazone improves learning and memory ability in rats with type 2 diabetes through the insulin signaling pathway
    • Ma, L., Shao, Z., Wang, R., Zhao, Z., Dong, W., Zhang, J., Zhang, X., Sheng, S., Ji, Z., Zhang, J., Rosiglitazone improves learning and memory ability in rats with type 2 diabetes through the insulin signaling pathway. Am. J. Med. Sci. 350 (2015), 121–128.
    • (2015) Am. J. Med. Sci. , vol.350 , pp. 121-128
    • Ma, L.1    Shao, Z.2    Wang, R.3    Zhao, Z.4    Dong, W.5    Zhang, J.6    Zhang, X.7    Sheng, S.8    Ji, Z.9    Zhang, J.10
  • 151
    • 84866972198 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 cleavage product GLP-1(9–36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice
    • Ma, T., Du, X., Pick, J.E., Sui, G., Brownlee, M., Klann, E., Glucagon-like peptide-1 cleavage product GLP-1(9–36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. J. Neurosci. 32 (2012), 13701–13708.
    • (2012) J. Neurosci. , vol.32 , pp. 13701-13708
    • Ma, T.1    Du, X.2    Pick, J.E.3    Sui, G.4    Brownlee, M.5    Klann, E.6
  • 155
    • 0027319561 scopus 로고
    • Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose
    • Mattson, M.P., Zhang, Y., Bose, S., Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose. Exp. Neurol. 121 (1993), 1–13.
    • (1993) Exp. Neurol. , vol.121 , pp. 1-13
    • Mattson, M.P.1    Zhang, Y.2    Bose, S.3
  • 156
    • 84886592674 scopus 로고    scopus 로고
    • Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
    • McClean, P.L., Holscher, C., Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. Neuropharmacology 76:Pt A (2014), 57–67.
    • (2014) Neuropharmacology , vol.76 , pp. 57-67
    • McClean, P.L.1    Holscher, C.2
  • 157
    • 84907302200 scopus 로고    scopus 로고
    • Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease
    • McClean, P.L., Holscher, C., Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease. Neuropharmacology 86 (2014), 241–258.
    • (2014) Neuropharmacology , vol.86 , pp. 241-258
    • McClean, P.L.1    Holscher, C.2
  • 158
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean, P.L., Parthsarathy, V., Faivre, E., Holscher, C., The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J. Neurosci. 31 (2011), 6587–6594.
    • (2011) J. Neurosci. , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Holscher, C.4
  • 159
    • 84895799430 scopus 로고    scopus 로고
    • Exenatide twice daily: a review of its use in the management of patients with type 2 diabetes mellitus
    • McCormack, P.L., Exenatide twice daily: a review of its use in the management of patients with type 2 diabetes mellitus. Drugs 74 (2014), 325–351.
    • (2014) Drugs , vol.74 , pp. 325-351
    • McCormack, P.L.1
  • 160
    • 42549161859 scopus 로고    scopus 로고
    • The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes
    • McCrimmon, R., The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes. Diabetic Med.: J. British Diabetic Assoc. 25 (2008), 513–522.
    • (2008) Diabetic Med.: J. British Diabetic Assoc. , vol.25 , pp. 513-522
    • McCrimmon, R.1
  • 162
    • 84865521108 scopus 로고    scopus 로고
    • Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain
    • McGovern, S.F., Hunter, K., Holscher, C., Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain. Brain Res. 1473 (2012), 204–213.
    • (2012) Brain Res. , vol.1473 , pp. 204-213
    • McGovern, S.F.1    Hunter, K.2    Holscher, C.3
  • 163
    • 79952597213 scopus 로고    scopus 로고
    • CREB in adult neurogenesis–master and partner in the development of adult-born neurons?
    • Merz, K., Herold, S., Lie, D.C., CREB in adult neurogenesis–master and partner in the development of adult-born neurons?. Eur. J. Neurosci. 33 (2011), 1078–1086.
    • (2011) Eur. J. Neurosci. , vol.33 , pp. 1078-1086
    • Merz, K.1    Herold, S.2    Lie, D.C.3
  • 165
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • Moloney, A.M., Griffin, R.J., Timmons, S., O'Connor, R., Ravid, R., O'Neill, C., Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging 31 (2010), 224–243.
    • (2010) Neurobiol. Aging , vol.31 , pp. 224-243
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 166
    • 84902298760 scopus 로고    scopus 로고
    • Impaired hippocampal neurogenesis and its enhancement with ghrelin in 5XFAD mice
    • Moon, M., Cha, M.Y., Mook-Jung, I., Impaired hippocampal neurogenesis and its enhancement with ghrelin in 5XFAD mice. J. Alzheimer's Disease: JAD 41 (2014), 233–241.
    • (2014) J. Alzheimer's Disease: JAD , vol.41 , pp. 233-241
    • Moon, M.1    Cha, M.Y.2    Mook-Jung, I.3
  • 167
    • 67650459465 scopus 로고    scopus 로고
    • Ghrelin regulates hippocampal neurogenesis in adult mice
    • Moon, M., Kim, S., Hwang, L., Park, S., Ghrelin regulates hippocampal neurogenesis in adult mice. Endocr. J. 56 (2009), 525–531.
    • (2009) Endocr. J. , vol.56 , pp. 525-531
    • Moon, M.1    Kim, S.2    Hwang, L.3    Park, S.4
  • 169
    • 84963780554 scopus 로고    scopus 로고
    • Brain-wide insulin resistance, tau phosphorylation changes, and hippocampal neprilysin and amyloid-beta alterations in a monkey model of type 1 diabetes
    • Morales-Corraliza, J., Wong, H., Mazzella, M.J., Che, S., Lee, S.H., Petkova, E., Wagner, J.D., Hemby, S.E., Ginsberg, S.D., Mathews, P.M., Brain-wide insulin resistance, tau phosphorylation changes, and hippocampal neprilysin and amyloid-beta alterations in a monkey model of type 1 diabetes. J. Neurosci. 36 (2016), 4248–4258.
    • (2016) J. Neurosci. , vol.36 , pp. 4248-4258
    • Morales-Corraliza, J.1    Wong, H.2    Mazzella, M.J.3    Che, S.4    Lee, S.H.5    Petkova, E.6    Wagner, J.D.7    Hemby, S.E.8    Ginsberg, S.D.9    Mathews, P.M.10
  • 173
    • 84902239478 scopus 로고    scopus 로고
    • Long-term metformin usage and cognitive function among older adults with diabetes
    • Ng, T.P., Feng, L., Yap, K.B., Lee, T.S., Tan, C.H., Winblad, B., Long-term metformin usage and cognitive function among older adults with diabetes. J. Alzheimer's Disease: JAD 41 (2014), 61–68.
    • (2014) J. Alzheimer's Disease: JAD , vol.41 , pp. 61-68
    • Ng, T.P.1    Feng, L.2    Yap, K.B.3    Lee, T.S.4    Tan, C.H.5    Winblad, B.6
  • 174
    • 84900333085 scopus 로고    scopus 로고
    • Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex
    • Ohtake, N., Saito, M., Eto, M., Seki, K., Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex. Regul. Pept. 190–191 (2014), 1–11.
    • (2014) Regul. Pept. , vol.190-191 , pp. 1-11
    • Ohtake, N.1    Saito, M.2    Eto, M.3    Seki, K.4
  • 177
    • 77952554583 scopus 로고    scopus 로고
    • Pathways involved in the generation of reactive oxygen and nitrogen species during glucose deprivation and its role on the death of cultured hippocampal neurons
    • Paramo, B., Hernandez-Fonseca, K., Estrada-Sanchez, A.M., Jimenez, N., Hernandez-Cruz, A., Massieu, L., Pathways involved in the generation of reactive oxygen and nitrogen species during glucose deprivation and its role on the death of cultured hippocampal neurons. Neuroscience 167 (2010), 1057–1069.
    • (2010) Neuroscience , vol.167 , pp. 1057-1069
    • Paramo, B.1    Hernandez-Fonseca, K.2    Estrada-Sanchez, A.M.3    Jimenez, N.4    Hernandez-Cruz, A.5    Massieu, L.6
  • 178
    • 33750454798 scopus 로고    scopus 로고
    • Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats
    • Pathan, A.R., Viswanad, B., Sonkusare, S.K., Ramarao, P., Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats. Life Sci. 79 (2006), 2209–2216.
    • (2006) Life Sci. , vol.79 , pp. 2209-2216
    • Pathan, A.R.1    Viswanad, B.2    Sonkusare, S.K.3    Ramarao, P.4
  • 179
    • 84907032242 scopus 로고    scopus 로고
    • Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice
    • Patil, S.P., Jain, P.D., Ghumatkar, P.J., Tambe, R., Sathaye, S., Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice. Neuroscience 277 (2014), 747–754.
    • (2014) Neuroscience , vol.277 , pp. 747-754
    • Patil, S.P.1    Jain, P.D.2    Ghumatkar, P.J.3    Tambe, R.4    Sathaye, S.5
  • 180
    • 84895456459 scopus 로고    scopus 로고
    • Diabetes drugs and neurological disorders: new views and therapeutic possibilities
    • Patrone, C., Eriksson, O., Lindholm, D., Diabetes drugs and neurological disorders: new views and therapeutic possibilities. Lancet Diabetes Endocrinol. 2 (2014), 256–262.
    • (2014) Lancet Diabetes Endocrinol. , vol.2 , pp. 256-262
    • Patrone, C.1    Eriksson, O.2    Lindholm, D.3
  • 181
    • 0035449745 scopus 로고    scopus 로고
    • Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus
    • Pencea, V., Bingaman, K.D., Wiegand, S.J., Luskin, M.B., Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J. Neurosci. 21 (2001), 6706–6717.
    • (2001) J. Neurosci. , vol.21 , pp. 6706-6717
    • Pencea, V.1    Bingaman, K.D.2    Wiegand, S.J.3    Luskin, M.B.4
  • 183
    • 69149095731 scopus 로고    scopus 로고
    • Early diagnosis of Alzheimer's disease: is MCI too late?
    • Petersen, R.C., Early diagnosis of Alzheimer's disease: is MCI too late?. Curr. Alzheimer Res. 6 (2009), 324–330.
    • (2009) Curr. Alzheimer Res. , vol.6 , pp. 324-330
    • Petersen, R.C.1
  • 184
    • 84924891364 scopus 로고    scopus 로고
    • Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning
    • Petzold, A., Psotta, L., Brigadski, T., Endres, T., Lessmann, V., Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning. Neurobiol. Learn. Mem. 120 (2015), 52–60.
    • (2015) Neurobiol. Learn. Mem. , vol.120 , pp. 52-60
    • Petzold, A.1    Psotta, L.2    Brigadski, T.3    Endres, T.4    Lessmann, V.5
  • 185
    • 84878781836 scopus 로고    scopus 로고
    • DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats
    • Pintana, H., Apaijai, N., Chattipakorn, N., Chattipakorn, S.C., DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats. J. Endocrinol. 218 (2013), 1–11.
    • (2013) J. Endocrinol. , vol.218 , pp. 1-11
    • Pintana, H.1    Apaijai, N.2    Chattipakorn, N.3    Chattipakorn, S.C.4
  • 186
    • 84866365752 scopus 로고    scopus 로고
    • Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats
    • Pintana, H., Apaijai, N., Pratchayasakul, W., Chattipakorn, N., Chattipakorn, S.C., Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats. Life Sci. 91 (2012), 409–414.
    • (2012) Life Sci. , vol.91 , pp. 409-414
    • Pintana, H.1    Apaijai, N.2    Pratchayasakul, W.3    Chattipakorn, N.4    Chattipakorn, S.C.5
  • 187
    • 84874525661 scopus 로고    scopus 로고
    • DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption
    • Pipatpiboon, N., Pintana, H., Pratchayasakul, W., Chattipakorn, N., Chattipakorn, S.C., DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption. Eur. J. Neurosci. 37 (2013), 839–849.
    • (2013) Eur. J. Neurosci. , vol.37 , pp. 839-849
    • Pipatpiboon, N.1    Pintana, H.2    Pratchayasakul, W.3    Chattipakorn, N.4    Chattipakorn, S.C.5
  • 193
    • 84885922148 scopus 로고    scopus 로고
    • Adipose tissue inflammation: feeding the development of type 2 diabetes mellitus
    • Richardson, V.R., Smith, K.A., Carter, A.M., Adipose tissue inflammation: feeding the development of type 2 diabetes mellitus. Immunobiology 218 (2013), 1497–1504.
    • (2013) Immunobiology , vol.218 , pp. 1497-1504
    • Richardson, V.R.1    Smith, K.A.2    Carter, A.M.3
  • 194
    • 84906246754 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors have protective effect on cognitive impairment in aged diabetic patients with mild cognitive impairment
    • Rizzo, M.R., Barbieri, M., Boccardi, V., Angellotti, E., Marfella, R., Paolisso, G., Dipeptidyl peptidase-4 inhibitors have protective effect on cognitive impairment in aged diabetic patients with mild cognitive impairment. J. Gerontol. Ser. A, Biol. Sci. Med. Sci. 69 (2014), 1122–1131.
    • (2014) J. Gerontol. Ser. A, Biol. Sci. Med. Sci. , vol.69 , pp. 1122-1131
    • Rizzo, M.R.1    Barbieri, M.2    Boccardi, V.3    Angellotti, E.4    Marfella, R.5    Paolisso, G.6
  • 197
    • 84880747916 scopus 로고    scopus 로고
    • The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis
    • Russo, E., Citraro, R., Constanti, A., De Sarro, G., The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis. Mol. Neurobiol. 46 (2012), 662–681.
    • (2012) Mol. Neurobiol. , vol.46 , pp. 662-681
    • Russo, E.1    Citraro, R.2    Constanti, A.3    De Sarro, G.4
  • 198
    • 33646383887 scopus 로고    scopus 로고
    • Improving metabolic control leads to better working memory in adults with type 2 diabetes
    • Ryan, C.M., Freed, M.I., Rood, J.A., Cobitz, A.R., Waterhouse, B.R., Strachan, M.W., Improving metabolic control leads to better working memory in adults with type 2 diabetes. Diabetes Care 29 (2006), 345–351.
    • (2006) Diabetes Care , vol.29 , pp. 345-351
    • Ryan, C.M.1    Freed, M.I.2    Rood, J.A.3    Cobitz, A.R.4    Waterhouse, B.R.5    Strachan, M.W.6
  • 199
    • 84888235042 scopus 로고    scopus 로고
    • Effect of sitagliptin on the working memory and reference memory in type 2 diabetic Sprague-Dawley rats: possible role of adiponectin receptors 1
    • Sakr, H.F., Effect of sitagliptin on the working memory and reference memory in type 2 diabetic Sprague-Dawley rats: possible role of adiponectin receptors 1. J. Physiol. Pharmacol.: Off. J. Polish Physiol. Soc. 64 (2013), 613–623.
    • (2013) J. Physiol. Pharmacol.: Off. J. Polish Physiol. Soc. , vol.64 , pp. 613-623
    • Sakr, H.F.1
  • 200
  • 202
    • 0033664539 scopus 로고    scopus 로고
    • Insulin receptors and insulin action in the brain: review and clinical implications
    • Schulingkamp, R.J., Pagano, T.C., Hung, D., Raffa, R.B., Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci. Biobehav. Rev. 24 (2000), 855–872.
    • (2000) Neurosci. Biobehav. Rev. , vol.24 , pp. 855-872
    • Schulingkamp, R.J.1    Pagano, T.C.2    Hung, D.3    Raffa, R.B.4
  • 203
    • 84966359603 scopus 로고    scopus 로고
    • Gender differences in the relationship between diabetes process of care indicators and cardiovascular outcomes
    • Seghieri, C., Policardo, L., Francesconi, P., Seghieri, G., Gender differences in the relationship between diabetes process of care indicators and cardiovascular outcomes. Eur. J. Pub. Health 26 (2016), 219–224.
    • (2016) Eur. J. Pub. Health , vol.26 , pp. 219-224
    • Seghieri, C.1    Policardo, L.2    Francesconi, P.3    Seghieri, G.4
  • 205
    • 84942435321 scopus 로고    scopus 로고
    • Exenatide reduces TNF-alpha expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
    • Solmaz, V., Cinar, B.P., Yigitturk, G., Cavusoglu, T., Taskiran, D., Erbas, O., Exenatide reduces TNF-alpha expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats. Eur. J. Pharmacol. 765 (2015), 482–487.
    • (2015) Eur. J. Pharmacol. , vol.765 , pp. 482-487
    • Solmaz, V.1    Cinar, B.P.2    Yigitturk, G.3    Cavusoglu, T.4    Taskiran, D.5    Erbas, O.6
  • 206
    • 4644233538 scopus 로고    scopus 로고
    • Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes
    • Sommerfield, A.J., Deary, I.J., Frier, B.M., Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. Diabetes Care 27 (2004), 2335–2340.
    • (2004) Diabetes Care , vol.27 , pp. 2335-2340
    • Sommerfield, A.J.1    Deary, I.J.2    Frier, B.M.3
  • 207
    • 84878222639 scopus 로고    scopus 로고
    • Effects of type 2 diabetes on 12-year cognitive change: results from the Maastricht aging study
    • Spauwen, P.J., Kohler, S., Verhey, F.R., Stehouwer, C.D., van Boxtel, M.P., Effects of type 2 diabetes on 12-year cognitive change: results from the Maastricht aging study. Diabetes Care 36 (2013), 1554–1561.
    • (2013) Diabetes Care , vol.36 , pp. 1554-1561
    • Spauwen, P.J.1    Kohler, S.2    Verhey, F.R.3    Stehouwer, C.D.4    van Boxtel, M.P.5
  • 208
    • 73049090241 scopus 로고    scopus 로고
    • Differential NMDA receptor-dependent calcium loading and mitochondrial dysfunction in CA1 vs. CA3 hippocampal neurons
    • Stanika, R.I., Winters, C.A., Pivovarova, N.B., Andrews, S.B., Differential NMDA receptor-dependent calcium loading and mitochondrial dysfunction in CA1 vs. CA3 hippocampal neurons. Neurobiol. Disease 37 (2010), 403–411.
    • (2010) Neurobiol. Disease , vol.37 , pp. 403-411
    • Stanika, R.I.1    Winters, C.A.2    Pivovarova, N.B.3    Andrews, S.B.4
  • 209
    • 6344250713 scopus 로고    scopus 로고
    • Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans
    • Stockhorst, U., de Fries, D., Steingrueber, H.J., Scherbaum, W.A., Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol. Behav. 83 (2004), 47–54.
    • (2004) Physiol. Behav. , vol.83 , pp. 47-54
    • Stockhorst, U.1    de Fries, D.2    Steingrueber, H.J.3    Scherbaum, W.A.4
  • 210
    • 79251635233 scopus 로고    scopus 로고
    • Cognitive function, dementia and type 2 diabetes mellitus in the elderly
    • Strachan, M.W., Reynolds, R.M., Marioni, R.E., Price, J.F., Cognitive function, dementia and type 2 diabetes mellitus in the elderly. Nat. Rev. Endocrinol. 7 (2011), 108–114.
    • (2011) Nat. Rev. Endocrinol. , vol.7 , pp. 108-114
    • Strachan, M.W.1    Reynolds, R.M.2    Marioni, R.E.3    Price, J.F.4
  • 211
    • 77953724950 scopus 로고    scopus 로고
    • Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells
    • Sugino, T., Maruyama, M., Tanno, M., Kuno, A., Houkin, K., Horio, Y., Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells. FEBS Lett. 584 (2010), 2821–2826.
    • (2010) FEBS Lett. , vol.584 , pp. 2821-2826
    • Sugino, T.1    Maruyama, M.2    Tanno, M.3    Kuno, A.4    Houkin, K.5    Horio, Y.6
  • 212
    • 0344011439 scopus 로고    scopus 로고
    • Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia
    • Suh, S.W., Aoyama, K., Chen, Y., Garnier, P., Matsumori, Y., Gum, E., Liu, J., Swanson, R.A., Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. J. Neurosci. 23 (2003), 10681–10690.
    • (2003) J. Neurosci. , vol.23 , pp. 10681-10690
    • Suh, S.W.1    Aoyama, K.2    Chen, Y.3    Garnier, P.4    Matsumori, Y.5    Gum, E.6    Liu, J.7    Swanson, R.A.8
  • 213
    • 34547783158 scopus 로고    scopus 로고
    • Hypoglycemia, brain energetics, and hypoglycemic neuronal death
    • Suh, S.W., Hamby, A.M., Swanson, R.A., Hypoglycemia, brain energetics, and hypoglycemic neuronal death. Glia 55 (2007), 1280–1286.
    • (2007) Glia , vol.55 , pp. 1280-1286
    • Suh, S.W.1    Hamby, A.M.2    Swanson, R.A.3
  • 215
    • 84867412992 scopus 로고    scopus 로고
    • Hyperphosphorylation of Tau induced by naturally secreted amyloid-beta at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3beta signaling pathway
    • Tokutake, T., Kasuga, K., Yajima, R., Sekine, Y., Tezuka, T., Nishizawa, M., Ikeuchi, T., Hyperphosphorylation of Tau induced by naturally secreted amyloid-beta at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3beta signaling pathway. J. Biol. Chem. 287 (2012), 35222–35233.
    • (2012) J. Biol. Chem. , vol.287 , pp. 35222-35233
    • Tokutake, T.1    Kasuga, K.2    Yajima, R.3    Sekine, Y.4    Tezuka, T.5    Nishizawa, M.6    Ikeuchi, T.7
  • 216
    • 77249109792 scopus 로고    scopus 로고
    • Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease
    • Toledo, E.M., Inestrosa, N.C., Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. Mol. Psychiatry, 15(272–285), 2010, 228.
    • (2010) Mol. Psychiatry , vol.15 , Issue.272-285 , pp. 228
    • Toledo, E.M.1    Inestrosa, N.C.2
  • 218
    • 84938973780 scopus 로고    scopus 로고
    • Intensive glycaemic control and cognitive decline in patients with type 2 diabetes: a meta-analysis
    • Tuligenga, R.H., Intensive glycaemic control and cognitive decline in patients with type 2 diabetes: a meta-analysis. Endocrine Connect. 4 (2015), R16–R24.
    • (2015) Endocrine Connect. , vol.4 , pp. R16-R24
    • Tuligenga, R.H.1
  • 219
    • 84895430950 scopus 로고    scopus 로고
    • Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study
    • Tuligenga, R.H., Dugravot, A., Tabak, A.G., Elbaz, A., Brunner, E.J., Kivimaki, M., Singh-Manoux, A., Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study. Lancet Diabetes Endocrinol. 2 (2014), 228–235.
    • (2014) Lancet Diabetes Endocrinol. , vol.2 , pp. 228-235
    • Tuligenga, R.H.1    Dugravot, A.2    Tabak, A.G.3    Elbaz, A.4    Brunner, E.J.5    Kivimaki, M.6    Singh-Manoux, A.7
  • 222
    • 84891473103 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor-mediated inhibition of A-type K(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of Akt
    • Wang, H., Qin, J., Gong, S., Feng, B., Zhang, Y., Tao, J., Insulin-like growth factor-1 receptor-mediated inhibition of A-type K(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of Akt. Endocrinology 155 (2014), 168–179.
    • (2014) Endocrinology , vol.155 , pp. 168-179
    • Wang, H.1    Qin, J.2    Gong, S.3    Feng, B.4    Zhang, Y.5    Tao, J.6
  • 223
    • 84860850000 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease in relation to diabetes: a population-based cohort study
    • Wang, K.C., Woung, L.C., Tsai, M.T., Liu, C.C., Su, Y.H., Li, C.Y., Risk of Alzheimer's disease in relation to diabetes: a population-based cohort study. Neuroepidemiology 4 (2012), 237–244.
    • (2012) Neuroepidemiology , vol.4 , pp. 237-244
    • Wang, K.C.1    Woung, L.C.2    Tsai, M.T.3    Liu, C.C.4    Su, Y.H.5    Li, C.Y.6
  • 224
    • 23844466317 scopus 로고    scopus 로고
    • Hypoglycaemia and cognitive function
    • Warren, R.E., Frier, B.M., Hypoglycaemia and cognitive function. Diabetes Obes. Metab. 7 (2005), 493–503.
    • (2005) Diabetes Obes. Metab. , vol.7 , pp. 493-503
    • Warren, R.E.1    Frier, B.M.2
  • 228
    • 84947495884 scopus 로고    scopus 로고
    • Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: molecular evidence for mechanism of diabetes-induced cognitive dysfunction
    • Xiang, Q., Zhang, J., Li, C.Y., Wang, Y., Zeng, M.J., Cai, Z.X., Tian, R.B., Jia, W., Li, X.H., Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: molecular evidence for mechanism of diabetes-induced cognitive dysfunction. Neuropeptides 54 (2015), 9–15.
    • (2015) Neuropeptides , vol.54 , pp. 9-15
    • Xiang, Q.1    Zhang, J.2    Li, C.Y.3    Wang, Y.4    Zeng, M.J.5    Cai, Z.X.6    Tian, R.B.7    Jia, W.8    Li, X.H.9
  • 229
    • 34247240590 scopus 로고    scopus 로고
    • Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons
    • Xing, C., Yin, Y., Chang, R., Gong, X., He, X., Xie, Z., Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons. Exp. Neurol. 205 (2007), 222–229.
    • (2007) Exp. Neurol. , vol.205 , pp. 222-229
    • Xing, C.1    Yin, Y.2    Chang, R.3    Gong, X.4    He, X.5    Xie, Z.6
  • 230
    • 84908632327 scopus 로고    scopus 로고
    • SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
    • Xu, F., Li, Z., Zheng, X., Liu, H., Liang, H., Xu, H., Chen, Z., Zeng, K., Weng, J., SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis. Diabetes 63 (2014), 3637–3646.
    • (2014) Diabetes , vol.63 , pp. 3637-3646
    • Xu, F.1    Li, Z.2    Zheng, X.3    Liu, H.4    Liang, H.5    Xu, H.6    Chen, Z.7    Zeng, K.8    Weng, J.9
  • 232
    • 84878481429 scopus 로고    scopus 로고
    • Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice
    • Yang, D., Nakajo, Y., Iihara, K., Kataoka, H., Yanamoto, H., Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice. Brain Res. 1517 (2013), 104–113.
    • (2013) Brain Res. , vol.1517 , pp. 104-113
    • Yang, D.1    Nakajo, Y.2    Iihara, K.3    Kataoka, H.4    Yanamoto, H.5
  • 233
    • 84890808796 scopus 로고    scopus 로고
    • Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes
    • Yang, Y., Zhang, J., Ma, D., Zhang, M., Hu, S., Shao, S., Gong, C.X., Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes. J. Alzheimer's Disease: JAD 37 (2013), 637–648.
    • (2013) J. Alzheimer's Disease: JAD , vol.37 , pp. 637-648
    • Yang, Y.1    Zhang, J.2    Ma, D.3    Zhang, M.4    Hu, S.5    Shao, S.6    Gong, C.X.7
  • 234
    • 0037101617 scopus 로고    scopus 로고
    • Myelination is altered in insulin-like growth factor-I null mutant mice
    • Ye, P., Li, L., Richards, R.G., DiAugustine, R.P., D'Ercole, A.J., Myelination is altered in insulin-like growth factor-I null mutant mice. J. Neurosci. 22 (2002), 6041–6051.
    • (2002) J. Neurosci. , vol.22 , pp. 6041-6051
    • Ye, P.1    Li, L.2    Richards, R.G.3    DiAugustine, R.P.4    D'Ercole, A.J.5
  • 235
    • 80052719486 scopus 로고    scopus 로고
    • Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease
    • Yiu, A.P., Rashid, A.J., Josselyn, S.A., Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacol.: Off. Publ. Am. College Neuropsychopharmacol. 36 (2011), 2169–2186.
    • (2011) Neuropsychopharmacol.: Off. Publ. Am. College Neuropsychopharmacol. , vol.36 , pp. 2169-2186
    • Yiu, A.P.1    Rashid, A.J.2    Josselyn, S.A.3
  • 236
    • 80755169655 scopus 로고    scopus 로고
    • Reduced cell proliferation and neuroblast differentiation in the dentate gyrus of high fat diet-fed mice are ameliorated by metformin and glimepiride treatment
    • Yoo, D.Y., Kim, W., Nam, S.M., Yoo, K.Y., Lee, C.H., Choi, J.H., Won, M.H., Hwang, I.K., Yoon, Y.S., Reduced cell proliferation and neuroblast differentiation in the dentate gyrus of high fat diet-fed mice are ameliorated by metformin and glimepiride treatment. Neurochem. Res. 36 (2011), 2401–2408.
    • (2011) Neurochem. Res. , vol.36 , pp. 2401-2408
    • Yoo, D.Y.1    Kim, W.2    Nam, S.M.3    Yoo, K.Y.4    Lee, C.H.5    Choi, J.H.6    Won, M.H.7    Hwang, I.K.8    Yoon, Y.S.9
  • 237
    • 33645972284 scopus 로고    scopus 로고
    • Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway
    • Yu, X.R., Jia, G.R., Gao, G.D., Wang, S.H., Han, Y., Cao, W., Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway. Acta Biochim. Biophys. Sin. 38 (2006), 241–248.
    • (2006) Acta Biochim. Biophys. Sin. , vol.38 , pp. 241-248
    • Yu, X.R.1    Jia, G.R.2    Gao, G.D.3    Wang, S.H.4    Han, Y.5    Cao, W.6
  • 238
    • 84907861812 scopus 로고    scopus 로고
    • The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications
    • Zemva, J., Schubert, M., The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications. CNS Neurol. Disord.: Drug Targets 13 (2014), 322–337.
    • (2014) CNS Neurol. Disord.: Drug Targets , vol.13 , pp. 322-337
    • Zemva, J.1    Schubert, M.2
  • 239
    • 84901849879 scopus 로고    scopus 로고
    • Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice
    • Zhao, R.R., Xu, X.C., Xu, F., Zhang, W.L., Zhang, W.L., Liu, L.M., Wang, W.P., Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. Biochem. Biophys. Res. Commun. 448 (2014), 414–417.
    • (2014) Biochem. Biophys. Res. Commun. , vol.448 , pp. 414-417
    • Zhao, R.R.1    Xu, X.C.2    Xu, F.3    Zhang, W.L.4    Zhang, W.L.5    Liu, L.M.6    Wang, W.P.7
  • 240
    • 0033521130 scopus 로고    scopus 로고
    • Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats
    • Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M.J., Alkon, D.L., Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J. Biol. Chem. 274 (1999), 34893–34902.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34893-34902
    • Zhao, W.1    Chen, H.2    Xu, H.3    Moore, E.4    Meiri, N.5    Quon, M.J.6    Alkon, D.L.7
  • 241
    • 79953657859 scopus 로고    scopus 로고
    • Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats
    • Zhao, W., Wu, X., Xie, H., Ke, Y., Yung, W.H., Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats. Neuro-Signals 18 (2010), 236–245.
    • (2010) Neuro-Signals , vol.18 , pp. 236-245
    • Zhao, W.1    Wu, X.2    Xie, H.3    Ke, Y.4    Yung, W.H.5
  • 242
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • Zhao, W.Q., Alkon, D.L., Role of insulin and insulin receptor in learning and memory. Mol. Cell. Endocrinol. 177 (2001), 125–134.
    • (2001) Mol. Cell. Endocrinol. , vol.177 , pp. 125-134
    • Zhao, W.Q.1    Alkon, D.L.2
  • 243
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • Zhao, W.Q., Chen, H., Quon, M.J., Alkon, D.L., Insulin and the insulin receptor in experimental models of learning and memory. Eur. J. Pharmacol. 490 (2004), 71–81.
    • (2004) Eur. J. Pharmacol. , vol.490 , pp. 71-81
    • Zhao, W.Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 244
    • 84890131140 scopus 로고    scopus 로고
    • Ghrelin administration enhances neurogenesis but impairs spatial learning and memory in adult mice
    • Zhao, Z., Liu, H., Xiao, K., Yu, M., Cui, L., Zhu, Q., Zhao, R., Li, G.D., Zhou, Y., Ghrelin administration enhances neurogenesis but impairs spatial learning and memory in adult mice. Neuroscience 257 (2014), 175–185.
    • (2014) Neuroscience , vol.257 , pp. 175-185
    • Zhao, Z.1    Liu, H.2    Xiao, K.3    Yu, M.4    Cui, L.5    Zhu, Q.6    Zhao, R.7    Li, G.D.8    Zhou, Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.