메뉴 건너뛰기




Volumn 155, Issue 1, 2014, Pages 168-179

Insulin-like growth factor-1 receptor-mediated inhibition of a-type K + Current Induces Sensory Neuronal Hyperexcitability Through the Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase 1/2 Pathways, Independently of Akt

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; 4 AMINOPYRIDINE; A TYPE POTASSIUM CHANNEL CURRENT; INSULIN GROWTH FACTOR 1 RECEPTOR; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL; PROTEIN KINASE B INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; SMALL INTERFERING RNA; SOMATOMEDIN; UNCLASSIFIED DRUG;

EID: 84891473103     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1559     Document Type: Article
Times cited : (40)

References (43)
  • 2
    • 1842785189 scopus 로고    scopus 로고
    • Signaling by insulin-like growth factor 1 in brain
    • Bondy CA, Cheng CM. Signaling by insulin-like growth factor 1 in brain. Eur J Pharmacol. 2004;490:25-31.
    • (2004) Eur J Pharmacol , vol.490 , pp. 25-31
    • Bondy, C.A.1    Cheng, C.M.2
  • 5
    • 34248176762 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor type-i up-regulate the vanilloid receptor-1 (trpv1) in stably trpv1-expressing sh-sy5y neuroblastoma cells
    • Lilja J, Laulund F, Forsby A. Insulin and insulin-like growth factor type-I up-regulate the vanilloid receptor-1 (TRPV1) in stably TRPV1-expressing SH-SY5Y neuroblastoma cells. J Neurosci Res. 2007;85:1413-1419.
    • (2007) J Neurosci Res , vol.85 , pp. 1413-1419
    • Lilja, J.1    Laulund, F.2    Forsby, A.3
  • 6
    • 0027284049 scopus 로고
    • Insulin receptor-related receptor messenger ribonucleic acid is focally expressed in sympathetic and sensory neurons and renal distal tubule cells
    • Reinhardt RR, Chin E, Zhang B, Roth RA, Bondy CA. Insulin receptor-related receptor messenger ribonucleic acid is focally expressed in sympathetic and sensory neurons and renal distal tubule cells. Endocrinology. 1993;133:3-10.
    • (1993) Endocrinology , vol.133 , pp. 3-10
    • Reinhardt, R.R.1    Chin, E.2    Zhang, B.3    Roth, R.A.4    Bondy, C.A.5
  • 7
    • 79953044610 scopus 로고    scopus 로고
    • Peripheral sensitization caused by insulin-like growth factor 1 contributes to pain hypersensitivity after tissue injury
    • Miura M, Sasaki M, Mizukoshi K, et al. Peripheral sensitization caused by insulin-like growth factor 1 contributes to pain hypersensitivity after tissue injury. Pain. 2011;152:888-895.
    • (2011) Pain , vol.152 , pp. 888-895
    • Miura, M.1    Sasaki, M.2    Mizukoshi, K.3
  • 8
    • 79551522541 scopus 로고    scopus 로고
    • Localization and function of insulin-like growth factor 1 in dorsal root ganglia in a rat disc herniation model
    • Takayama B, Sekiguchi M, Yabuki S, Kikuchi S, Konno S. Localization and function of insulin-like growth factor 1 in dorsal root ganglia in a rat disc herniation model. Spine (Phila Pa 1976). 2011; 36:E75-E79.
    • (2011) Spine (Phila Pa 1976) , vol.36
    • Takayama, B.1    Sekiguchi, M.2    Yabuki, S.3    Kikuchi, S.4    Konno, S.5
  • 9
    • 0041819529 scopus 로고    scopus 로고
    • Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus
    • Mohamed-Ali V, Pinkney J. Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus. Treat Endocrinol. 2002;1:399-410.
    • (2002) Treat Endocrinol , vol.1 , pp. 399-410
    • Mohamed-Ali, V.1    Pinkney, J.2
  • 10
    • 84876286107 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 and musculoskeletal pain among breast cancer patients on aromatase inhibitor therapy andwomenwithout a history of cancer
    • Gallicchio L, MacDonald R, Helzlsouer KJ. Insulin-like growth factor 1 and musculoskeletal pain among breast cancer patients on aromatase inhibitor therapy andwomenwithout a history of cancer. J Cancer Res Clin Oncol. 2013;139:837-843.
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 837-843
    • Gallicchio, L.1    MacDonald, R.2    Helzlsouer, K.J.3
  • 11
    • 0033233119 scopus 로고    scopus 로고
    • Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion
    • Zhang JM, Song XJ, LaMotte RH. Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion. J Neurophysiol. 1999;82: 3359-3366.
    • (1999) J Neurophysiol , vol.82 , pp. 3359-3366
    • Zhang, J.M.1    Song, X.J.2    LaMotte, R.H.3
  • 12
    • 0043127363 scopus 로고    scopus 로고
    • Kcnq/m currents in sensory neurons: Significance for pain therapy
    • Passmore GM, Selyanko AA, Mistry M, et al. KCNQ/M currents in sensory neurons: significance for pain therapy. J Neurosci. 2003; 23:7227-7236.
    • (2003) J Neurosci , vol.23 , pp. 7227-7236
    • Passmore, G.M.1    Selyanko, A.A.2    Mistry, M.3
  • 13
    • 42749095162 scopus 로고    scopus 로고
    • Redox modulation of a-type k+ currents in pain-sensing dorsal root ganglion neurons
    • Hsieh CP. Redox modulation of A-type K+ currents in pain-sensing dorsal root ganglion neurons. Biochem Biophys Res Commun. 2008;370:445-449.
    • (2008) Biochem Biophys Res Commun , vol.370 , pp. 445-449
    • Hsieh, C.P.1
  • 14
    • 34548641073 scopus 로고    scopus 로고
    • Reduced expression of a-type potassium channels in primary sensory neurons induces mechanical hypersensitivity
    • Chien LY, Cheng JK, Chu D, Cheng CF, Tsaur ML. Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity. J Neurosci. 2007;27:9855-9865.
    • (2007) J Neurosci , vol.27 , pp. 9855-9865
    • Chien, L.Y.1    Cheng, J.K.2    Chu, D.3    Cheng, C.F.4    Tsaur, M.L.5
  • 15
    • 33646014745 scopus 로고    scopus 로고
    • The kv4.2 potassium channel subunit is required for pain plasticity
    • Hu HJ, Carrasquillo Y, Karim F, et al. The kv4.2 potassium channel subunit is required for pain plasticity. Neuron. 2006;50:89-100.
    • (2006) Neuron , vol.50 , pp. 89-100
    • Hu, H.J.1    Carrasquillo, Y.2    Karim, F.3
  • 17
    • 0027225257 scopus 로고
    • Peptides and the primary afferent nociceptor
    • Levine JD, Fields HL, Basbaum AI. Peptides and the primary afferent nociceptor. J Neurosci. 1993;13:2273-2286.
    • (1993) J Neurosci , vol.13 , pp. 2273-2286
    • Levine, J.D.1    Fields, H.L.2    Basbaum, A.I.3
  • 18
    • 0027501342 scopus 로고
    • Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic amp
    • Akins PT, McCleskey EW. Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP. Neuroscience. 1993;56:759-769.
    • (1993) Neuroscience , vol.56 , pp. 759-769
    • Akins, P.T.1    McCleskey, E.W.2
  • 19
    • 10744223902 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor induces physiological heart growth via the phos-phoinositide 3-kinase (p110) pathway
    • McMullen JR, Shioi T, Huang WY, et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phos-phoinositide 3-kinase(p110-) pathway. J Biol Chem. 2004;279: 4782-4793.
    • (2004) J Biol Chem , Issue.279
    • McMullen, J.R.1    Shioi, T.2    Huang, W.Y.3
  • 20
    • 0031903015 scopus 로고    scopus 로고
    • Downstream signalling events regulated by phosphatidylinositol 3-kinase activity
    • Duronio V, Scheid MP, Ettinger S. Downstream signalling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal. 1998;10:233-239.
    • (1998) Cell Signal , vol.10 , pp. 233-239
    • Duronio, V.1    Scheid, M.P.2    Ettinger, S.3
  • 21
    • 0141856610 scopus 로고    scopus 로고
    • Gereaurw4th. Erk integrates pka and pkc signaling in superficial dorsal horn neurons i. Modulation of a type k+ currents
    • Hu HJ, Glauner KS, GereauRW4th. ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K+ currents. J Neurophysiol. 2003;90:1671-1679.
    • (2003) J Neurophysiol , vol.90 , pp. 1671-1679
    • Hu, H.J.1    Glauner, K.S.2
  • 22
    • 15244340082 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase a/c-raf pathway
    • Subramaniam S, Shahani N, Strelau J, et al. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway. J Neurosci. 2005;25:2838-2852.
    • (2005) J Neurosci , vol.25 , pp. 2838-2852
    • Subramaniam, S.1    Shahani, N.2    Strelau, J.3
  • 23
    • 84875001127 scopus 로고    scopus 로고
    • Thrombin-induced nf-αb activation and il-8cxcl8 release is mediated by c-src-dependent shc raf-1 and erk pathways in lung epithelial cells
    • Lin CH, Yu MC, Chiang CC, Bien MY, Chien MH, Chen BC. Thrombin-induced NF-αB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells. Cell Signal. 2013;25:1166-1175.
    • (2013) Cell Signal , vol.25 , pp. 1166-1175
    • Lin, C.H.1    Yu, M.C.2    Chiang, C.C.3    Bien, M.Y.4    Chien, M.H.5    Chen, B.C.6
  • 24
    • 78650971719 scopus 로고    scopus 로고
    • Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain
    • Takeda M, Tsuboi Y, Kitagawa J, Nakagawa K, Iwata K, Matsumoto S. Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain. Mol Pain. 2011;7:5.
    • (2011) Mol Pain , vol.7 , pp. 5
    • Takeda, M.1    Tsuboi, Y.2    Kitagawa, J.3    Nakagawa, K.4    Iwata, K.5    Matsumoto, S.6
  • 25
    • 71549130405 scopus 로고    scopus 로고
    • Sp protects cerebellar granule cells against -Amyloid-induced apoptosis by down-regulation and reduced activity of kv4 potassium channels
    • Pieri M, Amadoro G, Carunchio I, et al. SP protects cerebellar granule cells against -Amyloid-induced apoptosis by down-regulation and reduced activity of Kv4 potassium channels. Neuropharmacology. 2010;58:268-276.
    • (2010) Neuropharmacology , vol.58 , pp. 268-276
    • Pieri, M.1    Amadoro, G.2    Carunchio, I.3
  • 26
    • 84870365696 scopus 로고    scopus 로고
    • Neuritin activates insulin receptor pathway to up-regulate kv4.2-mediated transient outward k+ current in rat cerebellar granule neurons
    • Yao JJ, Gao XF, Chow CW, Zhan XQ, Hu CL, Mei YA. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons. J Biol Chem. 2012;287:41534-41545.
    • (2012) J Biol Chem , vol.287 , pp. 41534-41545
    • Yao, J.J.1    Gao, X.F.2    Chow, C.W.3    Zhan, X.Q.4    Hu, C.L.5    Mei, Y.A.6
  • 27
    • 34748829647 scopus 로고    scopus 로고
    • Estrogen regulation of genes important for k+ channel signaling in the arcuate nucleus
    • Roepke TA, Malyala A, Bosch MA, Kelly MJ, Rønnekleiv OK. Estrogen regulation of genes important for K+ channel signaling in the arcuate nucleus. Endocrinology. 2007;148:4937-4951.
    • (2007) Endocrinology , vol.148 , pp. 4937-4951
    • Roepke, T.A.1    Malyala, A.2    Bosch, M.A.3    Kelly, M.J.4    Rønnekleiv, O.K.5
  • 28
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 mapk in primary sensory neurons
    • Schafers M, Svensson CI, Sommer C, Sorkin LS. Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci. 2003;23:2517-2521.
    • (2003) J Neurosci , vol.23 , pp. 2517-2521
    • Schafers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 29
    • 0037179755 scopus 로고    scopus 로고
    • P38 mapk activation by ngf in primary sensory neurons after inflammation increases trpv1 levels and maintains heat hyperalgesia
    • Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron. 2002;36:57-68.
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3    Schmoll, R.4    Woolf, C.J.5
  • 30
    • 84862839698 scopus 로고    scopus 로고
    • Regulation of neuronal proapoptotic potassium currents by the hepatitis c virus nonstructural protein 5a
    • Norris CA, He K, Springer MG, Hartnett KA, Horn JP, Aizenman E. Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A. J Neurosci. 2012;32: 8865-8870.
    • (2012) J Neurosci , vol.32 , pp. 8865-8870
    • Norris, C.A.1    He, K.2    Springer, M.G.3    Hartnett, K.A.4    Horn, J.P.5    Aizenman, E.6
  • 31
    • 77957662526 scopus 로고    scopus 로고
    • Myricetin reduces voltage activated potassium channel currents in drg neurons by a p38 dependent mechanism
    • Hagenacker T, Hillebrand I, Busselberg D, Schafers M. Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mechanism. Brain Res Bull. 2010;83:292-296.
    • (2010) Brain Res Bull , vol.83
    • Hagenacker, T.1    Hillebrand, I.2    Busselberg, D.3    Schafers, M.4
  • 32
    • 70450169908 scopus 로고    scopus 로고
    • Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling
    • Redman PT, Hartnett KA, Aras MA, Levitan ES, Aizenman E. Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling. J Physiol. 2009;587:4393-4404.
    • (2009) J Physiol , vol.587 , pp. 4393-4404
    • Redman, P.T.1    Hartnett, K.A.2    Aras, M.A.3    Levitan, E.S.4    Aizenman, E.5
  • 33
    • 33750519461 scopus 로고    scopus 로고
    • A vital role for voltagedependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity
    • Redman PT, Jefferson BS, Ziegler CB, et al. A vital role for voltagedependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. 2006;143:1-6.
    • (2006) Neuroscience , vol.143 , pp. 1-6
    • Redman, P.T.1    Jefferson, B.S.2    Ziegler, C.B.3
  • 34
    • 33645460750 scopus 로고    scopus 로고
    • Erk/mapk regulates the kv4.2 potassium channel by direct phosphorylation of the poreforming subunit
    • Schrader LA, Birnbaum SG, Nadin BM, et al. ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the poreforming subunit.AmJ Physiol Cell Physiol. 2006;290:C852-C861.
    • (2006) AmJ Physiol Cell Physiol , vol.290
    • Schrader, L.A.1    Birnbaum, S.G.2    Nadin, B.M.3
  • 36
    • 14944356887 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide induces neuroendocrine differentiation in the lncap prostate cancer cell line through pka erk and pi3k
    • Gutiérrez-Cañas I, Juarranz MG, Collado B, et al. Vasoactive intestinal peptide induces neuroendocrine differentiation in the LNCaP prostate cancer cell line through PKA, ERK, and PI3K. Prostate. 2005;63:44-55.
    • (2005) Prostate , vol.63 , pp. 44-55
    • Gutiérrez-Cañas, I.1    Juarranz, M.G.2    Collado, B.3
  • 37
    • 0037096396 scopus 로고    scopus 로고
    • Protein kinase modulation of dendritic k+ channels in hippocampus involves a mitogen-Activated protein kinase pathway
    • Yuan LL, Adams JP, Swank M, Sweatt JD, Johnston D. Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-Activated protein kinase pathway. J Neurosci. 2002;22:4860-4868.
    • (2002) J Neurosci , vol.22 , pp. 4860-4868
    • Yuan, L.L.1    Adams, J.P.2    Swank, M.3    Sweatt, J.D.4    Johnston, D.5
  • 38
    • 48249154241 scopus 로고    scopus 로고
    • Il-4 and il-13 upregulate ornithine decarboxylase expression by pi3k and map kinase pathways in vascular smooth muscle cells
    • Wei LH, Yang Y, Wu G, Ignarro LJ. IL-4 and IL-13 upregulate ornithine decarboxylase expression by PI3K and MAP kinase pathways in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2008;294:C1198-C1205.
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Wei, L.H.1    Yang, Y.2    Wu, G.3    Ignarro, L.J.4
  • 39
    • 17144470224 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase/pkb pathway by cb(1) and cb (2) cannabinoid receptors expressed in prostate pc-3 cells. Involvement in raf-1 stimulation and ngf induction
    • Sánchez MG, Ruiz-Llorente L, Sánchez AM, Díaz-Laviada I. Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal. 2003;15:851-859.
    • (2003) Cell Signal , vol.15 , pp. 851-859
    • Sánchez, M.G.1    Ruiz-Llorente, L.2    Sánchez, A.M.3    Díaz-Laviada, I.4
  • 40
    • 84873939572 scopus 로고    scopus 로고
    • Hydrogen sulfide increases excitability through suppression of sustained potassium channel currents of rat trigeminal ganglion neurons
    • Feng X, Zhou YL, Meng X, Qi FH, Chen W, Jiang X, Xu GY. Hydrogen sulfide increases excitability through suppression of sustained potassium channel currents of rat trigeminal ganglion neurons. Mol Pain. 2013;9:4.
    • (2013) Mol Pain , vol.9 , pp. 4
    • Feng, X.1    Zhou, Y.L.2    Meng, X.3    Qi, F.H.4    Chen, W.5    Jiang, X.6    Xu, G.Y.7
  • 41
    • 0028350894 scopus 로고
    • Contribution of a slowly inactivating potassium current to the transition to firing of neostriatal spiny projection neurons
    • Nisenbaum ES, Xu ZC, Wilson CJ. Contribution of a slowly inactivating potassium current to the transition to firing of neostriatal spiny projection neurons. J Neurophysiol. 1994;71:1174-1189.
    • (1994) J Neurophysiol , vol.71 , pp. 1174-1189
    • Nisenbaum, E.S.1    Xu, Z.C.2    Wilson, C.J.3
  • 42
    • 61449227314 scopus 로고    scopus 로고
    • The sparseness of neuronal responses in ferret primary visual cortex
    • Tolhurst DJ, Smyth D, Thompson ID. The sparseness of neuronal responses in ferret primary visual cortex. J Neurosci. 2009;29: 2355-2370.
    • (2009) J Neurosci , vol.29 , pp. 2355-2370
    • Tolhurst, D.J.1    Smyth, D.2    Thompson, I.D.3
  • 43
    • 0030597077 scopus 로고    scopus 로고
    • Antinociceptive action of intrathecally administered igf-i and the expression of its receptor in rat spinal cord
    • Bitar MS, Al-Bustan M, Nehme CL, Pilcher CW. Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord. Brain Res. 1996;737:292-294.
    • (1996) Brain Res , vol.737
    • Bitar, M.S.1    Al-Bustan, M.2    Nehme, C.L.3    Pilcher, C.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.