메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages

Rapamycin Reverses Status Epilepticus-Induced Memory Deficits and Dendritic Damage

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC NUCLEOTIDE GATED CHANNEL; GLUTAMATE DECARBOXYLASE 67; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICROTUBULE ASSOCIATED PROTEIN 2; PILOCARPINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV1.4; POTASSIUM CHANNEL KV4.2; RAPAMYCIN; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

EID: 84874902329     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057808     Document Type: Article
Times cited : (92)

References (70)
  • 1
    • 4944255000 scopus 로고    scopus 로고
    • Effects of early seizures on later behavior and epileptogenicity
    • Holmes GL, (2004) Effects of early seizures on later behavior and epileptogenicity. Ment Retard Dev Disabil Res Rev 10: 101-105.
    • (2004) Ment Retard Dev Disabil Res Rev , vol.10 , pp. 101-105
    • Holmes, G.L.1
  • 2
    • 2442707459 scopus 로고    scopus 로고
    • Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model
    • McKay BE, Persinger MA, (2004) Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model. Pharmacol Biochem Behav 78: 111-119.
    • (2004) Pharmacol Biochem Behav , vol.78 , pp. 111-119
    • McKay, B.E.1    Persinger, M.A.2
  • 3
    • 65649153301 scopus 로고    scopus 로고
    • Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy
    • Chauviere L, Rafrafi N, Thinus-Blanc C, Bartolomei F, Esclapez M, et al. (2009) Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy. J Neurosci 29: 5402-5410.
    • (2009) J Neurosci , vol.29 , pp. 5402-5410
    • Chauviere, L.1    Rafrafi, N.2    Thinus-Blanc, C.3    Bartolomei, F.4    Esclapez, M.5
  • 4
    • 78651305570 scopus 로고    scopus 로고
    • Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience
    • Jensen FE, (2012) Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience. Epilepsia 52 (Suppl 1): 1-6.
    • (2012) Epilepsia , vol.52 , Issue.SUPPL. 1 , pp. 1-6
    • Jensen, F.E.1
  • 5
    • 33646142995 scopus 로고    scopus 로고
    • Pten regulates neuronal arborization and social interaction in mice
    • Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, et al. (2006) Pten regulates neuronal arborization and social interaction in mice. Neuron 50: 377-388.
    • (2006) Neuron , vol.50 , pp. 377-388
    • Kwon, C.H.1    Luikart, B.W.2    Powell, C.M.3    Zhou, J.4    Matheny, S.A.5
  • 6
    • 49149088555 scopus 로고    scopus 로고
    • Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis
    • Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, et al. (2008) Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med 14: 843-848.
    • (2008) Nat Med , vol.14 , pp. 843-848
    • Ehninger, D.1    Han, S.2    Shilyansky, C.3    Zhou, Y.4    Li, W.5
  • 7
    • 60849109211 scopus 로고    scopus 로고
    • Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
    • Zhou J, Blundell J, Ogawa S, Kwon CH, Zhang W, et al. (2009) Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci 29: 1773-1783.
    • (2009) J Neurosci , vol.29 , pp. 1773-1783
    • Zhou, J.1    Blundell, J.2    Ogawa, S.3    Kwon, C.H.4    Zhang, W.5
  • 8
    • 67649382228 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    • Buckmaster PS, Ingram EA, Wen X, (2009) Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J Neurosci 29: 8259-8269.
    • (2009) J Neurosci , vol.29 , pp. 8259-8269
    • Buckmaster, P.S.1    Ingram, E.A.2    Wen, X.3
  • 9
    • 66149169973 scopus 로고    scopus 로고
    • The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    • Zeng LH, Rensing NR, Wong M, (2009) The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci 29: 6964-6972.
    • (2009) J Neurosci , vol.29 , pp. 6964-6972
    • Zeng, L.H.1    Rensing, N.R.2    Wong, M.3
  • 10
    • 58149469090 scopus 로고    scopus 로고
    • Translational control of long-lasting synaptic plasticity and memory
    • Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N, (2009) Translational control of long-lasting synaptic plasticity and memory. Neuron 61: 10-26.
    • (2009) Neuron , vol.61 , pp. 10-26
    • Costa-Mattioli, M.1    Sossin, W.S.2    Klann, E.3    Sonenberg, N.4
  • 11
    • 58149485508 scopus 로고    scopus 로고
    • Making synaptic plasticity and memory last: mechanisms of translational regulation
    • Richter JD, Klann E, (2009) Making synaptic plasticity and memory last: mechanisms of translational regulation. Genes Dev 23: 1-11.
    • (2009) Genes Dev , vol.23 , pp. 1-11
    • Richter, J.D.1    Klann, E.2
  • 12
    • 33749639034 scopus 로고    scopus 로고
    • Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites
    • Raab-Graham KF, Haddick PC, Jan YN, Jan LY, (2006) Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science 314: 144-148.
    • (2006) Science , vol.314 , pp. 144-148
    • Raab-Graham, K.F.1    Haddick, P.C.2    Jan, Y.N.3    Jan, L.Y.4
  • 13
    • 84155177066 scopus 로고    scopus 로고
    • Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein
    • Lee HY, Ge WP, Huang W, He Y, Wang GX, et al. (2011) Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron 72: 630-642.
    • (2011) Neuron , vol.72 , pp. 630-642
    • Lee, H.Y.1    Ge, W.P.2    Huang, W.3    He, Y.4    Wang, G.X.5
  • 14
    • 33745924695 scopus 로고    scopus 로고
    • Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons
    • Gong R, Park CS, Abbassi NR, Tang SJ, (2006) Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. J Biol Chem 281: 18802-18815.
    • (2006) J Biol Chem , vol.281 , pp. 18802-18815
    • Gong, R.1    Park, C.S.2    Abbassi, N.R.3    Tang, S.J.4
  • 15
    • 30544449810 scopus 로고    scopus 로고
    • Control of dendritic arborization by the phosphoinositide-3′-kinase-Akt-mammalian target of rapamycin pathway
    • Jaworski J, Spangler S, Seeburg DP, Hoogenraad CC, Sheng M, (2005) Control of dendritic arborization by the phosphoinositide-3′-kinase-Akt-mammalian target of rapamycin pathway. J Neurosci 25: 11300-11312.
    • (2005) J Neurosci , vol.25 , pp. 11300-11312
    • Jaworski, J.1    Spangler, S.2    Seeburg, D.P.3    Hoogenraad, C.C.4    Sheng, M.5
  • 16
    • 30544442753 scopus 로고    scopus 로고
    • Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways
    • Kumar V, Zhang MX, Swank MW, Kunz J, Wu GY, (2005) Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways. J Neurosci 25: 11288-11299.
    • (2005) J Neurosci , vol.25 , pp. 11288-11299
    • Kumar, V.1    Zhang, M.X.2    Swank, M.W.3    Kunz, J.4    Wu, G.Y.5
  • 17
    • 69549139978 scopus 로고    scopus 로고
    • Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
    • Dello Russo C, Lisi L, Tringali G, Navarra P, (2009) Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation. Biochem Pharmacol 78: 1242-1251.
    • (2009) Biochem Pharmacol , vol.78 , pp. 1242-1251
    • Dello Russo, C.1    Lisi, L.2    Tringali, G.3    Navarra, P.4
  • 18
    • 33748562106 scopus 로고    scopus 로고
    • Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha
    • Lu DY, Liou HC, Tang CH, Fu WM, (2006) Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha. Biochem Pharmacol 72: 992-1000.
    • (2006) Biochem Pharmacol , vol.72 , pp. 992-1000
    • Lu, D.Y.1    Liou, H.C.2    Tang, C.H.3    Fu, W.M.4
  • 19
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N, (2004) Upstream and downstream of mTOR. Genes Dev 18: 1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 20
    • 0033766442 scopus 로고    scopus 로고
    • Spine loss and other dendritic abnormalities in epilepsy
    • Swann JW, Al-Noori S, Jiang M, Lee CL, (2000) Spine loss and other dendritic abnormalities in epilepsy. Hippocampus 10: 617-625.
    • (2000) Hippocampus , vol.10 , pp. 617-625
    • Swann, J.W.1    Al-Noori, S.2    Jiang, M.3    Lee, C.L.4
  • 21
    • 35549009827 scopus 로고    scopus 로고
    • Kainate seizures cause acute dendritic injury and actin depolymerization in vivo
    • Zeng LH, Xu L, Rensing NR, Sinatra PM, Rothman SM, et al. (2007) Kainate seizures cause acute dendritic injury and actin depolymerization in vivo. J Neurosci 27: 11604-11613.
    • (2007) J Neurosci , vol.27 , pp. 11604-11613
    • Zeng, L.H.1    Xu, L.2    Rensing, N.R.3    Sinatra, P.M.4    Rothman, S.M.5
  • 22
    • 33847100127 scopus 로고    scopus 로고
    • Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus
    • Jalava NS, Lopez-Picon FR, Kukko-Lukjanov TK, Holopainen IE, (2007) Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus. Int J Dev Neurosci 25: 121-131.
    • (2007) Int J Dev Neurosci , vol.25 , pp. 121-131
    • Jalava, N.S.1    Lopez-Picon, F.R.2    Kukko-Lukjanov, T.K.3    Holopainen, I.E.4
  • 23
    • 80052288856 scopus 로고    scopus 로고
    • Seizures in early life suppress hippocampal dendrite growth while impairing spatial learning
    • Nishimura M, Gu X, Swann JW, (2011) Seizures in early life suppress hippocampal dendrite growth while impairing spatial learning. Neurobiol Dis 44: 205-214.
    • (2011) Neurobiol Dis , vol.44 , pp. 205-214
    • Nishimura, M.1    Gu, X.2    Swann, J.W.3
  • 24
    • 3242743584 scopus 로고    scopus 로고
    • Acquired dendritic channelopathy in temporal lobe epilepsy
    • Bernard C, Anderson A, Becker A, Poolos NP, Beck H, et al. (2004) Acquired dendritic channelopathy in temporal lobe epilepsy. Science 305: 532-535.
    • (2004) Science , vol.305 , pp. 532-535
    • Bernard, C.1    Anderson, A.2    Becker, A.3    Poolos, N.P.4    Beck, H.5
  • 25
    • 36348978149 scopus 로고    scopus 로고
    • Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy
    • Jung S, Jones TD, Lugo JN Jr, Sheerin AH, Miller JW, et al. (2007) Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy. J Neurosci 27: 13012-13021.
    • (2007) J Neurosci , vol.27 , pp. 13012-13021
    • Jung, S.1    Jones, T.D.2    Lugo Jr., J.N.3    Sheerin, A.H.4    Miller, J.W.5
  • 26
    • 53249083930 scopus 로고    scopus 로고
    • Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy
    • Monaghan MM, Menegola M, Vacher H, Rhodes KJ, Trimmer JS, (2008) Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy. Neuroscience 156: 550-562.
    • (2008) Neuroscience , vol.156 , pp. 550-562
    • Monaghan, M.M.1    Menegola, M.2    Vacher, H.3    Rhodes, K.J.4    Trimmer, J.S.5
  • 27
    • 0015309163 scopus 로고
    • Modification of seizure activity by electrical stimulation. II. Motor seizure
    • Racine RJ, (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32: 281-294.
    • (1972) Electroencephalogr Clin Neurophysiol , vol.32 , pp. 281-294
    • Racine, R.J.1
  • 28
    • 80155189536 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice
    • Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, et al. (2011) Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice. Epilepsia 52: 2065-2075.
    • (2011) Epilepsia , vol.52 , pp. 2065-2075
    • Sunnen, C.N.1    Brewster, A.L.2    Lugo, J.N.3    Vanegas, F.4    Turcios, E.5
  • 29
    • 84861124663 scopus 로고    scopus 로고
    • Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits
    • Lugo JN, Brewster AL, Spencer CM, Anderson AE, (2012) Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learn Mem 19: 182-189.
    • (2012) Learn Mem , vol.19 , pp. 182-189
    • Lugo, J.N.1    Brewster, A.L.2    Spencer, C.M.3    Anderson, A.E.4
  • 30
    • 23844485616 scopus 로고    scopus 로고
    • Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor
    • Fenoglio KA, Brunson KL, Avishai-Eliner S, Stone BA, Kapadia BJ, et al. (2005) Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Endocrinology 146: 4090-4096.
    • (2005) Endocrinology , vol.146 , pp. 4090-4096
    • Fenoglio, K.A.1    Brunson, K.L.2    Avishai-Eliner, S.3    Stone, B.A.4    Kapadia, B.J.5
  • 31
    • 48749126744 scopus 로고    scopus 로고
    • Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus
    • Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, et al. (2008) Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus. J Neurochem 106: 1929-1940.
    • (2008) J Neurochem , vol.106 , pp. 1929-1940
    • Lugo, J.N.1    Barnwell, L.F.2    Ren, Y.3    Lee, W.L.4    Johnston, L.D.5
  • 32
    • 68349100270 scopus 로고    scopus 로고
    • Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    • Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G, (2009) Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech 2: 389-398.
    • (2009) Dis Model Mech , vol.2 , pp. 389-398
    • Ljungberg, M.C.1    Sunnen, C.N.2    Lugo, J.N.3    Anderson, A.E.4    D'Arcangelo, G.5
  • 33
    • 33846942645 scopus 로고    scopus 로고
    • Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus
    • Brewster AL, Chen Y, Bender RA, Yeh A, Shigemoto R, et al. (2007) Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cereb Cortex 17: 702-712.
    • (2007) Cereb Cortex , vol.17 , pp. 702-712
    • Brewster, A.L.1    Chen, Y.2    Bender, R.A.3    Yeh, A.4    Shigemoto, R.5
  • 34
    • 84055217030 scopus 로고    scopus 로고
    • Valosin-containing protein and neurofibromin interact to regulate dendritic spine density
    • Wang HF, Shih YT, Chen CY, Chao HW, Lee MJ, et al. (2011) Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. J Clin Invest 121: 4820-4837.
    • (2011) J Clin Invest , vol.121 , pp. 4820-4837
    • Wang, H.F.1    Shih, Y.T.2    Chen, C.Y.3    Chao, H.W.4    Lee, M.J.5
  • 36
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng LH, Xu L, Gutmann DH, Wong M, (2008) Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol 63: 444-453.
    • (2008) Ann Neurol , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 37
    • 77955845741 scopus 로고    scopus 로고
    • Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    • Huang X, Zhang H, Yang J, Wu J, McMahon J, et al. (2010) Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy. Neurobiol Dis 40: 193-199.
    • (2010) Neurobiol Dis , vol.40 , pp. 193-199
    • Huang, X.1    Zhang, H.2    Yang, J.3    Wu, J.4    McMahon, J.5
  • 38
    • 34347242470 scopus 로고    scopus 로고
    • RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
    • Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, et al. (2007) RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem 282: 14056-14064.
    • (2007) J Biol Chem , vol.282 , pp. 14056-14064
    • Roux, P.P.1    Shahbazian, D.2    Vu, H.3    Holz, M.K.4    Cohen, M.S.5
  • 39
    • 11144356304 scopus 로고    scopus 로고
    • S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
    • Pende M, Um SH, Mieulet V, Sticker M, Goss VL, et al. (2004) S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 24: 3112-3124.
    • (2004) Mol Cell Biol , vol.24 , pp. 3112-3124
    • Pende, M.1    Um, S.H.2    Mieulet, V.3    Sticker, M.4    Goss, V.L.5
  • 40
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    • Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, et al. (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22: 159-168.
    • (2006) Mol Cell , vol.22 , pp. 159-168
    • Sarbassov, D.D.1    Ali, S.M.2    Sengupta, S.3    Sheen, J.H.4    Hsu, P.P.5
  • 41
    • 84862994959 scopus 로고    scopus 로고
    • Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy
    • Sha LZ, Xing XL, Zhang D, Yao Y, Dou WC, et al. (2012) Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy. PLoS One 7: e39152.
    • (2012) PLoS One , vol.7
    • Sha, L.Z.1    Xing, X.L.2    Zhang, D.3    Yao, Y.4    Dou, W.C.5
  • 42
    • 38449102377 scopus 로고    scopus 로고
    • Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats
    • Shapiro LA, Wang L, Ribak CE, (2008) Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats. Epilepsia 49: 33-41.
    • (2008) Epilepsia , vol.49 , pp. 33-41
    • Shapiro, L.A.1    Wang, L.2    Ribak, C.E.3
  • 44
    • 33845236201 scopus 로고    scopus 로고
    • Triggering the brain's pathology sensor
    • Kettenmann H, (2006) Triggering the brain's pathology sensor. Nat Neurosci 9: 1463-1464.
    • (2006) Nat Neurosci , vol.9 , pp. 1463-1464
    • Kettenmann, H.1
  • 45
    • 38149007728 scopus 로고    scopus 로고
    • Effects of chronic network hyperexcitability on the growth of hippocampal dendrites
    • Nishimura M, Owens J, Swann JW, (2008) Effects of chronic network hyperexcitability on the growth of hippocampal dendrites. Neurobiol Dis 29: 267-277.
    • (2008) Neurobiol Dis , vol.29 , pp. 267-277
    • Nishimura, M.1    Owens, J.2    Swann, J.W.3
  • 46
    • 77955713466 scopus 로고    scopus 로고
    • Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats
    • Oliveira MS, Skinner F, Arshadmansab MF, Garcia I, Mello CF, et al. (2010) Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Brain Res 1348: 187-199.
    • (2010) Brain Res , vol.1348 , pp. 187-199
    • Oliveira, M.S.1    Skinner, F.2    Arshadmansab, M.F.3    Garcia, I.4    Mello, C.F.5
  • 47
    • 8844278361 scopus 로고    scopus 로고
    • A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons
    • Nolan MF, Malleret G, Dudman JT, Buhl DL, Santoro B, et al. (2004) A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons. Cell 119: 719-732.
    • (2004) Cell , vol.119 , pp. 719-732
    • Nolan, M.F.1    Malleret, G.2    Dudman, J.T.3    Buhl, D.L.4    Santoro, B.5
  • 48
    • 32544433136 scopus 로고    scopus 로고
    • Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity
    • Hammond RS, Bond CT, Strassmaier T, Ngo-Anh TJ, Adelman JP, et al. (2006) Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity. J Neurosci 26: 1844-1853.
    • (2006) J Neurosci , vol.26 , pp. 1844-1853
    • Hammond, R.S.1    Bond, C.T.2    Strassmaier, T.3    Ngo-Anh, T.J.4    Adelman, J.P.5
  • 49
    • 33751311255 scopus 로고    scopus 로고
    • Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons
    • Chen X, Yuan LL, Zhao C, Birnbaum SG, Frick A, et al. (2006) Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons. J Neurosci 26: 12143-12151.
    • (2006) J Neurosci , vol.26 , pp. 12143-12151
    • Chen, X.1    Yuan, L.L.2    Zhao, C.3    Birnbaum, S.G.4    Frick, A.5
  • 50
    • 84860491069 scopus 로고    scopus 로고
    • The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway
    • Talos DM, Sun H, Zhou X, Fitzgerald EC, Jackson MC, et al. (2012) The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway. PLoS One 7: e35885.
    • (2012) PLoS One , vol.7
    • Talos, D.M.1    Sun, H.2    Zhou, X.3    Fitzgerald, E.C.4    Jackson, M.C.5
  • 51
    • 79952763934 scopus 로고    scopus 로고
    • Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
    • Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, et al. (2011) Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. Proc Natl Acad Sci 108: 3791-3796.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 3791-3796
    • Stoica, L.1    Zhu, P.J.2    Huang, W.3    Zhou, H.4    Kozma, S.C.5
  • 52
    • 79958184395 scopus 로고    scopus 로고
    • A pulse rapamycin therapy for infantile spasms and associated cognitive decline
    • Raffo E, Coppola A, Ono T, Briggs SW, Galanopoulou AS, (2011) A pulse rapamycin therapy for infantile spasms and associated cognitive decline. Neurobiol Dis 43: 322-329.
    • (2011) Neurobiol Dis , vol.43 , pp. 322-329
    • Raffo, E.1    Coppola, A.2    Ono, T.3    Briggs, S.W.4    Galanopoulou, A.S.5
  • 53
    • 84861818199 scopus 로고    scopus 로고
    • Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy
    • Huang X, McMahon J, Huang Y, (2012) Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy. Neuroscience 215: 90-97.
    • (2012) Neuroscience , vol.215 , pp. 90-97
    • Huang, X.1    McMahon, J.2    Huang, Y.3
  • 54
    • 33748128950 scopus 로고    scopus 로고
    • Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway
    • Dash PK, Orsi SA, Moore AN, (2006) Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway. J Neurosci 26: 8048-8056.
    • (2006) J Neurosci , vol.26 , pp. 8048-8056
    • Dash, P.K.1    Orsi, S.A.2    Moore, A.N.3
  • 55
    • 33845606405 scopus 로고    scopus 로고
    • Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons
    • Parsons RG, Gafford GM, Helmstetter FJ, (2006) Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons. J Neurosci 26: 12977-12983.
    • (2006) J Neurosci , vol.26 , pp. 12977-12983
    • Parsons, R.G.1    Gafford, G.M.2    Helmstetter, F.J.3
  • 56
    • 84869080559 scopus 로고    scopus 로고
    • Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats
    • Chachua T, Poon KL, Yum MS, Nesheiwat L, Desantis K, et al. (2012) Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats. Epilepsia 53: 2015-2025.
    • (2012) Epilepsia , vol.53 , pp. 2015-2025
    • Chachua, T.1    Poon, K.L.2    Yum, M.S.3    Nesheiwat, L.4    Desantis, K.5
  • 57
    • 84866331178 scopus 로고    scopus 로고
    • The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice
    • Hartman AL, Santos P, Dolce A, Hardwick JM, (2012) The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. PLoS One 7: e45156.
    • (2012) PLoS One , vol.7
    • Hartman, A.L.1    Santos, P.2    Dolce, A.3    Hardwick, J.M.4
  • 58
    • 79951531485 scopus 로고    scopus 로고
    • Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    • Buckmaster PS, Lew FH, (2011) Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J Neurosci 31: 2337-2347.
    • (2011) J Neurosci , vol.31 , pp. 2337-2347
    • Buckmaster, P.S.1    Lew, F.H.2
  • 59
    • 85129126354 scopus 로고    scopus 로고
    • Interictal spikes and epileptogenesis
    • Staley KJ, Dudek FE, (2006) Interictal spikes and epileptogenesis. Epilepsy Curr 6: 199-202.
    • (2006) Epilepsy Curr , vol.6 , pp. 199-202
    • Staley, K.J.1    Dudek, F.E.2
  • 61
    • 39149117362 scopus 로고    scopus 로고
    • Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells
    • Hailer NP, (2008) Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells. Prog Neurobiol 84: 211-233.
    • (2008) Prog Neurobiol , vol.84 , pp. 211-233
    • Hailer, N.P.1
  • 62
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, et al. (2011) Synaptic pruning by microglia is necessary for normal brain development. Science 333: 1456-1458.
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1    Bolasco, G.2    Pagani, F.3    Maggi, L.4    Scianni, M.5
  • 63
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J, (2009) Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 29: 3974-3980.
    • (2009) J Neurosci , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 64
    • 0347064328 scopus 로고    scopus 로고
    • Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum
    • Milatovic D, Zaja-Milatovic S, Montine KS, Horner PJ, Montine TJ, (2003) Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. J Neurochem 87: 1518-1526.
    • (2003) J Neurochem , vol.87 , pp. 1518-1526
    • Milatovic, D.1    Zaja-Milatovic, S.2    Montine, K.S.3    Horner, P.J.4    Montine, T.J.5
  • 65
    • 33644910893 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats
    • Tanaka S, Ide M, Shibutani T, Ohtaki H, Numazawa S, et al. (2006) Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats. J Neurosci Res 83: 557-566.
    • (2006) J Neurosci Res , vol.83 , pp. 557-566
    • Tanaka, S.1    Ide, M.2    Shibutani, T.3    Ohtaki, H.4    Numazawa, S.5
  • 66
    • 69749090963 scopus 로고    scopus 로고
    • Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage
    • Muller CJ, Bankstahl M, Groticke I, Loscher W, (2009) Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage. Eur J Pharmacol 619: 15-24.
    • (2009) Eur J Pharmacol , vol.619 , pp. 15-24
    • Muller, C.J.1    Bankstahl, M.2    Groticke, I.3    Loscher, W.4
  • 67
    • 0036323447 scopus 로고    scopus 로고
    • MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction
    • Harada A, Teng J, Takei Y, Oguchi K, Hirokawa N, (2002) MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J Cell Biol 158: 541-549.
    • (2002) J Cell Biol , vol.158 , pp. 541-549
    • Harada, A.1    Teng, J.2    Takei, Y.3    Oguchi, K.4    Hirokawa, N.5
  • 68
    • 19744382953 scopus 로고    scopus 로고
    • The MAP2/Tau family of microtubule-associated proteins
    • Dehmelt L, Halpain S, (2005) The MAP2/Tau family of microtubule-associated proteins. Genome Biol 6: 204.
    • (2005) Genome Biol , vol.6 , pp. 204
    • Dehmelt, L.1    Halpain, S.2
  • 69
    • 0029070496 scopus 로고
    • Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro
    • Maletic-Savatic M, Lenn NJ, Trimmer JS, (1995) Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. J Neurosci 15: 3840-3851.
    • (1995) J Neurosci , vol.15 , pp. 3840-3851
    • Maletic-Savatic, M.1    Lenn, N.J.2    Trimmer, J.S.3
  • 70
    • 71249131218 scopus 로고    scopus 로고
    • Immunosuppression using the mammalian target of rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement
    • Lang UE, Heger J, Willbring M, Domula M, Matschke K, et al. (2009) Immunosuppression using the mammalian target of rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement. Transplant Proc 41: 4285-4288.
    • (2009) Transplant Proc , vol.41 , pp. 4285-4288
    • Lang, U.E.1    Heger, J.2    Willbring, M.3    Domula, M.4    Matschke, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.