Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

Neuropharmacology

Volumn 76, Issue PART A, 2014, Pages 57-67

  McClean, Paula L ^a   Hölscher, Christian ^a,b  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

Cognition; GLP 1; Incretins; Inflammation; Insulin; Memory; Neurodegeneration; Neuroprotection; Stem cells; Synapse

Indexed keywords

AMYLOID PRECURSOR PROTEIN; EXENDIN 4; LIRAGLUTIDE; LIXISENATIDE; SYNAPTOPHYSIN;

AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL COUNT; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; DISEASE COURSE; DRUG ACTIVITY; HIPPOCAMPUS; IN VIVO STUDY; INFLAMMATION; MAZE TEST; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SPATIAL MEMORY; SYNAPTOGENESIS;

COGNITION; GLP-1; INCRETINS; INFLAMMATION; INSULIN; MEMORY; NEURODEGENERATION; NEUROPROTECTION; STEM CELLS; SYNAPSE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL COUNT; DISEASE MODELS, ANIMAL; GLUCAGON-LIKE PEPTIDE 1; INFLAMMATION; LONG-TERM POTENTIATION; MALE; MEMORY; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PLAQUE, AMYLOID; STEM CELLS; SYNAPSES;

EID: 84886592674     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.08.005     Document Type: Article

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