Cognitive disorders in diabetic patients

Handbook of Clinical Neurology

Volumn 126, Issue , 2014, Pages 145-166

  Koekkoek, Paula S ^a   Rutten, Guy E H M ^a   Biessels, Geert Jan ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Alzheimer's disease; Brain MRI; Cognitive functioning; Dementia; Risk factors; Type 1 diabetes; Type 2 diabetes

Indexed keywords

COGNITION DISORDERS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; HUMAN; LONGITUDINAL STUDY; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGY; RISK FACTOR;

COGNITION DISORDERS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; HUMANS; LONGITUDINAL STUDIES; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS;

EID: 84921982464     PISSN: 00729752     EISSN: 22124152     Source Type: Book Series    
DOI: 10.1016/B978-0-444-53480-4.00011-4     Document Type: Chapter

References (214)

1. Alafuzoff I., Aho L., Helisalmi S., et al. Beta-amyloid deposition in brains of subjects with diabetes. Neuropathol Appl Neurobiol 2009, 35:60-68.
2. Albert M.S., Jones K., Savage C.R., et al. Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychol Aging 1995, 10:578-589.
3. Alberti K.G., Eckel R.H., Grundy S.M., et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645.
4. Amieva H., Jacqmin-Gadda H., Orgogozo J.M., et al. The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study. Brain 2005, 128:1093-1101.
5. Anderson R.J., Freedland K.E., Clouse R.E., et al. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care 2001, 24:1069-1078.
6. Angevaren M., Aufdemkampe G., Verhaar H.J., et al. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev, 2008, CD005381.
7. Annweiler C., Rolland Y., Schott A.M., et al. Serum vitamin D deficiency as a predictor of incident non-Alzheimer dementias: a 7-year longitudinal study. Dement Geriatr Cogn Disord 2011, 32:273-278.
8. Arvanitakis Z., Schneider J.A., Wilson R.S., et al. Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology 2006, 67:1960-1965.
9. Atiea J.A., Moses J.L., Sinclair A.J. Neuropsychological function in older subjects with noninsulin-dependent diabetes mellitus. Diabetic Med 1995, 12:679-685.
10. Aung P.P., Strachan M.W., Frier B.M., et al. Severe hypoglycaemia and late-life cognitive ability in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabet Med 2012, 29:328-336.
11. Awad N., Gagnon M., Messier C. The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function. J Clin Exp Neuropsychol 2004, 26:1044-1080.
12. Baldwin R.C., O'Brien J. Vascular basis of late-onset depressive disorder. Br J Psychiatry 2002, 180:157-160.
13. Barberger-Gateau P., Letenneur L., Deschamps V., et al. Fish, meat, and risk of dementia: cohort study. BMJ 2002, 325:932-933.
14. Barzilay J.I., Gao P., O'Donnell M., et al. Albuminuria and decline in cognitive function: the ONTARGET/TRANSCEND studies. Arch Intern Med 2011, 171:142-150.
15. Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed 2002, 15:435-455.
16. Beckman J.A., Creager M.A., Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 2002, 287:2570-2581.
17. Beeri M.S., Silverman J.M., Davis K.L., et al. Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology. J Gerontol A Biol Sci Med Sci 2005, 60:471-475.
18. Benedict C., Frey W.H., Schioth H.B., et al. Intranasal insulin as a therapeutic option in the treatment of cognitive impairments. Exp Gerontol 2011, 46:112-115.
19. Berk-Planken I., de Konig I., Stolk R., et al. Atorvastatin, diabetic dyslipidemia, and cognitive functioning. Diabetes Care 2002, 25:1250-1251.
20. Berry E.M. Dietary fatty acids in the management of diabetes mellitus. Am J Clin Nutr 1997, 66:991S-997S.
21. Biessels G.J. Diabetes: hypoglycemia and dementia in type 2 diabetes: chick or egg?. Nat Rev Endocrinol 2009, 5:532-534.
22. Biessels G.J. Caffeine, diabetes, cognition, and dementia. J Alzheimers Dis 2010, 20:S143-S150.
23. Biessels G.J., Luchsinger J.A. Diabetes and the Brain 2009, Humana Press, Totowa, NJ.
24. Biessels G.J., Staekenborg S., Brunner E., et al. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 2006, 5:64-74.
25. Blair C.K., Folsom A.R., Knopman D.S., et al. APOE genotype and cognitive decline in a middle-aged cohort. Neurology 2005, 64:268-276.
26. Brands A.M., Biessels G.J., De Haan E.H.F., et al. The effects of type 1 diabetes on cognitive performance: a meta-analysis. Diabetes Care 2005, 28:726-735.
27. Brands A.M., Kessels R.P., Hoogma R.P., et al. Cognitive performance, psychological well-being, and brain magnetic resonance imaging in older patients with type 1 diabetes. Diabetes 2006, 55:1800-1806.
28. Brands A.M., van den Berg E., Manschot S.M., et al. A detailed profile of cognitive dysfunction and its relation to psychological distress in patients with type 2 diabetes mellitus. J Int Neuropsychol Soc 2007, 13:288-297.
29. Breteler M.M., Claus J.J., Grobbee D.E., et al. Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam Study. BMJ 1994, 308:1604-1608.
30. Brismar T., Maurex L., Cooray G., et al. Predictors of cognitive impairment in type 1 diabetes. Psychoneuroendocrinology 2007, 32:1041-1051.
31. Brown J., Pengas G., Dawson K., et al. Self administered cognitive screening test (TYM) for detection of Alzheimer's disease: cross sectional study. BMJ 2009, 338:b2030.
32. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414:813-820.
33. Bruce D.G., Casey G., Davis W.A., et al. Vascular depression in older people with diabetes. Diabetologia 2006, 49:2828-2836.
34. Bruce D.G., Davis W.A., Casey G.P., et al. Predictors of cognitive decline in older individuals with diabetes. Diabetes Care 2008, 31:2103-2107.
35. Bruce D.G., Davis W.A., Casey G.P., et al. Severe hypoglycaemia and cognitive impairment in older patients with diabetes: the Fremantle Diabetes Study. Diabetologia 2009, 52:1808-1815.
36. Bruehl H., Wolf O.T., Sweat V., et al. Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus. Brain Res 2009, 1280:186-194.
37. Bruehl H., Sweat V., Hassenstab J., et al. Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance. J Clin Exp Neuropsychol 2010, 32:487-493.
38. Brundel M., Van Den Heuvel M., de Bresser J., et al. Cerebral cortical thickness in patients with type 2 diabetes. J Neurol Sci 2010, 299:126-130.
39. Caccamo A., Oddo S., Sugarman M.C., et al. Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging 2005, 26:645-654.
40. Charlton R.A., Barrick T.R., McIntyre D.J., et al. White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology 2006, 66:217-222.
41. Christman A.L., Vannorsdall T.D., Pearlson G.D., et al. Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sample. Arch Clin Neuropsychol 2010, 25:49-59.
42. Cohen J. Statistical Power Analysis for the Behavioral Sciences 1988, Laurence Erlbaum, New Jersey. 2nd edn.
43. Colberg S.R., Somma C.T., Sechrist S.R. Physical activity participation may offset some of the negative impact of diabetes on cognitive function. J Am Med Dir Assoc 2008, 9:434-438.
44. Cordonnier C., Al-Shahi S.R., Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007, 130:1988-2003.
45. Corrigan J.D., Hinkeldey N.S. Relationships between parts A and B of the Trail Making Test. J Clin Psychol 1987, 43:402-409.
46. Cosway R., Strachan M.W., Dougall A., et al. Cognitive function and information processing in type 2 diabetes. Diabet Med 2001, 18:803-810.
47. Cox D.J., Kovatchev B.P., Gonder-Frederick L.A., et al. Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes. Diabetes Care 2005, 28:71-77.
48. Craft S., Baker L.D., Montine T.J., et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 2012, 69:29-38.
49. Cukierman T., Gerstein H.C., Williamson J.D. Cognitive decline and dementia in diabetes - systematic overview of prospective observational studies. Diabetologia 2005, 48:2460-2469.
50. Cukierman-Yaffe T., Gerstein H.C., Williamson J.D., et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care 2009, 32:221-226.
51. DCCT Research Group Effects of intensive diabetes therapy on neuropsychological function in adults in the Diabetes Control and Complications Trial. Ann Intern Med 1996, 124:379-388.
52. de Bresser J., Reijmer Y.D., van den Berg E., et al. Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes. Dement Geriatr Cogn Disord 2010, 30:381-386.
53. de Bresser J., Tiehuis A.M., van den Berg E., et al. Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes. Diabetes Care 2010, 33:1309-1314.
54. de Galan B.E., Zoungas S., Chalmers J., et al. Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) Trial. Diabetologia 2009, 52:2328-2336.
55. de Groot J.C., de Leeuw F.E., Oudkerk M., et al. Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann Neurol 2002, 52:335-341.
56. Deary I.J., Frier B.M. Severe hypoglycaemia and cognitive impairment in diabetes. BMJ 1996, 313:767-768.
57. Deary I.J., Crawford J.R., Hepburn D.A., et al. Severe hypoglycemia and intelligence in adult patients with insulin-treated diabetes. Diabetes 1993, 42:341-344.
58. Deelman B.G., Koning-Haanstra M., Liebrand W.B.G. SAN test, an aphasia test for auditory and oral linguistics 1981, Swets and Zeitlinger, Lisse, Netherlands.
59. den Heijer T., Vermeer S.E., van Dijk E.J., et al. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia 2003, 46:1604-1610.
60. Desmond D.W., Tatemichi T.K., Paik M., et al. Risk factors for cerebrovascular disease as correlates of cognitive function in a stroke-free cohort. Arch Neurol 1993, 50:162-166.
61. Desrocher M., Rovet J. Neurocognitive correlates of type 1 diabetes mellitus in childhood. Child Neuropsychol 2004, 10:36-52.
62. Devore E.E., Stampfer M.J., Breteler M.M., et al. Dietary fat intake and cognitive decline in women with type 2 diabetes. Diabetes Care 2009, 32:635-640.
63. Dey J., Misra A., Desai N.G., et al. Cognitive function in younger type II diabetes. Diabetes Care 1997, 20:32-35.
64. Dik M.G., Jonker C., Comijs H.C., et al. Contribution of metabolic syndrome components to cognition in older individuals. Diabetes Care 2007, 30:2655-2660.
65. Ding J., Strachan M.W., Reynolds R.M., et al. Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes 2010, 59:2883-2889.
66. Dore G.A., Elias M.F., Robbins M.A., et al. Presence of the APOE epsilon4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine-Syracuse Study. Diabetologia 2009, 52:2551-2560.
67. Edland S.D. Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease. J Mol Neurosci 2004, 23:213-217.
68. Edland S.D., Wavrant-De-Vriese F., Compton D., et al. Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE). Neurosci Lett 2003, 345:21-24.
69. Egede L.E., Zheng D. Modifiable cardiovascular risk factors in adults with diabetes: prevalence and missed opportunities for physician counseling. Arch Intern Med 2002, 162:427-433.
70. Elias P.K., Elias M.F., D'Agostino R.B., et al. NIDDM and blood pressure as risk factors for poor cognitive performance. The Framingham Study. Diabetes Care 1997, 20:1388-1395.
71. Euser S.M., Sattar N., Witteman J.C., et al. A prospective analysis of elevated fasting glucose levels and cognitive function in older people: results from PROSPER and the Rotterdam Study. Diabetes 2010, 59:1601-1607.
72. Fazekas F., Chawluk J.B., Alavi A., et al. MR signal abnormalities at 1.5T in Alzheimer's dementia and normal aging. Am J Roentgenol 1987, 149:351-356.
73. Feart C., Samieri C., Rondeau V., et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA 2009, 302:638-648.
74. Ferguson S.C., Blane A., Perros P., et al. Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia. Diabetes 2003, 52:149-156.
75. Feskens E.J., Havekes L.M., Kalmijn S., et al. Apolipoprotein e4 allele and cognitive decline in elderly men. BMJ 1994, 309:1202-1206.
76. Folstein M.F., Folstein S.E., McHugh P.R. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12:189-198.
77. Fontbonne A., Berr C., Ducimetiere P., et al. Changes in cognitive abilities over a 4-year period are unfavorably affected in elderly diabetic subjects: results of the Epidemiology of Vascular Aging Study. Diabetes Care 2001, 24:366-370.
78. Freitas S., Simões M.R., Alves L., et al. Montreal cognitive assessment: validation study for mild cognitive impairment and Alzheimer disease. Alzheimer Dis Assoc Disord 2013, 27:37-43.
79. Frolich L., Blum-Degen D., Bernstein H.G., et al. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm 1998, 105:423-438.
80. Fuh J.L., Wang S.J., Hwu C.M., et al. Glucose tolerance status and cognitive impairment in early middle-aged women. Diabet Med 2007, 24:788-791.
81. Gasparini L., Xu H. Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci 2003, 26:404-406.
82. Gispen W.H., Biessels G.J. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 2000, 23:542-549.
83. Gold M., Alderton C., Zvartau-Hind M., et al. Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study. Dement Geriatr Cogn Disord 2010, 30:131-146.
84. Gomez D., Martinez J.A., Hanson L.R., et al. Intranasal treatment of neurodegenerative diseases and stroke. Front Biosci (Schol Ed) 2012, 4:74-89.
85. Gouw A.A., Seewann A., van der Flier W.M., et al. Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry 2011, 82:126-135.
86. Greenberg S.M., Vernooij M.W., Cordonnier C., et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009, 8:165-174.
87. Gregg E.W., Yaffe K., Cauley J.A., et al. Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group. Arch Intern Med 2000, 160:174-180.
88. Grodstein F., Chen J., Wilson R.S., et al. Type 2 diabetes and cognitive function in community-dwelling elderly women. Diabetes Care 2001, 24:1060-1065.
89. Haan M.N., Shemanski L., Jagust W.J., et al. The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons. JAMA 1999, 282:40-46.
90. Hamer M., Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med 2009, 39:3-11.
91. Hassing L.B., Hofer S.M., Nilsson S.E., et al. Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study. Age Ageing 2004, 33:355-361.
92. Irie F., Fitzpatrick A.L., Lopez O.L., et al. Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. Arch Neurol 2008, 65:89-93.
93. Jacobson A.M., Samson J.A., Weinger K., et al. Diabetes, the brain, and behavior: is there a biological mechanism underlying the association between diabetes and depression?. Int Rev Neurobiol 2002, 51:455-479.
94. Jacobson A.M., Musen G., Ryan C.M., et al. Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med 2007, 356:1842-1852.
95. Jacobson A.M., Paterson A.D., Ryan C.M., et al. The associations of apolipoprotein E and angiotensin-converting enzyme polymorphisms and cognitive function in type 1 diabetes based on an 18-year follow-up of the DCCT cohort. Diabet Med 2010, 27:15-22.
96. Jacobson A.M., Ryan C.M., Cleary P.A., et al. Biomedical risk factors for decreased cognitive functioning in type 1 diabetes: an 18 year follow-up of the Diabetes Control and Complications Trial (DCCT) cohort. Diabetologia 2011, 54:245-255.
97. Jolivalt C.G., Lee C.A., Beiswenger K.K., et al. Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin. J Neurosci Res 2008, 86:3265-3274.
98. Jones D.K. Studying connections in the living human brain with diffusion MRI. Cortex 2008, 44:936-952.
99. Jongen C., Biessels G.J. Structural brain imaging in diabetes: a methodological perspective. Eur J Pharmacol 2008, 585:208-218.
100. Kadoi Y., Saito S., Fujita N., et al. Risk factors for cognitive dysfunction after coronary artery bypass graft surgery in patients with type 2 diabetes. J Thorac Cardiovasc Surg 2005, 129:576-583.
101. Kalmijn S., Launer L.J., Ott A., et al. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 1997, 42:776-782.
102. Kalmijn S., Foley D., White L., et al. Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia Aging Study. Arterioscler Thromb Vasc Biol 2000, 20:2255-2260.
103. Kanaya A.M., Barrett-Connor E., Gildengorin G., et al. Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo Study cohort. Arch Intern Med 2004, 164:1327-1333.
104. Katon W., Lyles C.R., Parker M.M., et al. Association of depression with increased risk of dementia in patients with type 2 diabetes. The Diabetes and Aging Study. Arch Gen Psychiatry 2012, 69:410-417.
105. Kilander L., Nyman H., Boberg M., et al. Cognitive function, vascular risk factors and education. A cross-sectional study based on a cohort of 70-year-old men. J Intern Med 1997, 242:313-321.
106. Kloppenborg R.P., van den Berg E., Kappelle L.J., et al. Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review. Eur J Pharmacol 2008, 585:97-108.
107. Knopman D., Boland L.L., Mosley T., et al. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology 2001, 56:42-48.
108. Kodl C.T., Franc D.T., Rao J.P., et al. Diffusion tensor imaging (DTI) identifies deficits in white matter microstructure in subjects with type 1 diabetes mellitus that correlate with reduced neurocognitive function. Diabetes 2008, 57:3083-3089.
109. Koekkoek P.S., Ruis C., van den Donk M., et al. Intensive multifactorial treatment and cognitive functioning in screen-detected type 2 diabetes - the ADDITION-Netherlands Study: a cluster-randomized trial. J Neurol Sci 2012, 314:71-77.
110. Komulainen P., Lakka T.A., Kivipelto M., et al. Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women. Dement Geriatr Cogn Disord 2007, 23:29-34.
111. Korf E.S., van Straaten E.C., de Leeuw F.E., et al. Diabetes mellitus, hypertension and medial temporal lobe atrophy: the LADIS study. Diabet Med 2007, 24:166-171.
112. Krabbe K.S., Nielsen A.R., Krogh-Madsen R., et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 2007, 50:431-438.
113. Kramer J.H., Mungas D., Reed B.R., et al. Longitudinal MRI and cognitive change in healthy elderly. Neuropsychology 2007, 21:412-418.
114. Kumari M., Marmot M. Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II study. Neurology 2005, 65:1597-1603.
115. Launer L.J., Andersen K., Dewey M.E., et al. Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology 1999, 52:78-84.
116. Launer L.J., Miller M.E., Williamson J.D., et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol 2011, 10:969-977.
117. Lawson J.S., Erdahl D.L., Monga T.N., et al. Neuropsychological function in diabetic patients with neuropathy. Br J Psychiatry 1984, 145:263-268.
118. Lehmann D.J., Cortina-Borja M., Warden D.R., et al. Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. Am J Epidemiol 2005, 162:305-317.
119. Lezak M.D., Howieson D.B., Loring D.W. Neuropsychological Assessment 2004, Oxford University Press, New York.
120. Li L., Holscher C. Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev 2007, 56:384-402.
121. Li Z.G., Zhang W., Sima A.A. Alzheimer-like changes in rat models of spontaneous diabetes. Diabetes 2007, 56:1817-1824.
122. Ligthart S.A., Moll van Charante E.P., Van Gool W.A., et al. Treatment of cardiovascular risk factors to prevent cognitive decline and dementia: a systematic review. Vasc Health Risk Manag 2010, 6:775-785.
123. Lindeman R.D., Romero L.J., LaRue A., et al. A biethnic community survey of cognition in participants with type 2 diabetes, impaired glucose tolerance, and normal glucose tolerance: the New Mexico Elder Health Survey. Diabetes Care 2001, 24:1567-1572.
124. Lobnig B.M., Kromeke O., Optenhostert-Porst C., et al. Hippocampal volume and cognitive performance in long-standing type 1 diabetic patients without macrovascular complications. Diabet Med 2006, 23:32-39.
125. Longstreth W.T., Bernick C., Manolio T.A., et al. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study. Arch Neurol 1998, 55:1217-1225.
126. Lu F.P., Lin K.P., Kuo H.K. Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis. PLoS One 2009, 4:e4144.
127. Luchsinger J.A., Tang M.X., Stern Y., et al. Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol 2001, 154:635-641.
128. Luchsinger J.A., Reitz C., Patel B., et al. Relation of diabetes to mild cognitive impairment. Arch Neurol 2007, 64:570-575.
129. Manolio T.A., Kronmal R.A., Burke G.L., et al. Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study. Stroke 1994, 25:318-327.
130. Manschot S.M., Biessels G.J., de Valk H.W., et al. Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia 2007, 50:2388-2397.
131. Manschot S.M., Biessels G.J., Rutten G.E., et al. Peripheral and central neurologic complications in type 2 diabetes mellitus: no association in individual patients. J Neurol Sci 2008, 264:157-162.
132. McKhann G.M., Knopman D.S., Chertkow H., et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:263-269.
133. Middleton L.E., Yaffe K. Targets for the prevention of dementia. J Alzheimers Dis 2010, 20:915-924.
134. Mitchell A.J., Malladi S. Screening and case finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain tests. Am J Geriatr Psychiatry 2010, 18:759-782.
135. Muller M., Tang M.X., Schupf N., et al. Metabolic syndrome and dementia risk in a multiethnic elderly cohort. Dement Geriatr Cogn Disord 2007, 24:185-192.
136. Naor M., Steingruber H.J., Westhoff K., et al. Cognitive function in elderly non-insulin-dependent diabetic patients before and after inpatient treatment for metabolic control. J Diabetes Complications 1997, 11:40-46.
137. Nelson P.T., Smith C.D., Abner E.A., et al. Human cerebral neuropathology of type 2 diabetes mellitus. Biochim Biophys Acta 2008, 1792:454-469.
138. Northam E.A., Rankins D., Cameron F.J. Therapy insight: the impact of type 1 diabetes on brain development and function. Nat Clin Pract Neurol 2006, 2:78-86.
139. Nouwen A., Winkley K., Twisk J., et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia 2010, 53:2480-2486.
140. Okura T., Heisler M., Langa K.M. Association between cognitive function and social support with glycemic control in adults with diabetes mellitus. J Am Geriatr Soc 2009, 57:1816-1824.
141. Ott A., Stolk R.P., van Harskamp F., et al. Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology 1999, 53:1937-1942.
142. Pan A., Lucas M., Sun Q., et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med 2010, 170:1884-1891.
143. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010, 9:689-701.
144. Paranthaman R., Greenstein A.S., Burns A.S., et al. Vascular function in older adults with depressive disorder. Biol Psychiatry 2010, 68:133-139.
145. Peila R., Rodriguez B.L., Launer L.J. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study. Diabetes 2002, 51:1256-1262.
146. Petersen R.C., Stevens J.C., Ganguli M., et al. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001, 56:1133-1142.
147. Petersen R.C., Aisen P.S., Beckett L.A., et al. Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology 2010, 74:201-209.
148. Profenno L.A., Porsteinsson A.P., Faraone S.V. Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 2009, 67:505-512.
149. Qiu W.Q., Folstein M.F. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol Aging 2006, 27:190-198.
150. Qiu C., Backman L., Winblad B., et al. The influence of education on clinically diagnosed dementia incidence and mortality data from the Kungsholmen project. Arch Neurol 2001, 58:2034-2039.
151. Raffaitin C., Feart C., Le G.M., et al. Metabolic syndrome and cognitive decline in French elders: the Three-City Study. Neurology 2011, 76:518-525.
152. Reaven G.M., Thompson L.W., Nahum D., et al. Relationship between hyperglycemia and cognitive function in older NIDDM patients. Diabetes Care 1990, 13:16-21.
153. Reger M.A., Watson G.S., Green P.S., et al. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 2008, 70:440-448.
154. Reijmer Y.D., van den Berg E., Ruis C., et al. Cognitive dysfunction in patients with type 2 diabetes. Diabetes Metab Res Rev 2010, 26:507-519.
155. Reijmer Y.D., van den Berg E., de Bresser J., et al. Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors. Diabetes Metab Res Rev 2011, 27:195-202.
156. Risner M.E., Saunders A.M., Altman J.F., et al. Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J 2006, 6:246-254.
157. Ritchie K., Artero S., Touchon J. Classification criteria for mild cognitive impairment: a population-based validation study. Neurology 2001, 56:37-42.
158. Rossor M.N., Fox N.C., Mummery C.J., et al. The diagnosis of young-onset dementia. Lancet Neurol 2010, 9:793-806.
159. Ruis C., Biessels G.J., Gorter K.J., et al. Cognition in the early stage of type 2 diabetes. Diabetes Care 2009, 32:1261-1265.
160. Ryan C.M. Why is cognitive dysfunction associated with the development of diabetes early in life? The diathesis hypothesis. Pediatr Diabetes 2006, 7:289-297.
161. Ryan C.M., Williams T.M., Orchard T.J., et al. Psychomotor slowing is associated with distal symmetrical polyneuropathy in adults with diabetes mellitus. Diabetes 1992, 41:107-113.
162. Ryan C.M., Geckle M.O., Orchard T.J. Cognitive efficiency declines over time in adults with type 1 diabetes: effects of micro- and macrovascular complications. Diabetologia 2003, 46:940-948.
163. Ryan C.M., Freed M.I., Rood J.A., et al. Improving metabolic control leads to better working memory in adults with type 2 diabetes. Diabetes Care 2006, 29:345-351.
164. Sachon C., Grimaldi A., Digy J.P., et al. Cognitive function, insulin-dependent diabetes and hypoglycaemia. J Intern Med 1992, 231:471-475.
165. Savva G.M., Wharton S.B., Ince P.G., et al. Age, neuropathology, and dementia. N Engl J Med 2009, 360:2302-2309.
166. Scarmeas N., Stern Y., Mayeux R., et al. Mediterranean diet, Alzheimer disease, and vascular mediation. Arch Neurol 2006, 63:1709-1717.
167. Scarmeas N., Stern Y., Mayeux R., et al. Mediterranean diet and mild cognitive impairment. Arch Neurol 2009, 66:216-225.
168. Scharre D.W., Chang S.I., Murden R.A., et al. Self-administered Gerocognitive Examination (SAGE): a brief cognitive assessment instrument for mild cognitive impairment (MCI) and early dementia. Alzheimer Dis Assoc Disord 2010, 24:64-71.
169. Scheltens P., Barkhof F., Leys D., et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 1993, 114:7-12.
170. Scheltens P., Pasquier F., Weerts J.G., et al. Qualitative assessment of cerebral atrophy on MRI: inter- and intra-observer reproducibility in dementia and normal aging. Eur Neurol 1997, 37:95-99.
171. Schramm T.K., Gislason G.H., Kober L., et al. Diabetes patients requiring glucose-lowering therapy and nondiabetics with a prior myocardial infarction carry the same cardiovascular risk: a population study of 3.3 million people. Circulation 2008, 117:1945-1954.
172. Scott R.D., Kritz-Silverstein D., Barrett-Connor E., et al. The association of noninsulin-dependent diabetes mellitus and cognitive function in an older cohort. J Am Geriatr Soc 1998, 46:1217-1222.
173. Sinclair A.J., Girling A.J., Bayer A.J. Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. All Wales Research into Elderly (AWARE) Study. Diabetes Res Clin Pract 2000, 50:203-212.
174. Smith P.J., Blumenthal J.A., Hoffman B.M., et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med 2010, 72:239-252.
175. Sofi F., Valecchi D., Bacci D., et al. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern Med 2011, 269:107-117.
176. Solfrizzi V., Panza F., Colacicco A.M., et al. Vascular risk factors, incidence of MCI, and rates of progression to dementia. Neurology 2004, 63:1882-1891.
177. Stein M.S., Scherer S.C., Ladd K.S., et al. A randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer's disease. J Alzheimers Dis 2011, 26:477-484.
178. Stroop J. Studies of interference in serial verbal reactions. J Exp Psychol 1935, 18:643-662.
179. Tuokko H., Frerichs R., Graham J., et al. Five-year follow-up of cognitive impairment with no dementia. Arch Neurol 2003, 60:577-582.
180. UK Hypoglycaemia Study Group Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia 2007, 50:1140-1147.
181. Umegaki H., Iimuro S., Kaneko T., et al. Factors associated with lower Mini Mental State Examination scores in elderly Japanese diabetes mellitus patients. Neurobiol Aging 2008, 29:1022-1026.
182. U'Ren R.C., Riddle M.C., Lezak M.D., et al. The mental efficiency of the elderly person with type II diabetes mellitus. J Am Geriatr Soc 1990, 38:505-510.
183. van Boxtel M.P., Buntinx F., Houx P.J., et al. The relation between morbidity and cognitive performance in a normal aging population. J Gerontol A Biol Sci Med Sci 1998, 53:M147-M154.
184. van de Pol L., van der Flier W., Scheltens P. Diabetes and the Brain 2009, Humana Press, New York, pp. 103-127.
185. van den Berg E., Kessels R.P.C., Kappelle L.J., et al. Type 2 diabetes, cognitive function and dementia: vascular and metabolic determinants. Drugs Today (Barc) 2006, 42:741-754.
186. van den Berg E., Dekker J.M., Nijpels G., et al. Cognitive functioning in elderly persons with type 2 diabetes and metabolic syndrome: the Hoorn Study. Dement Geriatr Cogn Disord 2008, 26:261-269.
187. van den Berg E., Kloppenborg R.P., Kessels R.P., et al. Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: a systematic comparison of their impact on cognition. Biochim Biophys Acta 2009, 1792:470-481.
188. van den Berg E., Reijmer Y.D., de Bresser J., et al. A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus. Diabetologia 2010, 53:58-65.
189. van Elderen S.G., de Roos A., de Craen A.J., et al. Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up. Neurology 2010, 75:997-1002.
190. van Harten B., de Leeuw F.E., Weinstein H.C., et al. Brain imaging in patients with diabetes: a systematic review. Diabetes Care 2006, 29:2539-2548.
191. van Harten B., Oosterman J., Muslimovic D., et al. Cognitive impairment and MRI correlates in the elderly patients with type 2 diabetes mellitus. Age Ageing 2007, 36:164-170.
192. Vanhanen M., Koivisto K., Karjalainen L., et al. Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function. NeuroReport 1997, 8:1527-1530.
193. Vanhanen M., Koivisto K., Kuusisto J., et al. Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care 1998, 21:398-402.
194. Vanhanen M., Kuusisto J., Koivisto K., et al. Type-2 diabetes and cognitive function in a non-demented population. Acta Neurol Scand 1999, 100:97-101.
195. Vermeer S.E., Koudstaal P.J., Oudkerk M., et al. Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke 2002, 33:21-25.
196. Vermeer S.E., Longstreth W.T., Koudstaal P.J. Silent brain infarcts: a systematic review. Lancet Neurol 2007, 6:611-619.
197. Wahlin A., Nilsson E., Fastbom J. Cognitive performance in very old diabetic persons: the impact of semantic structure, preclinical dementia, and impending death. Neuropsychology 2002, 16:208-216.
198. Watari K., Letamendi A., Elderkin-Thompson V., et al. Cognitive function in adults with type 2 diabetes and major depression. Arch Clin Neuropsychol 2006, 21:787-796.
199. Watson G.S., Cholerton B.A., Reger M.A., et al. Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry 2005, 13:950-958.
200. Wechsler D. Wechsler Adult Intelligence Scale 1997, Psychological Corporation, San Antonio, Texas. 3rd edn.
201. Weiner D.E., Bartolomei K., Scott T., et al. Albuminuria, Cognitive Functioning, and White Matter Hyperintensities in Homebound Elders. Am J Kidney Dis 2008, 53:438-447.
202. Werring D.J., Frazer D.W., Coward L.J., et al. Cognitive dysfunction in patients with cerebral microbleeds on T2-weighted gradient-echo MRI. Brain 2004, 127:2265-2275.
203. Wessels A.M., Rombouts S.A., Remijnse P.L., et al. Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume. Diabetologia 2007, 50:1763-1769.
204. Whitmer R.A., Karter A.J., Yaffe K., et al. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 2009, 301:1565-1572.
205. Whitwell J.L., Petersen R.C., Negash S., et al. Patterns of atrophy differ among specific subtypes of mild cognitive impairment. Arch Neurol 2007, 64:1130-1138.
206. Winblad B., Palmer K., Kivipelto M., et al. Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004, 256:240-246.
207. Wong T.Y., Klein R., Sharrett A.R., et al. Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the Atherosclerosis Risk in Communities Study. Stroke 2002, 33:1487-1492.
208. Wong T.Y., Mosley T.H., Klein R., et al. Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people. Neurology 2003, 61:806-811.
209. Wredling R., Levander S., Adamson U., et al. Permanent neuropsychological impairment after recurrent episodes of severe hypoglycaemia in man. Diabetologia 1990, 33:152-157.
210. Xu W.L., Qiu C.X., Wahlin A., et al. Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology 2004, 63:1181-1186.
211. Yaffe K., Blackwell T., Kanaya A.M., et al. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology 2004, 63:658-663.
212. Yaffe K., Kanaya A., Lindquist K., et al. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 2004, 292:2237-2242.
213. Yaffe K., Haan M., Blackwell T., et al. Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc 2007, 55:758-762.
214. Zhao W., Alkon D.L. Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 2001, 177:125-134.