Ghrelin increases anxiety-like behavior and memory retention in rats

Biochemical and Biophysical Research Communications

Volumn 299, Issue 5, 2002, Pages 739-743

  Carlini, Valeria P ^a   Monzón, María E ^a   Varas, Mariana M ^a   Cragnolini, Andrea B ^a   Schiöth, Helgi B ^b   Scimonelli, Teresa N ^a   De Barioglio, Susana R ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Anxiety; Food intake; Ghrelin; Memory retention; Open field test; Plus maze test; Step down test

Indexed keywords

GHRELIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FOOD INTAKE; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY CONSOLIDATION; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; RAT;

ANIMALS; ANXIETY; APPETITE REGULATION; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; HABITUATION, PSYCHOPHYSIOLOGIC; LOCOMOTION; MALE; MEMORY; PEPTIDE HORMONES; RATS; RATS, WISTAR;

EID: 0036930643     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02740-7     Document Type: Article

References (24)

1. S.U. Devaskar, Neurohumoral regulation of body weight gain, Pediatr. Diab. 2 (2001) 131144.
2. M. Kojima, H. Hosoda, Y. Date, M. Nakasato, H. Matsuo, K. Kangawa, Ghrelin is a growth-hormone-releasing acylated peptide from stomach, Nature 402 (1999) 656-660.
3. X.M. Guan, H. Yu, O.C. Palyha, K.K. McKee, S.D. Feighner, D.J. Sirinathsinghji, R.G. Smith, L.H. Van der Ploeg, A.D. Howard, Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues, Brain Res. Mol. Brain Res. 48 (1997) 23-29.
4. M. Tschop, D.L. Smiley, M.L. Heiman, Ghrelin induces adiposity in rodents, Nature 407 (2000) 908-913.
5. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa, S. Matsukura, A role for ghrelin in the central regulation of feeding, Nature 409 (2001) 194-198.
6. A.M. Wren, C.J. Small, H.L. Ward, K.G. Murphy, C.L. Dakin, S. Taher, A.R. Kennedy, G.H. Roberts, D.G. Morgan, M.A. Ghatei, S.R. Bloom, The novel hypothalamic peptide ghrelin stimulates food intake and GH secretion, Endocrinology 141 (2000) 4325-4328.
7. A. Asakawa, A. Inui, T. Kaga, H. Yuzuriha, T. Nagata, N. Ueno, S. Makino, M. Fujiyama, A. Nijina, M.A. Fujino, M. Kasuga, Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin, Gastroenterology 120 (2001) 337-345.
8. Y. Masuda, T. Tanaka, N. Inomata, N. Ohnuma, S. Tanaka, Z. Itoh, H. Hosoda, M. Kojima, K. Kangawa, Ghrelin stimulates gastric acid secretion and motility in rats, Biochem. Biophys. Res. Commun. 276 (2000) 905-908.
9. M.G. Willesen, P. Kristensen, J. Romer, Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat, Neuroendocrinology 70 (1999) 306-316.
10. D.E. Cummings, J.Q. Purnell, R.S. Frayo, K. Schmidova, B. Wisse, D.S. Weigle, A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans, Diabetes 50 (2001) 1714-1719.
11. M. Tschöp, C. Weyer, P.A. Tataranni, V. Devanarayan, E. Ravussin, M.I. Heiman, Circulating ghrelin levels are decreased in human obesity, Diabetes 50 (2001) 707-709.
12. H. Ariyasu, K. Takaya, Tagami T., et al., Plasma ghrelin levels are influenced by acute and chronic feeding states in humans, in: Proceedings of the 83rd Annual Meeting of the Endocrine Society, Denver, CO, 2001, p. 336.
13. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, San Diego, Academic Press, 1986.
14. A. Cerbone, A.G. Sadile, Behavioral habituation to spacial novelty. Interference an non-interference studies, Neurosci. Biobehav. Rev. 18 (1994) 497-518.
15. W.E. Crusio, H. Schwegler, Hippocampal mossy fibers distribution covaries with open field habituation in the mouse, Behav. Brain Res. 26 (1987) 153-158.
16. M.R. Vianna, L.A. Izquierdo, D.M. Barros, M.M. deSouza, C. Rodrigues, M.K. Sant' Anna, J.H. Medina, I. Izquierdo, Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning, Braz. J. Med. Biol. Res. 34 (2001) 233-240.
17. C.M. Thiel, C.P. Müller, J.P. Huston, R.J.K. Schwarting, High versus low reactivity to a novel enviroment: Behavioural pharmacology and neurochemical assessments, Neuroscience 93 (1999) 243-251.
18. H. Dai, M. Krost, R.J. Corey, A new methodological approach to the study of habituation: The use of positive and negative behavioral indices of habituation, J. Neurosci. Method 62 (1995) 169-174.
19. J. Lat, The analysis of habituation, Acta Neurobiol. Exp. (Warsz.) 33 (1973) 771-789.
20. A.P. Cruz, F. Frei, F.G. Graeff, Ethopharmacological analysis of rat behavior on elevated plus-maze, Pharmacol. Biochem. Behav. 49 (1994) 171-176.
21. A. Asakawa, A. Inui, T. Kaga, H. Yuzuriha, T. Nagata, M. Fujimiya, G. Katsuura, S. Makino, M. Fujino, M. Kasuga, A role of ghrelin in neuroendocrine and behavioral responses to stress in mice, Neuroendocrinology 74 (2001) 143-147.
22. A. Tracy, L. Jarrard, T.L. Davidson, The hippocampus and motivation revisited: Appetite and activity, Behav. Brain Res. 127 (2001) 13-23.
23. L.R. Squire, Memory and the hippocampus: A synthesis from finding with rats, monkeys and humans, Psychol. Rev. 99 (1992) 195-231.
24. I. Izquierdo, J.H. Medina, Memory formation: The sequence of biochemical events in the hippocampus and its connections to activity in other brain structures, Neurobiol. Learn. Mem. 68 (1997) 285-316.