Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction

Neuropeptides

Volumn 54, Issue , 2015, Pages 9-15

  Xiang, Qiong ^a   Zhang, Jie ^a   Li, Chun Yan ^a   Wang, Yan ^b   Zeng, Mao Jun ^a   Cai, Zhi Xin ^a   Tian, Rong Bo ^a   Jia, Wei ^a   Li, Xian Hui ^a  

^a JISHOU UNIVERSITY   (China)

^b THE FIRST PEOPLE S HOSPITAL OF FOSHAN   (China)

Author keywords

Akt CREB signal pathway; Alzheimer's disease; Cognitive deficits; Diabetic encephalopathy; Insulin resistance

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PROTEIN KINASE B; SYNAPTOPHYSIN; GLUCOSE BLOOD LEVEL; INSULIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; DENDRITIC SPINE; DOWN REGULATION; ENZYME ACTIVATION; HIPPOCAMPUS; HYPERGLYCEMIA; INSULIN RESISTANCE; LATENT PERIOD; LEARNING; MALE; MEMORY; METABOLIC DISORDER; NERVE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BLOOD; CELL SURVIVAL; COGNITION DISORDERS; DISEASE MODEL; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD GLUCOSE; CELL SURVIVAL; COGNITION DISORDERS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DENDRITIC SPINES; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; INSULIN; MALE; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84947495884     PISSN: 01434179     EISSN: 15322785     Source Type: Journal    
DOI: 10.1016/j.npep.2015.08.009     Document Type: Article

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