Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

Life Sciences

Volumn 91, Issue 11-12, 2012, Pages 409-414

  Pintana, Hiranya ^a   Apaijai, Nattayaporn ^a   Pratchayasakul, Wasana ^a   Chattipakorn, Nipon ^a   Chattipakorn, Siriporn C ^a,b  

^a THAMMASAT UNIVERSITY   (Thailand)

^b CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

High fat diet consumption; Insulin resistance; Memory decline; Metformin; Neuronal mitochondrial dysfunction

Indexed keywords

FAT; GLUCOSE; INSULIN; MALONALDEHYDE; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MITOCHONDRION; COGNITION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFICACY; FAT INTAKE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEARNING; LEARNING DISORDER; LIPID DIET; MALE; MEMORY; NONHUMAN; OXIDATIVE STRESS; RAT; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; BRAIN; DIETARY FATS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMORY; METFORMIN; MITOCHONDRIA; OXIDATIVE STRESS; RATS; RATS, WISTAR;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84866365752     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.08.017     Document Type: Article

References (51)

1. K.G. Alberti, R.H. Eckel, S.M. Grundy, P.Z. Zimmet, J.I. Cleeman, and K.A. Donato Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 120 2009 1640 1645
2. K.H. Alzoubi, K.K. Abdul-Razzak, O.F. Khabour, G.M. Al-Tuweiq, M.A. Alzubi, and K.A. Alkadhi Adverse effect of combination of chronic psychosocial stress and high fat diet on hippocampus-dependent memory in rats Behav. Brain Res. 204 2009 117 123
3. N. Apaijai, H. Pintana, S.C. Chattipakorn, and N. Chattipakorn Cardioprotective effects of metformin and vildagliptin in adult rats with insulin resistance induced by a high-fat diet Endocrinology 153 8 2012 3878 3885
4. D.J. Appleton, J.S. Rand, and G.D. Sunvold Basal plasma insulin and homeostasis model assessment (HOMA) are indicators of insulin sensitivity in cats J. Feline Med. Surg. 7 2005 183 193 (Pubitemid 40716484)
5. H. Arakawa Age dependent effects of space limitation and social tension on open-field behavior in male rats Physiol. Behav. 84 2005 429 436 (Pubitemid 40342597)
6. D. Argaud, H. Roth, N. Wiernsperger, and X.M. Leverve Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes Eur. J. Biochem. 213 1993 1341 1348 (Pubitemid 23152246)
7. C. Bonnard, A. Durand, S. Peyrol, E. Chanseaume, M.A. Chauvin, and B. Morio Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice J. Clin. Invest. 118 2008 789 800 (Pubitemid 351206566)
8. N. Candan, and N. Tuzmen Very rapid quantification of malondialdehyde (MDA) in rat brain exposed to lead, aluminium and phenolic antioxidants by high-performance liquid chromatography-fluorescence detection Neurotoxicology 29 2008 708 713
9. C.C. Chen, H.J. Wang, H.C. Shih, L.Y. Sheen, C.T. Chang, and R.H. Chen Comparison of the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats J. Formos. Med. Assoc. 100 2001 176 180
10. D.J. Clegg, K. Gotoh, C. Kemp, M.D. Wortman, S.C. Benoit, and L.M. Brown Consumption of a high-fat diet induces central insulin resistance independent of adiposity Physiol. Behav. 103 2011 10 16
11. S. Correia, C. Carvalho, M.S. Santos, R. Seica, C.R. Oliveira, and P.I. Moreira Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview Mini. Rev. Med. Chem. 8 2008 1343 1354
12. P.K. Dash, S.A. Orsi, and A.N. Moore Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-mammalian target of rapamycin pathway J. Neurosci. 26 2006 8048 8056 (Pubitemid 44315129)
13. D. Detaille, B. Guigas, C. Chauvin, C. Batandier, E. Fontaine, and N. Wiernsperger Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process Diabetes 54 2005 2179 2187 (Pubitemid 40911282)
14. A. Eckert, U. Keil, C.A. Marques, A. Bonert, C. Frey, and K. Schussel Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease Biochem. Pharmacol. 66 2003 1627 1634 (Pubitemid 38373355)
15. M.Y. El-Mir, D. Detaille, G. RV, M. Delgado-Esteban, B. Guigas, and S. Attia Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons J. Mol. Neurosci. 34 2008 77 87 (Pubitemid 351378091)
16. P. Faure, E. Rossini, N. Wiernsperger, M.J. Richard, A. Favier, and S. Halimi An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats Diabetes 48 1999 353 357 (Pubitemid 29061110)
17. D. Grotto, L.D. Santa Maria, S. Boeira, J. Valentini, M.F. Charao, and A.M. Moro Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection J. Pharm. Biomed. Anal. 43 2007 619 624 (Pubitemid 44960559)
18. S.M. Haffner, H. Miettinen, and M.P. Stern The homeostasis model in the San Antonio Heart Study Diabetes Care 20 1997 1087 1092 (Pubitemid 27274268)
19. S.A. Hawley, A.E. Gadalla, G.S. Olsen, and D.G. Hardie The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism Diabetes 51 2002 2420 2425 (Pubitemid 34827390)
20. L. He, A. Sabet, S. Djedjos, R. Miller, X. Sun, and M.A. Hussain Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein Cell 137 2009 635 646
21. F.F. Horber, S. Krayer, J. Miles, P. Cryer, K. Rehder, and M.W. Haymond Isoflurane and whole body leucine, glucose, and fatty acid metabolism in dogs Anesthesiology 73 1990 82 92 (Pubitemid 20210499)
22. R.S. Hundal, M. Krssak, S. Dufour, D. Laurent, V. Lebon, and V. Chandramouli Mechanism by which metformin reduces glucose production in type 2 diabetes Diabetes 49 2000 2063 2069
23. H.E. Jin, S.S. Hong, M.K. Choi, H.J. Maeng, D.D. Kim, and S.J. Chung Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis Pharm. Res. 26 2009 549 559
24. S.E. Kahn, R.L. Hull, and K.M. Utzschneider Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 2006 840 846 (Pubitemid 46024990)
25. K.J. Kaiyala, R.L. Prigeon, S.E. Kahn, S.C. Woods, and M.W. Schwartz Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs Diabetes 49 2000 1525 1533
26. P.V. Katakam, M.R. Ujhelyi, M. Hoenig, and A.W. Miller Metformin improves vascular function in insulin-resistant rats Hypertension 35 2000 108 112 (Pubitemid 30054245)
27. D. Kirpichnikov, S.I. McFarlane, and J.R. Sowers Metformin: an update Ann. Intern. Med. 137 2002 25 33 (Pubitemid 34705373)
28. K. Labuzek, D. Suchy, B. Gabryel, A. Bielecka, S. Liber, and B. Okopien Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide Pharmacol. Rep. 62 2010 956 965
29. A.W. Leung, and A.P. Halestrap Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore Biochim. Biophys. Acta 1777 2008 946 952
30. M. Mahrouf, N. Ouslimani, J. Peynet, R. Djelidi, M. Couturier, and P. Therond Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C Biochem. Pharmacol. 72 2006 176 183 (Pubitemid 43850435)
31. S. Matthaei, J.P. Reibold, A. Hamann, H. Benecke, H.U. Haring, and H. Greten In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes Endocrinology 133 1993 304 311 (Pubitemid 23206408)
32. P.I. Moreira, M.S. Santos, R. Seica, and C.R. Oliveira Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes J. Neurol. Sci. 257 2007 206 214 (Pubitemid 46856489)
33. I.G. Onyango, J. Lu, M. Rodova, E. Lezi, A.B. Crafter, and R.H. Swerdlow Regulation of neuron mitochondrial biogenesis and relevance to brain health Biochim. Biophys. Acta 1802 2010 228 234
34. N. Ouslimani, J. Peynet, D. Bonnefont-Rousselot, P. Therond, A. Legrand, and J.L. Beaudeux Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells Metabolism 54 2005 829 834 (Pubitemid 40725333)
35. N. Pipatpiboon, W. Pratchayasakul, N. Chattipakorn, and S.C. Chattipakorn PPARgamma agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets Endocrinology 153 1 2012 329 338
36. W.B. Potter, K.J. O'Riordan, D. Barnett, S.M. Osting, M. Wagoner, and C. Burger Metabolic regulation of neuronal plasticity by the energy sensor AMPK PLoS One 5 2010 e8996
37. W. Pratchayasakul, S. Kerdphoo, P. Petsophonsakul, A. Pongchaidecha, N. Chattipakorn, and S.C. Chattipakorn Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone Life Sci. 88 2011 619 627
38. S. Przedborski, K. Tieu, C. Perier, and M. Vila MPTP as a mitochondrial neurotoxic model of Parkinson's disease J. Bioenerg. Biomembr. 36 2004 375 379 (Pubitemid 39619844)
39. D. Ricquier, and F. Bouillaud Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance J. Physiol. 529 Pt 1 2000 3 10
40. S.L. Schwartz, J.F. Wu, and B. Berner Metformin extended release for the treatment of type 2 diabetes mellitus Expert. Opin. Pharmacother. 7 2006 803 809
41. L.M. Sparks, H. Xie, R.A. Koza, R. Mynatt, M.W. Hulver, and G.A. Bray A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle Diabetes 54 2005 1926 1933 (Pubitemid 40911253)
42. G.R. Steinberg Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance Cell Cycle 6 2007 888 894 (Pubitemid 46658739)
43. A.M. Stranahan, E.D. Norman, K. Lee, R.G. Cutler, R.S. Telljohann, and J.M. Egan Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats Hippocampus 18 2008 1085 1088
44. S. Thummasorn, S. Kumfu, S. Chattipakorn, and N. Chattipakorn Granulocyte-colony stimulating factor attenuates mitochondrial dysfunction induced by oxidative stress in cardiac mitochondria Mitochondrion 11 2011 457 466
45. S. Verma, S. Bhanot, and J.H. McNeill Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats J. Pharmacol. Exp. Ther. 271 1994 1334 1337 (Pubitemid 24382642)
46. C.V. Vorhees, and M.T. Williams Morris water maze: procedures for assessing spatial and related forms of learning and memory Nat. Protoc. 1 2006 848 858
47. C.H. Wang, C.C. Wang, and Y.H. Wei Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes Ann. N. Y. Acad. Sci. 1201 2010 157 165
48. C.L. White, P.J. Pistell, M.N. Purpera, S. Gupta, S.O. Fernandez-Kim, and T.L. Hise Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet Neurobiol. Dis. 35 2009 3 13
49. G. Winocur, and C.E. Greenwood Studies of the effects of high fat diets on cognitive function in a rat model Neurobiol. Aging 26 Suppl. 1 2005 46 49
50. G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, and J. Fenyk-Melody Role of AMP-activated protein kinase in mechanism of metformin action J. Clin. Invest. 108 2001 1167 1174 (Pubitemid 32995375)
51. C.J. Zuurbier, P.J. Keijzers, A. Koeman, H.B. Van Wezel, and M.W. Hollmann Anesthesia's effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed rats Anesth. Analg. 106 2008 135 142 (table of contents)