Insulin Rescues Retinal Neurons from Apoptosis by a Phosphatidylinositol 3-Kinase/Akt-mediated Mechanism That Reduces the Activation of Caspase-3

Journal of Biological Chemistry

Volumn 276, Issue 35, 2001, Pages 32814-32821

  Barber, Alistair J ^a   Nakamura, Makoto ^a   Wolpert, Ellen B ^a   Reiter, Chad E N ^a   Seigel, Gail M ^b   Antonetti, David A ^a   Gardner, Thomas W ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; ENZYMES; IMMUNOLOGY; INSULIN;

APOPTOSIS;

BIOCHEMISTRY;

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN INHIBITOR; PROTEIN KINASE B; PROTEIN P53; SOMATOMEDIN C; WORTMANNIN; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; AKT1 PROTEIN, HUMAN; AKT1 PROTEIN, RAT; ANDROSTANE DERIVATIVE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, RAT; CASPASE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; FLAVONOID; INSULIN RECEPTOR; MORPHOLINE DERIVATIVE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; NEUROPROTECTION; NEWBORN; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RETINA NERVE CELL; ANIMAL; CATTLE; CELL LINE; CYTOLOGY; DRUG EFFECT; GENETIC TRANSFECTION; HUMAN; METABOLISM; NERVE CELL; PHYSIOLOGY; RETINA;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CATTLE; CELL LINE; CHROMONES; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MORPHOLINES; NEURONS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; RETINA; TRANSFECTION;

EID: 0035980149     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104738200     Document Type: Article

References (75)

1. Huck, S. (1983) Brain Res. Bull. 10, 667-674
2. Naeser, P. (1997) Upsala J. Med. Sci. 102, 35-40
3. Rodrigues, M., Waldbillig, R. J., Rajagopalan, S., Hackett, J., LeRoith, D., and Chader, G. J. (1988) Brain Res. 443, 389-394
4. Meyer-Franke, A., Kaplan, M. R., Pfrieger, F. W., and Barres, B. A. (1995) Neuron 15, 805-819
5. Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. (1997) Science 275, 661-665
6. Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Genes Dev. 13, 2905-2927
7. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S., and Reed, J. C. (1998) Science 282, 1318-1321
8. Hetman, M., Cavanaugh, J. E., Kimelman, D., and Xia, Z. G. (2000) J. Neurosci. 20, 2567-2574
9. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Cell 91, 231-241
10. Kops, G. J., de Ruiter, N. D., De Vries-Smits, A. M., Powell, D. R., Bos, J. L., and Burgering, B. M. (1999) Nature 398, 630-634
11. Nakae, J., Park, B. C., and Accili, D. (1999) J. Biol. Chem. 274, 15982-15985
12. Rena, G., Guo, S., Cichy, S. C., Unterman, T. G., and Cohen, P. (1999) J. Biol. Chem. 274, 17179-17183
13. Kennedy, S. G., Kandel, E. S., Cross, T. K., and Hay, N. (1999) Mol. Cell. Biol. 19, 5800-5810
14. Benoliel, A. M., Kahn-Peries, B., Imbert, J., and Verrando, P. (1997) J. Cell Sci. 110, 2089-2097
15. Bertrand, F., Philippe, C., Antoine, P. J., Baud, L., Groyer, A., Capeau, J., and Cherqui, G. (1995) J. Biol. Chem. 270, 24435-24441
16. Zhou, G., and Kuo, M. T. (1997) J. Biol. Chem. 272, 15174-15183
17. Blakesley, V. A., Scrimgeour, A., Esposito, D., and Le Roith, D. (1996) Cytokine Growth Factor Rev. 7, 153-159
18. Baserga, R., Resnicoff, M., D'Ambrosio, C., and Valentinis, B. (1997) Vitam. Horm. 53, 65-98
19. Mattson, M. P., Culmsee, C., Yu, Z., and Camandola, S. (2000) J. Neurochem. 74, 443-456
20. Bertrand, F., Atfi, A., Cadoret, A., L'Allemain, G., Robin, H., Lascols, O., Capeau, J., and Cherqui, G. (1998) J. Biol. Chem. 273, 2931-2938
21. Bertrand, F., Desbois-Mouthon, C., Cadoret, A., Prunier, C., Robin, H., Capeau, J., Atfi, A., and Cherqui, G. (1999) J. Biol. Chem. 274, 30596-30602
22. Heck, S., Lezoualc'h, F., Engert, S., and Behl, C. (1999) J. Biol. Chem. 274, 9828-9835
23. Hughes, P. E., Alexi, T., and Schreiber, S. S. (1997) Neuroreport 8, v-xii
24. Inamura, N., Araki, T., Enokido, Y., Nishio, C., Aizawa, S., and Hatanaka, H. (2000) J. Neurosci. Res. 60, 450-457
25. Bennett, M. R. (1999) Biochem. Pharmacol. 58, 1089-1095
26. Slack, R. S., Belliveau, D. J., Rosenberg, M., Atwal, J., Lochmuller, H., Aloyz, R., Haghighi, A., Lach, B., Seth, P., Cooper, E., and Miller, F. D. (1996) J. Cell Biol. 135, 1085-1096
27. Cregan, S. P., MacLaurin, J. G., Craig, C. G., Robertson, G. S., Nicholson, D. W., Park, D. S., and Slack, R. S. (1999) J. Neurosci. 19, 7860-7869
28. Chen, R. W., Saunders, P. A., Wei, H., Li, Z., Seth, P., and Chuang, D. M. (1999) J. Neurosci. 19, 9654-9662
29. Enokido, Y., Araki, T., Tanaka, K., Aizawa, S., and Hatanaka, H. (1996) Eur. J. Neurosci. 8, 1812-1821
30. Paterson, I. A., Zhang, D., Warrington, R. C., and Boulton, A. A. (1998) J. Neurochem. 70, 515-523
31. Joo, C. K., Choi, J. S., Ko, H. W., Park, K. Y., Sohn, S., Chun, M. H., Oh, Y. J., and Gwag, B. J. (1999) Invest. Ophthalmol. Visual Sci. 40, 713-720
32. Seigel, G. M., and Liu, L. (1997) Mol. Vis. 3, 14
33. Seigel, G. M. (1996) In Vitro Cell. Dev. Biol. 32, 66-68
34. Seigel, G. M., Mutchler, A. L., and Imperato, E. L. (1996) Mol. Vis. 2, 2
35. Seigel, G. M. (1999) Mol. Vis. 5, 4
36. Davis, G. E., Varon, S., Engvall, E., and Manthorpe, M. (1985) Trends Neurosci. 8, 528-532
37. Smith, L. E., Shen, W., Perruzzi, C., Soker, S., Kinose, F., Xu, X., Robinson, G., Driver, S., Bischoff, J., Zhang, B., Schaeffer, J. M., and Senger, D. R. (1999) Nat. Med. 5, 1390-1395
38. Antonetti, D. A., Barber, A. J., Hollinger, L. A., Wolpert, E. B., and Gardner, T. W. (1999) J. Biol. Chem. 274, 23463-23467
39. Francis, G. L., Ross, M., Ballard, F. J., Milner, S. J., Senn, C., McNeil, K. A., Wallace, J. C., King, R., and Wells, J. R. (1992) J. Mol. Endocrinol. 8, 213-223
40. Sun, S., Elwood, J., and Greene, W. C. (1996) Mol. Cell. Biol. 16, 1058-1065
41. Waldbillig, R. J., Fletcher, R. T., Chader, G. J., Rajagopalan, S., Rodrigues, M., and LeRoith, D. (1987) Exp. Eye Res. 45, 823-835
42. Almira, E. C., and Reddy, W. J. (1979) Endocrinology 104, 205-211
43. Srinivasan, A., Roth, K. A., Sayers, R. O., Shindler, K. S., Wong, A. M., Fritz, L. C., and Tomaselli, K. J. (1998) Cell Death Differ. 5, 1004-1016
44. Maggirwar, S. B., Sarmiere, P. D., Dewhurst, S., and Freeman, R. S. (1998) J. Neurosci. 18, 10356-10365
45. Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., and Kaltschmidt, C. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9409-9414
46. Lin, Y.-Z., Yao, S., Veach, R. A., Torgerson, T. R., and Hawiger, J. (1995) J. Biol. Chem. 270, 14255-14258
47. Merlo, G. R., Basolo, F., Fiore, L., Duboc, L., and Hynes, N. E. (1995) J. Cell Biol. 128, 1185-1196
48. Sabbatini, P., and McCormick, F. (1999) J. Biol. Chem. 274, 24263-24269
49. Fernyhough, P., Willars, G. B., Lindsay, R. M., and Tomlinson, D. R. (1993) Brain Res. 607, 117-124
50. Ryu, B. R., Ko, H. W., Jou, I., Noh, J. S., and Gwag, B. J. (1999) J. Neurobiol. 39, 536-546
51. Foulstone, E. J., Tavare, J. M., and Gunn-Moore, F. J. (1999) Neurosci. Lett. 264, 125-128
52. Ang, L. C., Bhaumick, B., Munoz, D. G., Sass, J., and Juurlink, B. H. (1992) J. Neurol. Sci. 109, 168-172
53. Estevez, A. G., Radi, R., Barbeito, L., Shin, J. T., Thompson, J. A., and Beckman, J. S. (1995) J. Neurochem. 65, 1543-1550
54. Feman, S. S., Turinsky, J., and Lam, K. W. (1978) Am. J. Ophthalmol. 85, 387-391
55. Dorn, A., Bernstein, H. G., Rinne, A., Hahn, H. J., and Ziegler, M. (1982) Histochemistry 74, 293-300
56. Banks, W. A., Jaspan, J. B., and Kastin, A. J. (1997) Peptides 18, 1257-1262
57. Banks, W. A., Jaspan, J. B., Huang, W., and Kastin, A. J. (1997) Peptides 18, 1423-1429
58. Budd, G. C., Pansky, B., and Glatzer, L. (1993) Invest. Ophthalmol. Visual Sci. 34, 463-469
59. Rosenzweig, S. A., Zetterstrom, C., and Benjamin, A. (1990) J. Biol. Chem. 265, 18030-18034
60. Hyndman, A. G. (1993) Exp. Brain Res. 75, 289-292
61. Gupta, G., Azam, M., and Baquer, N. Z. (1992) Neurochem. Int. 20, 487-492
62. Clarke, D. W., Mudd, L., Boyd, F. T., Jr., Fields, M., and Raizada, M. K. (1986) J. Neurochem. 47, 831-836
63. Wei, L. T., Matsumoto, H., and Rhoads, D. E. (1990) J. Neurochem. 54, 1661-1665
64. Kadle, R., Suksang, C., Roberson, E. D., and Fellows, R. E. (1988) Brain Res. 460, 60-67
65. Tezel, G., and Wax, M. B. (1999) Invest. Ophthalmol. Visual Sci. 40, 2660-2667
66. Weeks, B. S., Wilson, P. J., Heffernan, C. C., Ahmad, A., and Mahadeo, K. (1999) Biochem. Biophys. Res. Commun. 256, 98-103
67. Hanson, M. G., Jr., Shen, S., Wiemelt, A. P., McMorris, F. A., and Barres, B. A. (1998) J. Neurosci. 18, 7361-7371
68. Barres, B. A., Schmid, R., Sendnter, M., and Raff, M. C. (1993) Development 118, 283-295
69. Gardner, T. W., Reiter, C. E. N., and Antonetti, D. A. (2001) Invest. Ophthalmol. Visual Sci. 42, S664
70. Torgerson, T. R., Colosia, A. D., Donahue, J. P., Lin, Y. Z., and Hawiger, J. (1998) J. Immunol. 161, 6084-6092
71. Barber, A. J., Lieth, E., Khin, S. A., Antonetti, D. A., Buchanan, A. G., and Gardner, T. W. (1998) J. Clin. Invest. 102, 783-791
72. Lieth, E., Gardner, T. W., Barber, A. J., Antonetti, D. A. (2000) Clin. Exp. Ophthalmol. 28, 3-8
73. Lieth, E., LaNoue, K. F., Antonetti, D. A., Ratz, M. (2000) Exp. Eye Res. 70, 723-730
74. Lieth, E., Barber, A. J., Xu, B., Dice, C., Ratz, M. J., Tanase, D., and Strother, J. M. (1998) Diabetes 47, 815-820
75. Barber, A. J., Antonetti, D. A., and Gardner, T. W. (2000) Invest. Ophthalmol. Visual Sci. 41, 3561-3568