Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice

Brain Research

Volumn 1517, Issue , 2013, Pages 104-113

  Yang, Dong ^a,c   Nakajo, Yukako ^a,b   Iihara, Koji ^a   Kataoka, Hiroharu ^a   Yanamoto, Hiroji ^a,d  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b RAKUWAKAI OTOWA HOSPITAL   (Japan)

^c CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

DPP 4 inhibitor; Focal ischemia; Ischemic stroke; Neuroprotection; Neurotrophic factor; Preclinical study

Indexed keywords

ALOGLIPTIN; BRAIN DERIVED NEUROTROPHIC FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DETERIORATION; DRUG EFFICACY; INSULIN LIKE ACTIVITY; MALE; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; RISK ASSESSMENT; TREATMENT DURATION;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; LASER-DOPPLER FLOWMETRY; MALE; MICE; MICE, INBRED C57BL; MICROCIRCULATION; NERVOUS SYSTEM DISEASES; PIPERIDINES; PROSENCEPHALON; TIME FACTORS; URACIL;

MUS;

EID: 84878481429     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.04.015     Document Type: Article

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