-
1
-
-
84865472821
-
Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease
-
Rask-Madsen C, Kahn CR. Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol 2012;32:2052-2059
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 2052-2059
-
-
Rask-Madsen, C.1
Kahn, C.R.2
-
2
-
-
70849120946
-
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
-
Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev 2009;30:586-623
-
(2009)
Endocr Rev
, vol.30
, pp. 586-623
-
-
Belfiore, A.1
Frasca, F.2
Pandini, G.3
Sciacca, L.4
Vigneri, R.5
-
3
-
-
84858631674
-
The many faces of insulin-like peptide signalling in the brain
-
Fernandez AM, Torres-Alemán I. The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci 2012;13:225-239
-
(2012)
Nat Rev Neurosci
, vol.13
, pp. 225-239
-
-
Fernandez, A.M.1
Torres-Alemán, I.2
-
4
-
-
1842633872
-
Insulin and the insulin receptor in experimental models of learning and memory
-
DOI 10.1016/j.ejphar.2004.02.045, PII S001429990400202X
-
Zhao WQ, Chen H, Quon MJ, Alkon DL. Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 2004;490:71-81 (Pubitemid 38482161)
-
(2004)
European Journal of Pharmacology
, vol.490
, Issue.1-3
, pp. 71-81
-
-
Zhao, W.-Q.1
Chen, H.2
Quon, M.J.3
Alkon, D.L.4
-
5
-
-
28844495644
-
Insulin receptor signaling in long-term memory consolidation following spatial learning
-
DOI 10.1101/lm.88005
-
Dou JT, Chen M, Dufour F, Alkon DL, Zhao WQ. Insulin receptor signaling in long-term memory consolidation following spatial learning. Learn Mem 2005;12:646-655 (Pubitemid 41770090)
-
(2005)
Learning and Memory
, vol.12
, Issue.6
, pp. 646-655
-
-
Dou, J.-T.1
Chen, M.2
Dufour, F.3
Alkon, D.L.4
Zhao, W.-Q.5
-
6
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Brüning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Brüning, J.C.1
Gautam, D.2
Burks, D.J.3
-
7
-
-
54949143977
-
Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism
-
Kappeler L, De Magalhaes Filho C, Dupont J, et al. Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol 2008;6:e254
-
(2008)
PLoS Biol
, vol.6
-
-
Kappeler, L.1
De Magalhaes Filho, C.2
Dupont, J.3
-
8
-
-
0022647664
-
Oligosaccharide heterogeneity of insulin receptors. Comparison of N-linked glycosylation of insulin receptors in adipocytes and brain
-
Heidenreich KA, Brandenburg D. Oligosaccharide heterogeneity of insulin receptors. Comparison of N-linked glycosylation of insulin receptors in adipocytes and brain. Endocrinology 1986;118:1835-1842 (Pubitemid 16106778)
-
(1986)
Endocrinology
, vol.118
, Issue.5
, pp. 1835-1842
-
-
Heidenreich, K.A.1
Brandenburg, D.2
-
9
-
-
0023949315
-
A comparison of the insulin and insulin-like growth factor I receptors from rat brain and liver
-
McElduff A, Poronnik P, Baxter RC, Williams P. A comparison of the insulin and insulin-like growth factor I receptors from rat brain and liver. Endocrinology 1988;122:1933-1939
-
(1988)
Endocrinology
, vol.122
, pp. 1933-1939
-
-
McElduff, A.1
Poronnik, P.2
Baxter, R.C.3
Williams, P.4
-
10
-
-
0030693249
-
Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: Quantification of individual receptor species by selective immunoprecipitation and immunoblotting
-
Bailyes EM, Navé BT, Soos MA, Orr SR, Hayward AC, Siddle K. Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem J 1997;327:209-215 (Pubitemid 27455481)
-
(1997)
Biochemical Journal
, vol.327
, Issue.1
, pp. 209-215
-
-
Bailyes, E.M.1
Nave, B.T.2
Soos, M.A.3
Orr, S.R.4
Hayward, A.C.5
Siddle, K.6
-
11
-
-
0032941110
-
Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene
-
Fantin VR, Lavan BE, Wang Q, et al. Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene. Endocrinology 1999;140:1329-1337 (Pubitemid 29104237)
-
(1999)
Endocrinology
, vol.140
, Issue.3
, pp. 1329-1337
-
-
Fantin, V.R.1
Lavan, B.E.2
Wang, Q.3
Jenkins, N.A.4
Gilbert, D.J.5
Copeland, N.G.6
Keller, S.R.7
Lienhard, G.E.8
-
12
-
-
0032853976
-
Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain
-
DOI 10.1016/S0169-328X(99)00160-6, PII S0169328X99001606
-
Numan S, Russell DS. Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain. Brain Res Mol Brain Res 1999;72:97-102 (Pubitemid 29474919)
-
(1999)
Molecular Brain Research
, vol.72
, Issue.1
, pp. 97-102
-
-
Numan, S.1
Russell, D.S.2
-
13
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
DOI 10.1038/372186a0
-
Araki E, Lipes MA, Patti ME, et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994;372:186-190 (Pubitemid 24347839)
-
(1994)
Nature
, vol.372
, Issue.6502
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.-E.3
Bruning, J.C.4
Haag III, B.5
Johnson, R.S.6
Kahn, C.R.7
-
14
-
-
0043127453
-
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
-
Schubert M, Brazil DP, Burks DJ, et al. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003;23:7084-7092 (Pubitemid 36975873)
-
(2003)
Journal of Neuroscience
, vol.23
, Issue.18
, pp. 7084-7092
-
-
Schubert, M.1
Brazil, D.P.2
Burks, D.J.3
Kushner, J.A.4
Ye, J.5
Flint, C.L.6
Farhang-Fallah, J.7
Dikkes, P.8
Warot, X.M.9
Rio, C.10
Corfas, G.11
White, M.F.12
-
15
-
-
34547097247
-
Brain IRS2 signaling coordinates life span and nutrient homeostasis
-
DOI 10.1126/science.1142179
-
Taguchi A, Wartschow LM, White MF. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 2007;317:369-372 (Pubitemid 47106376)
-
(2007)
Science
, vol.317
, Issue.5836
, pp. 369-372
-
-
Taguchi, A.1
Wartschow, L.M.2
White, M.F.3
-
16
-
-
84895092552
-
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis
-
Sadagurski M, Dong XC, Myers MG Jr, White MF. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Mol Metab 2013;3:55-63
-
(2013)
Mol Metab
, vol.3
, pp. 55-63
-
-
Sadagurski, M.1
Dong, X.C.2
Myers Jr., M.G.3
White, M.F.4
-
17
-
-
80054736907
-
Structural basis for activation and inhibition of class I phosphoinositide 3-kinases
-
Vadas O, Burke JE, Zhang X, Berndt A, Williams RL. Structural basis for activation and inhibition of class I phosphoinositide 3-kinases. Sci Signal 2011;4:re2
-
(2011)
Sci Signal
, vol.4
-
-
Vadas, O.1
Burke, J.E.2
Zhang, X.3
Berndt, A.4
Williams, R.L.5
-
18
-
-
79952763934
-
Selective pharmacogenetic inhibition of mammalian target of rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
-
Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M. Selective pharmacogenetic inhibition of mammalian target of rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. Proc Natl Acad Sci U S A 2011;108:3791-3796
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3791-3796
-
-
Stoica, L.1
Zhu, P.J.2
Huang, W.3
Zhou, H.4
Kozma, S.C.5
Costa-Mattioli, M.6
-
19
-
-
84863229959
-
Neuronal autophagy and neurodegenerative diseases
-
Son JH, Shim JH, Kim KH, Ha JY, Han JY. Neuronal autophagy and neurodegenerative diseases. Exp Mol Med 2012;44:89-98
-
(2012)
Exp Mol Med
, vol.44
, pp. 89-98
-
-
Son, J.H.1
Shim, J.H.2
Kim, K.H.3
Ha, J.Y.4
Han, J.Y.5
-
20
-
-
79959223383
-
GSK3 function in the brain during development, neuronal plasticity, and neurodegeneration
-
Salcedo-Tello P, Ortiz-Matamoros A, Arias C. GSK3 function in the brain during development, neuronal plasticity, and neurodegeneration. Int J Alzheimers Dis 2011;2011:189728
-
(2011)
Int J Alzheimers Dis
, vol.2011
, pp. 189728
-
-
Salcedo-Tello, P.1
Ortiz-Matamoros, A.2
Arias, C.3
-
21
-
-
12144290448
-
Role for neuronal insulin resistance in neurodegenerative diseases
-
DOI 10.1073/pnas.0308724101
-
Schubert M, Gautam D, Surjo D, et al. Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 2004;101:3100-3105 (Pubitemid 38327741)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.9
, pp. 3100-3105
-
-
Schubert, M.1
Gautam, D.2
Surjo, D.3
Ueki, K.4
Baudler, S.5
Schubert, D.6
Kondo, T.7
Alber, J.8
Galldiks, N.9
Kustermann, E.10
Arndt, S.11
Jacobs, A.H.12
Krone, W.13
Ronald, K.C.14
Bruning, J.C.15
-
22
-
-
84891522535
-
Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons
-
Ren H, Plum-Morschel L, Gutierrez-Juarez R, et al. Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons. Diabetes 2013;62:3373-3383
-
(2013)
Diabetes
, vol.62
, pp. 3373-3383
-
-
Ren, H.1
Plum-Morschel, L.2
Gutierrez-Juarez, R.3
-
23
-
-
84863549071
-
FOXO1 in the ventromedial hypothalamus regulates energy balance
-
Kim KW, Donato J Jr, Berglund ED, et al. FOXO1 in the ventromedial hypothalamus regulates energy balance. J Clin Invest 2012;122:2578-2589
-
(2012)
J Clin Invest
, vol.122
, pp. 2578-2589
-
-
Kim, K.W.1
Donato Jr., J.2
Berglund, E.D.3
-
24
-
-
0036178441
-
Molecular psychology: Roles for the ERK MAP kinase cascade in memory
-
DOI 10.1146/annurev.pharmtox.42.082701.145401
-
Adams JP, Sweatt JD. Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 2002;42:135-163 (Pubitemid 34160523)
-
(2002)
Annual Review of Pharmacology and Toxicology
, vol.42
, pp. 135-163
-
-
Adams, J.P.1
Sweatt, J.D.2
-
25
-
-
79951953438
-
Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: Neurotrophic effects of leptin and insulin
-
Desai M, Li T, Ross MG. Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: neurotrophic effects of leptin and insulin. Brain Res 2011;1378:29-42
-
(2011)
Brain Res
, vol.1378
, pp. 29-42
-
-
Desai, M.1
Li, T.2
Ross, M.G.3
-
26
-
-
0014214923
-
Insulin in the cerebrospinal fluid
-
Margolis RU, Altszuler N. Insulin in the cerebrospinal fluid. Nature 1967;215:1375-1376
-
(1967)
Nature
, vol.215
, pp. 1375-1376
-
-
Margolis, R.U.1
Altszuler, N.2
-
28
-
-
84887446231
-
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling
-
Kleinridders A, Lauritzen HP, Ussar S, et al. Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest 2013;123:4667-4680
-
(2013)
J Clin Invest
, vol.123
, pp. 4667-4680
-
-
Kleinridders, A.1
Lauritzen, H.P.2
Ussar, S.3
-
29
-
-
0344833819
-
Identification of insulin in rat brain
-
Havrankova J, Schmechel D, Roth J, Brownstein M. Identification of insulin in rat brain. Proc Natl Acad Sci U S A 1978;75:5737-5741 (Pubitemid 9101469)
-
(1978)
Proceedings of the National Academy of Sciences of the United States of America
, vol.75
, Issue.11
, pp. 5737-5741
-
-
Havrankova, J.1
Schmechel, D.2
Roth, J.3
Brownstein, M.4
-
30
-
-
0028310417
-
Insulin gene expression and insulin synthesis in mammalian neuronal cells
-
Devaskar SU, Giddings SJ, Rajakumar PA, Carnaghi LR, Menon RK, Zahm DS. Insulin gene expression and insulin synthesis in mammalian neuronal cells. J Biol Chem 1994;269:8445-8454 (Pubitemid 24200266)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.11
, pp. 8445-8454
-
-
Devaskar, S.U.1
Giddings, S.J.2
Rajakumar, P.A.3
Carnaghi, L.R.4
Menon, R.K.5
Zahm, D.S.6
-
31
-
-
84901389370
-
Isolation and immortalization of MIP-GFP neurons from the hypothalamus
-
10 March Epub ahead of print
-
Wang ZC, Wheeler MB, Belsham DD. Isolation and immortalization of MIP-GFP neurons from the hypothalamus. Endocrinology 10 March 2014 [Epub ahead of print]
-
(2014)
Endocrinology
-
-
Wang, Z.C.1
Wheeler, M.B.2
Belsham, D.D.3
-
32
-
-
9644260562
-
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
-
DOI 10.1172/JCI200421484
-
Kubota N, Terauchi Y, Tobe K, et al. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 2004;114:917-927 (Pubitemid 39578719)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.7
, pp. 917-927
-
-
Kubota, N.1
Terauchi, Y.2
Tobe, K.3
Yano, W.4
Suzuki, R.5
Ueki, K.6
Takamoto, I.7
Satoh, H.8
Maki, T.9
Kubota, T.10
Moroi, M.11
Okada-Iwabu, M.12
Ezaki, O.13
Nagai, R.14
Ueta, Y.15
Kadowaki, T.16
Noda, T.17
-
33
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
-
DOI 10.1172/JCI200422217
-
Lin X, Taguchi A, Park S, et al. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 2004;114:908-916 (Pubitemid 39578718)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.7
, pp. 908-916
-
-
Lin, X.1
Taguchi, A.2
Park, S.3
Kushner, J.A.4
Li, F.5
Li, Y.6
White, M.F.7
-
34
-
-
84870537777
-
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production
-
Mehran AE, Templeman NM, Brigidi GS, et al. Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. Cell Metab 2012;16:723- 737
-
(2012)
Cell Metab
, vol.16
, pp. 723-737
-
-
Mehran, A.E.1
Templeman, N.M.2
Brigidi, G.S.3
-
35
-
-
0018621289
-
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
-
Woods SC, Lotter EC, McKay LD, Porte D Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979;282:503-505 (Pubitemid 10126541)
-
(1979)
Nature
, vol.282
, Issue.5738
, pp. 503-505
-
-
Woods, S.C.1
Lotter, E.C.2
McKay, L.D.3
Porte Jr., D.4
-
36
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000;404:661-671 (Pubitemid 30205071)
-
(2000)
Nature
, vol.404
, Issue.6778
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte Jr., D.3
Seeley, R.J.4
Baskin, D.G.5
-
37
-
-
34249651956
-
Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
-
DOI 10.1016/j.cmet.2007.05.004, PII S1550413107001313
-
Könner AC, Janoschek R, Plum L, et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 2007;5:438-449 (Pubitemid 46825497)
-
(2007)
Cell Metabolism
, vol.5
, Issue.6
, pp. 438-449
-
-
Konner, A.C.1
Janoschek, R.2
Plum, L.3
Jordan, S.D.4
Rother, E.5
Ma, X.6
Xu, C.7
Enriori, P.8
Hampel, B.9
Barsh, G.S.10
Kahn, C.R.11
Cowley, M.A.12
Ashcroft, F.M.13
Bruning, J.C.14
-
39
-
-
84873051124
-
White matter microstructural integrity in youth with type 1 diabetes
-
Antenor-Dorsey JA, Meyer E, Rutlin J, et al. White matter microstructural integrity in youth with type 1 diabetes. Diabetes 2013;62:581-589
-
(2013)
Diabetes
, vol.62
, pp. 581-589
-
-
Antenor-Dorsey, J.A.1
Meyer, E.2
Rutlin, J.3
-
40
-
-
0346216156
-
Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI
-
DOI 10.1007/s00125-003-1235-0
-
den Heijer T, Vermeer SE, van Dijk EJ, et al. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia 2003;46:1604-1610 (Pubitemid 38005322)
-
(2003)
Diabetologia
, vol.46
, Issue.12
, pp. 1604-1610
-
-
Den, H.T.1
Vermeer, S.E.2
Van Dijk, E.J.3
Prins, N.D.4
Koudstaal, P.J.5
Hofman, A.6
Breteler, M.M.B.7
-
41
-
-
84883046836
-
Network-level structural abnormalities of cerebral cortex in type 1 diabetes mellitus
-
Lyoo IK, Yoon S, Renshaw PF, et al. Network-level structural abnormalities of cerebral cortex in type 1 diabetes mellitus. PLoS One 2013;8:e71304
-
(2013)
PLoS One
, vol.8
-
-
Lyoo, I.K.1
Yoon, S.2
Renshaw, P.F.3
-
42
-
-
82255185827
-
Brain activation during working memory is altered in patients with type 1 diabetes during hypoglycemia
-
Bolo NR, Musen G, Jacobson AM, et al. Brain activation during working memory is altered in patients with type 1 diabetes during hypoglycemia. Diabetes 2011;60:3256-3264
-
(2011)
Diabetes
, vol.60
, pp. 3256-3264
-
-
Bolo, N.R.1
Musen, G.2
Jacobson, A.M.3
-
43
-
-
84865467874
-
Resting-state brain functional connectivity is altered in type 2 diabetes
-
Musen G, Jacobson AM, Bolo NR, et al. Resting-state brain functional connectivity is altered in type 2 diabetes. Diabetes 2012;61:2375-2379
-
(2012)
Diabetes
, vol.61
, pp. 2375-2379
-
-
Musen, G.1
Jacobson, A.M.2
Bolo, N.R.3
-
44
-
-
0029821906
-
Place learning and hippocampal synaptic plasticity in streptozotocin- induced diabetic rats
-
Biessels GJ, Kamal A, Ramakers GM, et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes 1996;45:1259-1266 (Pubitemid 26296329)
-
(1996)
Diabetes
, vol.45
, Issue.9
, pp. 1259-1266
-
-
Biessels, G.-J.1
Kamal, A.2
Ramakers, G.M.3
Urban, I.J.4
Spruijt, B.M.5
Erkelens, D.W.6
Gispen, W.H.7
-
45
-
-
0037008873
-
Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents
-
DOI 10.1016/S0306-4522(02)00162-8, PII S0306452202001628
-
Li XL, Aou S, Oomura Y, Hori N, Fukunaga K, Hori T. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 2002;113:607-615 (Pubitemid 34874684)
-
(2002)
Neuroscience
, vol.113
, Issue.3
, pp. 607-615
-
-
Li, X.-L.1
Aou, S.2
Oomura, Y.3
Hori, N.4
Fukunaga, K.5
Hori, T.6
-
46
-
-
0034012731
-
Intracerebroventricular insulin enhances memory in a passive-avoidance task
-
DOI 10.1016/S0031-9384(99)00220-6, PII S0031938499002206
-
Park CR, Seeley RJ, Craft S, Woods SC. Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol Behav 2000;68:509-514 (Pubitemid 30129236)
-
(2000)
Physiology and Behavior
, vol.68
, Issue.4
, pp. 509-514
-
-
Park, C.R.1
Seeley, R.J.2
Craft, S.3
Woods, S.C.4
-
47
-
-
0032572613
-
Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: Effects of insulin treatment
-
DOI 10.1016/S0006-8993(98)00510-1, PII S0006899398005101
-
Biessels GJ, Kamal A, Urban IJ, Spruijt BM, Erkelens DW, Gispen WH. Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain Res 1998;800:125-135 (Pubitemid 28361929)
-
(1998)
Brain Research
, vol.800
, Issue.1
, pp. 125-135
-
-
Biessels, G.-J.1
Kamal, A.2
Urban, I.J.A.3
Spruijt, B.M.4
Erkelens, D.W.5
Gispen, W.H.6
-
48
-
-
79959652223
-
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
-
Klöckener T, Hess S, Belgardt BF, et al. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci 2011;14:911-918
-
(2011)
Nat Neurosci
, vol.14
, pp. 911-918
-
-
Klöckener, T.1
Hess, S.2
Belgardt, B.F.3
-
49
-
-
0033058656
-
Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus
-
DOI 10.1046/j.1471-4159.1999.721523.x
-
Christie JM, Wenthold RJ, Monaghan DT. Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus. J Neurochem 1999;72:1523-1528 (Pubitemid 29140824)
-
(1999)
Journal of Neurochemistry
, vol.72
, Issue.4
, pp. 1523-1528
-
-
Christie, J.M.1
Wenthold, R.J.2
Monaghan, D.T.3
-
50
-
-
0035853124
-
Insulin promotes rapid delivery of N-methyl-D-aspartate receptors to the cell surface by exocytosis
-
DOI 10.1073/pnas.051634698
-
Skeberdis VA, Lan J, Zheng X, Zukin RS, Bennett MV. Insulin promotes rapid delivery of N-methyl-D-aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci U S A 2001;98:3561-3566 (Pubitemid 32220884)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.6
, pp. 3561-3566
-
-
Skeberdis, V.A.1
Lan, J.-Y.2
Zheng, X.3
Zukin, R.S.4
Bennett, M.V.L.5
-
51
-
-
23844470857
-
Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-D-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner
-
DOI 10.1111/j.1471-4159.2005.03269.x
-
van der Heide LP, Kamal A, Artola A, Gispen WH, Ramakers GM. Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner. J Neurochem 2005;94:1158-1166 (Pubitemid 41170602)
-
(2005)
Journal of Neurochemistry
, vol.94
, Issue.4
, pp. 1158-1166
-
-
Van Der, H.L.P.1
Kamal, A.2
Artola, A.3
Gispen, W.H.4
Ramakers, G.M.J.5
-
52
-
-
1842562359
-
An investigation into signal transduction mechanisms involved in insulin-induced long-term depression in the CA1 region of the hippocampus
-
Huang CC, Lee CC, Hsu KS. An investigation into signal transduction mechanisms involved in insulin-induced long-term depression in the CA1 region of the hippocampus. J Neurochem 2004;89:217-231
-
(2004)
J Neurochem
, vol.89
, pp. 217-231
-
-
Huang, C.C.1
Lee, C.C.2
Hsu, K.S.3
-
53
-
-
0033713293
-
Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis
-
Wang YT, Linden DJ. Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 2000;25:635-647
-
(2000)
Neuron
, vol.25
, pp. 635-647
-
-
Wang, Y.T.1
Linden, D.J.2
-
54
-
-
78049255785
-
Hippocampal long-term depression is required for the consolidation of spatial memory
-
Ge Y, Dong Z, Bagot RC, et al. Hippocampal long-term depression is required for the consolidation of spatial memory. Proc Natl Acad Sci U S A 2010;107:16697-16702
-
(2010)
Proc Natl Acad Sci U S a
, vol.107
, pp. 16697-16702
-
-
Ge, Y.1
Dong, Z.2
Bagot, R.C.3
-
55
-
-
0030800192
-
Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin
-
DOI 10.1038/41792
-
Wan Q, Xiong ZG, Man HY, et al. Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin. Nature 1997;388:686-690 (Pubitemid 27366441)
-
(1997)
Nature
, vol.388
, Issue.6643
, pp. 686-690
-
-
Wan, Q.1
Xiong, Z.G.2
Man, H.Y.3
Ackerley, C.A.4
Braunton, J.5
Lu, W.Y.6
Becker, L.E.7
MacDonald, J.F.8
Wang, Y.T.9
-
56
-
-
44649198605
-
Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo
-
DOI 10.1016/j.neuron.2008.04.014, PII S0896627308003668
-
Chiu SL, Chen CM, Cline HT. Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 2008;58:708-719 (Pubitemid 351778469)
-
(2008)
Neuron
, vol.58
, Issue.5
, pp. 708-719
-
-
Chiu, S.-L.1
Chen, C.-M.2
Cline, H.T.3
-
57
-
-
24044474689
-
Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway
-
Lee CC, Huang CC, Wu MY, Hsu KS. Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway. J Biol Chem 2005;280:18543-18550
-
(2005)
J Biol Chem
, vol.280
, pp. 18543-18550
-
-
Lee, C.C.1
Huang, C.C.2
Wu, M.Y.3
Hsu, K.S.4
-
58
-
-
0025847968
-
Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
-
Unger JW, Livingston JN, Moss AM. Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog Neurobiol 1991;36:343-362
-
(1991)
Prog Neurobiol
, vol.36
, pp. 343-362
-
-
Unger, J.W.1
Livingston, J.N.2
Moss, A.M.3
-
59
-
-
79959576516
-
Insulin promotes glycogen storage and cell proliferation in primary human astrocytes
-
Heni M, Hennige AM, Peter A, et al. Insulin promotes glycogen storage and cell proliferation in primary human astrocytes. PLoS One 2011;6:e21594
-
(2011)
PLoS One
, vol.6
-
-
Heni, M.1
Hennige, A.M.2
Peter, A.3
-
60
-
-
79951950577
-
Insulin increases glutamate transporter GLT1 in cultured astrocytes
-
Ji YF, Xu SM, Zhu J, Wang XX, Shen Y. Insulin increases glutamate transporter GLT1 in cultured astrocytes. Biochem Biophys Res Commun 2011;405:691-696
-
(2011)
Biochem Biophys Res Commun
, vol.405
, pp. 691-696
-
-
Ji, Y.F.1
Xu, S.M.2
Zhu, J.3
Wang, X.X.4
Shen, Y.5
-
61
-
-
78649513976
-
Diabetes and insulin in regulation of brain cholesterol metabolism
-
Suzuki R, Lee K, Jing E, et al. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab 2010;12:567 -579
-
(2010)
Cell Metab
, vol.12
, pp. 567-579
-
-
Suzuki, R.1
Lee, K.2
Jing, E.3
-
62
-
-
84875932474
-
Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
-
Stobart JL, Anderson CM. Multifunctional role of astrocytes as gatekeepers of neuronal energy supply. Front Cell Neurosci 2013;7:38
-
(2013)
Front Cell Neurosci
, vol.7
, pp. 38
-
-
Stobart, J.L.1
Anderson, C.M.2
-
64
-
-
0035153212
-
Immune function of astrocytes
-
DOI 10.1002/glia.1107
-
Dong Y, Benveniste EN. Immune function of astrocytes. Glia 2001;36:180-190 (Pubitemid 33055906)
-
(2001)
GLIA
, vol.36
, Issue.2
, pp. 180-190
-
-
Dong, Y.1
Benveniste, E.N.2
-
65
-
-
0037324750
-
Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production
-
DOI 10.1172/JCI200316426
-
Fisher SJ, Kahn CR. Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. J Clin Invest 2003;111:463-468 (Pubitemid 36228003)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.4
, pp. 463-468
-
-
Fisher, S.J.1
Kahn, C.R.2
-
66
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
DOI 10.1038/nm798
-
Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002;8:1376-1382 (Pubitemid 36019422)
-
(2002)
Nature Medicine
, vol.8
, Issue.12
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
67
-
-
77956367937
-
Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia
-
Diggs-Andrews KA, Zhang X, Song Z, Daphna-Iken D, Routh VH, Fisher SJ. Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia. Diabetes 2010;59:2271-2280
-
(2010)
Diabetes
, vol.59
, pp. 2271-2280
-
-
Diggs-Andrews, K.A.1
Zhang, X.2
Song, Z.3
Daphna-Iken, D.4
Routh, V.H.5
Fisher, S.J.6
-
68
-
-
45749158925
-
Central insulin action regulates peripheral glucose and fat metabolism in mice
-
DOI 10.1172/JCI31073
-
Koch L, Wunderlich FT, Seibler J, et al. Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest 2008;118:2132-2147 (Pubitemid 351872332)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.6
, pp. 2132-2147
-
-
Koch, L.1
Wunderlich, F.T.2
Seibler, J.3
Konner, A.C.4
Hampel, B.5
Irlenbusch, S.6
Brabant, G.7
Kahn, C.R.8
Schwenk, F.9
Bruning, J.C.10
-
69
-
-
0024520153
-
Role of brain in counterregulation of insulin-induced hypoglycemia in dogs
-
Biggers DW, Myers SR, Neal D, et al. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 1989;38:7-16 (Pubitemid 19021810)
-
(1989)
Diabetes
, vol.38
, Issue.1
, pp. 7-16
-
-
Biggers, D.W.1
Myers, S.R.2
Neal, D.3
Stinson, R.4
Cooper, N.B.5
Jaspan, J.B.6
Williams, P.E.7
Cherrington, A.D.8
Frizzell, R.T.9
-
70
-
-
17844391064
-
Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia
-
DOI 10.2337/diabetes.54.5.1447
-
Fisher SJ, Brüning JC, Lannon S, Kahn CR. Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes 2005;54:1447-1451 (Pubitemid 40586676)
-
(2005)
Diabetes
, vol.54
, Issue.5
, pp. 1447-1451
-
-
Fisher, S.J.1
Bruning, J.C.2
Lannon, S.3
Kahn, C.R.4
-
71
-
-
79955394878
-
Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors
-
Sanchez-Alavez M, Osborn O, Tabarean IV, et al. Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem 2011;286:14983-14990
-
(2011)
J Biol Chem
, vol.286
, pp. 14983-14990
-
-
Sanchez-Alavez, M.1
Osborn, O.2
Tabarean, I.V.3
-
72
-
-
78751485383
-
Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men
-
Benedict C, Brede S, Schiöth HB, et al. Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes 2011;60:114-118
-
(2011)
Diabetes
, vol.60
, pp. 114-118
-
-
Benedict, C.1
Brede, S.2
Schiöth, H.B.3
-
74
-
-
0034699544
-
IRS-2 pathways integrate female reproduction and energy homeostasis
-
Burks DJ, Font de Mora J, Schubert M, et al. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 2000;407:377-382
-
(2000)
Nature
, vol.407
, pp. 377-382
-
-
Burks, D.J.1
Font De Mora, J.2
Schubert, M.3
-
75
-
-
77956336197
-
Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor
-
Brothers KJ, Wu S, DiVall SA, et al. Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab 2010;12:295-305
-
(2010)
Cell Metab
, vol.12
, pp. 295-305
-
-
Brothers, K.J.1
Wu, S.2
DiVall, S.A.3
-
77
-
-
0027561888
-
The relationship between diabetes mellitus and Parkinson's disease
-
Sandyk R. The relationship between diabetes mellitus and Parkinson's disease. Int J Neurosci 1993;69:125-130
-
(1993)
Int J Neurosci
, vol.69
, pp. 125-130
-
-
Sandyk, R.1
-
78
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - Is this type 3 diabetes?
-
Steen E, Terry BM, Rivera EJ, et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes? J Alzheimers Dis 2005;7:63-80 (Pubitemid 40387185)
-
(2005)
Journal of Alzheimer's Disease
, vol.7
, Issue.1
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
De La, M.S.M.9
-
79
-
-
84859718265
-
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
-
Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 2012;122:1316-1338
-
(2012)
J Clin Invest
, vol.122
, pp. 1316-1338
-
-
Talbot, K.1
Wang, H.Y.2
Kazi, H.3
-
80
-
-
84878864610
-
Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
-
Claxton A, Baker LD, Wilkinson CW, et al. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. J Alzheimers Dis 2013;35:789-797
-
(2013)
J Alzheimers Dis
, vol.35
, pp. 789-797
-
-
Claxton, A.1
Baker, L.D.2
Wilkinson, C.W.3
-
81
-
-
84856496197
-
Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease
-
de la Monte SM. Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease. Curr Alzheimer Res 2012;9:35-66
-
(2012)
Curr Alzheimer Res
, vol.9
, pp. 35-66
-
-
De La Monte, S.M.1
-
82
-
-
0036917631
-
Serum insulin-like growth factor I regulates brain amyloid-beta levels
-
DOI 10.1038/nm793
-
Carro E, Trejo JL, Gomez-Isla T, LeRoith D, Torres-Aleman I. Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med 2002;8:1390-1397 (Pubitemid 36019424)
-
(2002)
Nature Medicine
, vol.8
, Issue.12
, pp. 1390-1397
-
-
Carro, E.1
Trejo, J.L.2
Gomez-Isla, T.3
LeRoith, D.4
Torres-Aleman, I.5
-
83
-
-
33746215099
-
Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis
-
DOI 10.1016/j.neurobiolaging.2005.06.015, PII S0197458005001892
-
Carro E, Trejo JL, Gerber A, et al. Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis. Neurobiol Aging 2006;27:1250-1257 (Pubitemid 44088577)
-
(2006)
Neurobiology of Aging
, vol.27
, Issue.9
, pp. 1250-1257
-
-
Carro, E.1
Trejo, J.L.2
Gerber, A.3
Loetscher, H.4
Torrado, J.5
Metzger, F.6
Torres-Aleman, I.7
-
84
-
-
0035871641
-
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
-
Gasparini L, Gouras GK, Wang R, et al. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 2001;21:2561-2570 (Pubitemid 32298198)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.8
, pp. 2561-2570
-
-
Gasparini, L.1
Gouras, G.K.2
Wang, R.3
Gross, R.S.4
Beal, M.F.5
Greengard, P.6
Xu, H.7
-
85
-
-
70349672704
-
Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
-
Freude S, Hettich MM, Schumann C, et al. Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J 2009;23:3315-3324
-
(2009)
FASEB J
, vol.23
, pp. 3315-3324
-
-
Freude, S.1
Hettich, M.M.2
Schumann, C.3
-
86
-
-
84872603163
-
Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease
-
Stöhr O, Schilbach K, Moll L, et al. Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease. Age (Dordr) 2013;35:83-101
-
(2013)
Age (Dordr)
, vol.35
, pp. 83-101
-
-
Stöhr, O.1
Schilbach, K.2
Moll, L.3
-
87
-
-
84859726053
-
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers
-
Bomfim TR, Forny-Germano L, Sathler LB, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers. J Clin Invest 2012;122:1339-1353
-
(2012)
J Clin Invest
, vol.122
, pp. 1339-1353
-
-
Bomfim, T.R.1
Forny-Germano, L.2
Sathler, L.B.3
-
88
-
-
84872431424
-
Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes
-
Yang Y, Ma D, Wang Y, et al. Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes. J Alzheimers Dis 2013;33:329-338
-
(2013)
J Alzheimers Dis
, vol.33
, pp. 329-338
-
-
Yang, Y.1
Ma, D.2
Wang, Y.3
-
89
-
-
56549112905
-
Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy
-
Francis GJ, Martinez JA, Liu WQ, et al. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008;131:3311-3334
-
(2008)
Brain
, vol.131
, pp. 3311-3334
-
-
Francis, G.J.1
Martinez, J.A.2
Liu, W.Q.3
-
90
-
-
60549084867
-
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Abeta oligomers
-
De Felice FG, Vieira MN, Bomfim TR, et al. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A 2009;106:1971-1976
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1971-1976
-
-
De Felice, F.G.1
Vieira, M.N.2
Bomfim, T.R.3
-
91
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
-
DOI 10.1073/pnas.0230450100
-
Farris W, Mansourian S, Chang Y, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A 2003;100:4162-4167 (Pubitemid 36418174)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.7
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
Eckman, C.B.7
Tanzi, R.E.8
Selkoe, D.J.9
Guenette, S.10
-
92
-
-
84893726788
-
Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans
-
Iwen KA, Scherer T, Heni M, et al. Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans. J Clin Endocrinol Metab 2014;99:E246-E251
-
(2014)
J Clin Endocrinol Metab
, vol.99
-
-
Iwen, K.A.1
Scherer, T.2
Heni, M.3
-
93
-
-
34147190028
-
Type 2 diabetes and the risk of Parkinson's disease
-
DOI 10.2337/dc06-2011
-
Hu G, Jousilahti P, Bidel S, Antikainen R, Tuomilehto J. Type 2 diabetes and the risk of Parkinson's disease. Diabetes Care 2007;30:842-847 (Pubitemid 46562366)
-
(2007)
Diabetes Care
, vol.30
, Issue.4
, pp. 842-847
-
-
Hu, G.1
Jousilahti, P.2
Bidel, S.3
Antikainen, R.4
Tuomilehto, J.5
-
94
-
-
65549103889
-
Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: Potential role of manganese neurotoxicity
-
Tong M, Dong M, de la Monte SM. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. J Alzheimers Dis 2009;16:585-599
-
(2009)
J Alzheimers Dis
, vol.16
, pp. 585-599
-
-
Tong, M.1
Dong, M.2
De La Monte, S.M.3
-
95
-
-
84888062088
-
Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice
-
Wang L, Zhai YQ, Xu LL, et al. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Exp Neurol 2014;251:22-29
-
(2014)
Exp Neurol
, vol.251
, pp. 22-29
-
-
Wang, L.1
Zhai, Y.Q.2
Xu, L.L.3
-
96
-
-
79958115666
-
Direct interaction of α-synuclein and AKT regulates IGF-1 signaling: Implication of Parkinson disease
-
Chung JY, Lee SJ, Lee SH, et al. Direct interaction of α-synuclein and AKT regulates IGF-1 signaling: implication of Parkinson disease. Neurosignals 2011;19:86-96
-
(2011)
Neurosignals
, vol.19
, pp. 86-96
-
-
Chung, J.Y.1
Lee, S.J.2
Lee, S.H.3
-
97
-
-
84873722367
-
Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy
-
Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 2013;9:106-118
-
(2013)
Nat Rev Neurol
, vol.9
, pp. 106-118
-
-
Liu, C.C.1
Kanekiyo, T.2
Xu, H.3
Bu, G.4
-
98
-
-
0035834416
-
CNS synaptogenesis promoted by glia-derived cholesterol
-
DOI 10.1126/science.294.5545.1354
-
Mauch DH, Nägler K, Schumacher S, et al. CNS synaptogenesis promoted by glia-derived cholesterol. Science 2001;294:1354-1357 (Pubitemid 33063104)
-
(2001)
Science
, vol.294
, Issue.5545
, pp. 1354-1357
-
-
Mauch, D.H.1
Nagier, K.2
Schumacher, S.3
Goritz, C.4
Muller, E.-C.5
Otto, A.6
Pfrieger, F.W.7
-
99
-
-
84876967280
-
Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function
-
Suzuki R, Ferris HA, Chee MJ, Maratos-Flier E, Kahn CR. Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function. PLoS Biol 2013;11:e1001532
-
(2013)
PLoS Biol
, vol.11
-
-
Suzuki, R.1
Ferris, H.A.2
Chee, M.J.3
Maratos-Flier, E.4
Kahn, C.R.5
-
100
-
-
79960459422
-
Cholesterol metabolism in neurons and astrocytes
-
Pfrieger FW, Ungerer N. Cholesterol metabolism in neurons and astrocytes. Prog Lipid Res 2011;50:357-371
-
(2011)
Prog Lipid Res
, vol.50
, pp. 357-371
-
-
Pfrieger, F.W.1
Ungerer, N.2
-
102
-
-
84884877043
-
Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity
-
Dietrich MO, Liu ZW, Horvath TL. Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell 2013;155:188-199
-
(2013)
Cell
, vol.155
, pp. 188-199
-
-
Dietrich, M.O.1
Liu, Z.W.2
Horvath, T.L.3
-
103
-
-
82855165012
-
Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity
-
Stuart MJ, Baune BT. Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidity. Neurosci Biobehav Rev 2012;36:658-676
-
(2012)
Neurosci Biobehav Rev
, vol.36
, pp. 658-676
-
-
Stuart, M.J.1
Baune, B.T.2
-
104
-
-
84872937372
-
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
-
Tye KM, Mirzabekov JJ, Warden MR, et al. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 2013;493:537-541
-
(2013)
Nature
, vol.493
, pp. 537-541
-
-
Tye, K.M.1
Mirzabekov, J.J.2
Warden, M.R.3
-
105
-
-
0032821347
-
Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior
-
DOI 10.1016/S0893-133X(99)00040-8, PII S0893133X99000408
-
Mann JJ. Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 1999;21(Suppl.):99S- 105S (Pubitemid 29396477)
-
(1999)
Neuropsychopharmacology
, vol.21
, Issue.2 SUPPL.
-
-
Mann, J.J.1
-
106
-
-
0028230437
-
Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra
-
DOI 10.1016/0006-8993(94)91698-5
-
Figlewicz DP, Szot P, Chavez M, Woods SC, Veith RC. Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra. Brain Res 1994;644:331-334 (Pubitemid 24127991)
-
(1994)
Brain Research
, vol.644
, Issue.2
, pp. 331-334
-
-
Figlewicz, D.P.1
Szot, P.2
Chavez, M.3
Woods, S.C.4
Veith, R.C.5
-
107
-
-
79958026765
-
Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis
-
Könner AC, Hess S, Tovar S, et al. Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Cell Metab 2011;13:720-728
-
(2011)
Cell Metab
, vol.13
, pp. 720-728
-
-
Könner, A.C.1
Hess, S.2
Tovar, S.3
-
108
-
-
35648964732
-
Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine
-
Williams JM, Owens WA, Turner GH, et al. Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. PLoS Biol 2007;5:e274
-
(2007)
PLoS Biol
, vol.5
-
-
Williams, J.M.1
Owens, W.A.2
Turner, G.H.3
-
109
-
-
84872925363
-
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
-
Chaudhury D, Walsh JJ, Friedman AK, et al. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 2013;493:532-536
-
(2013)
Nature
, vol.493
, pp. 532-536
-
-
Chaudhury, D.1
Walsh, J.J.2
Friedman, A.K.3
-
110
-
-
0015209704
-
Brain serotonin content: Increase following ingestion of carbohydrate diet
-
Fernstrom JD, Wurtman RJ. Brain serotonin content: increase following ingestion of carbohydrate diet. Science 1971;174:1023-1025
-
(1971)
Science
, vol.174
, pp. 1023-1025
-
-
Fernstrom, J.D.1
Wurtman, R.J.2
-
111
-
-
84874954509
-
Streptozotocin-induced insulin deficiency leads to development of behavioral deficits in rats
-
Haider S, Ahmed S, Tabassum S, Memon Z, Ikram M, Haleem DJ. Streptozotocin-induced insulin deficiency leads to development of behavioral deficits in rats. Acta Neurol Belg 2013;113:35 -41
-
(2013)
Acta Neurol Belg
, vol.113
, pp. 35-41
-
-
Haider, S.1
Ahmed, S.2
Tabassum, S.3
Memon, Z.4
Ikram, M.5
Haleem, D.J.6
-
113
-
-
84896034951
-
Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system
-
Gupta D, Kurhe Y, Radhakrishnan M. Antidepressant effects of insulin in streptozotocin induced diabetic mice: modulation of brain serotonin system. Physiol Behav 2014;129:73-78
-
(2014)
Physiol Behav
, vol.129
, pp. 73-78
-
-
Gupta, D.1
Kurhe, Y.2
Radhakrishnan, M.3
-
114
-
-
84861822831
-
Rosiglitazone treatment reversed depression- But not psychosis-like behavior of db/db diabetic mice
-
Sharma AN, Elased KM, Lucot JB. Rosiglitazone treatment reversed depression- but not psychosis-like behavior of db/db diabetic mice. J Psychopharmacol 2012;26:724- 732
-
(2012)
J Psychopharmacol
, vol.26
, pp. 724-732
-
-
Sharma, A.N.1
Elased, K.M.2
Lucot, J.B.3
-
115
-
-
13944269223
-
The plasticity of aging: Insights from long-lived mutants
-
DOI 10.1016/j.cell.2005.02.002
-
Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 2005;120:449-460 (Pubitemid 40269760)
-
(2005)
Cell
, vol.120
, Issue.4
, pp. 449-460
-
-
Kenyon, C.1
-
117
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
DOI 10.1126/science.1057987
-
Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001;292:107-110 (Pubitemid 32289137)
-
(2001)
Science
, vol.292
, Issue.5514
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.-P.4
Yin, C.-M.5
Garofalo, R.S.6
-
118
-
-
80053424337
-
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease
-
Sadagurski M, Cheng Z, Rozzo A, et al. IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. J Clin Invest 2011;121:4070-4081
-
(2011)
J Clin Invest
, vol.121
, pp. 4070-4081
-
-
Sadagurski, M.1
Cheng, Z.2
Rozzo, A.3
-
119
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
DOI 10.1126/science.1078223
-
Blüher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003;299:572-574 (Pubitemid 36135156)
-
(2003)
Science
, vol.299
, Issue.5606
, pp. 572-574
-
-
Bluher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
120
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
DOI 10.1038/nature01298
-
Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003;421:182-187 (Pubitemid 36090987)
-
(2003)
Nature
, vol.421
, Issue.6919
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Geloen, A.5
Even, P.C.6
Cervera, P.7
Le, B.Y.8
-
121
-
-
70349484212
-
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and dietinduced obesity
-
Kleinridders A, Schenten D, Könner AC, et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and dietinduced obesity. Cell Metab 2009;10:249-259
-
(2009)
Cell Metab
, vol.10
, pp. 249-259
-
-
Kleinridders, A.1
Schenten, D.2
Könner, A.C.3
-
123
-
-
52949122885
-
FOXO3A genotype is strongly associated with human longevity
-
Willcox BJ, Donlon TA, He Q, et al. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A 2008;105:13987-13992
-
(2008)
Proc Natl Acad Sci U S a
, vol.105
, pp. 13987-13992
-
-
Willcox, B.J.1
Donlon, T.A.2
He, Q.3
-
124
-
-
84889059035
-
Diabetes augments in vivo microvascular blood flow dynamics after stroke
-
Tennant KA, Brown CE. Diabetes augments in vivo microvascular blood flow dynamics after stroke. J Neurosci 2013;33:19194-19204
-
(2013)
J Neurosci
, vol.33
, pp. 19194-19204
-
-
Tennant, K.A.1
Brown, C.E.2
-
125
-
-
84888015715
-
Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats
-
Li W, Qu Z, Prakash R, et al. Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats. Brain Res 2013;1541:106-114
-
(2013)
Brain Res
, vol.1541
, pp. 106-114
-
-
Li, W.1
Qu, Z.2
Prakash, R.3
-
126
-
-
78650862930
-
Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity
-
Wang H, Astarita G, Taussig MD, et al. Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity. Cell Metab 2011;13:105-113
-
(2011)
Cell Metab
, vol.13
, pp. 105-113
-
-
Wang, H.1
Astarita, G.2
Taussig, M.D.3
|