메뉴 건너뛰기




Volumn 120, Issue , 2015, Pages 52-60

Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning

Author keywords

Aging; Brain derived neurotrophic factor; Hippocampus; Spatial learning; TrkB receptor

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR;

EID: 84924891364     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2015.02.009     Document Type: Article
Times cited : (60)

References (66)
  • 1
    • 54749091291 scopus 로고    scopus 로고
    • Proteolysis of proBDNF is a key regulator in the formation of memory
    • Barnes P., Thomas K.L. Proteolysis of proBDNF is a key regulator in the formation of memory. PLoS ONE 2008, 3:e3248.
    • (2008) PLoS ONE , vol.3 , pp. e3248
    • Barnes, P.1    Thomas, K.L.2
  • 2
    • 33846101430 scopus 로고    scopus 로고
    • Persistence of long-term memory storage requires a late protein synthesis- and BDNF-dependent phase in the hippocampus
    • Bekinschtein P., Cammarota M., Igaz L.M., Bevilaqua L.R.M., Izquierdo I., Medina J.H. Persistence of long-term memory storage requires a late protein synthesis- and BDNF-dependent phase in the hippocampus. Neuron 2007, 53:261-277.
    • (2007) Neuron , vol.53 , pp. 261-277
    • Bekinschtein, P.1    Cammarota, M.2    Igaz, L.M.3    Bevilaqua, L.R.M.4    Izquierdo, I.5    Medina, J.H.6
  • 3
    • 77951295329 scopus 로고    scopus 로고
    • Exercise and time-dependent benefits to learning and memory
    • Berchtold N.C., Castello N., Cotman C.W. Exercise and time-dependent benefits to learning and memory. Neuroscience 2010, 167:588-597.
    • (2010) Neuroscience , vol.167 , pp. 588-597
    • Berchtold, N.C.1    Castello, N.2    Cotman, C.W.3
  • 4
    • 84884132576 scopus 로고    scopus 로고
    • Reduced neuroplasticity in aged rats: A role for the neurotrophin brain-derived neurotrophic factor
    • Calabrese F., Guidotti G., Racagni G., Riva M.A. Reduced neuroplasticity in aged rats: A role for the neurotrophin brain-derived neurotrophic factor. Neurobiology of Aging 2013, 34:2768-2776.
    • (2013) Neurobiology of Aging , vol.34 , pp. 2768-2776
    • Calabrese, F.1    Guidotti, G.2    Racagni, G.3    Riva, M.A.4
  • 5
    • 84864804010 scopus 로고    scopus 로고
    • Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels
    • Carreton O., Giralt A., Torres-Peraza J.F., Brito V., Lucas J.J., Gines S., et al. Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels. Experimental Neurology 2012, 237:335-345.
    • (2012) Experimental Neurology , vol.237 , pp. 335-345
    • Carreton, O.1    Giralt, A.2    Torres-Peraza, J.F.3    Brito, V.4    Lucas, J.J.5    Gines, S.6
  • 7
    • 4544321541 scopus 로고    scopus 로고
    • Intrahippocampal administration of BDNF in adult rats affects short-term behavioral plasticity in the Morris water maze and performance in the elevated plus-maze
    • Cirulli F., Berry A., Chiarotti F., Alleva E. Intrahippocampal administration of BDNF in adult rats affects short-term behavioral plasticity in the Morris water maze and performance in the elevated plus-maze. Hippocampus 2004, 14:802-807.
    • (2004) Hippocampus , vol.14 , pp. 802-807
    • Cirulli, F.1    Berry, A.2    Chiarotti, F.3    Alleva, E.4
  • 8
    • 84984562888 scopus 로고    scopus 로고
    • The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats
    • Costa M.S., Ardais A.P., Fioreze G.T., Mioranzza S., Botton P.H., Souza D.O., et al. The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats. Neuroscience 2012, 222:100-109.
    • (2012) Neuroscience , vol.222 , pp. 100-109
    • Costa, M.S.1    Ardais, A.P.2    Fioreze, G.T.3    Mioranzza, S.4    Botton, P.H.5    Souza, D.O.6
  • 9
    • 77952349119 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor: A dynamic gatekeeper of neural plasticity
    • Cowansage K.K., Ledoux J.E., Monfils M.H. Brain-derived neurotrophic factor: A dynamic gatekeeper of neural plasticity. Current Molecular Pharmacology 2010, 3:12-29.
    • (2010) Current Molecular Pharmacology , vol.3 , pp. 12-29
    • Cowansage, K.K.1    Ledoux, J.E.2    Monfils, M.H.3
  • 10
    • 0032561737 scopus 로고    scopus 로고
    • Expression of BDNF and trkB as a function of age and cognitive performance
    • Croll S.D., Ip N.Y., Lindsay R.M., Wiegand S.J. Expression of BDNF and trkB as a function of age and cognitive performance. Brain Research 1998, 812:200-208.
    • (1998) Brain Research , vol.812 , pp. 200-208
    • Croll, S.D.1    Ip, N.Y.2    Lindsay, R.M.3    Wiegand, S.J.4
  • 11
    • 0037462449 scopus 로고    scopus 로고
    • The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    • Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
    • (2003) Cell , vol.112 , pp. 257-269
    • Egan, M.F.1    Kojima, M.2    Callicott, J.H.3    Goldberg, T.E.4    Kolachana, B.S.5    Bertolino, A.6
  • 13
    • 84870546420 scopus 로고    scopus 로고
    • Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice
    • Endres T., Lessmann V. Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice. Learning & Memory 2012, 19:561-570.
    • (2012) Learning & Memory , vol.19 , pp. 561-570
    • Endres, T.1    Lessmann, V.2
  • 14
    • 84863012681 scopus 로고    scopus 로고
    • The aging hippocampus: Interactions between exercise, depression, and BDNF
    • Erickson K.I., Miller D.L., Roecklein K.A. The aging hippocampus: Interactions between exercise, depression, and BDNF. Neuroscientist 2012, 18:82-97.
    • (2012) Neuroscientist , vol.18 , pp. 82-97
    • Erickson, K.I.1    Miller, D.L.2    Roecklein, K.A.3
  • 15
    • 73549123839 scopus 로고    scopus 로고
    • Are the dorsal and ventral hippocampus functionally distinct structures?
    • Fanselow M.S., Dong H.W. Are the dorsal and ventral hippocampus functionally distinct structures?. Neuron 2010, 65:7-19.
    • (2010) Neuron , vol.65 , pp. 7-19
    • Fanselow, M.S.1    Dong, H.W.2
  • 16
    • 33644964952 scopus 로고    scopus 로고
    • Spatial memory deficits in middle-aged mice correlate with lower exploratory activity and a subordinate status: Role of hippocampal neurotrophins
    • Francia N., Cirulli F., Chiarotti F., Antonelli A., Aloe L., Alleva E. Spatial memory deficits in middle-aged mice correlate with lower exploratory activity and a subordinate status: Role of hippocampal neurotrophins. European Journal of Neuroscience 2006, 23:711-728.
    • (2006) European Journal of Neuroscience , vol.23 , pp. 711-728
    • Francia, N.1    Cirulli, F.2    Chiarotti, F.3    Antonelli, A.4    Aloe, L.5    Alleva, E.6
  • 17
    • 1542267747 scopus 로고    scopus 로고
    • Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice
    • Genoud C., Knott G.W., Sakata K., Lu B., Welker E. Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice. Journal of Neuroscience 2004, 24:2394-2400.
    • (2004) Journal of Neuroscience , vol.24 , pp. 2394-2400
    • Genoud, C.1    Knott, G.W.2    Sakata, K.3    Lu, B.4    Welker, E.5
  • 18
    • 0035875794 scopus 로고    scopus 로고
    • Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus
    • Gomez-Pinilla F., So V., Kesslak J.P. Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus. Brain Research 2001, 904:13-19.
    • (2001) Brain Research , vol.904 , pp. 13-19
    • Gomez-Pinilla, F.1    So, V.2    Kesslak, J.P.3
  • 19
    • 0035999634 scopus 로고    scopus 로고
    • Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus: Evidence for a role for brain-derived neurotrophic factor
    • Gooney M., Shaw K., Kelly A., O'Mara S.M., Lynch M.A. Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus: Evidence for a role for brain-derived neurotrophic factor. Behavioral Neuroscience 2002, 116:455-463.
    • (2002) Behavioral Neuroscience , vol.116 , pp. 455-463
    • Gooney, M.1    Shaw, K.2    Kelly, A.3    O'Mara, S.M.4    Lynch, M.A.5
  • 20
    • 0141867812 scopus 로고    scopus 로고
    • Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice
    • Gorski J.A., Balogh S.A., Wehner J.M., Jones K.R. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 2003, 121:341-354.
    • (2003) Neuroscience , vol.121 , pp. 341-354
    • Gorski, J.A.1    Balogh, S.A.2    Wehner, J.M.3    Jones, K.R.4
  • 21
    • 73349135323 scopus 로고    scopus 로고
    • BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
    • Gottmann K., Mittmann T., Lessmann V. BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Experimental Brain Research 2009.
    • (2009) Experimental Brain Research
    • Gottmann, K.1    Mittmann, T.2    Lessmann, V.3
  • 22
    • 41649098353 scopus 로고    scopus 로고
    • Emergence of an egocentric cue guiding and allocentric inferring strategy that mirrors hippocampal brain-derived neurotrophic factor (BDNF) expression in the Morris water maze
    • Harvey D.R., McGauran A.M., Murphy J., Burns L., McMonagle E., Commins S. Emergence of an egocentric cue guiding and allocentric inferring strategy that mirrors hippocampal brain-derived neurotrophic factor (BDNF) expression in the Morris water maze. Neurobiology of Learning and Memory 2008, 89:462-479.
    • (2008) Neurobiology of Learning and Memory , vol.89 , pp. 462-479
    • Harvey, D.R.1    McGauran, A.M.2    Murphy, J.3    Burns, L.4    McMonagle, E.5    Commins, S.6
  • 23
    • 34247856252 scopus 로고    scopus 로고
    • Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
    • Heldt S.A., Stanek L., Chhatwal J.P., Ressler K.J. Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Molecular Psychiatry 2007, 12:656-670.
    • (2007) Molecular Psychiatry , vol.12 , pp. 656-670
    • Heldt, S.A.1    Stanek, L.2    Chhatwal, J.P.3    Ressler, K.J.4
  • 24
    • 15744365886 scopus 로고    scopus 로고
    • Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases
    • Hwang J.J., Park M.H., Choi S.Y., Koh J.Y. Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases. Journal of Biological Chemistry 2005, 280:11995-12001.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 11995-12001
    • Hwang, J.J.1    Park, M.H.2    Choi, S.Y.3    Koh, J.Y.4
  • 25
    • 34547470520 scopus 로고    scopus 로고
    • Copper activates TrkB in cortical neurons in a metalloproteinase-dependent manner
    • Hwang J.J., Park M.H., Koh J.Y. Copper activates TrkB in cortical neurons in a metalloproteinase-dependent manner. Journal of Neuroscience Research 2007, 85:2160-2166.
    • (2007) Journal of Neuroscience Research , vol.85 , pp. 2160-2166
    • Hwang, J.J.1    Park, M.H.2    Koh, J.Y.3
  • 28
    • 0031709896 scopus 로고    scopus 로고
    • Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: A comparison to those of nerve growth factor and neurotrophin-3
    • Katoh-Semba R., Semba R., Takeuchi I.K., Kato K. Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: A comparison to those of nerve growth factor and neurotrophin-3. Neuroscience Research 1998, 31:227-234.
    • (1998) Neuroscience Research , vol.31 , pp. 227-234
    • Katoh-Semba, R.1    Semba, R.2    Takeuchi, I.K.3    Kato, K.4
  • 29
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie S.G., Liebl D.J., Parada L.F. BDNF regulates eating behavior and locomotor activity in mice. EMBO Journal 2000, 19:1290-1300.
    • (2000) EMBO Journal , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 30
    • 0035499282 scopus 로고    scopus 로고
    • Reduced number of functional glutamatergic synapses in hippocampal neurons overexpressing full-length TrkB receptors
    • Klau M., Hartmann M., Erdmann K.S., Heumann R., Lessmann V. Reduced number of functional glutamatergic synapses in hippocampal neurons overexpressing full-length TrkB receptors. Journal of Neuroscience Research 2001, 66:327-336.
    • (2001) Journal of Neuroscience Research , vol.66 , pp. 327-336
    • Klau, M.1    Hartmann, M.2    Erdmann, K.S.3    Heumann, R.4    Lessmann, V.5
  • 31
    • 84860838938 scopus 로고    scopus 로고
    • Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice
    • Klug M., Hill R.A., Choy K.H., Kyrios M., Hannan A.J., van den Buuse M. Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice. Neurobiology of Diseases 2012, 46:722-731.
    • (2012) Neurobiology of Diseases , vol.46 , pp. 722-731
    • Klug, M.1    Hill, R.A.2    Choy, K.H.3    Kyrios, M.4    Hannan, A.J.5    van den Buuse, M.6
  • 32
    • 2342472745 scopus 로고    scopus 로고
    • Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning
    • Koponen E., Voikar V., Riekki R., Saarelainen T., Rauramaa T., Rauvala H., et al. Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Molecular and Cellular Neuroscience 2004, 26:166-181.
    • (2004) Molecular and Cellular Neuroscience , vol.26 , pp. 166-181
    • Koponen, E.1    Voikar, V.2    Riekki, R.3    Saarelainen, T.4    Rauramaa, T.5    Rauvala, H.6
  • 36
    • 84878261678 scopus 로고    scopus 로고
    • The contextual brain: Implications for fear conditioning, extinction and psychopathology
    • Maren S., Phan K.L., Liberzon I. The contextual brain: Implications for fear conditioning, extinction and psychopathology. Nature Reviews Neuroscience 2013, 14:417-428.
    • (2013) Nature Reviews Neuroscience , vol.14 , pp. 417-428
    • Maren, S.1    Phan, K.L.2    Liberzon, I.3
  • 37
    • 78649962088 scopus 로고    scopus 로고
    • Dependence receptors: The trophic theory revisited
    • Mehlen P. Dependence receptors: The trophic theory revisited. Science Signaling 2010, 3:e47.
    • (2010) Science Signaling , vol.3 , pp. e47
    • Mehlen, P.1
  • 38
    • 84855175745 scopus 로고    scopus 로고
    • Postsynaptic BDNF signalling regulates long-term potentiation at thalamo-amygdala afferents
    • Meis S., Endres T., Lessmann V. Postsynaptic BDNF signalling regulates long-term potentiation at thalamo-amygdala afferents. Journal of Physiology 2012, 590:193-208.
    • (2012) Journal of Physiology , vol.590 , pp. 193-208
    • Meis, S.1    Endres, T.2    Lessmann, V.3
  • 40
    • 0030991457 scopus 로고    scopus 로고
    • Intact spatial learning and memory in transgenic mice with reduced BDNF
    • Montkowski A., Holsboer F. Intact spatial learning and memory in transgenic mice with reduced BDNF. NeuroReport 1997, 8:779-782.
    • (1997) NeuroReport , vol.8 , pp. 779-782
    • Montkowski, A.1    Holsboer, F.2
  • 41
    • 0033600503 scopus 로고    scopus 로고
    • Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats
    • Mu J.S., Li W.P., Yao Z.B., Zhou X.F. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain Research 1999, 835:259-265.
    • (1999) Brain Research , vol.835 , pp. 259-265
    • Mu, J.S.1    Li, W.P.2    Yao, Z.B.3    Zhou, X.F.4
  • 42
    • 55549142974 scopus 로고    scopus 로고
    • Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory
    • Nakajo Y., Miyamoto S., Nakano Y., Xue J.H., Hori T., Yanamoto H. Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory. Brain Research 2008, 1241:103-109.
    • (2008) Brain Research , vol.1241 , pp. 103-109
    • Nakajo, Y.1    Miyamoto, S.2    Nakano, Y.3    Xue, J.H.4    Hori, T.5    Yanamoto, H.6
  • 43
    • 79960837544 scopus 로고    scopus 로고
    • Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF
    • Obiang P., Maubert E., Bardou I., Nicole O., Launay S., Bezin L., et al. Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF. Neurobiology of Learning and Memory 2011, 96:121-129.
    • (2011) Neurobiology of Learning and Memory , vol.96 , pp. 121-129
    • Obiang, P.1    Maubert, E.2    Bardou, I.3    Nicole, O.4    Launay, S.5    Bezin, L.6
  • 44
    • 77950691765 scopus 로고    scopus 로고
    • Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory
    • Ou L.C., Yeh S.H., Gean P.W. Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory. Neurobiology of Learning and Memory 2010, 93:372-382.
    • (2010) Neurobiology of Learning and Memory , vol.93 , pp. 372-382
    • Ou, L.C.1    Yeh, S.H.2    Gean, P.W.3
  • 45
    • 84856100262 scopus 로고    scopus 로고
    • Mouse models of genetic effects on cognition: Relevance to schizophrenia
    • Papaleo F., Lipska B.K., Weinberger D.R. Mouse models of genetic effects on cognition: Relevance to schizophrenia. Neuropharmacology 2012, 62:1204-1220.
    • (2012) Neuropharmacology , vol.62 , pp. 1204-1220
    • Papaleo, F.1    Lipska, B.K.2    Weinberger, D.R.3
  • 46
    • 84871408179 scopus 로고    scopus 로고
    • Neurotrophin regulation of neural circuit development and function
    • Park H., Poo M.M. Neurotrophin regulation of neural circuit development and function. Nature Reviews Neuroscience 2013, 14:7-23.
    • (2013) Nature Reviews Neuroscience , vol.14 , pp. 7-23
    • Park, H.1    Poo, M.M.2
  • 47
  • 48
    • 84892554109 scopus 로고    scopus 로고
    • BDNF transcripts, proBDNF and proNGF, in the cortex and hippocampus throughout the life span of the rat
    • Perovic M., Tesic V., Mladenovic D.A., Smiljanic K., Loncarevic-Vasiljkovic N., Ruzdijic S., et al. BDNF transcripts, proBDNF and proNGF, in the cortex and hippocampus throughout the life span of the rat. Age 2013, 35:2057-2070.
    • (2013) Age , vol.35 , pp. 2057-2070
    • Perovic, M.1    Tesic, V.2    Mladenovic, D.A.3    Smiljanic, K.4    Loncarevic-Vasiljkovic, N.5    Ruzdijic, S.6
  • 49
    • 34548409641 scopus 로고    scopus 로고
    • Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus
    • Pietropaolo S., Paterna J.C., Bueler H., Feldon J., Yee B.K. Bidirectional changes in water-maze learning following recombinant adenovirus-associated viral vector (rAAV)-mediated brain-derived neurotrophic factor expression in the rat hippocampus. Behavioural Pharmacology 2007, 18:533-547.
    • (2007) Behavioural Pharmacology , vol.18 , pp. 533-547
    • Pietropaolo, S.1    Paterna, J.C.2    Bueler, H.3    Feldon, J.4    Yee, B.K.5
  • 50
    • 84877352263 scopus 로고    scopus 로고
    • Impaired fear extinction learning in adult heterozygous BDNF knock-out mice
    • Psotta L., Lessmann V., Endres T. Impaired fear extinction learning in adult heterozygous BDNF knock-out mice. Neurobiology of Learning and Memory 2013, 103:34-38.
    • (2013) Neurobiology of Learning and Memory , vol.103 , pp. 34-38
    • Psotta, L.1    Lessmann, V.2    Endres, T.3
  • 51
    • 84879763913 scopus 로고    scopus 로고
    • The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease
    • Rantamaki T., Kemppainen S., Autio H., Staven S., Koivisto H., Kojima M., et al. The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS ONE 2013, 8:e68722.
    • (2013) PLoS ONE , vol.8 , pp. e68722
    • Rantamaki, T.1    Kemppainen, S.2    Autio, H.3    Staven, S.4    Koivisto, H.5    Kojima, M.6
  • 52
    • 84878121762 scopus 로고    scopus 로고
    • Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus
    • Schildt S., Endres T., Lessmann V., Edelmann E. Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus. Neuropharmacology 2013, 71:247-254.
    • (2013) Neuropharmacology , vol.71 , pp. 247-254
    • Schildt, S.1    Endres, T.2    Lessmann, V.3    Edelmann, E.4
  • 55
    • 11444261071 scopus 로고    scopus 로고
    • Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synuclein
    • Siegmund A., Langnaese K., Wotjak C.T. Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synuclein. Behavioural Brain Research 2005, 157:291-298.
    • (2005) Behavioural Brain Research , vol.157 , pp. 291-298
    • Siegmund, A.1    Langnaese, K.2    Wotjak, C.T.3
  • 56
    • 34247892268 scopus 로고    scopus 로고
    • Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats
    • Silhol M., Arancibia S., Maurice T., Tapia-Arancibia L. Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats. Neuroscience 2007, 146:962-973.
    • (2007) Neuroscience , vol.146 , pp. 962-973
    • Silhol, M.1    Arancibia, S.2    Maurice, T.3    Tapia-Arancibia, L.4
  • 57
    • 17044369611 scopus 로고    scopus 로고
    • Age-related changes in brain-derived neurotrophic factor and tyrosine kinase receptor isoforms in the hippocampus and hypothalamus in male rats
    • Silhol M., Bonnichon V., Rage F., Tapia-Arancibia L. Age-related changes in brain-derived neurotrophic factor and tyrosine kinase receptor isoforms in the hippocampus and hypothalamus in male rats. Neuroscience 2005, 132:613-624.
    • (2005) Neuroscience , vol.132 , pp. 613-624
    • Silhol, M.1    Bonnichon, V.2    Rage, F.3    Tapia-Arancibia, L.4
  • 58
    • 0035789203 scopus 로고    scopus 로고
    • Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
    • Specht C.G., Schoepfer R. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neuroscience 2001, 2:11.
    • (2001) BMC Neuroscience , vol.2 , pp. 11
    • Specht, C.G.1    Schoepfer, R.2
  • 60
    • 78349297184 scopus 로고    scopus 로고
    • Role of adenosine A(2A) receptors in modulating synaptic functions and brain levels of BDNF: A possible key mechanism in the pathophysiology of Huntington's disease
    • Tebano M.T., Martire A., Chiodi V., Ferrante A., Popoli P. Role of adenosine A(2A) receptors in modulating synaptic functions and brain levels of BDNF: A possible key mechanism in the pathophysiology of Huntington's disease. Scientific World Journal 2010, 10:1768-1782.
    • (2010) Scientific World Journal , vol.10 , pp. 1768-1782
    • Tebano, M.T.1    Martire, A.2    Chiodi, V.3    Ferrante, A.4    Popoli, P.5
  • 61
    • 84863209197 scopus 로고    scopus 로고
    • Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits
    • Uutela M., Lindholm J., Louhivuori V., Wei H., Louhivuori L.M., Pertovaara A., et al. Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits. Genes, Brain and Behavior 2012, 11:513-523.
    • (2012) Genes, Brain and Behavior , vol.11 , pp. 513-523
    • Uutela, M.1    Lindholm, J.2    Louhivuori, V.3    Wei, H.4    Louhivuori, L.M.5    Pertovaara, A.6
  • 62
    • 9644270414 scopus 로고    scopus 로고
    • Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    • Vaynman S., Ying Z., Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. European Journal of Neuroscience 2004, 20:2580-2590.
    • (2004) European Journal of Neuroscience , vol.20 , pp. 2580-2590
    • Vaynman, S.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 64
    • 43549105602 scopus 로고    scopus 로고
    • Repeated application of an electric field increases BDNF in the brain, enhances spatial learning, and induces infarct tolerance
    • Yanamoto H., Miyamoto S., Nakajo Y., Nakano Y., Hori T., Naritomi H., et al. Repeated application of an electric field increases BDNF in the brain, enhances spatial learning, and induces infarct tolerance. Brain Research 2008, 1212:79-88.
    • (2008) Brain Research , vol.1212 , pp. 79-88
    • Yanamoto, H.1    Miyamoto, S.2    Nakajo, Y.3    Nakano, Y.4    Hori, T.5    Naritomi, H.6
  • 65
    • 84864124228 scopus 로고    scopus 로고
    • 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats
    • Zeng Y., Lv F., Li L., Yu H., Dong M., Fu Q. 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. Journal of Neurochemistry 2012, 122:800-811.
    • (2012) Journal of Neurochemistry , vol.122 , pp. 800-811
    • Zeng, Y.1    Lv, F.2    Li, L.3    Yu, H.4    Dong, M.5    Fu, Q.6
  • 66
    • 84862207028 scopus 로고    scopus 로고
    • Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease
    • Zhang F., Kang Z., Li W., Xiao Z., Zhou X. Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease. Journal of Clinical Neuroscience 2012, 19:946-949.
    • (2012) Journal of Clinical Neuroscience , vol.19 , pp. 946-949
    • Zhang, F.1    Kang, Z.2    Li, W.3    Xiao, Z.4    Zhou, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.