Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

British Journal of Pharmacology

Volumn 171, Issue 2, 2014, Pages 523-535

  Arunachalam, Gnanapragasam ^a   Samuel, Samson Mathews ^a   Marei, Isra ^a   Ding, Hong ^a   Triggle, Chris R ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (Qatar)

Author keywords

endothelial dysfunction; forkhead box O1 transcription factor; FoxO 1; hyperglycaemia; metformin; microvascular endothelial cells; reactive oxygen species; sirtuin1; vascular senescence

Indexed keywords

BETA GALACTOSIDASE; GLUCOSE; METFORMIN; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; SIRTUIN 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE SILENCING; HYPERGLYCEMIA; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; SIRT1 GENE; UPREGULATION;

ENDOTHELIAL DYSFUNCTION; FORKHEAD BOX O1 TRANSCRIPTION FACTOR; FOXO-1; HYPERGLYCAEMIA; METFORMIN; MICROVASCULAR ENDOTHELIAL CELLS; REACTIVE OXYGEN SPECIES; SIRTUIN1; VASCULAR SENESCENCE;

ACETYLATION; ADENYLATE KINASE; ANIMALS; APOPTOSIS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CAPILLARIES; CELL AGING; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; GENE SILENCING; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; METFORMIN; MICE; MICE, INBRED C57BL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 84891275812     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12496     Document Type: Article

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