Systemic Insulin-Like Growth Factor-I Administration Prevents Cognitive Impairment in Diabetic Rats, and Brain IGF Regulates Learning/Memory in Normal Adult Rats

Journal of Neuroscience Research

Volumn 74, Issue 4, 2003, Pages 512-523

  Lupien, Sean B ^a   Bluhm, Erik J ^a   Ishii, Douglas N ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Blood brain barrier; Cognition; Diabetic dementia; Encephalopathy; Neurotrophic factor

Indexed keywords

ANTISERUM; NEUROTROPHIC FACTOR; PROTEIN ANTIBODY; SOMATOMEDIN C; SOMATOMEDIN C ANTIBODY; STREPTOZOCIN; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY WEIGHT; BRAIN ATROPHY; BRAIN FUNCTION; BRAIN WEIGHT; CATABOLISM; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DISEASE MODEL; DRUG EFFECT; HIPPOCAMPUS; HYPERGLYCEMIA; INFUSION PUMP; LATENT PERIOD; LEARNING; LEARNING DISORDER; MALE; MAZE TEST; MEMORY; MEMORY DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SPATIAL MEMORY; STREPTOZOCIN DIABETES; TASK PERFORMANCE;

ANALYSIS OF VARIANCE; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; BRAIN; COGNITION DISORDERS; DIABETES MELLITUS, EXPERIMENTAL; HIPPOCAMPUS; HYPERGLYCEMIA; INFUSION PUMPS, IMPLANTABLE; INJECTIONS, SUBCUTANEOUS; INSULIN-LIKE GROWTH FACTOR I; MAZE LEARNING; MEMORY; RANDOM ALLOCATION; RATS; REFERENCE VALUES; STREPTOZOCIN;

EID: 0242330837     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10791     Document Type: Article

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