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Volumn 20, Issue 4, 2011, Pages 549-557

Lixisenatide for type 2 diabetes mellitus

Author keywords

AVE0010; GETGOAL; GLP 1; incretin mimetics; lixisenatide; type 2 diabetes

Indexed keywords

DRUG ANTIBODY; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; INSULIN; INSULIN GLARGINE; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; PARACETAMOL; PLACEBO; SULFONYLUREA;

EID: 79952690188     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.2011.562191     Document Type: Review
Times cited : (73)

References (49)
  • 1
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;20(1):4-14
    • (2010) Diabetes Res Clin Pract , vol.20 , Issue.1 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 2
    • 38949125456 scopus 로고    scopus 로고
    • Islet cell function: alpha and beta cells - Partners towards normoglycaemia
    • DOI 10.1111/j.1742-1241.2007.01686.x
    • Goke B. Islet cell function: alpha and beta cells-partners towards normoglycaemia. Int J Clin Pract 2008;62(Suppl s159):2-7 (Pubitemid 351229610)
    • (2008) International Journal of Clinical Practice , vol.62 , Issue.SUPPL. 159 , pp. 2-7
    • Goke, B.1
  • 3
    • 77951793008 scopus 로고    scopus 로고
    • Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?
    • Meier JJ, Nauck MA. Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function? Diabetes 2010;59(5):1117-25
    • (2010) Diabetes , vol.59 , Issue.5 , pp. 1117-1125
    • Meier, J.J.1    Nauck, M.A.2
  • 4
    • 77955657408 scopus 로고    scopus 로고
    • Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis
    • Schernthaner G, Barnett AH, Betteridge DJ, et al. Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis. Diabetologia 2010;53(7):1258-69
    • (2010) Diabetologia , vol.53 , Issue.7 , pp. 1258-1269
    • Schernthaner, G.1    Barnett, A.H.2    Betteridge, D.J.3
  • 5
    • 64749100501 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32(1):193-203
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 6
    • 77958597752 scopus 로고    scopus 로고
    • Therapy: What evidence should guide the use of thiazolidinediones?
    • Riddle MC. Therapy: what evidence should guide the use of thiazolidinediones? Nat Rev Endocrinol 2010;6(11):600-2
    • (2010) Nat Rev Endocrinol , vol.6 , Issue.11 , pp. 600-602
    • Riddle, M.C.1
  • 7
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 2009;5(5):262-9
    • (2009) Nat Rev Endocrinol , vol.5 , Issue.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 8
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • DOI 10.1152/physrev.00034.2006
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007;87(4):1409-39 (Pubitemid 350041474)
    • (2007) Physiological Reviews , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 9
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • DOI 10.1210/jc.87.3.1239
    • Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab 2002;87(3):1239-46 (Pubitemid 36121094)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.3 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3    Holst, J.J.4    Nauck, M.S.5    Ritzel, R.6    Hufner, M.7    Schmiegel, W.H.8
  • 10
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon CF, Nauck MA, Toft-Nielsen M, et al. Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 1995;44(9):1126-31
    • (1995) Diabetes , vol.44 , Issue.9 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3
  • 11
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 1995;80(3):952-7
    • (1995) J Clin Endocrinol Metab , vol.80 , Issue.3 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 12
    • 77953613604 scopus 로고    scopus 로고
    • Once-weekly GLP-1 agonists: How do they differ from exenatide and liraglutide?
    • Christensen M, Knop FK. Once-weekly GLP-1 agonists: how do they differ from exenatide and liraglutide? Curr Diab Rep 2010;10(2):124-32
    • (2010) Curr Diab Rep , vol.10 , Issue.2 , pp. 124-132
    • Christensen, M.1    Knop, F.K.2
  • 13
    • 84855637020 scopus 로고    scopus 로고
    • Available from: Cited 5 November 2010
    • European Medicines Agency. European Public Assessment Reports - Byetta - Scientific Discussion [Internet]. Available from: http://www.ema.europa.eu/ema/ index.jsp?curl=pages/medicines/human/ medicines/000698/human-med-000682. jsp&murl=menus/medicines/medicines. jsp&mid=WC0b01ac058001d125 [Cited 5 November 2010]
    • European Public Assessment Reports - Byetta - Scientific Discussion [Internet]
  • 14
    • 0008348082 scopus 로고    scopus 로고
    • Available from: Cited 9 November 2010
    • European Medicines Agency. European Public Assessment Reports - Victoza [Internet]. Available from: http://www. ema.europa.eu/ema/index.jsp?curl=pages/ medicines/human/medicines/001026/ human-med-001137.jsp&murl=menus/ medicines/medicines. jsp&mid=WC0b01ac058001d125 [Cited 9 November 2010]
    • European Public Assessment Reports - Victoza [Internet]
  • 15
    • 69949163754 scopus 로고    scopus 로고
    • Exenatide and liraglutide: Different approaches to develop GLP-1 receptor agonists (incretin mimetics)-preclinical and clinical results
    • Madsbad S. Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)-preclinical and clinical results. Best Pract Res Clin Endocrinol Metab 2009;23(4):463-77
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , Issue.4 , pp. 463-477
    • Madsbad, S.1
  • 16
  • 17
    • 77955847376 scopus 로고    scopus 로고
    • Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes
    • Werner U, Haschke G, Herling AW, Kramer W. Pharmacological profile of lixisenatide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. Regul Pept 2010;164(2-3):58-64
    • (2010) Regul Pept , vol.164 , Issue.2-3 , pp. 58-64
    • Werner, U.1    Haschke, G.2    Herling, A.W.3    Kramer, W.4
  • 18
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 2003;46(1):3-19 (Pubitemid 36237741)
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kahn, S.E.1
  • 19
    • 43249085016 scopus 로고    scopus 로고
    • Enhanced protection against cytokine- And fatty acid-induced apoptosis in pancreatic beta cells by combined treatment with glucagon-like peptide-1 receptor agonists and insulin analogues
    • DOI 10.1055/s-2008-1042426
    • Tews D, Werner U, Eckel J. Enhanced protection against cytokine- and fatty acid-induced apoptosis in pancreatic beta cells by combined treatment with glucagon-like peptide-1 receptor agonists and insulin analogues. Horm Metab Res 2008;40(3):172-80 (Pubitemid 351690520)
    • (2008) Hormone and Metabolic Research , vol.40 , Issue.3 , pp. 172-180
    • Tews, D.1    Werner, U.2    Eckel, J.3
  • 20
    • 70349252642 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist AVE0010 improves GSIS, prevents lipotoxicity-induced insulin depletion and preserves beta-cell function in human pancreatic islets
    • U. abstract 11-OR
    • Werner U, Vandewalle B, Kerr Conte J, et al. U. The GLP-1 receptor agonist AVE0010 improves GSIS, prevents lipotoxicity-induced insulin depletion and preserves beta-cell function in human pancreatic islets [abstract 11-OR]. Diabetes 2008;57(Suppl 1):A3-4
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Werner, U.1    Vandewalle, B.2    Kerr Conte, J.3
  • 21
    • 43049116613 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist AVE0010 preserves beta cell function and insulin secretion after a 6 week treatment in male obese Zucker diabetic fatty rats - An isolated perfused pancreas study
    • Haschke G, Haag-Diergarten S, Werner U, et al. The GLP-1 receptor agonist AVE0010 preserves beta cell function and insulin secretion after a 6 week treatment in male obese Zucker diabetic fatty rats - an isolated perfused pancreas study. Diabetologia 2006;49(Suppl 1):400-1
    • (2006) Diabetologia , vol.49 , Issue.SUPPL. 1 , pp. 400-401
    • Haschke, G.1    Haag-Diergarten, S.2    Werner, U.3
  • 22
    • 43049143998 scopus 로고    scopus 로고
    • Effect of the glucagon like peptide-1 receptor agonist AVE0010 on postprandial hepatic glucose metabolism in the conscious dog
    • Moore MC, Werner U, Smith MS, et al. Effect of the glucagon like peptide-1 receptor agonist AVE0010 on postprandial hepatic glucose metabolism in the conscious dog. Diabetologia 2007;50(Suppl 1):S242
    • (2007) Diabetologia , vol.50 , Issue.SUPPL. 1
    • Moore, M.C.1    Werner, U.2    Smith, M.S.3
  • 23
    • 43049116991 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist AVE0010 abolishes OGTT-induced blood glucose excursion in healthy, normoglycemic dog without risk of hypoglycaemia
    • abstract
    • Werner U, Gerlach M, Hofmann M, Herling AW. The GLP-1 receptor agonist AVE0010 abolishes OGTT-induced blood glucose excursion in healthy, normoglycemic dog without risk of hypoglycaemia [abstract]. Diabetes 2007;56(Suppl 1):A129-30
    • (2007) Diabetes , vol.56 , Issue.SUPPL. 1
    • Werner, U.1    Gerlach, M.2    Hofmann, M.3    Herling, A.W.4
  • 24
    • 58349104177 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of GLP-1 agonist AVE0010 in type 2 diabetes patients
    • abstract 520-P
    • Distiller L, Ruus PE. Pharmacokinetics and pharmacodynamics of GLP-1 agonist AVE0010 in type 2 diabetes patients [abstract 520-P]. 68th Ann Meet Am Diabetes Assoc; 08 June 2008
    • 68th Ann Meet Am Diabetes Assoc; 08 June 2008
    • Distiller, L.1    Ruus, P.E.2
  • 25
    • 79952670009 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of the GLP-1 agonist AVE0010 in patient with renal impairment
    • abstract 557-P
    • Liu Y, Ruus P. Pharmacokinetics and safety of the GLP-1 agonist AVE0010 in patient with renal impairment [abstract 557-P]. 69 Ann Meet Am Diabetes Assoc
    • 69 Ann Meet Am Diabetes Assoc
    • Liu, Y.1    Ruus, P.2
  • 27
    • 84868240821 scopus 로고    scopus 로고
    • Effect of the GLP-1 agonist AVE0010 on absorption of concomitant oral drugs
    • abstract 495-P
    • Liu Y, Ruus P. Effect of the GLP-1 agonist AVE0010 on absorption of concomitant oral drugs [abstract 495-P]. 69 Ann Meet Am Diabetes Assoc; 2009
    • 69 Ann Meet Am Diabetes Assoc; 2009
    • Liu, Y.1    Ruus, P.2
  • 28
    • 79952663607 scopus 로고    scopus 로고
    • Post-meal effects of AVE0010, a once-daily GLP-1 receptor agonist, in type 2 diabetes inadequately controlled on metformin
    • abstract 564-P
    • Rosenstock J, Ratner R. Post-meal effects of AVE0010, a once-daily GLP-1 receptor agonist, in type 2 diabetes inadequately controlled on metformin [abstract 564-P]. 69 Ann Meet Am Diabetes Assoc
    • 69 Ann Meet Am Diabetes Assoc
    • Rosenstock, J.1    Ratner, R.2
  • 29
    • 79952675497 scopus 로고    scopus 로고
    • Monotherapy with GLP-1 receptor agonist, Lixisenatide, significantly improves glycaemic control in type 2 diabetic patients. Poster 830 at
    • Gerich JE, Fonseca VA. Monotherapy with GLP-1 receptor agonist, Lixisenatide, significantly improves glycaemic control in type 2 diabetic patients. Poster 830 at EASD 46th Annual Meeting; 20 - 24 September 2010; Stockholm, Sweden
    • EASD 46th Annual Meeting; 20 - 24 September 2010; Stockholm, Sweden
    • Gerich, J.E.1    Fonseca, V.A.2
  • 30
    • 79952633467 scopus 로고    scopus 로고
    • A dose-finding study of the new GLP-1 agonist AVE0010 in type 2 diabetes insufficiently controlled with metformin
    • abstract 433-P
    • Ratner R, Rosenstock J, Boka G. A dose-finding study of the new GLP-1 agonist AVE0010 in type 2 diabetes insufficiently controlled with metformin [abstract 433-P]. 68th Ann Meet Am Diabetes Assoc; 8 June 2008
    • 68th Ann Meet Am Diabetes Assoc; 8 June 2008
    • Ratner, R.1    Rosenstock, J.2    Boka, G.3
  • 31
    • 77955887980 scopus 로고    scopus 로고
    • Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with type 2 diabetes inadequately controlled with metformin: A randomized, double-blind, placebo-controlled trial
    • Ratner RE, Rosenstock J, Boka G. Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled trial. Diabet Med 2010;27(9):1024-32
    • (2010) Diabet Med , vol.27 , Issue.9 , pp. 1024-1032
    • Ratner, R.E.1    Rosenstock, J.2    Boka, G.3
  • 33
    • 0022527438 scopus 로고
    • Clinical aspects of islet B-cell function in non-insulin-dependent diabetes mellitus
    • Ward WK, Beard JC, Porte D. Clinical aspects of islet B-cell function in non-insulin-dependent diabetes mellitus. Diabetes Metab Rev 1986;2(3-4):297-313 (Pubitemid 16009511)
    • (1986) Diabetes/Metabolism Reviews , vol.2 , Issue.3-4 , pp. 297-313
    • Ward, W.K.1    Beard, J.C.2    Porte Jr., D.3
  • 34
    • 34250854205 scopus 로고    scopus 로고
    • The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications
    • DOI 10.1210/er.2006-0026
    • Dunning BE, Gerich JE. The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 2007;28(3):253-83 (Pubitemid 46984828)
    • (2007) Endocrine Reviews , vol.28 , Issue.3 , pp. 253-283
    • Dunning, B.E.1    Gerich, J.E.2
  • 35
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27(5):1047-53
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3
  • 36
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • Butler AE, Janson J, Bonner-Weir S, et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52(1):102-10 (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 37
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K, et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008;372(9645):1240-50
    • (2008) Lancet , vol.372 , Issue.9645 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 38
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009;374(9683):39-47
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 40
    • 0027184119 scopus 로고
    • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells
    • Goke R, Fehmann HC, Linn T, et al. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J Biol Chem 1993;268(26):19650-5
    • (1993) J Biol Chem , vol.268 , Issue.26 , pp. 19650-19655
    • Goke, R.1    Fehmann, H.C.2    Linn, T.3
  • 41
    • 0028233622 scopus 로고
    • Signal transduction of the GLP-1-receptor cloned from a human insulinoma
    • van Eyll B, Lankat-Buttgereit B, Bode HP, et al. Signal transduction of the GLP-1-receptor cloned from a human insulinoma. FEBS Lett 1994;348(1):7-13
    • (1994) FEBS Lett , vol.348 , Issue.1 , pp. 7-13
    • Van Eyll, B.1    Lankat-Buttgereit, B.2    Bode, H.P.3
  • 42
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • Astrup A, Rossner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 2009;374(9701):1606-16
    • (2009) Lancet , vol.374 , Issue.9701 , pp. 1606-1616
    • Astrup, A.1    Rossner, S.2    Van Gaal, L.3
  • 43
    • 77956090389 scopus 로고    scopus 로고
    • Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes
    • Rosenstock J, Klaff LJ, Schwartz S, et al. Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes. Diabetes Care 2010;33(6):1173-5
    • (2010) Diabetes Care , vol.33 , Issue.6 , pp. 1173-1175
    • Rosenstock, J.1    Klaff, L.J.2    Schwartz, S.3
  • 45
    • 1442311383 scopus 로고    scopus 로고
    • Effects of Glucagon-Like Peptide-1 in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction after Successful Reperfusion
    • DOI 10.1161/01.CIR.0000120505.91348.58
    • Nikolaidis LA, Mankad S, Sokos GG, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004;109(8):962-5 (Pubitemid 38282847)
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6    Shannon, R.P.7
  • 46
    • 8544258807 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
    • Nystrom T, Gutniak MK, Zhang Q, et al. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004;287(6):E1209-15
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , Issue.6
    • Nystrom, T.1    Gutniak, M.K.2    Zhang, Q.3
  • 47
    • 76949099016 scopus 로고    scopus 로고
    • Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: A double-blind, placebo-controlled, randomized pilot study
    • Gill A, Hoogwerf BJ, Burger J, et al. Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study. Cardiovasc Diabetol 2010;9:6
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 6
    • Gill, A.1    Hoogwerf, B.J.2    Burger, J.3
  • 48
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009;373(9662):473-81
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 49
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, parallel-group study
    • Moretto TJ, Milton DR, Ridge TD, et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2008;30(8):1448-60
    • (2008) Clin Ther , vol.30 , Issue.8 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3


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