-
1
-
-
0042838303
-
Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Gong Y, et al. (2003) Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci USA 100:10417-10422.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10417-10422
-
-
Gong, Y.1
-
2
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430:631-639.
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
4
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry RD, et al. (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
-
5
-
-
0035297712
-
Targeting small A beta oligomers: The solution to an Alzheimer's disease conundrum?
-
Klein WL, Krafft GA, Finch CE (2001) Targeting small A beta oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci 24:219-224.
-
(2001)
Trends Neurosci
, vol.24
, pp. 219-224
-
-
Klein, W.L.1
Krafft, G.A.2
Finch, C.E.3
-
6
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298:789-791.
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
7
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
-
Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8:101-112.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
8
-
-
34248547813
-
Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases
-
Ferreira ST, Vieira MN, De Felice FG (2007) Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases. IUBMB Life 59:332-345.
-
(2007)
IUBMB Life
, vol.59
, pp. 332-345
-
-
Ferreira, S.T.1
Vieira, M.N.2
De Felice, F.G.3
-
9
-
-
38049110692
-
Amyloid beta oligomers induce impairment of neuronal insulin receptors
-
Zhao WQ, et al. (2008) Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J 22:246-260.
-
(2008)
FASEB J
, vol.22
, pp. 246-260
-
-
Zhao, W.Q.1
-
10
-
-
2542455537
-
Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease
-
Klein WL, Stine WB, Jr, Teplow DB (2004) Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiol Aging 25:569-580.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 569-580
-
-
Klein, W.L.1
Stine Jr, W.B.2
Teplow, D.B.3
-
11
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from A beta1-42 are potent central nervous system neurotoxins
-
Lambert MP, et al. (1998) Diffusible, nonfibrillar ligands derived from A beta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 95:6448-6453.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
-
12
-
-
20844458090
-
Synaptic targeting by Alzheimer's-related amyloid beta oligomers
-
Lacor PN, et al. (2004) Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci 24:10191-10200.
-
(2004)
J Neurosci
, vol.24
, pp. 10191-10200
-
-
Lacor, P.N.1
-
13
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
-
14
-
-
44549087765
-
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
-
Selkoe DJ (2008) Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 192:106-113.
-
(2008)
Behav Brain Res
, vol.192
, pp. 106-113
-
-
Selkoe, D.J.1
-
15
-
-
47049120422
-
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers
-
De Felice FG, et al. (2008) Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiol Aging 29:1334-1347.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1334-1347
-
-
De Felice, F.G.1
-
16
-
-
34249672242
-
A beta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
-
De Felice FG, et al. (2007) A beta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem 282:11590-11601.
-
(2007)
J Biol Chem
, vol.282
, pp. 11590-11601
-
-
De Felice, F.G.1
-
17
-
-
30644475475
-
Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses
-
Roselli F, et al. (2005) Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses. J Neurosci 25:11061-11070.
-
(2005)
J Neurosci
, vol.25
, pp. 11061-11070
-
-
Roselli, F.1
-
18
-
-
33846633336
-
A beta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
Lacor PN, et al. (2007) A beta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27:796-807.
-
(2007)
J Neurosci
, vol.27
, pp. 796-807
-
-
Lacor, P.N.1
-
19
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
Shankar GM, et al. (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27:2866-2875.
-
(2007)
J Neurosci
, vol.27
, pp. 2866-2875
-
-
Shankar, G.M.1
-
20
-
-
23044445669
-
Regulation of NMDA receptor trafficking by amyloid-beta
-
Snyder EM, et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 8:1051-1058.
-
(2005)
Nat Neurosci
, vol.8
, pp. 1051-1058
-
-
Snyder, E.M.1
-
21
-
-
33845411954
-
AMPAR removal underlies A beta-induced synaptic depression and dendritic spine loss
-
Hsieh H, et al. (2006) AMPAR removal underlies A beta-induced synaptic depression and dendritic spine loss. Neuron 52:831-843.
-
(2006)
Neuron
, vol.52
, pp. 831-843
-
-
Hsieh, H.1
-
22
-
-
14044279957
-
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
-
Georganopoulou DG, et al. (2005) Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci USA 102:2273-2276.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2273-2276
-
-
Georganopoulou, D.G.1
-
23
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesné S, et al. (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesné, S.1
-
24
-
-
21044453723
-
Amyloid beta protein immunotherapy neutralizes A beta oligomers that disrupt synaptic plasticity in vivo
-
Klyubin I, et al. (2005) Amyloid beta protein immunotherapy neutralizes A beta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11:556-561.
-
(2005)
Nat Med
, vol.11
, pp. 556-561
-
-
Klyubin, I.1
-
25
-
-
43649102007
-
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
-
Epub ahead of print
-
Relkin NR, et al. (2008) 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging [Epub ahead of print]
-
(2008)
Neurobiol Aging
-
-
Relkin, N.R.1
-
26
-
-
0033521130
-
Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats
-
Zhao W, et al. (1999) Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem 274:34893-34902.
-
(1999)
J Biol Chem
, vol.274
, pp. 34893-34902
-
-
Zhao, W.1
-
27
-
-
0035947044
-
Role of insulin and insulin receptor in learning and memory
-
Zhao WQ, Alkon DL (2001) Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 177:125-134.
-
(2001)
Mol Cell Endocrinol
, vol.177
, pp. 125-134
-
-
Zhao, W.Q.1
Alkon, D.L.2
-
28
-
-
33644592598
-
Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study
-
Watson GS, et al. (2005) Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry 13:950-958.
-
(2005)
Am J Geriatr Psychiatry
, vol.13
, pp. 950-958
-
-
Watson, G.S.1
-
29
-
-
33745234766
-
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
-
Pedersen WA, et al. (2006) Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice. Exp Neurol 199:265-273.
-
(2006)
Exp Neurol
, vol.199
, pp. 265-273
-
-
Pedersen, W.A.1
-
30
-
-
40349091597
-
Intranasal insulin improves cognition and modulates beta-amyloid in early AD
-
Reger MA, et al. (2008) Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 70:440-448.
-
(2008)
Neurology
, vol.70
, pp. 440-448
-
-
Reger, M.A.1
-
31
-
-
34147173277
-
Insulin resistance and Alzheimer's disease pathogenesis: Potential mechanisms and implications for treatment
-
Craft S (2007) Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 4:147-152.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 147-152
-
-
Craft, S.1
-
32
-
-
4644286910
-
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
-
Ho L, et al. (2004) Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 18:902-904.
-
(2004)
FASEB J
, vol.18
, pp. 902-904
-
-
Ho, L.1
-
33
-
-
37549035051
-
Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
-
Cao D, Lu H, Lewis TL, Li L (2007) Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 282:36275-36282.
-
(2007)
J Biol Chem
, vol.282
, pp. 36275-36282
-
-
Cao, D.1
Lu, H.2
Lewis, T.L.3
Li, L.4
-
34
-
-
0035879068
-
cAMP-dependent protein kinase mediates activity-regulated synaptic targeting of NMDA receptors
-
Crump FT, Dillman KS, Craig AM (2001) cAMP-dependent protein kinase mediates activity-regulated synaptic targeting of NMDA receptors. J Neurosci 21:5079-5088.
-
(2001)
J Neurosci
, vol.21
, pp. 5079-5088
-
-
Crump, F.T.1
Dillman, K.S.2
Craig, A.M.3
-
35
-
-
0032527884
-
Comparison of hippocampal dendritic spines in culture and in brain
-
Boyer C, Schikorski T, Stevens CF (1998) Comparison of hippocampal dendritic spines in culture and in brain. J Neurosci 18:5294-5300.
-
(1998)
J Neurosci
, vol.18
, pp. 5294-5300
-
-
Boyer, C.1
Schikorski, T.2
Stevens, C.F.3
-
36
-
-
33845577779
-
The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease
-
Cole GM, Frautschy SA (2007) The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease. Exp Gerontol 42:10-21.
-
(2007)
Exp Gerontol
, vol.42
, pp. 10-21
-
-
Cole, G.M.1
Frautschy, S.A.2
-
37
-
-
33845515523
-
Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency
-
Clodfelder-Miller BJ, Zmijewska AA, Johnson GV, Jope RS (2006) Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes 55:3320-3325.
-
(2006)
Diabetes
, vol.55
, pp. 3320-3325
-
-
Clodfelder-Miller, B.J.1
Zmijewska, A.A.2
Johnson, G.V.3
Jope, R.S.4
-
38
-
-
34247324303
-
Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
-
Grünblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007) Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 101:757-770.
-
(2007)
J Neurochem
, vol.101
, pp. 757-770
-
-
Grünblatt, E.1
Salkovic-Petrisic, M.2
Osmanovic, J.3
Riederer, P.4
Hoyer, S.5
-
40
-
-
33845695894
-
Intranasal insulin improves memory in humans: Superiority of insulin aspart
-
Benedict C, et al. (2007b) Intranasal insulin improves memory in humans: superiority of insulin aspart. Neuropsychopharmacology 32:239-243.
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 239-243
-
-
Benedict, C.1
-
41
-
-
36348935683
-
Soluble A beta inhibits specific signal transduction cascades common to the insulin receptor pathway
-
Townsend M, Mehta T, Selkoe DJ (2007) Soluble A beta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 282:33305-33312.
-
(2007)
J Biol Chem
, vol.282
, pp. 33305-33312
-
-
Townsend, M.1
Mehta, T.2
Selkoe, D.J.3
-
42
-
-
37349101972
-
Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation
-
Epub ahead of print
-
Lee CC, Kuo YM, Huang CC, Hsu KS (2007) Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation. Neurobiol Aging. [Epub ahead of print]
-
(2007)
Neurobiol Aging
-
-
Lee, C.C.1
Kuo, Y.M.2
Huang, C.C.3
Hsu, K.S.4
-
43
-
-
33745266146
-
Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease
-
Risner ME, et al. (2006) Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J 6:246-254.
-
(2006)
Pharmacogenomics J
, vol.6
, pp. 246-254
-
-
Risner, M.E.1
-
44
-
-
33846135452
-
Monoclonal antibodies that target pathological assemblies of A beta
-
Lambert MP, et al. (2007) Monoclonal antibodies that target pathological assemblies of A beta. J Neurochem 100:23-35.
-
(2007)
J Neurochem
, vol.100
, pp. 23-35
-
-
Lambert, M.P.1
-
45
-
-
0035853124
-
Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis
-
Skeberdis VA, Lan J, Zheng X, Zukin RS, Bennett MV (2001) Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci USA 98:3561-3566.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3561-3566
-
-
Skeberdis, V.A.1
Lan, J.2
Zheng, X.3
Zukin, R.S.4
Bennett, M.V.5
-
46
-
-
0344305401
-
Insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus
-
Huang CC, You JL, Lee CC, Hsu KS (2003) Insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus. Mol Cell Neurosci 24:831-841.
-
(2003)
Mol Cell Neurosci
, vol.24
, pp. 831-841
-
-
Huang, C.C.1
You, J.L.2
Lee, C.C.3
Hsu, K.S.4
-
47
-
-
0034333018
-
Cognition and synaptic plasticity in diabetes mellitus
-
Gispen WH, Biessels GJ (2000) Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 23:542-549.
-
(2000)
Trends Neurosci
, vol.23
, pp. 542-549
-
-
Gispen, W.H.1
Biessels, G.J.2
-
48
-
-
0003374626
-
Tau protein pathology in neurodegenerative diseases
-
Spillantini MG, Goedert M (2008) Tau protein pathology in neurodegenerative diseases. Trends Neurosci 21:428-433.
-
(2008)
Trends Neurosci
, vol.21
, pp. 428-433
-
-
Spillantini, M.G.1
Goedert, M.2
-
49
-
-
57349153475
-
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
-
Epub ahead of print
-
Moloney AM, et al. (2008) Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging. [Epub ahead of print]
-
(2008)
Neurobiol Aging
-
-
Moloney, A.M.1
-
50
-
-
34147102288
-
Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease
-
Landreth G (2007) Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease. Curr Alzheimer Res 4:159-164.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 159-164
-
-
Landreth, G.1
-
51
-
-
33646383887
-
Improving metabolic control leads to better working memory in adults with type 2 diabetes
-
Ryan CM, et al. (2006) Improving metabolic control leads to better working memory in adults with type 2 diabetes. Diabetes Care 29:345-351.
-
(2006)
Diabetes Care
, vol.29
, pp. 345-351
-
-
Ryan, C.M.1
|