Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

Nature Medicine

Volumn 9, Issue 9, 2003, Pages 1173-1179

  During, Matthew J ^a,b   Cao, Lei ^b   Zuzga, David S ^b   Francis, Jeremy S ^a   Fitzsimons, Helen L ^a,b   Jiao, Xiangyang ^b   Bland, Ross J ^b   Klugmann, Matthias ^a   Banks, William A ^c   Drucker, Daniel J ^d   Haile, Colin N ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HORMONE RECEPTOR; KAINIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TRANSFER; HIPPOCAMPUS; HUMAN; HUMAN CELL; LEARNING; LEARNING DISORDER; MALE; MEMORY; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SEIZURE; STATE DEPENDENT LEARNING; WILD TYPE;

ADMINISTRATION, INTRANASAL; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; COGNITION; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; HIPPOCAMPUS; KAINIC ACID; LEARNING; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCAGON; SEIZURES; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0141461415     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm919     Document Type: Article

References (40)

1. Tseng, C.C., Zhang, X.Y. & Wolfe, M.M. Effect of GIP and GLP-1 antagonists on insulin release in the rat. Am. J. Physiol. 76, E1049-E1054 (1999).
2. Drucker, D.J. The glucagon-like peptides. Endocrinology 142, 521-527 (2001).
3. Stoffers, D.A. et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49, 741-748 (2000).
4. Turton, M.D. et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379, 69-72 (1996).
5. Jin, S.L.C. et al. Distribution of glucagon like peptide 1 (GLP-1), glucagon, and glicentin in the rat brain: an immunocytochemical study. J. Comp. Neurol. 271, 519-532 (1988).
6. Merchenthaler, I., Lane, M. & Shughrue, P. Distribution of pre-proglucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J. Comp. Neurol. 403, 261-280 (1999).
7. Alvarez, E., Roncero, I., Chowen, J.A., Thorens, B. & Blazquenz, E. Expression of the glucagons-like peptide receptor gene in rat brain. J. Neurochem. 66, 920-927 (1996).
8. Kandel, E.R. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294, 1030-1038 (2001).
9. Montrose-Rafizadeh, C. et al. Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells. Endocrinology 140, 1132-1140 (1999).
10. Wheeler, M.B. et al. Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C. Endocrinology 133, 57-62 (1993).
11. Raufman, J.P., Singh, L. & Eng, J. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J. Biol. Chem. 266, 2897-2902 (1991).
12. Gallwitz, B. et al. GLP-1-analogues resistant to degradation by dipeptidlyl-peptidase IV in vitro. Regul. Pept. 86, 103-111 (2000).
13. Praz, G.A. et al. Regulation of immunoreactive-insulin release from a rat cell line (RINm5F). Biochem. J. 15, 345-352 (1983).
14. Weatherly, L.S., Harding, J.W. & Wright, J.W. Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats. Brain Res. 716, 29-38 (1996).
15. Morris, R.G.M., Garrud, R. Rawlins, J.N.P. & O'Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683 (1982).
16. DeWied, D. Long term effect of vasopressin on the maintenance of a conditioned avoidance response in rats. Nature 232, 58-60 (1971).
17. Born, J. et al. Sniffing neuropeptides: a transnasal approach to the human brain. Nat. Neurosci. 5, 514-516 (2002).
18. Banks, W.A., Kastin, A.J. & Pan, W. Uptake and degradation of blood-borne insulin by the olfactory bulb. Peptides 20, 373-378 (1999).
19. Cashion, M.F. & Banks, W.A., Bost, K.L., Kastin, A.J. Transmission routes of HIV-1 gp120 from brain to lymphoid tissues. Brain Res. 822, 26-33 (1999).
20. Banks, W.A., Goulet, M., Rushe, J.R., Niehoff, M.L. & Boismenu, R. Differential transport of a secretin analog across the blood-brain and blood-cerebrospinal fluid barriers of the mouse. J. Pharmacol. Exp. Therap. 302, 1062-1069 (2002).
21. Setlow, B. & McGaugh, J.L. D2 dopamine receptor blockade immediately post-training enhances retention in hidden and visible platform versions of the water maze. Learn. Mem. 7, 187-191 (2000).
22. Santucci, A.C., Schroeder, H. & Riccio, D.C. Homeostatic disruption and memory: effect of insulin administration in rats. Behav. Neurol. Biol. 53, 321-333 (1990).
23. Scrocchi, L.A. et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagons-like peptide 1 receptor gene. Nat. Med. 2, 1254-1258 (1996).
24. Young, D., Lawlor, P.A., Leone, P., Dragunow, M. & During, M.J. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat. Med. 5, 448-453 (1999).
25. Gozes, I. Neuroprotective peptide drug delivery and development: potential new therapeutics. Trends Neurosci. 24, 700-705 (2001).
26. Perry, T. et al. A novel neurotrophic property of glucagon-like pepide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J. Pharmacol. Exp. Ther. 300, 958-966 (2002).
27. Perry, T., Haughey, N.J., Mattson, M.P., Egan, J.M. & Greig, N.H. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J. Pharmacol. Exp. Ther. 302, 881-888 (2002).
28. Schmued, L. C. & Hopkins, K. J. Fluoro-jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874, 123-130 (2000).
29. Buteau, J., Roduit, R., Susini, S. & Prentki, M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 42, 856-864 (1999).
30. Holz, G.G., Leech, C.A. & Habener, J.F. Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J. Biol. Chem. 270, 17749-17757 (1995).
31. Zhou, J., Wang, X., Pineyro, M.A. & Egan, J.M. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 48, 2358-2366 (1999).
32. Perfetti, R., Zhou, J., Doyle, M.E. & Egan, J.M. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141, 4600-4605 (2000).
33. Weeber, E.J. & Sweatt, J.D. Molecular neurobiology of human cognition. Neuron 33, 845-848 (2002).
34. Ramanathan, M. & Jaiswal, A.K., Bhattacharya, S.K. Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats. Psychopharmacology (Berl.) 135, 361-367 (1998).
35. Kastin, A.J., Ackerstrom, V. & Pan, W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Mol. Neurosci. 18, 7-14 (2002).
36. Kern, W., Born, J., Schreiber, H. & Fehm, H.L. Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes 48, 557-563 (1999).
37. Chowen, J.A. et al. Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain. Neuropeptides 33, 212-215 (1999).
38. Patterson, S.L. et al. Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase. Neuron 32, 123-130 (2001).
39. Venable, N. & Kelly, P.H. Effects of NMDA receptor antagonists on passive avoidance learning and retrieval in rats and mice. Psychopharmacology 100, 215-221 (1990).
40. Racine, R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32, 281-294 (1972).