Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis

Neuroscience

Volumn 107, Issue 4, 2001, Pages 603-613

  Lichtenwalner, R J ^a   Forbes, M E ^a   Bennett, S A ^a   Lynch, C D ^a   Sonntag, W E ^a   Riddle, D R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Bromodeoxyuridine; Dentate gyrus; Differentiation; Neuronal proliferation; Rodent

Indexed keywords

BROXURIDINE; SOMATOMEDIN C;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LABELING; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; IMMUNOFLUORESCENCE; MALE; NERVE CELL DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; SENESCENCE;

AGING; ANIMALS; ANTIMETABOLITES; BROMODEOXYURIDINE; CELL DIFFERENTIATION; CELL DIVISION; COGNITION; DENTATE GYRUS; INJECTIONS, INTRAVENTRICULAR; INSULIN-LIKE GROWTH FACTOR I; MALE; RATS; RATS, INBRED BN; RATS, INBRED F344;

EID: 0035965708     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00378-5     Document Type: Article

References (71)

1. Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus
2. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
3. Effect of long term treatment with the dihydropyridine-type calcium channel blocker darodipine (PY 108-068) on the cerebral capillary network in aged rats
4. Insulin-like growth factor-I and central nervous system development
5. Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain
6. Role of insulin-like growth factors in embryonic and postnatal growth
7. Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons
8. Transient IGF-I gene expression during the maturation of functionally related central projection neurons
9. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
10. Insulin-related growth factors stimulate proliferation of retinal progenitors in the goldfish
11. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus
12. Regulation of neurogenesis by growth factors and neurotransmitters
13. Restoring production of hippocampal neurons in old age
14. Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway
15. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
16. Circulating insulin-like growth factor I mediates effects of exercise on the brain
17. Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus
18. Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors
19. Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
20. Neurogenesis in the adult human hippocampus
21. Insulin-like growth factors regulate neuronal differentiation and survival
22. Regulation of neuronal birth, migration and death in the rat dentate gyrus
23. Adrenal hormones suppress cell division in the adult rat dentate gyrus
24. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation
25. Hippocampal neurogenesis in adult old world primates
26. Stress and hippocampal neurogenesis
27. Selective expression of insulin-like growth factor II in the songbird brain
28. More hippocampal neurons in adult mice living in an enriched environment
29. Experience-induced neurogenesis in the senescent dentate gyrus
30. Aging-related changes in IGF-II and c-fos gene expression in the rat brain
31. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation
32. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain
33. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
34. Insulin-like growth factor-1 ameliorates age-related behavioral deficits
35. Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination
36. Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells
37. NeuN, a neuronal specific nuclear protein in vertebrates
38. Insulin-like growth factor receptors
39. Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner
40. Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory
41. Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development
42. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS
43. Vascular niche for adult hippocampal neurogenesis
44. Interactions of IGF-1 with the blood-brain barrier in vivo and in situ
45. Genes for insulin-like growth factors I and II are expressed in senescent rat tissues
46. Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses
47. Uptake of circulating insulin-like growth factors (IGFs) into cerebrospinal fluid appears to be independent of the IGF receptors as well as IGF-binding proteins
48. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
49. Memory impaired aged rats: No loss of principal hippocampal and subicular neurons
50. The nature and regulation of the receptors for insulin-like growth factors
51. Insulin-like growth factors cross the blood-brain barrier
52. Differential expression of insulin-like growth factor genes in rat central nervous system
53. The adrenocortical stress-response in the aged male rat: Impairment of recovery from stress
54. Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period
55. Age-related production of new granule cells in the adult dentate gyrus
56. Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats
57. Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1
58. Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats
59. Neurogenesis in the adult is involved in the formation of trace memories
60. Apoptotic cell death and caspase-3 activation induced by N-methyl-D-aspartate receptor antagonists and their prevention by insulin-like growth factor I
61. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat
62. In vivo neurogenesis is inhibited by neutralizing antibodies to basic fibroblast growth factor
63. Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory
64. Insulin-like growth factor-I modulation of cerebellar cell populations is developmentally stage-dependent and mediated by specific intracellular pathways
65. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus
66. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
67. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
68. Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor
69. Regionally specific loss of neurons in the aging human hippocampus
70. Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons