-
1
-
-
81955161844
-
DNA double-strand break repair pathways, chromosomal rearrangements and cancer
-
Kasparek TR, Humphrey TC. DNA double-strand break repair pathways, chromosomal rearrangements and cancer. Semin Cell Dev Biol 2011;22:886-97.
-
(2011)
Semin Cell Dev Biol
, vol.22
, pp. 886-897
-
-
Kasparek, T.R.1
Humphrey, T.C.2
-
2
-
-
36949005417
-
DNA damage signalling guards against activated oncogenes and tumour progression
-
Bartek J, Bartkova J, Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007;26:7773-9.
-
(2007)
Oncogene
, vol.26
, pp. 7773-7779
-
-
Bartek, J.1
Bartkova, J.2
Lukas, J.3
-
3
-
-
84859239896
-
DNA repair mechanisms protect our genome from carcinogenesis
-
Moraes MC, Neto JB, Menck CF. DNA repair mechanisms protect our genome from carcinogenesis. Front Biosci 2012;17:1362-88.
-
(2012)
Front Biosci
, vol.17
, pp. 1362-1388
-
-
Moraes, M.C.1
Neto, J.B.2
Menck, C.F.3
-
4
-
-
70349859881
-
DNA damage, aging, and cancer
-
Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med 2009;361:1475-85.
-
(2009)
N Engl J Med
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.1
-
5
-
-
0027278557
-
Instability and decay of the primary structure of DNA
-
Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993;362:709-15.
-
(1993)
Nature
, vol.362
, pp. 709-715
-
-
Lindahl, T.1
-
6
-
-
84864326787
-
DNA damage by reactive species: Mechanisms, mutation and repair
-
Jena NR. DNA damage by reactive species: Mechanisms, mutation and repair. J Biosci 2012;37:503-17.
-
(2012)
J Biosci
, vol.37
, pp. 503-517
-
-
Jena, N.R.1
-
7
-
-
79960055675
-
Metabolism: alcohol, DNA and disease
-
Joenje H. Metabolism: alcohol, DNA and disease. Nature 2011;475:45-6.
-
(2011)
Nature
, vol.475
, pp. 45-46
-
-
Joenje, H.1
-
8
-
-
33747188326
-
Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation
-
Keeney S, Neale MJ. Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation. Biochem Soc Trans 2006;34:523-5.
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 523-525
-
-
Keeney, S.1
Neale, M.J.2
-
9
-
-
0028453264
-
The mechanism of V(D)J recombination: site-specificity, reaction fidelity and immunologic diversity
-
Lieber MR, Chang CP, Gallo M, et al. The mechanism of V(D)J recombination: site-specificity, reaction fidelity and immunologic diversity. Semin Immunol 1994;6:143-53.
-
(1994)
Semin Immunol
, vol.6
, pp. 143-153
-
-
Lieber, M.R.1
Chang, C.P.2
Gallo, M.3
-
10
-
-
80755187806
-
Double-strand break end resection and repair pathway choice
-
Symington LS, Gautier J. Double-strand break end resection and repair pathway choice. Annu Rev Genet 2011;45:247-71.
-
(2011)
Annu Rev Genet
, vol.45
, pp. 247-271
-
-
Symington, L.S.1
Gautier, J.2
-
11
-
-
84876016461
-
Mammalian Base Excision Repair: the Forgotten Archangel
-
Dianov GL, Hübscher U. Mammalian Base Excision Repair: the Forgotten Archangel. Nucleic Acids Res 2013;41:3483-90.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 3483-3490
-
-
Dianov, G.L.1
Hübscher, U.2
-
13
-
-
84872578210
-
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
-
Kottemann MC, Smogorzewska A. Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature 2013;493:356-63.
-
(2013)
Nature
, vol.493
, pp. 356-363
-
-
Kottemann, M.C.1
Smogorzewska, A.2
-
14
-
-
78649336706
-
The DNA damage response: making it safe to play with knives
-
Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010;40:179-204.
-
(2010)
Mol Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
15
-
-
58249109379
-
DNA damage tolerance: when it's OK to make mistakes
-
Chang DJ, Cimprich KA. DNA damage tolerance: when it's OK to make mistakes. Nat Chem Biol 2009;5:82-90.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 82-90
-
-
Chang, D.J.1
Cimprich, K.A.2
-
16
-
-
84877925540
-
The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability
-
Sharma S, Helchowski CM, Canman CE. The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability. Mutat Res 2013;743-744:97-110.
-
(2013)
Mutat Res
, vol.743-744
, pp. 97-110
-
-
Sharma, S.1
Helchowski, C.M.2
Canman, C.E.3
-
17
-
-
0034641724
-
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
-
Matsuoka S, Rotman G, Ogawa A, et al. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A 2000;97:10389-94.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10389-10394
-
-
Matsuoka, S.1
Rotman, G.2
Ogawa, A.3
-
18
-
-
0036500690
-
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
-
Yazdi PT, Wang Y, Zhao S, et al. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 2002;16:571-82.
-
(2002)
Genes Dev
, vol.16
, pp. 571-582
-
-
Yazdi, P.T.1
Wang, Y.2
Zhao, S.3
-
19
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel T, Lerenthal Y, Moyal L, et al. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 2003;22:5612-21.
-
(2003)
EMBO J
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
-
20
-
-
0035834693
-
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
-
Burma S, Chen BP, Murphy M, et al. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001;276:42462-7.
-
(2001)
J Biol Chem
, vol.276
, pp. 42462-42467
-
-
Burma, S.1
Chen, B.P.2
Murphy, M.3
-
21
-
-
77958498222
-
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
-
Smith J, Tho LM, Xu N, et al. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res 2010;108:73-112.
-
(2010)
Adv Cancer Res
, vol.108
, pp. 73-112
-
-
Smith, J.1
Tho, L.M.2
Xu, N.3
-
22
-
-
48249095920
-
Single-strand break repair and genetic disease
-
Caldecott KW. Single-strand break repair and genetic disease. Nat Rev Genet 2008;9:619-31.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 619-631
-
-
Caldecott, K.W.1
-
23
-
-
34548183836
-
PolyADP-ribosylation and cancer
-
Miwa M, Masutani M. PolyADP-ribosylation and cancer. Cancer Sci 2007;98:1528-35.
-
(2007)
Cancer Sci
, vol.98
, pp. 1528-1535
-
-
Miwa, M.1
Masutani, M.2
-
25
-
-
84857891632
-
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
-
Luo X, Kraus WL. On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes Dev 2012;26:417-32.
-
(2012)
Genes Dev
, vol.26
, pp. 417-432
-
-
Luo, X.1
Kraus, W.L.2
-
26
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun TS, Pacek M, Yee MC, et al. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev 2005;19:1040-52.
-
(2005)
Genes Dev
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
-
27
-
-
84863347829
-
Replication fork dynamics and the DNA damage response
-
Jones RM, Petermann E. Replication fork dynamics and the DNA damage response. Biochem J 2012;443:13-26.
-
(2012)
Biochem J
, vol.443
, pp. 13-26
-
-
Jones, R.M.1
Petermann, E.2
-
28
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003;300:1542-8.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
29
-
-
79960467426
-
ATR autophosphorylation as a molecular switch for checkpoint activation
-
Liu S, Shiotani B, Lahiri M, et al. ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell 2011;43:192-202.
-
(2011)
Mol Cell
, vol.43
, pp. 192-202
-
-
Liu, S.1
Shiotani, B.2
Lahiri, M.3
-
30
-
-
0036134979
-
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival
-
Yamane K, Wu X, Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 2002;22:555-66.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 555-566
-
-
Yamane, K.1
Wu, X.2
Chen, J.3
-
31
-
-
28544450740
-
Human TopBP1 ensures genome integrity during normal S phase
-
Kim JE, McAvoy SA, Smith DI, et al. Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol 2005;25:10907-15.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10907-10915
-
-
Kim, J.E.1
McAvoy, S.A.2
Smith, D.I.3
-
32
-
-
33644757806
-
TopBP1 activates the ATR-ATRIP complex
-
Kumagai A, Lee J, Yoo HY, et al. TopBP1 activates the ATR-ATRIP complex. Cell 2006;124:943-55.
-
(2006)
Cell
, vol.124
, pp. 943-955
-
-
Kumagai, A.1
Lee, J.2
Yoo, H.Y.3
-
33
-
-
0037080675
-
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
-
Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev 2002;16:198-208.
-
(2002)
Genes Dev
, vol.16
, pp. 198-208
-
-
Zou, L.1
Cortez, D.2
Elledge, S.J.3
-
34
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 2001;276:47759-62.
-
(2001)
J Biol Chem
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
35
-
-
79955516080
-
MDC1 collaborates with TopBP1 in DNA replication checkpoint control
-
Wang J, Gong Z, Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol 2011;193:267-73.
-
(2011)
J Cell Biol
, vol.193
, pp. 267-273
-
-
Wang, J.1
Gong, Z.2
Chen, J.3
-
36
-
-
75949092280
-
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control
-
Gong Z, Kim JE, Leung CC, et al. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell 2010;37:438-46.
-
(2010)
Mol Cell
, vol.37
, pp. 438-446
-
-
Gong, Z.1
Kim, J.E.2
Leung, C.C.3
-
37
-
-
64049105391
-
TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks
-
Yan S, Michael WM. TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks. J Cell Biol 2009;184:793-804.
-
(2009)
J Cell Biol
, vol.184
, pp. 793-804
-
-
Yan, S.1
Michael, W.M.2
-
38
-
-
0345564858
-
Replication protein A-mediated recruitment and activation of Rad17 complexes
-
Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A 2003;100:13827-32.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 13827-13832
-
-
Zou, L.1
Liu, D.2
Elledge, S.J.3
-
39
-
-
4243156107
-
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA
-
Ellison V, Stillman B. Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol 2003;1:E33.
-
(2003)
PLoS Biol
, vol.1
, pp. E33
-
-
Ellison, V.1
Stillman, B.2
-
40
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix S, Wagner JM, Kobayashi M, et al. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev 2007;21:1472-7.
-
(2007)
Genes Dev
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
-
41
-
-
77949467495
-
Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks
-
Lee J, Dunphy WG. Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks. Mol Biol Cell 2010;21:926-35.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 926-935
-
-
Lee, J.1
Dunphy, W.G.2
-
42
-
-
44849093460
-
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
-
Mordes DA, Glick GG, Zhao R, et al. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev 2008;22:1478-89.
-
(2008)
Genes Dev
, vol.22
, pp. 1478-1489
-
-
Mordes, D.A.1
Glick, G.G.2
Zhao, R.3
-
43
-
-
0030479885
-
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
-
Brush GS, Morrow DM, Hieter P, et al. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. Proc Natl Acad Sci U S A 1996;93:15075-80.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 15075-15080
-
-
Brush, G.S.1
Morrow, D.M.2
Hieter, P.3
-
44
-
-
33746948393
-
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
-
Liu S, Bekker-Jensen S, Mailand N, et al. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol 2006;26:6056-64.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6056-6064
-
-
Liu, S.1
Bekker-Jensen, S.2
Mailand, N.3
-
45
-
-
2342618116
-
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21
-
Block WD, Yu Y, Lees-Miller SP. Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Res 2004;32:997-1005.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 997-1005
-
-
Block, W.D.1
Yu, Y.2
Lees-Miller, S.P.3
-
46
-
-
0034312277
-
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
-
Guo Z, Kumagai A, Wang SX, et al. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 2000;14:2745-56.
-
(2000)
Genes Dev
, vol.14
, pp. 2745-2756
-
-
Guo, Z.1
Kumagai, A.2
Wang, S.X.3
-
47
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
Liu Q, Guntuku S, Cui XS, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000;14:1448-59.
-
(2000)
Genes Dev
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
-
48
-
-
33751419716
-
Surviving the breakup: the DNA damage checkpoint
-
Harrison JC, Haber JE. Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet 2006;40:209-35.
-
(2006)
Annu Rev Genet
, vol.40
, pp. 209-235
-
-
Harrison, J.C.1
Haber, J.E.2
-
49
-
-
33846327177
-
Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors
-
Gotter AL, Suppa C, Emanuel BS. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. J Mol Biol 2007;366:36-52.
-
(2007)
J Mol Biol
, vol.366
, pp. 36-52
-
-
Gotter, A.L.1
Suppa, C.2
Emanuel, B.S.3
-
50
-
-
14744299899
-
Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex
-
Nedelcheva MN, Roguev A, Dolapchiev LB, et al. Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex. J Mol Biol 2005;347:509-21.
-
(2005)
J Mol Biol
, vol.347
, pp. 509-521
-
-
Nedelcheva, M.N.1
Roguev, A.2
Dolapchiev, L.B.3
-
51
-
-
33845320139
-
Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function
-
Chou DM, Elledge SJ. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc Natl Acad Sci U S A 2006;103:18143-7.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 18143-18147
-
-
Chou, D.M.1
Elledge, S.J.2
-
52
-
-
34047261441
-
Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint
-
Yoshizawa-Sugata N, Masai H. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J Biol Chem 2007;282:2729-40.
-
(2007)
J Biol Chem
, vol.282
, pp. 2729-2740
-
-
Yoshizawa-Sugata, N.1
Masai, H.2
-
53
-
-
34147201111
-
The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement
-
Unsal-Kaçmaz K, Chastain PD, Qu PP, et al. The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol 2007;27:3131-42.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3131-3142
-
-
Unsal-Kaçmaz, K.1
Chastain, P.D.2
Qu, P.P.3
-
54
-
-
70449707748
-
Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis
-
Smith KD, Fu MA, Brown EJ. Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J Cell Biol 2009;187:15-23.
-
(2009)
J Cell Biol
, vol.187
, pp. 15-23
-
-
Smith, K.D.1
Fu, M.A.2
Brown, E.J.3
-
55
-
-
35448949105
-
Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts
-
Errico A, Costanzo V, Hunt T. Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci U S A 2007;104:14929-34.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 14929-14934
-
-
Errico, A.1
Costanzo, V.2
Hunt, T.3
-
56
-
-
34547134725
-
Circadian proteins in the regulation of cell cycle and genotoxic stress responses
-
Kondratov RV, Antoch MP. Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol 2007;17:311-7.
-
(2007)
Trends Cell Biol
, vol.17
, pp. 311-317
-
-
Kondratov, R.V.1
Antoch, M.P.2
-
57
-
-
77952764443
-
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress
-
Kemp MG, Akan Z, Yilmaz S, et al. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem 2010;285:16562-71.
-
(2010)
J Biol Chem
, vol.285
, pp. 16562-16571
-
-
Kemp, M.G.1
Akan, Z.2
Yilmaz, S.3
-
58
-
-
0043032435
-
Human claspin is required for replication checkpoint control
-
Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem 2003;278:30057-62.
-
(2003)
J Biol Chem
, vol.278
, pp. 30057-30062
-
-
Chini, C.C.1
Chen, J.2
-
59
-
-
0037291130
-
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17
-
Lee J, Kumagai A, Dunphy WG. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell 2003;11:329-40.
-
(2003)
Mol Cell
, vol.11
, pp. 329-340
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
60
-
-
0344443718
-
Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation
-
Jeong SY, Kumagai A, Lee J, et al. Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation. J Biol Chem 2003;278:46782-8.
-
(2003)
J Biol Chem
, vol.278
, pp. 46782-46788
-
-
Jeong, S.Y.1
Kumagai, A.2
Lee, J.3
-
61
-
-
67649253108
-
Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity
-
Walker M, Black EJ, Oehler V, et al. Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity. Oncogene 2009;28:2314-23.
-
(2009)
Oncogene
, vol.28
, pp. 2314-2323
-
-
Walker, M.1
Black, E.J.2
Oehler, V.3
-
62
-
-
34147206546
-
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
-
Niida H, Katsuno Y, Banerjee B, et al. Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol 2007;27:2572-81.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 2572-2581
-
-
Niida, H.1
Katsuno, Y.2
Banerjee, B.3
-
63
-
-
30944435598
-
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
-
Smits VA, Reaper PM, Jackson SP. Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr Biol 2006;16:150-9.
-
(2006)
Curr Biol
, vol.16
, pp. 150-159
-
-
Smits, V.A.1
Reaper, P.M.2
Jackson, S.P.3
-
64
-
-
0035545996
-
Mammalian G1-and S-phase checkpoints in response to DNA damage
-
Bartek J, Lukas J. Mammalian G1-and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol 2001;13:738-47.
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 738-747
-
-
Bartek, J.1
Lukas, J.2
-
65
-
-
60749109846
-
Cell cycle, CDKs and cancer: a changing paradigm
-
Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009;9:153-66.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
66
-
-
84855908936
-
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
-
Sørensen CS, Syljuasen RG. Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res 2012;40:477-86.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 477-486
-
-
Sørensen, C.S.1
Syljuasen, R.G.2
-
67
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003;3:421-9.
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
68
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004;432:316-23.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
69
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000;14:397-402.
-
(2000)
Genes Dev
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
70
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
-
Takai H, Tominaga K, Motoyama N, et al. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 2000;14:1439-47.
-
(2000)
Genes Dev
, vol.14
, pp. 1439-1447
-
-
Takai, H.1
Tominaga, K.2
Motoyama, N.3
-
71
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Xu Y, Ashley T, Brainerd EE, et al. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 1996;10:2411-22.
-
(1996)
Genes Dev
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
-
72
-
-
0038054343
-
The Chk2 tumor suppressor is not required for p53 responses in human cancer cells
-
Jallepalli PV, Lengauer C, Vogelstein B, et al. The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J Biol Chem 2003;278:20475-9.
-
(2003)
J Biol Chem
, vol.278
, pp. 20475-20479
-
-
Jallepalli, P.V.1
Lengauer, C.2
Vogelstein, B.3
-
73
-
-
0037415735
-
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
-
Zachos G, Rainey MD, Gillespie DA. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J 2003;22:713-23.
-
(2003)
EMBO J
, vol.22
, pp. 713-723
-
-
Zachos, G.1
Rainey, M.D.2
Gillespie, D.A.3
-
74
-
-
70350118815
-
The annealing helicase HARP protects stalled replication forks
-
Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes Dev 2009;23:2394-9.
-
(2009)
Genes Dev
, vol.23
, pp. 2394-2399
-
-
Yuan, J.1
Ghosal, G.2
Chen, J.3
-
75
-
-
70350111290
-
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
-
Bansbach CE, Betous R, Lovejoy CA, et al. The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev 2009;23:2405-14.
-
(2009)
Genes Dev
, vol.23
, pp. 2405-2414
-
-
Bansbach, C.E.1
Betous, R.2
Lovejoy, C.A.3
-
76
-
-
70350103969
-
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA
-
Yusufzai T, Kong X, Yokomori K, et al. The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA. Genes Dev 2009;23:2400-4.
-
(2009)
Genes Dev
, vol.23
, pp. 2400-2404
-
-
Yusufzai, T.1
Kong, X.2
Yokomori, K.3
-
77
-
-
70350088521
-
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart
-
Ciccia A, Bredemeyer AL, Sowa ME, et al. The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev 2009;23:2415-25.
-
(2009)
Genes Dev
, vol.23
, pp. 2415-2425
-
-
Ciccia, A.1
Bredemeyer, A.L.2
Sowa, M.E.3
-
78
-
-
72149132821
-
Identification of SMARCAL1 as a component of the DNA damage response
-
Postow L, Woo EM, Chait BT, et al. Identification of SMARCAL1 as a component of the DNA damage response. J Biol Chem 2009;284:35951-61.
-
(2009)
J Biol Chem
, vol.284
, pp. 35951-35961
-
-
Postow, L.1
Woo, E.M.2
Chait, B.T.3
-
79
-
-
79957996057
-
The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1
-
Ghosal G, Yuan J, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep 2011;12:574-80.
-
(2011)
EMBO Rep
, vol.12
, pp. 574-580
-
-
Ghosal, G.1
Yuan, J.2
Chen, J.3
-
80
-
-
84864923437
-
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress
-
Yuan J, Ghosal G, Chen J. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell 2012;47:410-21.
-
(2012)
Mol Cell
, vol.47
, pp. 410-421
-
-
Yuan, J.1
Ghosal, G.2
Chen, J.3
-
81
-
-
84864014165
-
ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response
-
Weston R, Peeters H, Ahel D. ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. Genes Dev 2012;26:1558-72.
-
(2012)
Genes Dev
, vol.26
, pp. 1558-1572
-
-
Weston, R.1
Peeters, H.2
Ahel, D.3
-
82
-
-
84864946159
-
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress
-
Ciccia A, Nimonkar AV, Hu Y, et al. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell 2012;47:396-409.
-
(2012)
Mol Cell
, vol.47
, pp. 396-409
-
-
Ciccia, A.1
Nimonkar, A.V.2
Hu, Y.3
-
83
-
-
43049162175
-
RecQ helicases: guardian angels of the DNA replication fork
-
Bachrati CZ, Hickson ID. RecQ helicases: guardian angels of the DNA replication fork. Chromosoma 2008;117:219-33.
-
(2008)
Chromosoma
, vol.117
, pp. 219-233
-
-
Bachrati, C.Z.1
Hickson, I.D.2
-
84
-
-
77149123028
-
FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling
-
Luke-Glaser S, Luke B, Grossi S, et al. FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling. EMBO J 2010;29:795-805.
-
(2010)
EMBO J
, vol.29
, pp. 795-805
-
-
Luke-Glaser, S.1
Luke, B.2
Grossi, S.3
-
85
-
-
77049127484
-
Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance
-
Unk I, Hajdu I, Blastyak A, et al. Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance. DNA Repair (Amst) 2010;9:257-67.
-
(2010)
DNA Repair (Amst)
, vol.9
, pp. 257-267
-
-
Unk, I.1
Hajdu, I.2
Blastyak, A.3
-
86
-
-
67649862225
-
Replication fork reversal and the maintenance of genome stability
-
Atkinson J, McGlynn P. Replication fork reversal and the maintenance of genome stability. Nucleic Acids Res 2009;37:3475-92.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 3475-3492
-
-
Atkinson, J.1
McGlynn, P.2
-
87
-
-
35148847451
-
Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression
-
Blastyák A, Pinter L, Unk I, et al. Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression. Mol Cell 2007;28:167-75.
-
(2007)
Mol Cell
, vol.28
, pp. 167-175
-
-
Blastyák, A.1
Pinter, L.2
Unk, I.3
-
88
-
-
77649165394
-
Maintaining genome stability at the replication fork
-
Branzei D, Foiani M. Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol 2010;11:208-19.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 208-219
-
-
Branzei, D.1
Foiani, M.2
-
89
-
-
53449085954
-
PCNA modifications for regulation of post-replication repair pathways
-
Lee KY, Myung K. PCNA modifications for regulation of post-replication repair pathways. Mol Cells 2008;26:5-11.
-
(2008)
Mol Cells
, vol.26
, pp. 5-11
-
-
Lee, K.Y.1
Myung, K.2
-
93
-
-
0033548231
-
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta
-
Johnson RE, Prakash S, Prakash L. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science 1999;283:1001-4.
-
(1999)
Science
, vol.283
, pp. 1001-1004
-
-
Johnson, R.E.1
Prakash, S.2
Prakash, L.3
-
94
-
-
0037180343
-
Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene
-
Ogi T, Shinkai Y, Tanaka K, et al. Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene. Proc Natl Acad Sci U S A 2002;99:15548-53.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15548-15553
-
-
Ogi, T.1
Shinkai, Y.2
Tanaka, K.3
-
95
-
-
0034738983
-
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions
-
Johnson RE, Washington MT, Haracska L, et al. Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Nature 2000;406:1015-9.
-
(2000)
Nature
, vol.406
, pp. 1015-1019
-
-
Johnson, R.E.1
Washington, M.T.2
Haracska, L.3
-
96
-
-
21244506437
-
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function
-
Prakash S, Johnson RE, Prakash L. Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem 2005;74:317-53.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 317-353
-
-
Prakash, S.1
Johnson, R.E.2
Prakash, L.3
-
97
-
-
63849131910
-
Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance
-
Waters LS, Minesinger BK, Wiltrout ME, et al. Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiol Mol Biol Rev 2009;73:134-54.
-
(2009)
Microbiol Mol Biol Rev
, vol.73
, pp. 134-154
-
-
Waters, L.S.1
Minesinger, B.K.2
Wiltrout, M.E.3
-
98
-
-
63049106529
-
Regulating post-translational modifications of the eukaryotic replication clamp PCNA
-
Ulrich HD. Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair (Amst) 2009;8:461-9.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 461-469
-
-
Ulrich, H.D.1
-
99
-
-
0037068455
-
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
-
Hoege C, Pfander B, Moldovan GL, et al. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 2002;419:135-41.
-
(2002)
Nature
, vol.419
, pp. 135-141
-
-
Hoege, C.1
Pfander, B.2
Moldovan, G.L.3
-
100
-
-
0141831006
-
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation
-
Stelter P, Ulrich HD. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature 2003;425:188-91.
-
(2003)
Nature
, vol.425
, pp. 188-191
-
-
Stelter, P.1
Ulrich, H.D.2
-
101
-
-
29144499065
-
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
-
Bienko M, Green CM, Crosetto N, et al. Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 2005;310:1821-4.
-
(2005)
Science
, vol.310
, pp. 1821-1824
-
-
Bienko, M.1
Green, C.M.2
Crosetto, N.3
-
102
-
-
13944256948
-
Ubiquitination of PCNA and the polymerase switch in human cells
-
Kannouche PL, Lehmann AR. Ubiquitination of PCNA and the polymerase switch in human cells. Cell Cycle 2004;3:1011-3.
-
(2004)
Cell Cycle
, vol.3
, pp. 1011-1013
-
-
Kannouche, P.L.1
Lehmann, A.R.2
-
103
-
-
18744413609
-
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells
-
Kannouche P, Fernandez de Henestrosa AR, Coull B, et al. Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO J 2002;21:6246-56.
-
(2002)
EMBO J
, vol.21
, pp. 6246-6256
-
-
Kannouche, P.1
Fernandez de Henestrosa, A.R.2
Coull, B.3
-
104
-
-
77953694683
-
Ubiquitin-dependent DNA damage bypass is separable from genome replication
-
Daigaku Y, Davies AA, Ulrich HD. Ubiquitin-dependent DNA damage bypass is separable from genome replication. Nature 2010;465:951-5.
-
(2010)
Nature
, vol.465
, pp. 951-955
-
-
Daigaku, Y.1
Davies, A.A.2
Ulrich, H.D.3
-
105
-
-
77951699996
-
The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase
-
Karras GI, Jentsch S. The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase. Cell 2010;141:255-67.
-
(2010)
Cell
, vol.141
, pp. 255-267
-
-
Karras, G.I.1
Jentsch, S.2
-
106
-
-
0035833662
-
DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae
-
Broomfield S, Hryciw T, Xiao W. DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae. Mutat Res 2001;486:167-84.
-
(2001)
Mutat Res
, vol.486
, pp. 167-184
-
-
Broomfield, S.1
Hryciw, T.2
Xiao, W.3
-
107
-
-
6344288785
-
Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination
-
Watanabe K, Tateishi S, Kawasuji M, et al. Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J 2004;23:3886-96.
-
(2004)
EMBO J
, vol.23
, pp. 3886-3896
-
-
Watanabe, K.1
Tateishi, S.2
Kawasuji, M.3
-
108
-
-
50449092205
-
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
-
Motegi A, Liaw HJ, Lee KY, et al. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A 2008;105:12411-6.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 12411-12416
-
-
Motegi, A.1
Liaw, H.J.2
Lee, K.Y.3
-
109
-
-
84869044878
-
En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs
-
Masuda Y, Suzuki M, Kawai H, et al. En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs. Nucleic Acids Res 2012;40:10394-407.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 10394-10407
-
-
Masuda, Y.1
Suzuki, M.2
Kawai, H.3
-
110
-
-
40649097306
-
Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a
-
Davies AA, Huttner D, Daigaku Y, et al. Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a. Mol Cell 2008;29:625-36.
-
(2008)
Mol Cell
, vol.29
, pp. 625-636
-
-
Davies, A.A.1
Huttner, D.2
Daigaku, Y.3
-
111
-
-
33845959940
-
Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities
-
Chang DJ, Lupardus PJ, Cimprich KA. Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities. J Biol Chem 2006;281:32081-8.
-
(2006)
J Biol Chem
, vol.281
, pp. 32081-32088
-
-
Chang, D.J.1
Lupardus, P.J.2
Cimprich, K.A.3
-
112
-
-
43249094413
-
Chk1 and Claspin potentiate PCNA ubiquitination
-
Yang XH, Shiotani B, Classon M, et al. Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev 2008;22:1147-52.
-
(2008)
Genes Dev
, vol.22
, pp. 1147-1152
-
-
Yang, X.H.1
Shiotani, B.2
Classon, M.3
-
113
-
-
55849091416
-
Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells
-
Niimi A, Brown S, Sabbioneda S, et al. Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells. Proc Natl Acad Sci U S A 2008;105:16125-30.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16125-16130
-
-
Niimi, A.1
Brown, S.2
Sabbioneda, S.3
-
114
-
-
38049123477
-
Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA
-
Andersen PL, Xu F, Xiao W. Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA. Cell Res 2008;18:162-73.
-
(2008)
Cell Res
, vol.18
, pp. 162-173
-
-
Andersen, P.L.1
Xu, F.2
Xiao, W.3
-
115
-
-
79957690359
-
ATR signalling: more than meeting at the fork
-
Nam EA, Cortez D. ATR signalling: more than meeting at the fork. Biochem J 2011;436:527-36.
-
(2011)
Biochem J
, vol.436
, pp. 527-536
-
-
Nam, E.A.1
Cortez, D.2
-
116
-
-
34247251276
-
Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response
-
Zou L. Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev 2007;21:879-85.
-
(2007)
Genes Dev
, vol.21
, pp. 879-885
-
-
Zou, L.1
-
117
-
-
34249066085
-
PCNA, the maestro of the replication fork
-
Moldovan GL, Pfander B, Jentsch S. PCNA, the maestro of the replication fork. Cell 2007;129:665-79.
-
(2007)
Cell
, vol.129
, pp. 665-679
-
-
Moldovan, G.L.1
Pfander, B.2
Jentsch, S.3
-
118
-
-
33645008019
-
ATR homolog Mec1 controls association of DNA polymerase zeta-Rev1 complex with regions near a double-strand break
-
Hirano Y, Sugimoto K. ATR homolog Mec1 controls association of DNA polymerase zeta-Rev1 complex with regions near a double-strand break. Curr Biol 2006;16:586-90.
-
(2006)
Curr Biol
, vol.16
, pp. 586-590
-
-
Hirano, Y.1
Sugimoto, K.2
-
119
-
-
0037224965
-
Checkpoint activation regulates mutagenic translesion synthesis
-
Kai M, Wang TS. Checkpoint activation regulates mutagenic translesion synthesis. Genes Dev 2003;17:64-76.
-
(2003)
Genes Dev
, vol.17
, pp. 64-76
-
-
Kai, M.1
Wang, T.S.2
-
120
-
-
33746162368
-
REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo
-
Guo C, Sonoda E, Tang TS, et al. REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. Mol Cell 2006;23:265-71.
-
(2006)
Mol Cell
, vol.23
, pp. 265-271
-
-
Guo, C.1
Sonoda, E.2
Tang, T.S.3
-
121
-
-
2442417331
-
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage
-
Kannouche PL, Wing J, Lehmann AR. Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell 2004;14:491-500.
-
(2004)
Mol Cell
, vol.14
, pp. 491-500
-
-
Kannouche, P.L.1
Wing, J.2
Lehmann, A.R.3
-
122
-
-
1942439667
-
Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases
-
Plosky BS, Woodgate R. Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases. Curr Opin Genet Dev 2004;14:113-9.
-
(2004)
Curr Opin Genet Dev
, vol.14
, pp. 113-119
-
-
Plosky, B.S.1
Woodgate, R.2
-
123
-
-
33845223494
-
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage
-
Guo C, Tang TS, Bienko M, et al. Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol 2006;26:8892-900.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8892-8900
-
-
Guo, C.1
Tang, T.S.2
Bienko, M.3
-
124
-
-
19444383801
-
Trading places: how do DNA polymerases switch during translesion DNA synthesis?
-
Friedberg EC, Lehmann AR, Fuchs RP. Trading places: how do DNA polymerases switch during translesion DNA synthesis? Mol Cell 2005;18:499-505.
-
(2005)
Mol Cell
, vol.18
, pp. 499-505
-
-
Friedberg, E.C.1
Lehmann, A.R.2
Fuchs, R.P.3
-
125
-
-
34548425656
-
Interplay among replicative and specialized DNA polymerases determines failure or success of translesion synthesis pathways
-
Fujii S, Fuchs RP. Interplay among replicative and specialized DNA polymerases determines failure or success of translesion synthesis pathways. J Mol Biol 2007;372:883-93.
-
(2007)
J Mol Biol
, vol.372
, pp. 883-893
-
-
Fujii, S.1
Fuchs, R.P.2
-
126
-
-
84861986798
-
Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response
-
Centore RC, Yazinski SA, Tse A, et al. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. Mol Cell 2012;46:625-35.
-
(2012)
Mol Cell
, vol.46
, pp. 625-635
-
-
Centore, R.C.1
Yazinski, S.A.2
Tse, A.3
-
127
-
-
84866745325
-
Spartan/C1orf124 is important to prevent UV-induced mutagenesis
-
Machida Y, Kim MS, Machida YJ. Spartan/C1orf124 is important to prevent UV-induced mutagenesis. Cell Cycle 2012;11:3395-402.
-
(2012)
Cell Cycle
, vol.11
, pp. 3395-3402
-
-
Machida, Y.1
Kim, M.S.2
Machida, Y.J.3
-
128
-
-
84867278911
-
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis
-
Ghosal G, Leung JW, Nair BC, et al. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem 2012;287:34225-33.
-
(2012)
J Biol Chem
, vol.287
, pp. 34225-34233
-
-
Ghosal, G.1
Leung, J.W.2
Nair, B.C.3
-
129
-
-
84870612586
-
Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance
-
Juhasz S, Balogh D, Hajdu I, et al. Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance. Nucleic Acids Res 2012;40:10795-808.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 10795-10808
-
-
Juhasz, S.1
Balogh, D.2
Hajdu, I.3
-
130
-
-
84869086918
-
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
-
Mosbech A, Gibbs-Seymour I, Kagias K, et al. DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nat Struct Mol Biol 2012;19:1084-92.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 1084-1092
-
-
Mosbech, A.1
Gibbs-Seymour, I.2
Kagias, K.3
-
131
-
-
84869093163
-
DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage
-
Davis EJ, Lachaud C, Appleton P, et al. DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. Nat Struct Mol Biol 2012;19:1093-100.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 1093-1100
-
-
Davis, E.J.1
Lachaud, C.2
Appleton, P.3
-
132
-
-
84873651128
-
Regulation of error-prone translesion synthesis by Spartan/C1orf124
-
Kim MS, Machida Y, Vashisht AA, et al. Regulation of error-prone translesion synthesis by Spartan/C1orf124. Nucleic Acids Res 2013;41:1661-8.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 1661-1668
-
-
Kim, M.S.1
Machida, Y.2
Vashisht, A.A.3
-
133
-
-
84867101049
-
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
-
Povlsen LK, Beli P, Wagner SA, et al. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat Cell Biol 2012;14:1089-98.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 1089-1098
-
-
Povlsen, L.K.1
Beli, P.2
Wagner, S.A.3
-
134
-
-
33646051551
-
Reversible monoubiquitination of PCNA: A novel slant on regulating translesion DNA synthesis
-
Friedberg EC. Reversible monoubiquitination of PCNA: A novel slant on regulating translesion DNA synthesis. Mol Cell 2006;22:150-2.
-
(2006)
Mol Cell
, vol.22
, pp. 150-152
-
-
Friedberg, E.C.1
-
135
-
-
0036124453
-
Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage
-
Van Sloun PP, Varlet I, Sonneveld E, et al. Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage. Mol Cell Biol 2002;22:2159-69.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2159-2169
-
-
Van Sloun, P.P.1
Varlet, I.2
Sonneveld, E.3
-
136
-
-
76749108600
-
Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links
-
Hicks JK, Chute CL, Paulsen MT, et al. Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol 2010;30:1217-30.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 1217-1230
-
-
Hicks, J.K.1
Chute, C.L.2
Paulsen, M.T.3
-
137
-
-
84863393545
-
REV1 and polymerase zeta facilitate homologous recombination repair
-
Sharma S, Hicks JK, Chute CL, et al. REV1 and polymerase zeta facilitate homologous recombination repair. Nucleic Acids Res 2012;40:682-91.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 682-691
-
-
Sharma, S.1
Hicks, J.K.2
Chute, C.L.3
-
138
-
-
21744447035
-
Multiple roles of vertebrate REV genes in DNA repair and recombination
-
Okada T, Sonoda E, Yoshimura M, et al. Multiple roles of vertebrate REV genes in DNA repair and recombination. Mol Cell Biol 2005;25:6103-11.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6103-6111
-
-
Okada, T.1
Sonoda, E.2
Yoshimura, M.3
-
139
-
-
7444233763
-
DNA polymerase zeta regulates cisplatin cytotoxicity, mutagenicity, and the rate of development of cisplatin resistance
-
Wu F, Lin X, Okuda T, et al. DNA polymerase zeta regulates cisplatin cytotoxicity, mutagenicity, and the rate of development of cisplatin resistance. Cancer Res 2004;64:8029-35.
-
(2004)
Cancer Res
, vol.64
, pp. 8029-8035
-
-
Wu, F.1
Lin, X.2
Okuda, T.3
-
140
-
-
70349317006
-
The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs
-
Roos WP, Tsaalbi-Shtylik A, Tsaryk R, et al. The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs. Mol Pharmacol 2009;76:927-34.
-
(2009)
Mol Pharmacol
, vol.76
, pp. 927-934
-
-
Roos, W.P.1
Tsaalbi-Shtylik, A.2
Tsaryk, R.3
-
141
-
-
84861434605
-
DNA polymerase zeta is a major determinant of resistance to platinum-based chemotherapeutic agents
-
Sharma S, Shah NA, Joiner AM, et al. DNA polymerase zeta is a major determinant of resistance to platinum-based chemotherapeutic agents. Mol Pharmacol 2012;81:778-87.
-
(2012)
Mol Pharmacol
, vol.81
, pp. 778-787
-
-
Sharma, S.1
Shah, N.A.2
Joiner, A.M.3
-
142
-
-
84863670930
-
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
-
Kim H, D'Andrea AD. Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 2012;26:1393-408.
-
(2012)
Genes Dev
, vol.26
, pp. 1393-1408
-
-
Kim, H.1
D'Andrea, A.D.2
-
143
-
-
0141484612
-
A novel ubiquitin ligase is deficient in Fanconi anemia
-
Meetei AR, de Winter JP, Medhurst AL, et al. A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet 2003;35:165-70.
-
(2003)
Nat Genet
, vol.35
, pp. 165-170
-
-
Meetei, A.R.1
de Winter, J.P.2
Medhurst, A.L.3
-
144
-
-
77954274685
-
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2
-
MacKay C, Declais AC, Lundin C, et al. Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell 2010;142:65-76.
-
(2010)
Cell
, vol.142
, pp. 65-76
-
-
MacKay, C.1
Declais, A.C.2
Lundin, C.3
-
145
-
-
77954279611
-
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents
-
Kratz K, Schopf B, Kaden S, et al. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell 2010;142:77-88.
-
(2010)
Cell
, vol.142
, pp. 77-88
-
-
Kratz, K.1
Schopf, B.2
Kaden, S.3
-
146
-
-
77955290719
-
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair
-
Liu T, Ghosal G, Yuan J, et al. FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science 2010;329:693-6.
-
(2010)
Science
, vol.329
, pp. 693-696
-
-
Liu, T.1
Ghosal, G.2
Yuan, J.3
-
147
-
-
77954286076
-
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair
-
Smogorzewska A, Desetty R, Saito TT, et al. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell 2010;39:36-47.
-
(2010)
Mol Cell
, vol.39
, pp. 36-47
-
-
Smogorzewska, A.1
Desetty, R.2
Saito, T.T.3
-
148
-
-
0032478718
-
DNA structural elements required for ERCC1-XPF endonuclease activity
-
de Laat WL, Appeldoorn E, Jaspers NG, et al. DNA structural elements required for ERCC1-XPF endonuclease activity. J Biol Chem 1998;273:7835-42.
-
(1998)
J Biol Chem
, vol.273
, pp. 7835-7842
-
-
de Laat, W.L.1
Appeldoorn, E.2
Jaspers, N.G.3
-
149
-
-
0037090816
-
The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif
-
Enzlin JH, Scharer OD. The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif. EMBO J 2002;21:2045-53.
-
(2002)
EMBO J
, vol.21
, pp. 2045-2053
-
-
Enzlin, J.H.1
Scharer, O.D.2
-
150
-
-
50649091874
-
Structural and functional relationships of the XPF/MUS81 family of proteins
-
Ciccia A, McDonald N, West SC. Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem 2008;77:259-87.
-
(2008)
Annu Rev Biochem
, vol.77
, pp. 259-287
-
-
Ciccia, A.1
McDonald, N.2
West, S.C.3
-
151
-
-
18244405819
-
Human Mus81-associated endonuclease cleaves Holliday junctions in vitro
-
Chen XB, Melchionna R, Denis CM, et al. Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Mol Cell 2001;8:1117-27.
-
(2001)
Mol Cell
, vol.8
, pp. 1117-1127
-
-
Chen, X.B.1
Melchionna, R.2
Denis, C.M.3
-
152
-
-
80052440005
-
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair
-
Wang AT, Sengerová B, Cattell E, et al. Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev 2011;25:1859-70.
-
(2011)
Genes Dev
, vol.25
, pp. 1859-1870
-
-
Wang, A.T.1
Sengerová, B.2
Cattell, E.3
-
153
-
-
67649655402
-
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases
-
Fekairi S, Scaglione S, Chahwan C, et al. Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell 2009;138:78-89.
-
(2009)
Cell
, vol.138
, pp. 78-89
-
-
Fekairi, S.1
Scaglione, S.2
Chahwan, C.3
-
154
-
-
67649662604
-
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
-
Svendsen JM, Smogorzewska A, Sowa ME, et al. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 2009;138:63-77.
-
(2009)
Cell
, vol.138
, pp. 63-77
-
-
Svendsen, J.M.1
Smogorzewska, A.2
Sowa, M.E.3
-
155
-
-
67649641641
-
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair
-
Muñoz IM, Hain K, Declais AC, et al. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell 2009;35:116-27.
-
(2009)
Mol Cell
, vol.35
, pp. 116-127
-
-
Muñoz, I.M.1
Hain, K.2
Declais, A.C.3
-
156
-
-
67649655954
-
Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination
-
Andersen SL, Bergstralh DT, Kohl KP, et al. Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination. Mol Cell 2009;35:128-35.
-
(2009)
Mol Cell
, vol.35
, pp. 128-135
-
-
Andersen, S.L.1
Bergstralh, D.T.2
Kohl, K.P.3
-
157
-
-
80052440005
-
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair
-
Wang AT, Sengerova B, Cattell E, et al. Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev 2011;25:1859-70.
-
(2011)
Genes Dev
, vol.25
, pp. 1859-1870
-
-
Wang, A.T.1
Sengerova, B.2
Cattell, E.3
-
158
-
-
72949123930
-
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair
-
Knipscheer P, Raschle M, Smogorzewska A, et al. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science 2009;326:1698-701.
-
(2009)
Science
, vol.326
, pp. 1698-1701
-
-
Knipscheer, P.1
Raschle, M.2
Smogorzewska, A.3
-
159
-
-
51549098159
-
Mechanism of replication-coupled DNA interstrand crosslink repair
-
Räschle M, Knipscheer P, Enoiu M, et al. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 2008;134:969-80.
-
(2008)
Cell
, vol.134
, pp. 969-980
-
-
Räschle, M.1
Knipscheer, P.2
Enoiu, M.3
-
160
-
-
0025059685
-
Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus
-
Papadopoulo D, Guillouf C, Mohrenweiser H, et al. Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus. Proc Natl Acad Sci U S A 1990;87:8383-7.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 8383-8387
-
-
Papadopoulo, D.1
Guillouf, C.2
Mohrenweiser, H.3
-
161
-
-
4344597147
-
The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair
-
Niedzwiedz W, Mosedale G, Johnson M, et al. The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol Cell 2004;15:607-20.
-
(2004)
Mol Cell
, vol.15
, pp. 607-620
-
-
Niedzwiedz, W.1
Mosedale, G.2
Johnson, M.3
-
162
-
-
43849098620
-
The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly
-
Mirchandani KD, McCaffrey RM, D'Andrea AD. The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly. DNA Repair (Amst) 2008;7:902-11.
-
(2008)
DNA Repair (Amst)
, vol.7
, pp. 902-911
-
-
Mirchandani, K.D.1
McCaffrey, R.M.2
D'Andrea, A.D.3
-
163
-
-
84862777927
-
Regulation of Rev1 by the Fanconi anemia core complex
-
Kim H, Yang K, Dejsuphong D, et al. Regulation of Rev1 by the Fanconi anemia core complex. Nat Struct Mol Biol 2012;19:164-70.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 164-170
-
-
Kim, H.1
Yang, K.2
Dejsuphong, D.3
-
164
-
-
84859564894
-
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway
-
Ali AM, Pradhan A, Singh TR, et al. FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Blood 2012;119:3285-94.
-
(2012)
Blood
, vol.119
, pp. 3285-3294
-
-
Ali, A.M.1
Pradhan, A.2
Singh, T.R.3
-
165
-
-
75749121458
-
DNA polymerase POLN participates in cross-link repair and homologous recombination
-
Moldovan GL, Madhavan MV, Mirchandani KD, et al. DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol 2010;30:1088-96.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 1088-1096
-
-
Moldovan, G.L.1
Madhavan, M.V.2
Mirchandani, K.D.3
-
166
-
-
84870738828
-
Diseases associated with defective responses to DNA damage
-
O'Driscoll M. Diseases associated with defective responses to DNA damage. Cold Spring Harb Perspect Biol 2012;4:a012773.
-
(2012)
Cold Spring Harb Perspect Biol
, vol.4
, pp. a012773
-
-
O'Driscoll, M.1
-
167
-
-
81955168032
-
The consequences of structural genomic alterations in humans: genomic disorders, genomic instability and cancer
-
Colnaghi R, Carpenter G, Volker M, et al. The consequences of structural genomic alterations in humans: genomic disorders, genomic instability and cancer. Semin Cell Dev Biol 2011;22:875-85.
-
(2011)
Semin Cell Dev Biol
, vol.22
, pp. 875-885
-
-
Colnaghi, R.1
Carpenter, G.2
Volker, M.3
-
168
-
-
44949238447
-
The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle
-
Biton S, Barzilai A, Shiloh Y. The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle. DNA Repair (Amst) 2008;7:1028-38.
-
(2008)
DNA Repair (Amst)
, vol.7
, pp. 1028-1038
-
-
Biton, S.1
Barzilai, A.2
Shiloh, Y.3
-
169
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009;461:1071-8.
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
172
-
-
52949096470
-
Genetic predisposition to breast cancer: past, present, and future
-
Turnbull C, Rahman N. Genetic predisposition to breast cancer: past, present, and future. Annu Rev Genomics Hum Genet 2008;9:321-45.
-
(2008)
Annu Rev Genomics Hum Genet
, vol.9
, pp. 321-345
-
-
Turnbull, C.1
Rahman, N.2
-
173
-
-
55749109888
-
Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?
-
Byrnes GB, Southey MC, Hopper JL. Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories? Breast Cancer Res 2008;10:208.
-
(2008)
Breast Cancer Res
, vol.10
, pp. 208
-
-
Byrnes, G.B.1
Southey, M.C.2
Hopper, J.L.3
-
174
-
-
34347265775
-
DNA repair pathways and hereditary cancer susceptibility syndromes
-
Spry M, Scott T, Pierce H, et al. DNA repair pathways and hereditary cancer susceptibility syndromes. Front Biosci 2007;12:4191-207.
-
(2007)
Front Biosci
, vol.12
, pp. 4191-4207
-
-
Spry, M.1
Scott, T.2
Pierce, H.3
-
175
-
-
84858432942
-
Lynch or not Lynch? Is that always a question?
-
Colas C, Coulet F, Svrcek M, et al. Lynch or not Lynch? Is that always a question? Adv Cancer Res 2012;113:121-66.
-
(2012)
Adv Cancer Res
, vol.113
, pp. 121-166
-
-
Colas, C.1
Coulet, F.2
Svrcek, M.3
-
176
-
-
65649112508
-
BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer
-
Hall MJ, Reid JE, Burbidge LA, et al. BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer. Cancer 2009;115:2222-33.
-
(2009)
Cancer
, vol.115
, pp. 2222-2233
-
-
Hall, M.J.1
Reid, J.E.2
Burbidge, L.A.3
-
177
-
-
36448996703
-
Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
-
Fackenthal JD, Olopade OI. Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer 2007;7:937-48.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 937-948
-
-
Fackenthal, J.D.1
Olopade, O.I.2
-
178
-
-
77649131406
-
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
-
Moynahan ME, Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 2010;11:196-207.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 196-207
-
-
Moynahan, M.E.1
Jasin, M.2
-
179
-
-
77951720395
-
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
-
Meindl A, Hellebrand H, Wiek C, et al. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet 2010;42:410-4.
-
(2010)
Nat Genet
, vol.42
, pp. 410-414
-
-
Meindl, A.1
Hellebrand, H.2
Wiek, C.3
-
180
-
-
84859054755
-
Translational advances regarding hereditary breast cancer syndromes
-
Gage M, Wattendorf D, Henry LR. Translational advances regarding hereditary breast cancer syndromes. J Surg Oncol 2012;105:444-51.
-
(2012)
J Surg Oncol
, vol.105
, pp. 444-451
-
-
Gage, M.1
Wattendorf, D.2
Henry, L.R.3
-
181
-
-
0033578040
-
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
-
Masutani C, Kusumoto R, Yamada A, et al. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature 1999;399:700-4.
-
(1999)
Nature
, vol.399
, pp. 700-704
-
-
Masutani, C.1
Kusumoto, R.2
Yamada, A.3
-
182
-
-
0037415391
-
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates
-
Kunkel TA, Pavlov YI, Bebenek K. Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. DNA Repair (Amst) 2003;2:135-49.
-
(2003)
DNA Repair (Amst)
, vol.2
, pp. 135-149
-
-
Kunkel, T.A.1
Pavlov, Y.I.2
Bebenek, K.3
-
183
-
-
0037805611
-
Role of DNA polymerase eta in the UV mutation spectrum in human cells
-
Stary A, Kannouche P, Lehmann AR, et al. Role of DNA polymerase eta in the UV mutation spectrum in human cells. J Biol Chem 2003;278:18767-75.
-
(2003)
J Biol Chem
, vol.278
, pp. 18767-18775
-
-
Stary, A.1
Kannouche, P.2
Lehmann, A.R.3
-
184
-
-
11144344392
-
Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers
-
Pan Q, Fang Y, Xu Y, et al. Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers. Cancer Lett 2005;217:139-47.
-
(2005)
Cancer Lett
, vol.217
, pp. 139-147
-
-
Pan, Q.1
Fang, Y.2
Xu, Y.3
-
185
-
-
61349137712
-
Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy
-
Ceppi P, Novello S, Cambieri A, et al. Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res 2009;15:1039-45.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1039-1045
-
-
Ceppi, P.1
Novello, S.2
Cambieri, A.3
-
186
-
-
16244375578
-
The overexpression of specialized DNA polymerases in cancer
-
Albertella MR, Lau A, O'Connor MJ. The overexpression of specialized DNA polymerases in cancer. DNA Repair (Amst) 2005;4:583-93.
-
(2005)
DNA Repair (Amst)
, vol.4
, pp. 583-593
-
-
Albertella, M.R.1
Lau, A.2
O'Connor, M.J.3
-
187
-
-
14644427768
-
Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach
-
Tan XH, Zhao M, Pan KF, et al. Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach. Cancer Lett 2005;220:101-14.
-
(2005)
Cancer Lett
, vol.220
, pp. 101-114
-
-
Tan, X.H.1
Zhao, M.2
Pan, K.F.3
-
188
-
-
68349139386
-
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta
-
Yoshizawa K, Jelezcova E, Brown AR, et al. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. PLoS One 2009;4:e6493.
-
(2009)
PLoS One
, vol.4
, pp. e6493
-
-
Yoshizawa, K.1
Jelezcova, E.2
Brown, A.R.3
-
189
-
-
77955820979
-
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability
-
Lemée F, Bergoglio V, Fernandez-Vidal A, et al. DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc Natl Acad Sci U S A 2010;107:13390-5.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 13390-13395
-
-
Lemée, F.1
Bergoglio, V.2
Fernandez-Vidal, A.3
-
190
-
-
84873096362
-
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
-
Palles C, Cazier JB, Howarth KM, et al. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet 2013;45:136-44.
-
(2013)
Nat Genet
, vol.45
, pp. 136-144
-
-
Palles, C.1
Cazier, J.B.2
Howarth, K.M.3
-
191
-
-
84866358168
-
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
-
Bouwman P, Jonkers J. The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer 2012;12:587-98.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 587-598
-
-
Bouwman, P.1
Jonkers, J.2
-
192
-
-
84870218588
-
DNA repair dysregulation from cancer driver to therapeutic target
-
Curtin NJ. DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer 2012;12:801-17.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 801-817
-
-
Curtin, N.J.1
-
193
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004;303:844-8.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
-
194
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva N, Bozko P, Enge M, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med 2004;10:1321-8.
-
(2004)
Nat Med
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
Bozko, P.2
Enge, M.3
-
196
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov VJ, Issaeva N, Shilov A, et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 2002;8:282-8.
-
(2002)
Nat Med
, vol.8
, pp. 282-288
-
-
Bykov, V.J.1
Issaeva, N.2
Shilov, A.3
-
197
-
-
80053144962
-
A decade of exploring the cancer epigenome - biological and translational implications
-
Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer 2011;11:726-34.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
198
-
-
70350236645
-
Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development
-
Panda H, Jaiswal AS, Corsino PE, et al. Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development. Biochemistry 2009;48:9952-8.
-
(2009)
Biochemistry
, vol.48
, pp. 9952-9958
-
-
Panda, H.1
Jaiswal, A.S.2
Corsino, P.E.3
-
199
-
-
42149157403
-
Inhibitors of DNA polymerase beta: activity and mechanism
-
Gao Z, Maloney DJ, Dedkova LM, et al. Inhibitors of DNA polymerase beta: activity and mechanism. Bioorg Med Chem 2008;16:4331-40.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 4331-4340
-
-
Gao, Z.1
Maloney, D.J.2
Dedkova, L.M.3
-
200
-
-
44849117230
-
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair
-
Chen X, Zhong S, Zhu X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res 2008;68:3169-77.
-
(2008)
Cancer Res
, vol.68
, pp. 3169-3177
-
-
Chen, X.1
Zhong, S.2
Zhu, X.3
-
201
-
-
84866564290
-
Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study
-
Samol J, Ranson M, Scott E, et al. Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study. Invest New Drugs 2012;30:1493-500.
-
(2012)
Invest New Drugs
, vol.30
, pp. 1493-1500
-
-
Samol, J.1
Ranson, M.2
Scott, E.3
-
202
-
-
24044516224
-
Isolation of a small molecule inhibitor of DNA base excision repair
-
Madhusudan S, Smart F, Shrimpton P, et al. Isolation of a small molecule inhibitor of DNA base excision repair. Nucleic Acids Res 2005;33:4711-24.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 4711-4724
-
-
Madhusudan, S.1
Smart, F.2
Shrimpton, P.3
-
203
-
-
79951675147
-
Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines
-
Mohammed MZ, Vyjayanti VN, Laughton CA, et al. Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer 2011;104:653-63.
-
(2011)
Br J Cancer
, vol.104
, pp. 653-663
-
-
Mohammed, M.Z.1
Vyjayanti, V.N.2
Laughton, C.A.3
-
204
-
-
41549156540
-
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control
-
Bhaskara S, Chyla BJ, Amann JM, et al. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 2008;30:61-72.
-
(2008)
Mol Cell
, vol.30
, pp. 61-72
-
-
Bhaskara, S.1
Chyla, B.J.2
Amann, J.M.3
-
205
-
-
78249276172
-
Hdac3 is essential for the maintenance of chromatin structure and genome stability
-
Bhaskara S, Knutson SK, Jiang G, et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 2010;18:436-47.
-
(2010)
Cancer Cell
, vol.18
, pp. 436-447
-
-
Bhaskara, S.1
Knutson, S.K.2
Jiang, G.3
-
206
-
-
52449111109
-
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
-
Evers B, Drost R, Schut E, et al. Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin. Clin Cancer Res 2008;14:3916-25.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3916-3925
-
-
Evers, B.1
Drost, R.2
Schut, E.3
-
207
-
-
55949092708
-
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
-
Rottenberg S, Jaspers JE, Kersbergen A, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A 2008;105:17079-84.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17079-17084
-
-
Rottenberg, S.1
Jaspers, J.E.2
Kersbergen, A.3
-
208
-
-
77954032829
-
Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
-
Fong PC, Yap TA, Boss DS, et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J Clin Oncol 2010;28:2512-9.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2512-2519
-
-
Fong, P.C.1
Yap, T.A.2
Boss, D.S.3
-
209
-
-
80052389761
-
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
-
Gelmon KA, Tischkowitz M, Mackay H, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 2011;12:852-61.
-
(2011)
Lancet Oncol
, vol.12
, pp. 852-861
-
-
Gelmon, K.A.1
Tischkowitz, M.2
Mackay, H.3
-
210
-
-
33748065304
-
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
-
McCabe N, Turner NC, Lord CJ, et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res 2006;66:8109-15.
-
(2006)
Cancer Res
, vol.66
, pp. 8109-8115
-
-
McCabe, N.1
Turner, N.C.2
Lord, C.J.3
-
211
-
-
84867082212
-
Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors
-
Sultana R, McNeill DR, Abbotts R, et al. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors. Int J Cancer 2012;131:2433-44.
-
(2012)
Int J Cancer
, vol.131
, pp. 2433-2444
-
-
Sultana, R.1
McNeill, D.R.2
Abbotts, R.3
-
212
-
-
78649321855
-
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo
-
Weston VJ, Oldreive CE, Skowronska A, et al. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Blood 2010;116:4578-87.
-
(2010)
Blood
, vol.116
, pp. 4578-4587
-
-
Weston, V.J.1
Oldreive, C.E.2
Skowronska, A.3
-
213
-
-
76649091939
-
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors
-
Williamson CT, Muzik H, Turhan AG, et al. ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. Mol Cancer Ther 2010;9:347-57.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 347-357
-
-
Williamson, C.T.1
Muzik, H.2
Turhan, A.G.3
-
214
-
-
79953313615
-
MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers
-
Vilar E, Bartnik CM, Stenzel SL, et al. MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers. Cancer Res 2011;71:2632-42.
-
(2011)
Cancer Res
, vol.71
, pp. 2632-2642
-
-
Vilar, E.1
Bartnik, C.M.2
Stenzel, S.L.3
-
215
-
-
34248184445
-
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated
-
Kennedy RD, Chen CC, Stuckert P, et al. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest 2007;117:1440-9.
-
(2007)
J Clin Invest
, vol.117
, pp. 1440-1449
-
-
Kennedy, R.D.1
Chen, C.C.2
Stuckert, P.3
-
216
-
-
65449142073
-
CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors
-
Chen CC, Kennedy RD, Sidi S, et al. CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer 2009;8:24.
-
(2009)
Mol Cancer
, vol.8
, pp. 24
-
-
Chen, C.C.1
Kennedy, R.D.2
Sidi, S.3
-
217
-
-
58149236866
-
Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells
-
Kuriyama I, Mizuno T, Fukudome K, et al. Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells. Molecules 2008;13:2948-61.
-
(2008)
Molecules
, vol.13
, pp. 2948-2961
-
-
Kuriyama, I.1
Mizuno, T.2
Fukudome, K.3
-
218
-
-
33751558603
-
Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha
-
Maeda N, Kokai Y, Ohtani S, et al. Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha. Biochem Biophys Res Commun 2007;352:390-6.
-
(2007)
Biochem Biophys Res Commun
, vol.352
, pp. 390-396
-
-
Maeda, N.1
Kokai, Y.2
Ohtani, S.3
-
219
-
-
77149155961
-
Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor
-
Kumamoto-Yonezawa Y, Sasaki R, Suzuki Y, et al. Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor. Int J Oncol 2010;36:577-84.
-
(2010)
Int J Oncol
, vol.36
, pp. 577-584
-
-
Kumamoto-Yonezawa, Y.1
Sasaki, R.2
Suzuki, Y.3
-
220
-
-
58949085243
-
The inhibitory action of kohamaic acid A derivatives on mammalian DNA polymerase beta
-
Mizushina Y, Manita D, Takeuchi T, et al. The inhibitory action of kohamaic acid A derivatives on mammalian DNA polymerase beta. Molecules 2009;14:102-21.
-
(2009)
Molecules
, vol.14
, pp. 102-121
-
-
Mizushina, Y.1
Manita, D.2
Takeuchi, T.3
-
221
-
-
75149154678
-
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation
-
Stachelek GC, Dalal S, Donigan KA, et al. Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Cancer Res 2010;70:409-17.
-
(2010)
Cancer Res
, vol.70
, pp. 409-417
-
-
Stachelek, G.C.1
Dalal, S.2
Donigan, K.A.3
-
222
-
-
75149151363
-
Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy
-
Yang J, Parsons J, Nicolay NH, et al. Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy. Oncogene 2010;29:463-8.
-
(2010)
Oncogene
, vol.29
, pp. 463-468
-
-
Yang, J.1
Parsons, J.2
Nicolay, N.H.3
-
223
-
-
75149192733
-
3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain
-
Mizushina Y, Motoshima H, Yamaguchi Y, et al. 3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain. Mar Drugs 2009;7:624-39.
-
(2009)
Mar Drugs
, vol.7
, pp. 624-639
-
-
Mizushina, Y.1
Motoshima, H.2
Yamaguchi, Y.3
-
224
-
-
78650580818
-
Error-prone translesion synthesis mediates acquired chemoresistance
-
Xie K, Doles J, Hemann MT, et al. Error-prone translesion synthesis mediates acquired chemoresistance. Proc Natl Acad Sci U S A 2010;107:20792-7.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 20792-20797
-
-
Xie, K.1
Doles, J.2
Hemann, M.T.3
-
225
-
-
78650575542
-
Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy
-
Doles J, Oliver TG, Cameron ER, et al. Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy. Proc Natl Acad Sci U S A 2010;107:20786-91.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 20786-20791
-
-
Doles, J.1
Oliver, T.G.2
Cameron, E.R.3
|