-
1
-
-
78649336706
-
The DNA damage response: Making it safe to play with knives
-
Ciccia, A. & Elledge, S. J. The DNA damage response: making it safe to play with knives. Mol. Cell 40, 179-204 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
2
-
-
63649144413
-
Principles of ubiquitin and SUMO modifications in DNA repair
-
Bergink, S. & Jentsch, S. Principles of ubiquitin and SUMO modifications in DNA repair. Nature 458, 461-467 (2009).
-
(2009)
Nature
, vol.458
, pp. 461-467
-
-
Bergink, S.1
Jentsch, S.2
-
3
-
-
0033213392
-
Brca1 controls homology-directed DNA repair
-
Moynahan, M. E., Chiu, J. W., Koller, B. H. & Jasin, M. Brca1 controls homology-directed DNA repair. Mol. Cell 4, 511-518 (1999).
-
(1999)
Mol. Cell
, vol.4
, pp. 511-518
-
-
Moynahan, M.E.1
Chiu, J.W.2
Koller, B.H.3
Jasin, M.4
-
4
-
-
0035099044
-
BRCA2 is required for homology-directed repair of chromosomal breaks
-
Moynahan, M. E., Pierce, A. J. & Jasin, M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263-272 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 263-272
-
-
Moynahan, M.E.1
Pierce, A.J.2
Jasin, M.3
-
5
-
-
0028113345
-
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
-
Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71 (1994).
-
(1994)
Science
, vol.266
, pp. 66-71
-
-
Miki, Y.1
-
6
-
-
0006713602
-
Identification of the breast cancer susceptibility gene BRCA2
-
Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-792 (1995).
-
(1995)
Nature
, vol.378
, pp. 789-792
-
-
Wooster, R.1
-
7
-
-
0027742295
-
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
-
Fishel, R. et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75, 1027-1038 (1993).
-
(1993)
Cell
, vol.75
, pp. 1027-1038
-
-
Fishel, R.1
-
8
-
-
0027145633
-
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
-
Leach, F. S. et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75, 1215-1225 (1993).
-
(1993)
Cell
, vol.75
, pp. 1215-1225
-
-
Leach, F.S.1
-
9
-
-
0028350601
-
Mutation of a mutL homolog in hereditary colon cancer
-
Papadopoulos, N. et al. Mutation of a mutL homolog in hereditary colon cancer. Science 263, 1625-1629 (1994).
-
(1994)
Science
, vol.263
, pp. 1625-1629
-
-
Papadopoulos, N.1
-
10
-
-
67650924286
-
Review of the Lynch syndrome: History, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
-
Lynch, H. T. et al. Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin. Genet. 76, 1-18 (2009).
-
(2009)
Clin. Genet.
, vol.76
, pp. 1-18
-
-
Lynch, H.T.1
-
11
-
-
40949130371
-
Platinum resistance: The role of DNA repair pathways
-
Martin, L. P., Hamilton, T. C. & Schilder, R. J. Platinum resistance: the role of DNA repair pathways. Clin. Cancer Res. 14, 1291-1295 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 1291-1295
-
-
Martin, L.P.1
Hamilton, T.C.2
Schilder, R.J.3
-
12
-
-
78449302142
-
Targeted radiosensitization of cells expressing truncated DNA polymerase β
-
Neijenhuis, S., Verwijs-Janssen, M., van den Broek, L. J., Begg, A. C. & Vens, C. Targeted radiosensitization of cells expressing truncated DNA polymerase β. Cancer Res. 70, 8706-8714 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 8706-8714
-
-
Neijenhuis, S.1
Verwijs-Janssen, M.2
Van Den Broek, L.J.3
Begg, A.C.4
Vens, C.5
-
13
-
-
77955039099
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
-
Audeh, M. W. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 376, 245-251 (2010).
-
(2010)
Lancet
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
-
14
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913-917 (2005).
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
-
15
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921 (2005).
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
-
16
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong, P. C. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361, 123-134 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
-
17
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
-
Tutt, A. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 376, 235-244 (2010).
-
(2010)
Lancet
, vol.376
, pp. 235-244
-
-
Tutt, A.1
-
18
-
-
79953283356
-
Genetic interactions in cancer progression and treatment
-
Ashworth, A., Lord, C. J. & Reis-Filho, J. S. Genetic interactions in cancer progression and treatment. Cell 145, 30-38 (2011).
-
(2011)
Cell
, vol.145
, pp. 30-38
-
-
Ashworth, A.1
Lord, C.J.2
Reis-Filho, J.S.3
-
19
-
-
79958694525
-
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling
-
Cotta-Ramusino, C. et al. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science 332, 1313-1317 (2011).
-
(2011)
Science
, vol.332
, pp. 1313-1317
-
-
Cotta-Ramusino, C.1
-
20
-
-
79959983476
-
A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
-
Menzel, T. et al. A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance. EMBO Rep. 12, 705-712 (2011).
-
(2011)
EMBO Rep.
, vol.12
, pp. 705-712
-
-
Menzel, T.1
-
21
-
-
79958254560
-
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
-
Jirawatnotai, S. et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474, 230-234 (2011).
-
(2011)
Nature
, vol.474
, pp. 230-234
-
-
Jirawatnotai, S.1
-
22
-
-
33845611951
-
Modeling the therapeutic efficacy of p53 restoration in tumors
-
Martins, C. P., Brown-Swigart, L. & Evan, G. I. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127, 1323-1334 (2006).
-
(2006)
Cell
, vol.127
, pp. 1323-1334
-
-
Martins, C.P.1
Brown-Swigart, L.2
Evan, G.I.3
-
23
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo. Nature 445, 661-665 (2007).
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
-
24
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660 (2007).
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
-
25
-
-
78649491016
-
Stage-specific sensitivity to p53 restoration during lung cancer progression
-
Feldser, D. M. et al. Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature 468, 572-575 (2010).
-
(2010)
Nature
, vol.468
, pp. 572-575
-
-
Feldser, D.M.1
-
26
-
-
78649492693
-
Selective activation of p53-mediated tumour suppression in high-grade tumours
-
Junttila, M. R. et al. Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature 468, 567-571 (2010).
-
(2010)
Nature
, vol.468
, pp. 567-571
-
-
Junttila, M.R.1
-
27
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B. & Evan, G. I. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 443, 214-217 (2006).
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
28
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
29
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva, N. et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nature Med. 10, 1321-1328 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
-
30
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov, V. J. et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nature Med. 8, 282-288 (2002).
-
(2002)
Nature Med
, vol.8
, pp. 282-288
-
-
Bykov, V.J.1
-
31
-
-
80053144962
-
A decade of exploring the cancer epigenome-biological and translational implications
-
Baylin, S. B. & Jones, P. A. A decade of exploring the cancer epigenome-biological and translational implications. Nature Rev. Cancer 11, 726-734 (2011).
-
(2011)
Nature Rev. Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
32
-
-
85028113437
-
Translating p53 into the clinic
-
Cheok, C. F., Verma, C. S., Baselga, J. & Lane, D. P. Translating p53 into the clinic. Nature Rev. Clin. Oncol. 8, 25-37 (2011).
-
(2011)
Nature Rev. Clin. Oncol.
, vol.8
, pp. 25-37
-
-
Cheok, C.F.1
Verma, C.S.2
Baselga, J.3
Lane, D.P.4
-
33
-
-
33846821915
-
P53-deficient cells rely on ATM-and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
Reinhardt, H. C., Aslanian, A. S., Lees, J. A. & Yaffe, M. B. p53-deficient cells rely on ATM-and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 11, 175-189 (2007).
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
34
-
-
77957361354
-
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization
-
Reinhardt, H. C. et al. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol. Cell 40, 34-49 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 34-49
-
-
Reinhardt, H.C.1
-
35
-
-
0029895439
-
UCN-01: A potent abrogator of G2 checkpoint function in cancer cells with disrupted p53
-
Wang, Q. et al. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J. Natl Cancer Inst. 88, 956-965 (1996).
-
(1996)
J. Natl Cancer Inst.
, vol.88
, pp. 956-965
-
-
Wang, Q.1
-
36
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek, J. & Lukas, J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3, 421-429 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
37
-
-
74549189337
-
New insights into checkpoint kinase 1 in the DNA damage response signaling network
-
Dai, Y. & Grant, S. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin. Cancer Res. 16, 376-383 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 376-383
-
-
Dai, Y.1
Grant, S.2
-
38
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
-
Liu, Q. et al. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev. 14, 1448-1459 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
-
39
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/-mice
-
Takai, H. et al. Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/-mice. Genes Dev. 14, 1439-1447 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 1439-1447
-
-
Takai, H.1
-
40
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao, A. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287, 1824-1827 (2000).
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
-
41
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai, H. et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21, 5195-5205 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
-
42
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756-760 (2006).
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
-
43
-
-
78650014447
-
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas
-
Squatrito, M. et al. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell 18, 619-629 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 619-629
-
-
Squatrito, M.1
-
44
-
-
77958480403
-
Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo
-
Niida, H. et al. Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J. 29, 3558-3570 (2010).
-
(2010)
EMBO J
, vol.29
, pp. 3558-3570
-
-
Niida, H.1
-
45
-
-
69249240178
-
The combined status of ATM and p53 link tumor development with therapeutic response
-
Jiang, H. et al. The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev. 23, 1895-1909 (2009).
-
(2009)
Genes Dev
, vol.23
, pp. 1895-1909
-
-
Jiang, H.1
-
46
-
-
77956517283
-
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma
-
Mir, S. E. et al. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell 18, 244-257 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 244-257
-
-
Mir, S.E.1
-
47
-
-
10744226451
-
Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361
-
Calabrese, C. R. et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. J. Natl Cancer Inst. 96, 56-67 (2004).
-
(2004)
J. Natl Cancer Inst.
, vol.96
, pp. 56-67
-
-
Calabrese, C.R.1
-
48
-
-
34249006299
-
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
-
Donawho, C. K. et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin. Cancer Res. 13, 2728-2737 (2007).
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 2728-2737
-
-
Donawho, C.K.1
-
49
-
-
52449111109
-
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
-
Evers, B. et al. Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin. Clin. Cancer Res. 14, 3916-3925 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3916-3925
-
-
Evers, B.1
-
50
-
-
55949092708
-
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
-
Rottenberg, S. et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc. Natl Acad. Sci. USA 105, 17079-17084 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 17079-17084
-
-
Rottenberg, S.1
-
51
-
-
44449097296
-
Targeting base excision repair for chemosensitization
-
Adhikari, S. et al. Targeting base excision repair for chemosensitization. Anticancer Agents Med. Chem. 8, 351-357 (2008).
-
(2008)
Anticancer Agents Med. Chem.
, vol.8
, pp. 351-357
-
-
Adhikari, S.1
-
52
-
-
78650575542
-
Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy
-
Doles, J. et al. Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy. Proc. Natl Acad. Sci. USA 107, 20786-20791 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 20786-20791
-
-
Doles, J.1
-
53
-
-
78650580818
-
Error-prone translesion synthesis mediates acquired chemoresistance
-
Xie, K., Doles, J., Hemann, M. T. & Walker, G. C. Error-prone translesion synthesis mediates acquired chemoresistance. Proc. Natl Acad. Sci. USA 107, 20792-20797 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 20792-20797
-
-
Xie, K.1
Doles, J.2
Hemann, M.T.3
Walker, G.C.4
-
54
-
-
41549156540
-
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control
-
Bhaskara, S. et al. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol. Cell 30, 61-72 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 61-72
-
-
Bhaskara, S.1
-
55
-
-
78249276172
-
Hdac3 is essential for the maintenance of chromatin structure and genome stability
-
Bhaskara, S. et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 18, 436-447 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 436-447
-
-
Bhaskara, S.1
-
56
-
-
0037417373
-
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
-
Kao, G. D. et al. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J. Cell Biol. 160, 1017-1027 (2003).
-
(2003)
J. Cell Biol.
, vol.160
, pp. 1017-1027
-
-
Kao, G.D.1
-
57
-
-
77956341931
-
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
-
Miller, K. M. et al. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nature Struct. Mol. Biol. 17, 1144-1151 (2010).
-
(2010)
Nature Struct. Mol. Biol.
, vol.17
, pp. 1144-1151
-
-
Miller, K.M.1
-
58
-
-
77955501963
-
SIRT1 regulates UV-induced DNA repair through deacetylating XPA
-
Fan, W. & Luo, J. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol. Cell 39, 247-258 (2010).
-
(2010)
Mol. Cell
, vol.39
, pp. 247-258
-
-
Fan, W.1
Luo, J.2
-
59
-
-
78651105018
-
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
-
Ming, M. et al. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc. Natl Acad. Sci. USA 107, 22623-22628 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 22623-22628
-
-
Ming, M.1
-
60
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang, R. H. et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14, 312-323 (2008).
-
(2008)
Cancer Cell
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
-
61
-
-
77950351604
-
SIRT1 deacetylates APE1 and regulates cellular base excision repair
-
Yamamori, T. et al. SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Res. 38, 832-845 (2010).
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 832-845
-
-
Yamamori, T.1
-
62
-
-
34250897968
-
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
-
Yuan, Z., Zhang, X., Sengupta, N., Lane, W. S. & Seto, E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27, 149-162 (2007).
-
(2007)
Mol. Cell
, vol.27
, pp. 149-162
-
-
Yuan, Z.1
Zhang, X.2
Sengupta, N.3
Lane, W.S.4
Seto, E.5
-
63
-
-
77956550868
-
Human SIRT6 promotes DNA end resection through CtIP deacetylation
-
Kaidi, A., Weinert, B. T., Choudhary, C. & Jackson, S. P. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329, 1348-1353 (2010).
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
Weinert, B.T.2
Choudhary, C.3
Jackson, S.P.4
-
64
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky, R. et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329 (2006).
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
-
65
-
-
53149144656
-
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
-
Wang, R. H. et al. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol. Cell 32, 11-20 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 11-20
-
-
Wang, R.H.1
-
66
-
-
79960150694
-
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
-
Johnson, N. et al. Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nature Med. 17, 875-882 (2011).
-
(2011)
Nature Med
, vol.17
, pp. 875-882
-
-
Johnson, N.1
-
67
-
-
68349141348
-
Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage
-
Johnson, N. et al. Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage. Mol. Cell 35, 327-339 (2009).
-
(2009)
Mol. Cell
, vol.35
, pp. 327-339
-
-
Johnson, N.1
-
68
-
-
79960003299
-
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
-
Krawczyk, P. M. et al. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proc. Natl Acad. Sci. USA 108, 9851-9856 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 9851-9856
-
-
Krawczyk, P.M.1
-
69
-
-
0036364467
-
Multidrug resistance in cancer: Role of ATP-dependent transporters
-
Gottesman, M. M., Fojo, T. & Bates, S. E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Rev. Cancer 2, 48-58 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
70
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K. P. et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461 (2009).
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
-
71
-
-
77953270903
-
Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator
-
Ishida, S., McCormick, F., Smith-McCune, K. & Hanahan, D. Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell 17, 574-583 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 574-583
-
-
Ishida, S.1
McCormick, F.2
Smith-Mccune, K.3
Hanahan, D.4
-
72
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
Edwards, S. L. et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 451, 1111-1115 (2008).
-
(2008)
Nature
, vol.451
, pp. 1111-1115
-
-
Edwards, S.L.1
-
73
-
-
39849106300
-
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
-
Sakai, W. et al. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 451, 1116-1120 (2008).
-
(2008)
Nature
, vol.451
, pp. 1116-1120
-
-
Sakai, W.1
-
74
-
-
80051642095
-
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas
-
Norquist, B. et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J. Clin. Oncol. 29, 3008-3015 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 3008-3015
-
-
Norquist, B.1
-
75
-
-
42349096328
-
Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
-
Swisher, E. M. et al. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res. 68, 2581-2586 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 2581-2586
-
-
Swisher, E.M.1
-
76
-
-
34547496282
-
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer
-
Liu, X. et al. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc. Natl Acad. Sci. USA 104, 12111-12116 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 12111-12116
-
-
Liu, X.1
-
77
-
-
34547504504
-
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer
-
Rottenberg, S. et al. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc. Natl Acad. Sci. USA 104, 12117-12122 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 12117-12122
-
-
Rottenberg, S.1
-
78
-
-
0037842201
-
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
-
Ikeda, H. et al. Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2. Cancer Res. 63, 2688-2694 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 2688-2694
-
-
Ikeda, H.1
-
79
-
-
24944575242
-
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ
-
Litman, R. et al. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell 8, 255-265 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 255-265
-
-
Litman, R.1
-
80
-
-
66349096607
-
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
-
Sy, S. M., Huen, M. S. & Chen, J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc. Natl Acad. Sci. USA 106, 7155-7160 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 7155-7160
-
-
Sy, S.M.1
Huen, M.S.2
Chen, J.3
-
81
-
-
67651166786
-
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2
-
Zhang, F., Fan, Q., Ren, K. & Andreassen, P. R. PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. Mol. Cancer Res. 7, 1110-1118 (2009).
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 1110-1118
-
-
Zhang, F.1
Fan, Q.2
Ren, K.3
Andreassen, P.R.4
-
82
-
-
62549115236
-
PALB2 links BRCA1 and BRCA2 in the DNA-damage response
-
Zhang, F. et al. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr. Biol. 19, 524-529 (2009).
-
(2009)
Curr. Biol.
, vol.19
, pp. 524-529
-
-
Zhang, F.1
-
83
-
-
33846601829
-
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
-
Xia, B. et al. Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nature Genet. 39, 159-161 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 159-161
-
-
Xia, B.1
-
84
-
-
12644293813
-
Somatic mosaicism in Fanconi anemia: Molecular basis and clinical significance
-
Lo, T. F. Jr et al. Somatic mosaicism in Fanconi anemia: molecular basis and clinical significance. Eur. J. Hum. Genet. 5, 137-148 (1997).
-
(1997)
Eur. J. Hum. Genet.
, vol.5
, pp. 137-148
-
-
Lo Jr., T.F.1
-
85
-
-
0032796554
-
Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism
-
Waisfisz, Q. et al. Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism. Nature Genet. 22, 379-383 (1999).
-
(1999)
Nature Genet
, vol.22
, pp. 379-383
-
-
Waisfisz, Q.1
-
86
-
-
70349442548
-
The first 30 years of p53: Growing ever more complex
-
Levine, A. J. & Oren, M. The first 30 years of p53: growing ever more complex. Nature Rev. Cancer 9, 749-758 (2009).
-
(2009)
Nature Rev. Cancer
, vol.9
, pp. 749-758
-
-
Levine, A.J.1
Oren, M.2
-
87
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang, G. A. et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119, 861-872 (2004).
-
(2004)
Cell
, vol.119
, pp. 861-872
-
-
Lang, G.A.1
-
88
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
Olive, K. P. et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119, 847-860 (2004).
-
(2004)
Cell
, vol.119
, pp. 847-860
-
-
Olive, K.P.1
-
89
-
-
10744230945
-
P53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
-
Bergamaschi, D. et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 3, 387-402 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 387-402
-
-
Bergamaschi, D.1
-
90
-
-
0041997348
-
Chemosensitivity linked to p73 function
-
Irwin, M. S. et al. Chemosensitivity linked to p73 function. Cancer Cell 3, 403-410 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 403-410
-
-
Irwin, M.S.1
-
91
-
-
34247329362
-
P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
-
Song, H., Hollstein, M. & Xu, Y. p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nature Cell Biol. 9, 573-580 (2007).
-
(2007)
Nature Cell Biol
, vol.9
, pp. 573-580
-
-
Song, H.1
Hollstein, M.2
Xu, Y.3
-
92
-
-
77950419842
-
Allele-specific tumor spectrum in Pten knockin mice
-
Wang, H. et al. Allele-specific tumor spectrum in Pten knockin mice. Proc. Natl Acad. Sci. USA 107, 5142-5147 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 5142-5147
-
-
Wang, H.1
-
93
-
-
77149157867
-
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
-
Mendes-Pereira, A. M. et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol. Med. 1, 315-322 (2009).
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 315-322
-
-
Mendes-Pereira, A.M.1
-
94
-
-
37549020704
-
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
-
Saal, L. H. et al. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nature Genet. 40, 102-107 (2008).
-
(2008)
Nature Genet
, vol.40
, pp. 102-107
-
-
Saal, L.H.1
-
95
-
-
80055092789
-
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity
-
Shakya, R. et al. BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science 334, 525-528 (2011).
-
(2011)
Science
, vol.334
, pp. 525-528
-
-
Shakya, R.1
-
96
-
-
83455229693
-
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
-
Drost, R. et al. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. Cancer Cell 20, 797-809 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 797-809
-
-
Drost, R.1
-
97
-
-
44849143103
-
Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors
-
Shafee, N. et al. Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res. 68, 3243-3250 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 3243-3250
-
-
Shafee, N.1
-
98
-
-
5444222008
-
Identification of BRCA1-IRIS, a BRCA1 locus product
-
ElShamy, W. M. & Livingston, D. M. Identification of BRCA1-IRIS, a BRCA1 locus product. Nature Cell Biol. 6, 954-967 (2004).
-
(2004)
Nature Cell Biol
, vol.6
, pp. 954-967
-
-
Elshamy, W.M.1
Livingston, D.M.2
-
99
-
-
72449165565
-
Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1
-
Pettigrew, C. A. et al. Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1. Breast Cancer Res. Treat. 119, 239-247 (2010).
-
(2010)
Breast Cancer Res. Treat.
, vol.119
, pp. 239-247
-
-
Pettigrew, C.A.1
-
100
-
-
78449285199
-
BRCA1-IRIS overexpression promotes cisplatin resistance in ovarian cancer cells
-
Chock, K. L., Allison, J. M., Shimizu, Y. & ElShamy, W. M. BRCA1-IRIS overexpression promotes cisplatin resistance in ovarian cancer cells. Cancer Res. 70, 8782-8791 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 8782-8791
-
-
Chock, K.L.1
Allison, J.M.2
Shimizu, Y.3
Elshamy, W.M.4
-
101
-
-
0037080115
-
Effect of BRCA mutations on the length of survival in epithelial ovarian tumors
-
Ben David, Y. et al. Effect of BRCA mutations on the length of survival in epithelial ovarian tumors. J. Clin. Oncol. 20, 463-466 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 463-466
-
-
Ben David, Y.1
-
102
-
-
24344479165
-
ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer
-
Viguier, J. et al. ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer. Clin. Cancer Res. 11, 6212-6217 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 6212-6217
-
-
Viguier, J.1
-
103
-
-
4143051317
-
Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy
-
Zhou, W. et al. Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin. Cancer Res. 10, 4939-4943 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 4939-4943
-
-
Zhou, W.1
-
104
-
-
0037223410
-
Nucleotide excision repair-and polymerase ε-mediated error-prone removal of mitomycin C interstrand cross-links
-
Zheng, H. et al. Nucleotide excision repair-and polymerase ε-mediated error-prone removal of mitomycin C interstrand cross-links. Mol. Cell. Biol. 23, 754-761 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 754-761
-
-
Zheng, H.1
-
105
-
-
70450224524
-
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
-
Al-Minawi, A. Z. et al. The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Res. 37, 6400-6413 (2009).
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 6400-6413
-
-
Al-Minawi, A.Z.1
-
106
-
-
33748435058
-
DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
-
Olaussen, K. A. et al. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N. Engl. J. Med. 355, 983-991 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 983-991
-
-
Olaussen, K.A.1
-
107
-
-
84857923067
-
The potential of exploiting DNA-repair defects for optimizing lung cancer treatment
-
Postel-Vinay, S. et al. The potential of exploiting DNA-repair defects for optimizing lung cancer treatment. Nature Rev. Clin. Oncol. 9, 144-155 (2012).
-
(2012)
Nature Rev. Clin. Oncol.
, vol.9
, pp. 144-155
-
-
Postel-Vinay, S.1
-
108
-
-
77954310242
-
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia
-
Adamo, A. et al. Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol. Cell 39, 25-35 (2010).
-
(2010)
Mol. Cell
, vol.39
, pp. 25-35
-
-
Adamo, A.1
-
109
-
-
77953879925
-
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway
-
Pace, P. et al. Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science 329, 219-223 (2010).
-
(2010)
Science
, vol.329
, pp. 219-223
-
-
Pace, P.1
-
110
-
-
77649225150
-
Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells
-
Fattah, F. et al. Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells. PLoS. Genet. 6, e1000855 (2010).
-
(2010)
PLoS. Genet.
, vol.6
-
-
Fattah, F.1
-
111
-
-
77953291328
-
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman, P. et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nature Struct. Mol. Biol. 17, 688-695 (2010).
-
(2010)
Nature Struct. Mol. Biol.
, vol.17
, pp. 688-695
-
-
Bouwman, P.1
-
112
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting, S. F. et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141, 243-254 (2010).
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
-
113
-
-
68949221567
-
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency
-
Cao, L. et al. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol. Cell 35, 534-541 (2009).
-
(2009)
Mol. Cell
, vol.35
, pp. 534-541
-
-
Cao, L.1
-
114
-
-
37349096996
-
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
-
Xie, A. et al. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol. Cell 28, 1045-1057 (2007).
-
(2007)
Mol. Cell
, vol.28
, pp. 1045-1057
-
-
Xie, A.1
-
115
-
-
0035893363
-
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
-
Pierce, A. J., Hu, P., Han, M., Ellis, N. & Jasin, M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15, 3237-3242 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 3237-3242
-
-
Pierce, A.J.1
Hu, P.2
Han, M.3
Ellis, N.4
Jasin, M.5
-
116
-
-
73349098442
-
Limiting the persistence of a chromosome break diminishes its mutagenic potential
-
Bennardo, N., Gunn, A., Cheng, A., Hasty, P. & Stark, J. M. Limiting the persistence of a chromosome break diminishes its mutagenic potential. PLoS. Genet. 5, e1000683 (2009).
-
(2009)
PLoS. Genet.
, vol.5
-
-
Bennardo, N.1
Gunn, A.2
Cheng, A.3
Hasty, P.4
Stark, J.M.5
-
117
-
-
0036902410
-
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
-
DiTullio, R. A. Jr et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nature Cell Biol. 4, 998-1002 (2002).
-
(2002)
Nature Cell Biol
, vol.4
, pp. 998-1002
-
-
DiTullio Jr., R.A.1
-
118
-
-
0036903037
-
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
-
Fernandez-Capetillo, O. et al. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nature Cell Biol. 4, 993-997 (2002).
-
(2002)
Nature Cell Biol
, vol.4
, pp. 993-997
-
-
Fernandez-Capetillo, O.1
-
119
-
-
0037112212
-
53BP1, a mediator of the DNA damage checkpoint
-
Wang, B., Matsuoka, S., Carpenter, P. B. & Elledge, S. J. 53BP1, a mediator of the DNA damage checkpoint. Science 298, 1435-1438 (2002).
-
(2002)
Science
, vol.298
, pp. 1435-1438
-
-
Wang, B.1
Matsuoka, S.2
Carpenter, P.B.3
Elledge, S.J.4
-
120
-
-
77950923924
-
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
-
Oliver, T. G. et al. Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev. 24, 837-852 (2010).
-
(2010)
Genes Dev
, vol.24
, pp. 837-852
-
-
Oliver, T.G.1
-
121
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma, S. V. et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141, 69-80 (2010).
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
-
122
-
-
4944229642
-
Hallmarks of 'BRCAness' in sporadic cancers
-
Turner, N., Tutt, A. & Ashworth, A. Hallmarks of 'BRCAness' in sporadic cancers. Nature Rev. Cancer 4, 814-819 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 814-819
-
-
Turner, N.1
Tutt, A.2
Ashworth, A.3
-
123
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sorlie, T. et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA 98, 10869-10874 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 10869-10874
-
-
Sorlie, T.1
-
124
-
-
18244409687
-
Gene expression profiling predicts clinical outcome of breast cancer
-
van 't Veer, L. J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002).
-
(2002)
Nature
, vol.415
, pp. 530-536
-
-
Van 'T Veer, L.J.1
-
125
-
-
58149334773
-
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
-
Farmer, P. et al. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nature Med. 15, 68-74 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 68-74
-
-
Farmer, P.1
-
126
-
-
78650349223
-
Do predictive signatures really predict response to cancer chemotherapy?
-
Borst, P. & Wessels, L. Do predictive signatures really predict response to cancer chemotherapy? Cell Cycle 9, 4836-4840 (2010).
-
(2010)
Cell Cycle
, vol.9
, pp. 4836-4840
-
-
Borst, P.1
Wessels, L.2
-
127
-
-
0036895886
-
Molecular classification of breast carcinomas by comparative genomic hybridization: A specific somatic genetic profile for BRCA1 tumors
-
Wessels, L. F. et al. Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors. Cancer Res. 62, 7110-7117 (2002).
-
(2002)
Cancer Res
, vol.62
, pp. 7110-7117
-
-
Wessels, L.F.1
-
128
-
-
79959733228
-
An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients
-
Vollebergh, M. A. et al. An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients. Ann. Oncol. 22, 1561-1570 (2011).
-
(2011)
Ann. Oncol.
, vol.22
, pp. 1561-1570
-
-
Vollebergh, M.A.1
-
129
-
-
0027285475
-
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
-
Ionov, Y., Peinado, M. A., Malkhosyan, S., Shibata, D. & Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363, 558-561 (1993).
-
(1993)
Nature
, vol.363
, pp. 558-561
-
-
Ionov, Y.1
Peinado, M.A.2
Malkhosyan, S.3
Shibata, D.4
Perucho, M.5
-
130
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
Esteller, M. et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N. Engl. J. Med. 343, 1350-1354 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1350-1354
-
-
Esteller, M.1
-
131
-
-
12144291692
-
Clinical trial substantiates the predictive value of O-6-methylguanine- DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
-
Hegi, M. E. et al. Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin. Cancer Res. 10, 1871-1874 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 1871-1874
-
-
Hegi, M.E.1
-
132
-
-
77958045536
-
A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer
-
Graeser, M. K. et al. A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer. Clin. Cancer Res. 16, 6159-6168 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 6159-6168
-
-
Graeser, M.K.1
-
133
-
-
70349454058
-
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
-
Bric, A. et al. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell 16, 324-335 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 324-335
-
-
Bric, A.1
-
134
-
-
70349536006
-
In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression
-
Meacham, C. E., Ho, E. E., Dubrovsky, E., Gertler, F. B. & Hemann, M. T. In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nature Genet. 41, 1133-1137 (2009).
-
(2009)
Nature Genet
, vol.41
, pp. 1133-1137
-
-
Meacham, C.E.1
Ho, E.E.2
Dubrovsky, E.3
Gertler, F.B.4
Hemann, M.T.5
-
135
-
-
47949130625
-
Topoisomerase levels determine chemotherapy response in vitro and in vivo
-
Burgess, D. J. et al. Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc. Natl Acad. Sci. USA 105, 9053-9058 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9053-9058
-
-
Burgess, D.J.1
-
136
-
-
33645532464
-
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
-
Bryant, H. E. & Helleday, T. Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res. 34, 1685-1691 (2006).
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1685-1691
-
-
Bryant, H.E.1
Helleday, T.2
-
137
-
-
77955407605
-
6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance
-
Issaeva, N. et al. 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res. 70, 6268-6276 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 6268-6276
-
-
Issaeva, N.1
-
138
-
-
74949093142
-
A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors
-
Evers, B. et al. A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors. Clin. Cancer Res. 16, 99-108 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 99-108
-
-
Evers, B.1
-
139
-
-
80053209565
-
Melphalan as a treatment for BRCA-related ovarian carcinoma: Can you teach an old drug new tricks?
-
Osher, D. J., Kushner, Y. B., Arseneau, J. & Foulkes, W. D. Melphalan as a treatment for BRCA-related ovarian carcinoma: can you teach an old drug new tricks? J. Clin. Pathol. 64, 924-926 (2011).
-
(2011)
J. Clin. Pathol.
, vol.64
, pp. 924-926
-
-
Osher, D.J.1
Kushner, Y.B.2
Arseneau, J.3
Foulkes, W.D.4
-
140
-
-
62349125979
-
High-dose chemotherapy for high-risk primary and metastatic breast cancer: Is another look warranted?
-
Nieto, Y. & Shpall, E. J. High-dose chemotherapy for high-risk primary and metastatic breast cancer: is another look warranted? Curr. Opin. Oncol. 21, 150-157 (2009).
-
(2009)
Curr. Opin. Oncol.
, vol.21
, pp. 150-157
-
-
Nieto, Y.1
Shpall, E.J.2
-
141
-
-
34547100275
-
The resurgence of platinum-based cancer chemotherapy
-
Kelland, L. The resurgence of platinum-based cancer chemotherapy. Nature Rev. Cancer 7, 573-584 (2007).
-
(2007)
Nature Rev. Cancer
, vol.7
, pp. 573-584
-
-
Kelland, L.1
-
142
-
-
84859202634
-
Drug candidates derailed in case of mistaken identity
-
Ledford, H. Drug candidates derailed in case of mistaken identity. Nature 483, 519 (2012).
-
(2012)
Nature
, vol.483
, pp. 519
-
-
Ledford, H.1
-
143
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist, L. V. et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 3, 75ra26 (2011).
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Sequist, L.V.1
-
144
-
-
69249100461
-
Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma
-
Sakai, W. et al. Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma. Cancer Res. 69, 6381-6386 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 6381-6386
-
-
Sakai, W.1
-
145
-
-
70349696230
-
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations
-
Chang, S., Biswas, K., Martin, B. K., Stauffer, S. & Sharan, S. K. Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations. J. Clin. Invest. 119, 3160-3171 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3160-3171
-
-
Chang, S.1
Biswas, K.2
Martin, B.K.3
Stauffer, S.4
Sharan, S.K.5
-
146
-
-
49149115625
-
Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2
-
Kuznetsov, S. G., Liu, P. & Sharan, S. K. Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2. Nature Med. 14, 875-881 (2008).
-
(2008)
Nature Med
, vol.14
, pp. 875-881
-
-
Kuznetsov, S.G.1
Liu, P.2
Sharan, S.K.3
-
147
-
-
77953796463
-
Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays
-
Lee, M. S. et al. Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays. Cancer Res. 70, 4880-4890 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 4880-4890
-
-
Lee, M.S.1
-
148
-
-
0028859671
-
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
-
Liu, B. et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet. 9, 48-55 (1995).
-
(1995)
Nature Genet
, vol.9
, pp. 48-55
-
-
Liu, B.1
-
149
-
-
84857043026
-
A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants
-
Drost, M. et al. A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants. Hum. Mutat. 33, 488-494 (2012).
-
(2012)
Hum. Mutat.
, vol.33
, pp. 488-494
-
-
Drost, M.1
-
150
-
-
77149143820
-
A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1
-
Drost, M. et al. A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1. Hum. Mutat. 31, 247-253 (2010).
-
(2010)
Hum. Mutat.
, vol.31
, pp. 247-253
-
-
Drost, M.1
|