MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers

Cancer Research

Volumn 71, Issue 7, 2011, Pages 2632-2642

  Vilar, Eduardo ^a   Bartnik, Catherine M ^a   Stenzel, Stephanie L ^a,b   Raskin, Leon ^a   Ahn, Jaeil ^b   Moreno, Victor ^b,c   Mukherjee, Bhramar ^b   Iniesta, Maria D ^a   Morgan, Meredith A ^a   Rennert, Gad ^d,e,f   Gruber, Stephen B ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

^d CLALIT HEALTH SERVICES   (Israel)

^e CARMEL MEDICAL CENTER   (Israel)

^f TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 ISOQUINOLINEDIOL; 8 HYDROXY 2 METHYL 4(3H) QUINAZOLINONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENANTHRIDINONE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VELIPARIB;

ARTICLE; CANCER CELL; CANCER MORTALITY; CELL PROLIFERATION; CHEMOSENSITIVITY; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; GENE; GENE MUTATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; MRE11 GENE; PRIMARY TUMOR; PRIORITY JOURNAL; WILD TYPE;

BENZIMIDAZOLES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA DAMAGE; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICROSATELLITE INSTABILITY; MUTATION; POLY(ADP-RIBOSE) POLYMERASES; RAD51 RECOMBINASE; RECOMBINATION, GENETIC;

EID: 79953313615     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1120     Document Type: Article

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