메뉴 건너뛰기




Volumn 22, Issue 8, 2011, Pages 886-897

DNA double-strand break repair pathways, chromosomal rearrangements and cancer

Author keywords

Cancer; Chromosomal rearrangement; DNA double strand break; Homologous recombination; Non homologous end joining

Indexed keywords

DOUBLE STRANDED DNA;

EID: 81955161844     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2011.10.007     Document Type: Review
Times cited : (99)

References (149)
  • 1
    • 33646065584 scopus 로고
    • Ueber asymmetrische zelltheilung in epithelkrebsen und deren biologische bedeutung
    • Hansemann D. Ueber asymmetrische zelltheilung in epithelkrebsen und deren biologische bedeutung. Arch Pathol Anat Physiol Klin Med 1890, 119:299-326.
    • (1890) Arch Pathol Anat Physiol Klin Med , vol.119 , pp. 299-326
    • Hansemann, D.1
  • 2
    • 81955167836 scopus 로고
    • G. Fischer, Jena, (in German), T. Boveri (Ed.)
    • Zur Frage der Entstehung Maligner Tumoren. 1914, 1-64. G. Fischer, Jena, (in German). T. Boveri (Ed.).
    • (1914) Zur Frage der Entstehung Maligner Tumoren. , pp. 1-64
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 0033855389 scopus 로고    scopus 로고
    • Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
    • Pfeiffer P., Goedecke W., Obe G. Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis 2000, 15:289-302.
    • (2000) Mutagenesis , vol.15 , pp. 289-302
    • Pfeiffer, P.1    Goedecke, W.2    Obe, G.3
  • 8
    • 0842303307 scopus 로고    scopus 로고
    • Unraveling V(D)J recombination; insights into gene regulation
    • Jung D., Alt F.W. Unraveling V(D)J recombination; insights into gene regulation. Cell 2004, 116:299-311.
    • (2004) Cell , vol.116 , pp. 299-311
    • Jung, D.1    Alt, F.W.2
  • 9
    • 67649852281 scopus 로고    scopus 로고
    • DNA repair: common approaches to fixing double-strand breaks
    • Hiom K. DNA repair: common approaches to fixing double-strand breaks. Curr Biol 2009, 19:R523-R525.
    • (2009) Curr Biol , vol.19
    • Hiom, K.1
  • 10
    • 33645781346 scopus 로고    scopus 로고
    • Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining
    • Bowater R., Doherty A.J. Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. PLoS Genet 2006, 2:e8.
    • (2006) PLoS Genet , vol.2
    • Bowater, R.1    Doherty, A.J.2
  • 11
    • 0017255643 scopus 로고
    • The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control
    • Resnick M.A., Martin P. The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control. Mol Gen Genet 1976, 143:119-129.
    • (1976) Mol Gen Genet , vol.143 , pp. 119-129
    • Resnick, M.A.1    Martin, P.2
  • 12
    • 2942525595 scopus 로고    scopus 로고
    • Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells
    • Guirouilh-Barbat J., Huck S., Bertrand P., Pirzio L., Desmaze C., Sabatier L., et al. Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol Cell 2004, 14:611-623.
    • (2004) Mol Cell , vol.14 , pp. 611-623
    • Guirouilh-Barbat, J.1    Huck, S.2    Bertrand, P.3    Pirzio, L.4    Desmaze, C.5    Sabatier, L.6
  • 13
    • 0029976325 scopus 로고    scopus 로고
    • Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae
    • Moore J.K., Haber J.E. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell Biol 1996, 16:2164-2173.
    • (1996) Mol Cell Biol , vol.16 , pp. 2164-2173
    • Moore, J.K.1    Haber, J.E.2
  • 14
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber M.R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 2010, 79:181-211.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 15
    • 0029791694 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
    • Boulton S.J., Jackson S.P. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J 1996, 15:5093-5103.
    • (1996) EMBO J , vol.15 , pp. 5093-5103
    • Boulton, S.J.1    Jackson, S.P.2
  • 16
    • 0020373190 scopus 로고
    • Somatic cells efficiently join unrelated DNA segments end-to-end
    • Wilson J.H., Berget P.B., Pipas J.M. Somatic cells efficiently join unrelated DNA segments end-to-end. Mol Cell Biol 1982, 2:1258-1269.
    • (1982) Mol Cell Biol , vol.2 , pp. 1258-1269
    • Wilson, J.H.1    Berget, P.B.2    Pipas, J.M.3
  • 17
    • 36949037544 scopus 로고    scopus 로고
    • V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining
    • Soulas-Sprauel P., Rivera-Munoz P., Malivert L., Le Guyader G., Abramowski V., Revy P., et al. V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining. Oncogene 2007, 26:7780-7791.
    • (2007) Oncogene , vol.26 , pp. 7780-7791
    • Soulas-Sprauel, P.1    Rivera-Munoz, P.2    Malivert, L.3    Le Guyader, G.4    Abramowski, V.5    Revy, P.6
  • 18
    • 0001294157 scopus 로고
    • The stability of broken ends of chromosomes of Zea mays
    • McClintock B. The stability of broken ends of chromosomes of Zea mays. Genetics 1941, 23:234-282.
    • (1941) Genetics , vol.23 , pp. 234-282
    • McClintock, B.1
  • 19
    • 33947581390 scopus 로고    scopus 로고
    • The impact of translocations and gene fusions on cancer causation
    • Mitelman F., Johansson B., Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer 2007, 7:233-245.
    • (2007) Nat Rev Cancer , vol.7 , pp. 233-245
    • Mitelman, F.1    Johansson, B.2    Mertens, F.3
  • 20
    • 0000286732 scopus 로고
    • A minute chromosome in human chronic granulocytic leukemia
    • Nowell P., Hungerford D. A minute chromosome in human chronic granulocytic leukemia. Science 1960, 142:1497.
    • (1960) Science , vol.142 , pp. 1497
    • Nowell, P.1    Hungerford, D.2
  • 21
    • 0001292985 scopus 로고
    • Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
    • Taub R., Kirsch I., Morton C., Lenoir G., Swan D., Tronick S., et al. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci USA 1982, 79:7837-7841.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 7837-7841
    • Taub, R.1    Kirsch, I.2    Morton, C.3    Lenoir, G.4    Swan, D.5    Tronick, S.6
  • 22
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • Stephens P.J., Greenman C.D., Fu B., Yang F., Bignell G.R., Mudie L.J., et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 2011, 144:27-40.
    • (2011) Cell , vol.144 , pp. 27-40
    • Stephens, P.J.1    Greenman, C.D.2    Fu, B.3    Yang, F.4    Bignell, G.R.5    Mudie, L.J.6
  • 23
    • 80052916562 scopus 로고    scopus 로고
    • Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements
    • Liu P., Erez A., Nagamani S.C., Dhar S.U., Kolodziejska K.E., Dharmadhikari A.V., et al. Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements. Cell 2011, 146:889-903.
    • (2011) Cell , vol.146 , pp. 889-903
    • Liu, P.1    Erez, A.2    Nagamani, S.C.3    Dhar, S.U.4    Kolodziejska, K.E.5    Dharmadhikari, A.V.6
  • 25
    • 57049132043 scopus 로고    scopus 로고
    • 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
    • Dimitrova N., Chen Y.C., Spector D.L., de Lange T. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 2008, 456:524-528.
    • (2008) Nature , vol.456 , pp. 524-528
    • Dimitrova, N.1    Chen, Y.C.2    Spector, D.L.3    de Lange, T.4
  • 26
    • 77951057068 scopus 로고    scopus 로고
    • 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
    • Bothmer A., Robbiani D.F., Feldhahn N., Gazumyan A., Nussenzweig A., Nussenzweig M.C. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med 2010, 207:855-865.
    • (2010) J Exp Med , vol.207 , pp. 855-865
    • Bothmer, A.1    Robbiani, D.F.2    Feldhahn, N.3    Gazumyan, A.4    Nussenzweig, A.5    Nussenzweig, M.C.6
  • 27
    • 47949092912 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations
    • Lee K., Zhang Y., Lee S.E. Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations. Nature 2008, 454:543-546.
    • (2008) Nature , vol.454 , pp. 543-546
    • Lee, K.1    Zhang, Y.2    Lee, S.E.3
  • 29
    • 70350786918 scopus 로고    scopus 로고
    • Human RAP1 inhibits non-homologous end joining at F telomeres
    • Sarthy J., Bae N.S., Scrafford J., Baumann P. Human RAP1 inhibits non-homologous end joining at F telomeres. EMBO J 2009, 28:3390-3399.
    • (2009) EMBO J , vol.28 , pp. 3390-3399
    • Sarthy, J.1    Bae, N.S.2    Scrafford, J.3    Baumann, P.4
  • 30
    • 77950955761 scopus 로고    scopus 로고
    • Origin of chromosomal translocations in lymphoid cancer
    • Nussenzweig A., Nussenzweig M.C. Origin of chromosomal translocations in lymphoid cancer. Cell 2010, 141:27-38.
    • (2010) Cell , vol.141 , pp. 27-38
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 31
    • 77955841149 scopus 로고    scopus 로고
    • Collaboration and competition between DNA double-strand break repair pathways
    • Kass E.M., Jasin M. Collaboration and competition between DNA double-strand break repair pathways. FEBS Lett 2010, 584:3703-3708.
    • (2010) FEBS Lett , vol.584 , pp. 3703-3708
    • Kass, E.M.1    Jasin, M.2
  • 32
    • 0022976432 scopus 로고
    • Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction
    • Roth D.B., Wilson J.H. Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction. Mol Cell Biol 1986, 6:4295-4304.
    • (1986) Mol Cell Biol , vol.6 , pp. 4295-4304
    • Roth, D.B.1    Wilson, J.H.2
  • 33
    • 54849404458 scopus 로고    scopus 로고
    • MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
    • McVey M., Lee S.E. MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends Genet 2008, 24:529-538.
    • (2008) Trends Genet , vol.24 , pp. 529-538
    • McVey, M.1    Lee, S.E.2
  • 34
    • 38649086357 scopus 로고    scopus 로고
    • Alternative endings
    • Haber J.E. Alternative endings. Proc Natl Acad Sci USA 2008, 105:405-406.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 405-406
    • Haber, J.E.1
  • 35
    • 58149308524 scopus 로고    scopus 로고
    • Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells
    • Han L., Yu K. Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells. J Exp Med 2008, 205:2745-2753.
    • (2008) J Exp Med , vol.205 , pp. 2745-2753
    • Han, L.1    Yu, K.2
  • 36
    • 0035839959 scopus 로고    scopus 로고
    • Mechanisms of chromosomal translocations in B cell lymphomas
    • Kuppers R., Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 2001, 20:5580-5594.
    • (2001) Oncogene , vol.20 , pp. 5580-5594
    • Kuppers, R.1    Dalla-Favera, R.2
  • 37
    • 0037136318 scopus 로고    scopus 로고
    • Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification
    • Difilippantonio M.J., Petersen S., Chen H.T., Johnson R., Jasin M., Kanaar R., et al. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med 2002, 196:469-480.
    • (2002) J Exp Med , vol.196 , pp. 469-480
    • Difilippantonio, M.J.1    Petersen, S.2    Chen, H.T.3    Johnson, R.4    Jasin, M.5    Kanaar, R.6
  • 38
    • 0037188898 scopus 로고    scopus 로고
    • Breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
    • Zhu C., Mills K.D., Ferguson D.O., Lee C., Manis J., Fleming J., et al. breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 2002, 109:811-821.
    • (2002) Cell , vol.109 , pp. 811-821
    • Zhu, C.1    Mills, K.D.2    Ferguson, D.O.3    Lee, C.4    Manis, J.5    Fleming, J.6
  • 39
    • 34547589577 scopus 로고    scopus 로고
    • Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70
    • Weinstock D.M., Brunet E., Jasin M. Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat Cell Biol 2007, 9:978-981.
    • (2007) Nat Cell Biol , vol.9 , pp. 978-981
    • Weinstock, D.M.1    Brunet, E.2    Jasin, M.3
  • 40
    • 0034732239 scopus 로고    scopus 로고
    • DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    • Difilippantonio M.J., Zhu J., Chen H.T., Meffre E., Nussenzweig M.C., Max E.E., et al. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 2000, 404:510-514.
    • (2000) Nature , vol.404 , pp. 510-514
    • Difilippantonio, M.J.1    Zhu, J.2    Chen, H.T.3    Meffre, E.4    Nussenzweig, M.C.5    Max, E.E.6
  • 41
    • 0034612308 scopus 로고    scopus 로고
    • The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
    • Ferguson D.O., Sekiguchi J.M., Chang S., Frank K.M., Gao Y., DePinho R.A., et al. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 2000, 97:6630-6633.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6630-6633
    • Ferguson, D.O.1    Sekiguchi, J.M.2    Chang, S.3    Frank, K.M.4    Gao, Y.5    DePinho, R.A.6
  • 42
    • 70350088548 scopus 로고    scopus 로고
    • Mechanisms of double-strand break repair in somatic mammalian cells
    • Hartlerode A.J., Scully R. Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J 2009, 423:157-168.
    • (2009) Biochem J , vol.423 , pp. 157-168
    • Hartlerode, A.J.1    Scully, R.2
  • 43
    • 80053502216 scopus 로고    scopus 로고
    • Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes
    • Klein I.A., Resch W., Jankovic M., Oliveira T., Yamane A., Nakahashi H., et al. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell 2011, 147:95-106.
    • (2011) Cell , vol.147 , pp. 95-106
    • Klein, I.A.1    Resch, W.2    Jankovic, M.3    Oliveira, T.4    Yamane, A.5    Nakahashi, H.6
  • 44
    • 80053558376 scopus 로고    scopus 로고
    • Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells
    • Chiarle R., Zhang Y., Frock R.L., Lewis S.M., Molinie B., Ho Y.J., et al. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell 2011, 147:107-119.
    • (2011) Cell , vol.147 , pp. 107-119
    • Chiarle, R.1    Zhang, Y.2    Frock, R.L.3    Lewis, S.M.4    Molinie, B.5    Ho, Y.J.6
  • 45
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • Paques F., Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 1999, 63:349-404.
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 46
    • 0035893363 scopus 로고    scopus 로고
    • Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    • Pierce A.J., Hu P., Han M., Ellis N., Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 2001, 15:3237-3242.
    • (2001) Genes Dev , vol.15 , pp. 3237-3242
    • Pierce, A.J.1    Hu, P.2    Han, M.3    Ellis, N.4    Jasin, M.5
  • 47
    • 0035977007 scopus 로고    scopus 로고
    • Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair
    • Fukushima T., Takata M., Morrison C., Araki R., Fujimori A., Abe M., et al. Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair. J Biol Chem 2001, 276:44413-44418.
    • (2001) J Biol Chem , vol.276 , pp. 44413-44418
    • Fukushima, T.1    Takata, M.2    Morrison, C.3    Araki, R.4    Fujimori, A.5    Abe, M.6
  • 48
    • 56049086017 scopus 로고    scopus 로고
    • Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting
    • Iiizumi S., Kurosawa A., So S., Ishii Y., Chikaraishi Y., Ishii A., et al. Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting. Nucleic Acids Res 2008, 36:6333-6342.
    • (2008) Nucleic Acids Res , vol.36 , pp. 6333-6342
    • Iiizumi, S.1    Kurosawa, A.2    So, S.3    Ishii, Y.4    Chikaraishi, Y.5    Ishii, A.6
  • 49
    • 55849102141 scopus 로고    scopus 로고
    • A mechanism for gene conversion in fungi
    • Holliday R. A mechanism for gene conversion in fungi. Genet Res 2007, 89(5-6):285-307.
    • (2007) Genet Res , vol.89 , Issue.5-6 , pp. 285-307
    • Holliday, R.1
  • 50
    • 39449096135 scopus 로고    scopus 로고
    • Genome instability: a mechanistic view of its causes and consequences
    • Aguilera A., Gomez-Gonzalez B. Genome instability: a mechanistic view of its causes and consequences. Nat Rev Genet 2008, 9:204-217.
    • (2008) Nat Rev Genet , vol.9 , pp. 204-217
    • Aguilera, A.1    Gomez-Gonzalez, B.2
  • 51
    • 79959843168 scopus 로고    scopus 로고
    • Mechanism of RAD51-dependent DNA interstrand cross-link repair
    • Long D.T., Raschle M., Joukov V., Walter J.C. Mechanism of RAD51-dependent DNA interstrand cross-link repair. Science 2011, 333:84-87.
    • (2011) Science , vol.333 , pp. 84-87
    • Long, D.T.1    Raschle, M.2    Joukov, V.3    Walter, J.C.4
  • 52
    • 78649449767 scopus 로고    scopus 로고
    • The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax
    • Goodarzi A.A., Jeggo P., Lobrich M. The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax. DNA Repair 2010, 9:1273-1282.
    • (2010) DNA Repair , vol.9 , pp. 1273-1282
    • Goodarzi, A.A.1    Jeggo, P.2    Lobrich, M.3
  • 53
    • 33750801681 scopus 로고    scopus 로고
    • The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres
    • Verdun R.E, Karlseder J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 2006, 127:709-720.
    • (2006) Cell , vol.127 , pp. 709-720
    • Verdun, R.E.1    Karlseder, J.2
  • 54
    • 79953070482 scopus 로고    scopus 로고
    • Homologous recombination proteins are associated with centrosomes and are required for mitotic stability
    • Cappelli E., Townsend S., Griffin C., Thacker J. Homologous recombination proteins are associated with centrosomes and are required for mitotic stability. Exp Cell Res 2011, 317:1203-1213.
    • (2011) Exp Cell Res , vol.317 , pp. 1203-1213
    • Cappelli, E.1    Townsend, S.2    Griffin, C.3    Thacker, J.4
  • 55
    • 4444339506 scopus 로고    scopus 로고
    • Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle
    • Ferreira M.G., Cooper J.P. Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle. Genes Dev 2004, 18:2249-2254.
    • (2004) Genes Dev , vol.18 , pp. 2249-2254
    • Ferreira, M.G.1    Cooper, J.P.2
  • 56
    • 0030000946 scopus 로고    scopus 로고
    • Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae
    • Ivanov E.L., Sugawara N., Fishman-Lobell J., Haber J.E. Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae. Genetics 1996, 142:693-704.
    • (1996) Genetics , vol.142 , pp. 693-704
    • Ivanov, E.L.1    Sugawara, N.2    Fishman-Lobell, J.3    Haber, J.E.4
  • 57
    • 0030463946 scopus 로고    scopus 로고
    • Lack of chromosome territoriality in yeast: promiscuous rejoining of broken chromosome ends
    • Haber J.E., Leung W.Y. Lack of chromosome territoriality in yeast: promiscuous rejoining of broken chromosome ends. Proc Natl Acad Sci U S A 1996, 93:13949-13954.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13949-13954
    • Haber, J.E.1    Leung, W.Y.2
  • 58
    • 49349085284 scopus 로고    scopus 로고
    • Chromosome fusions following telomere loss are mediated by single-strand annealing
    • Wang X., Baumann P. Chromosome fusions following telomere loss are mediated by single-strand annealing. Mol Cell 2008, 31:463-473.
    • (2008) Mol Cell , vol.31 , pp. 463-473
    • Wang, X.1    Baumann, P.2
  • 59
    • 33750339265 scopus 로고    scopus 로고
    • Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C
    • Nagaraju G., Odate S., Xie A., Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol Cell Biol 2006, 26:8075-8086.
    • (2006) Mol Cell Biol , vol.26 , pp. 8075-8086
    • Nagaraju, G.1    Odate, S.2    Xie, A.3    Scully, R.4
  • 60
    • 0034613170 scopus 로고    scopus 로고
    • The relationship between homology length and crossing over during the repair of a broken chromosome
    • Inbar O., Liefshitz B., Bitan G., Kupiec M. The relationship between homology length and crossing over during the repair of a broken chromosome. J Biol Chem 2000, 275:30833-30838.
    • (2000) J Biol Chem , vol.275 , pp. 30833-30838
    • Inbar, O.1    Liefshitz, B.2    Bitan, G.3    Kupiec, M.4
  • 61
    • 0034551792 scopus 로고    scopus 로고
    • Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae
    • Symington L.S., Kang L.E., Moreau S. Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae. Nucleic Acids Res 2000, 28:4649-4656.
    • (2000) Nucleic Acids Res , vol.28 , pp. 4649-4656
    • Symington, L.S.1    Kang, L.E.2    Moreau, S.3
  • 62
    • 77954328102 scopus 로고    scopus 로고
    • Increased mutagenesis and unique mutation signature associated with mitotic gene conversion
    • Hicks W.M., Kim M., Haber J.E. Increased mutagenesis and unique mutation signature associated with mitotic gene conversion. Science 2010, 329:82-85.
    • (2010) Science , vol.329 , pp. 82-85
    • Hicks, W.M.1    Kim, M.2    Haber, J.E.3
  • 63
    • 79955522790 scopus 로고    scopus 로고
    • Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes
    • Schwartz E.K., Heyer W.D. Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma 2011, 120:109-127.
    • (2011) Chromosoma , vol.120 , pp. 109-127
    • Schwartz, E.K.1    Heyer, W.D.2
  • 65
    • 0030776156 scopus 로고    scopus 로고
    • Loss of heterozygosity or: how I learned to stop worrying and love mitotic recombination
    • Tischfield J.A. Loss of heterozygosity or: how I learned to stop worrying and love mitotic recombination. Am J Hum Genet 1997, 61:995-999.
    • (1997) Am J Hum Genet , vol.61 , pp. 995-999
    • Tischfield, J.A.1
  • 66
    • 0029947714 scopus 로고    scopus 로고
    • Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication
    • Malkova A., Ivanov E.L., Haber J.E. Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication. Proc Natl Acad Sci USA 1996, 93:7131-7136.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7131-7136
    • Malkova, A.1    Ivanov, E.L.2    Haber, J.E.3
  • 67
    • 0031737723 scopus 로고    scopus 로고
    • Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture
    • Bosco G., Haber J.E. Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture. Genetics 1998, 150:1037-1047.
    • (1998) Genetics , vol.150 , pp. 1037-1047
    • Bosco, G.1    Haber, J.E.2
  • 68
    • 42449130956 scopus 로고    scopus 로고
    • Break-induced replication: what is it and what is it for?
    • Llorente B., Smith C.E., Symington L.S. Break-induced replication: what is it and what is it for?. Cell Cycle 2008, 7:859-864.
    • (2008) Cell Cycle , vol.7 , pp. 859-864
    • Llorente, B.1    Smith, C.E.2    Symington, L.S.3
  • 69
    • 70350780181 scopus 로고    scopus 로고
    • Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast
    • Tinline-Purvis H., Savory A.P., Cullen J.K., Dave A., Moss J., Bridge W.L., et al. Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast. EMBO J 2009, 28:3400-3412.
    • (2009) EMBO J , vol.28 , pp. 3400-3412
    • Tinline-Purvis, H.1    Savory, A.P.2    Cullen, J.K.3    Dave, A.4    Moss, J.5    Bridge, W.L.6
  • 70
    • 34547927220 scopus 로고    scopus 로고
    • Break-induced replication and telomerase-independent telomere maintenance require Pol32
    • Lydeard J.R., Jain S., Yamaguchi M., Haber J.E. Break-induced replication and telomerase-independent telomere maintenance require Pol32. Nature 2007, 448:820-823.
    • (2007) Nature , vol.448 , pp. 820-823
    • Lydeard, J.R.1    Jain, S.2    Yamaguchi, M.3    Haber, J.E.4
  • 71
    • 34247611513 scopus 로고    scopus 로고
    • Template switching during break-induced replication
    • Smith C.E., Llorente B., Symington L.S. Template switching during break-induced replication. Nature 2007, 447:102-105.
    • (2007) Nature , vol.447 , pp. 102-105
    • Smith, C.E.1    Llorente, B.2    Symington, L.S.3
  • 72
    • 0035963338 scopus 로고    scopus 로고
    • Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae
    • Myung K., Chen C., Kolodner R.D. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature 2001, 411:1073-1076.
    • (2001) Nature , vol.411 , pp. 1073-1076
    • Myung, K.1    Chen, C.2    Kolodner, R.D.3
  • 74
    • 67649878596 scopus 로고    scopus 로고
    • The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans
    • Zhang F., Khajavi M., Connolly A.M., Towne C.F., Batish S.D., Lupski J.R. The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans. Nat Genet 2009, 41:849-853.
    • (2009) Nat Genet , vol.41 , pp. 849-853
    • Zhang, F.1    Khajavi, M.2    Connolly, A.M.3    Towne, C.F.4    Batish, S.D.5    Lupski, J.R.6
  • 75
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou E.P., Symington L.S. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 2008, 455:770-774.
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 76
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z., Chung W.H., Shim E.Y., Lee S.E., Ira G. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 2008, 134:981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 78
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • Jazayeri A., Falck J., Lukas C., Bartek J., Smith G.C., Lukas J., et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006, 8:37-45.
    • (2006) Nat Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.C.5    Lukas, J.6
  • 79
    • 33646777679 scopus 로고    scopus 로고
    • Rapid activation of ATR by ionizing radiation requires ATM and Mre11
    • Myers J.S., Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 2006, 281:9346-9350.
    • (2006) J Biol Chem , vol.281 , pp. 9346-9350
    • Myers, J.S.1    Cortez, D.2
  • 80
    • 79951857925 scopus 로고    scopus 로고
    • DNA end resection-unraveling the tail
    • Mimitou E.P., Symington L.S. DNA end resection-unraveling the tail. DNA Repair (Amst) 2011, 10:344-348.
    • (2011) DNA Repair (Amst) , vol.10 , pp. 344-348
    • Mimitou, E.P.1    Symington, L.S.2
  • 81
    • 77957805302 scopus 로고    scopus 로고
    • Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
    • Mimitou E.P., Symington L.S. Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO J 2010, 29:3358-3369.
    • (2010) EMBO J , vol.29 , pp. 3358-3369
    • Mimitou, E.P.1    Symington, L.S.2
  • 82
    • 77957786786 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
    • Shim E.Y., Chung W.H., Nicolette M.L., Zhang Y., Davis M., Zhu Z., et al. Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J 2010, 29:3370-3380.
    • (2010) EMBO J , vol.29 , pp. 3370-3380
    • Shim, E.Y.1    Chung, W.H.2    Nicolette, M.L.3    Zhang, Y.4    Davis, M.5    Zhu, Z.6
  • 83
    • 34447129653 scopus 로고    scopus 로고
    • Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination
    • Zhang Y., Hefferin M.L., Chen L., Shim E.Y., Tseng H.M., Kwon Y., et al. Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat Struct Mol Biol 2007, 14:639-646.
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 639-646
    • Zhang, Y.1    Hefferin, M.L.2    Chen, L.3    Shim, E.Y.4    Tseng, H.M.5    Kwon, Y.6
  • 84
    • 53349162987 scopus 로고    scopus 로고
    • CDK targets Sae2 to control DNA-end resection and homologous recombination
    • Huertas P., Cortes-Ledesma F., Sartori A.A., Aguilera A., Jackson S.P. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 2008, 455:689-692.
    • (2008) Nature , vol.455 , pp. 689-692
    • Huertas, P.1    Cortes-Ledesma, F.2    Sartori, A.A.3    Aguilera, A.4    Jackson, S.P.5
  • 85
    • 67349246802 scopus 로고    scopus 로고
    • CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    • Yun M.H., Hiom K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 2009, 459:460-463.
    • (2009) Nature , vol.459 , pp. 460-463
    • Yun, M.H.1    Hiom, K.2
  • 86
    • 34948872046 scopus 로고    scopus 로고
    • Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
    • Limbo O., Chahwan C., Yamada Y., de Bruin R.A., Wittenberg C., Russell P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol Cell 2007, 28:134-146.
    • (2007) Mol Cell , vol.28 , pp. 134-146
    • Limbo, O.1    Chahwan, C.2    Yamada, Y.3    de Bruin, R.A.4    Wittenberg, C.5    Russell, P.6
  • 87
    • 0037169325 scopus 로고    scopus 로고
    • The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements
    • Lobachev K.S., Gordenin D.A., Resnick M.A. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 2002, 108:183-193.
    • (2002) Cell , vol.108 , pp. 183-193
    • Lobachev, K.S.1    Gordenin, D.A.2    Resnick, M.A.3
  • 88
    • 33744947315 scopus 로고    scopus 로고
    • BRCA1 promotes induction of ssDNA by ionizing radiation
    • Schlegel B.P., Jodelka F.M., Nunez R. BRCA1 promotes induction of ssDNA by ionizing radiation. Cancer Res 2006, 66:5181-5189.
    • (2006) Cancer Res , vol.66 , pp. 5181-5189
    • Schlegel, B.P.1    Jodelka, F.M.2    Nunez, R.3
  • 89
    • 6344264992 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains
    • Yu X., Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 2004, 24:9478-9486.
    • (2004) Mol Cell Biol , vol.24 , pp. 9478-9486
    • Yu, X.1    Chen, J.2
  • 90
    • 0030800325 scopus 로고    scopus 로고
    • A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells
    • Larson J.S., Tonkinson J.L., Lai M.T. A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells. Cancer Res 1997, 57:3351-3355.
    • (1997) Cancer Res , vol.57 , pp. 3351-3355
    • Larson, J.S.1    Tonkinson, J.L.2    Lai, M.T.3
  • 91
    • 0036510163 scopus 로고    scopus 로고
    • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
    • Yarden R.I., Pardo-Reoyo S., Sgagias M., Cowan K.H., Brody L.C. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 2002, 30:285-289.
    • (2002) Nat Genet , vol.30 , pp. 285-289
    • Yarden, R.I.1    Pardo-Reoyo, S.2    Sgagias, M.3    Cowan, K.H.4    Brody, L.C.5
  • 92
    • 77950958141 scopus 로고    scopus 로고
    • 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
    • Bunting S.F., Callen E., Wong N., Chen H.T., Polato F., Gunn A., et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 2010, 141:243-254.
    • (2010) Cell , vol.141 , pp. 243-254
    • Bunting, S.F.1    Callen, E.2    Wong, N.3    Chen, H.T.4    Polato, F.5    Gunn, A.6
  • 93
    • 77953291328 scopus 로고    scopus 로고
    • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    • Bouwman P., Aly A., Escandell J.M., Pieterse M., Bartkova J., van der Gulden H., et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 2010, 17:688-695.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 688-695
    • Bouwman, P.1    Aly, A.2    Escandell, J.M.3    Pieterse, M.4    Bartkova, J.5    van der Gulden, H.6
  • 94
    • 44349180168 scopus 로고    scopus 로고
    • Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres
    • Lazzaro F., Sapountzi V., Granata M., Pellicioli A., Vaze M., Haber J.E., et al. Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J 2008, 27:1502-1512.
    • (2008) EMBO J , vol.27 , pp. 1502-1512
    • Lazzaro, F.1    Sapountzi, V.2    Granata, M.3    Pellicioli, A.4    Vaze, M.5    Haber, J.E.6
  • 95
    • 77957351746 scopus 로고    scopus 로고
    • Extensive DNA End processing by exo1 and sgs1 inhibits break-induced replication
    • Marrero V.A., Symington L.S., Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replication. PLoS Genet 2010, 6:e1001007.
    • (2010) PLoS Genet , vol.6
    • Marrero, V.A.1    Symington, L.S.2
  • 96
    • 67650001851 scopus 로고    scopus 로고
    • Complex human chromosomal and genomic rearrangements
    • Zhang F., Carvalho C.M., Lupski J.R. Complex human chromosomal and genomic rearrangements. Trends Genet 2009, 25:298-307.
    • (2009) Trends Genet , vol.25 , pp. 298-307
    • Zhang, F.1    Carvalho, C.M.2    Lupski, J.R.3
  • 97
    • 78650413995 scopus 로고    scopus 로고
    • Chromosome integrity at a double-strand break requires exonuclease 1 and MRX
    • Nakai W., Westmoreland J., Yeh E., Bloom K., Resnick M.A. Chromosome integrity at a double-strand break requires exonuclease 1 and MRX. DNA Repair (Amst) 2011, 10:102-110.
    • (2011) DNA Repair (Amst) , vol.10 , pp. 102-110
    • Nakai, W.1    Westmoreland, J.2    Yeh, E.3    Bloom, K.4    Resnick, M.A.5
  • 98
    • 35748954645 scopus 로고    scopus 로고
    • Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition
    • Cullen J.K., Hussey S.P., Walker C., Prudden J., Wee B.Y., Dave A., et al. Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition. Mol Cell Biol 2007, 27:7745-7757.
    • (2007) Mol Cell Biol , vol.27 , pp. 7745-7757
    • Cullen, J.K.1    Hussey, S.P.2    Walker, C.3    Prudden, J.4    Wee, B.Y.5    Dave, A.6
  • 99
    • 77953219442 scopus 로고    scopus 로고
    • Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends
    • Lydeard J.R., Lipkin-Moore Z., Jain S., Eapen V.V., Haber J.E. Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends. PLoS Genet 2010, 6:e1000973.
    • (2010) PLoS Genet , vol.6
    • Lydeard, J.R.1    Lipkin-Moore, Z.2    Jain, S.3    Eapen, V.V.4    Haber, J.E.5
  • 100
    • 77953224210 scopus 로고    scopus 로고
    • Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting
    • Chung W.H., Zhu Z., Papusha A., Malkova A., Ira G. Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting. PLoS Genet 2010, 6:e1000948.
    • (2010) PLoS Genet , vol.6
    • Chung, W.H.1    Zhu, Z.2    Papusha, A.3    Malkova, A.4    Ira, G.5
  • 101
    • 77953161582 scopus 로고    scopus 로고
    • Telomere loss as a mechanism for chromosome instability in human cancer
    • Murnane J.P. Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res 2010, 70:4255-4259.
    • (2010) Cancer Res , vol.70 , pp. 4255-4259
    • Murnane, J.P.1
  • 102
    • 0034604503 scopus 로고    scopus 로고
    • Pif1p helicase, a catalytic inhibitor of telomerase in yeast
    • Zhou J., Monson E.K., Teng S.C., Schulz V.P., Zakian V.A. Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science 2000, 289:771-774.
    • (2000) Science , vol.289 , pp. 771-774
    • Zhou, J.1    Monson, E.K.2    Teng, S.C.3    Schulz, V.P.4    Zakian, V.A.5
  • 103
    • 70449522305 scopus 로고    scopus 로고
    • DNA damage signalling prevents deleterious telomere addition at DNA breaks
    • Makovets S., Blackburn E.H. DNA damage signalling prevents deleterious telomere addition at DNA breaks. Nat Cell Biol 2009, 11:1383-1386.
    • (2009) Nat Cell Biol , vol.11 , pp. 1383-1386
    • Makovets, S.1    Blackburn, E.H.2
  • 104
    • 77649116452 scopus 로고    scopus 로고
    • De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks
    • Zhang W., Durocher D. De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes Dev 2010, 24:502-515.
    • (2010) Genes Dev , vol.24 , pp. 502-515
    • Zhang, W.1    Durocher, D.2
  • 105
    • 53349165577 scopus 로고    scopus 로고
    • Large inverted repeats in the vicinity of a single double-strand break strongly affect repair in yeast diploids lacking Rad51
    • Downing B., Morgan R., Vanhulle K., Deem A., Malkova A. Large inverted repeats in the vicinity of a single double-strand break strongly affect repair in yeast diploids lacking Rad51. Mutat Res 2008, 645:9-18.
    • (2008) Mutat Res , vol.645 , pp. 9-18
    • Downing, B.1    Morgan, R.2    Vanhulle, K.3    Deem, A.4    Malkova, A.5
  • 106
    • 77955616567 scopus 로고    scopus 로고
    • Rad51 inhibits translocation formation by non-conservative homologous recombination in Saccharomyces cerevisiae
    • Manthey G.M., Bailis A.M. Rad51 inhibits translocation formation by non-conservative homologous recombination in Saccharomyces cerevisiae. PLoS One 2010, 5:e11889.
    • (2010) PLoS One , vol.5
    • Manthey, G.M.1    Bailis, A.M.2
  • 107
    • 6344234817 scopus 로고    scopus 로고
    • Genetic steps of mammalian homologous repair with distinct mutagenic consequences
    • Stark J.M., Pierce A.J., Oh J., Pastink A., Jasin M. Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol 2004, 24:9305-9316.
    • (2004) Mol Cell Biol , vol.24 , pp. 9305-9316
    • Stark, J.M.1    Pierce, A.J.2    Oh, J.3    Pastink, A.4    Jasin, M.5
  • 108
    • 11344268431 scopus 로고    scopus 로고
    • Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells
    • Cotta-Ramusino C., Fachinetti D., Lucca C., Doksani Y., Lopes M., Sogo J., et al. Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol Cell 2005, 17:153-159.
    • (2005) Mol Cell , vol.17 , pp. 153-159
    • Cotta-Ramusino, C.1    Fachinetti, D.2    Lucca, C.3    Doksani, Y.4    Lopes, M.5    Sogo, J.6
  • 109
    • 46249122812 scopus 로고    scopus 로고
    • Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks
    • Segurado M., Diffley J.F. Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev 2008, 22:1816-1827.
    • (2008) Genes Dev , vol.22 , pp. 1816-1827
    • Segurado, M.1    Diffley, J.F.2
  • 110
    • 78650753246 scopus 로고    scopus 로고
    • Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae
    • Kaochar S., Shanks L., Weinert T. Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2010, 107:21605-21610.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 21605-21610
    • Kaochar, S.1    Shanks, L.2    Weinert, T.3
  • 111
    • 79955799175 scopus 로고    scopus 로고
    • Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
    • Schlacher K., Christ N., Siaud N., Egashira A., Wu H., Jasin M. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell 2011, 145:529-542.
    • (2011) Cell , vol.145 , pp. 529-542
    • Schlacher, K.1    Christ, N.2    Siaud, N.3    Egashira, A.4    Wu, H.5    Jasin, M.6
  • 112
    • 77956395354 scopus 로고    scopus 로고
    • Mechanisms and regulation of DNA end resection
    • Longhese M.P., Bonetti D., Manfrini N., Clerici M. Mechanisms and regulation of DNA end resection. EMBO J 2010, 29:2864-2874.
    • (2010) EMBO J , vol.29 , pp. 2864-2874
    • Longhese, M.P.1    Bonetti, D.2    Manfrini, N.3    Clerici, M.4
  • 113
    • 0242721689 scopus 로고    scopus 로고
    • End resection initiates genomic instability in the absence of telomerase
    • Hackett J.A., Greider C.W. End resection initiates genomic instability in the absence of telomerase. Mol Cell Biol 2003, 23:8450-8461.
    • (2003) Mol Cell Biol , vol.23 , pp. 8450-8461
    • Hackett, J.A.1    Greider, C.W.2
  • 114
    • 68249143290 scopus 로고    scopus 로고
    • Taming the tiger by the tail: modulation of DNA damage responses by telomeres
    • Lydall D. Taming the tiger by the tail: modulation of DNA damage responses by telomeres. EMBO J 2009, 28:2174-2187.
    • (2009) EMBO J , vol.28 , pp. 2174-2187
    • Lydall, D.1
  • 115
    • 0028822203 scopus 로고
    • Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
    • Garvik B., Carson M., Hartwell L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol 1995, 15:6128-6138.
    • (1995) Mol Cell Biol , vol.15 , pp. 6128-6138
    • Garvik, B.1    Carson, M.2    Hartwell, L.3
  • 116
    • 0028882869 scopus 로고
    • Yeast checkpoint genes in DNA damage processing: implications for repair and arrest
    • Lydall D., Weinert T. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 1995, 270:1488-1491.
    • (1995) Science , vol.270 , pp. 1488-1491
    • Lydall, D.1    Weinert, T.2
  • 117
    • 0035839132 scopus 로고    scopus 로고
    • Telomere dysfunction increases mutation rate and genomic instability
    • Hackett J.A., Feldser D.M., Greider C.W. Telomere dysfunction increases mutation rate and genomic instability. Cell 2001, 106:275-286.
    • (2001) Cell , vol.106 , pp. 275-286
    • Hackett, J.A.1    Feldser, D.M.2    Greider, C.W.3
  • 118
    • 0027266758 scopus 로고
    • An alternative pathway for yeast telomere maintenance rescues est1-senescence
    • Lundblad V., Blackburn E.H. An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell 1993, 73:347-360.
    • (1993) Cell , vol.73 , pp. 347-360
    • Lundblad, V.1    Blackburn, E.H.2
  • 119
    • 7544247595 scopus 로고    scopus 로고
    • Telomerase- and recombination-independent immortalization of budding yeast
    • Maringele L., Lydall D. Telomerase- and recombination-independent immortalization of budding yeast. Genes Dev 2004, 18:2663-2675.
    • (2004) Genes Dev , vol.18 , pp. 2663-2675
    • Maringele, L.1    Lydall, D.2
  • 120
    • 0029880961 scopus 로고    scopus 로고
    • Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast
    • Gangloff S., Zou H., Rothstein R. Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast. EMBO J 1996, 15:1715-1725.
    • (1996) EMBO J , vol.15 , pp. 1715-1725
    • Gangloff, S.1    Zou, H.2    Rothstein, R.3
  • 122
    • 72849116104 scopus 로고    scopus 로고
    • Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast
    • Paek A.L., Kaochar S., Jones H., Elezaby A., Shanks L., Weinert T. Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast. Genes Dev 2009, 23:2861-2875.
    • (2009) Genes Dev , vol.23 , pp. 2861-2875
    • Paek, A.L.1    Kaochar, S.2    Jones, H.3    Elezaby, A.4    Shanks, L.5    Weinert, T.6
  • 123
    • 72849150228 scopus 로고    scopus 로고
    • Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism
    • Mizuno K., Lambert S., Baldacci G., Murray J.M., Carr A.M. Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism. Genes Dev 2009, 23:2876-2886.
    • (2009) Genes Dev , vol.23 , pp. 2876-2886
    • Mizuno, K.1    Lambert, S.2    Baldacci, G.3    Murray, J.M.4    Carr, A.M.5
  • 124
    • 80051632086 scopus 로고    scopus 로고
    • Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier
    • Sofueva S., Osman F., Lorenz A., Steinacher R., Castagnetti S., Ledesma J., et al. Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier. Nucleic Acids Res 2011, 39:6568-6584.
    • (2011) Nucleic Acids Res , vol.39 , pp. 6568-6584
    • Sofueva, S.1    Osman, F.2    Lorenz, A.3    Steinacher, R.4    Castagnetti, S.5    Ledesma, J.6
  • 125
    • 0026709385 scopus 로고
    • Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
    • Kadyk L.C., Hartwell L.H. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics 1992, 132:387-402.
    • (1992) Genetics , vol.132 , pp. 387-402
    • Kadyk, L.C.1    Hartwell, L.H.2
  • 126
    • 77957363057 scopus 로고    scopus 로고
    • Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes
    • Covo S., Westmoreland J.W., Gordenin D.A., Resnick M.A. Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes. PLoS Genet 2010, 6:e1001006.
    • (2010) PLoS Genet , vol.6
    • Covo, S.1    Westmoreland, J.W.2    Gordenin, D.A.3    Resnick, M.A.4
  • 127
    • 0026322337 scopus 로고
    • Chromosome rearrangement by ectopic recombination in Drosophila melanogaster: genome structure and evolution
    • Montgomery E.A., Huang S.M., Langley C.H., Judd B.H. Chromosome rearrangement by ectopic recombination in Drosophila melanogaster: genome structure and evolution. Genetics 1991, 129:1085-1098.
    • (1991) Genetics , vol.129 , pp. 1085-1098
    • Montgomery, E.A.1    Huang, S.M.2    Langley, C.H.3    Judd, B.H.4
  • 128
    • 81955168032 scopus 로고    scopus 로고
    • The consequences of structural genomic alterations in humans: genomic disorders, genomic instability and cancer
    • Colnaghi R., Carpenter G., Volker M., O'Driscoll M. The consequences of structural genomic alterations in humans: genomic disorders, genomic instability and cancer. Semin Cell Dev Biol 2011.
    • (2011) Semin Cell Dev Biol
    • Colnaghi, R.1    Carpenter, G.2    Volker, M.3    O'Driscoll, M.4
  • 130
    • 79958013665 scopus 로고    scopus 로고
    • A genetic and structural study of genome rearrangements mediated by high copy repeat Ty1 elements
    • Chan J.E., Kolodner R.D. A genetic and structural study of genome rearrangements mediated by high copy repeat Ty1 elements. PLoS Genet 2011, 7:e1002089.
    • (2011) PLoS Genet , vol.7
    • Chan, J.E.1    Kolodner, R.D.2
  • 131
    • 69249231999 scopus 로고    scopus 로고
    • Specific pathways prevent duplication-mediated genome rearrangements
    • Putnam C.D., Hayes T.K., Kolodner R.D. Specific pathways prevent duplication-mediated genome rearrangements. Nature 2009, 460:984-989.
    • (2009) Nature , vol.460 , pp. 984-989
    • Putnam, C.D.1    Hayes, T.K.2    Kolodner, R.D.3
  • 132
    • 77950862944 scopus 로고    scopus 로고
    • Double Holliday junctions are intermediates of DNA break repair
    • Bzymek M., Thayer N.H., Oh S.D., Kleckner N., Hunter N. Double Holliday junctions are intermediates of DNA break repair. Nature 2010, 464:937-941.
    • (2010) Nature , vol.464 , pp. 937-941
    • Bzymek, M.1    Thayer, N.H.2    Oh, S.D.3    Kleckner, N.4    Hunter, N.5
  • 133
    • 77951246052 scopus 로고    scopus 로고
    • Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing
    • Tay Y.D., Wu L. Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing. J Biol Chem 2010, 285:11427-11432.
    • (2010) J Biol Chem , vol.285 , pp. 11427-11432
    • Tay, Y.D.1    Wu, L.2
  • 134
    • 77949653925 scopus 로고    scopus 로고
    • Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae
    • Blanco M.G., Matos J., Rass U., Ip S.C., West S.C. Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae. DNA Repair (Amst) 2010, 9:394-402.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 394-402
    • Blanco, M.G.1    Matos, J.2    Rass, U.3    Ip, S.C.4    West, S.C.5
  • 135
    • 79953196154 scopus 로고    scopus 로고
    • Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage
    • Mankouri H.W., Ashton T.M., Hickson I.D. Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage. Proc Natl Acad Sci USA 2011, 108:4944-4949.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4944-4949
    • Mankouri, H.W.1    Ashton, T.M.2    Hickson, I.D.3
  • 137
    • 79953239469 scopus 로고    scopus 로고
    • Aberrant chromosome morphology in human cells defective for Holliday junction resolution
    • Wechsler T., Newman S., West S.C. Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature 2011, 471:642-646.
    • (2011) Nature , vol.471 , pp. 642-646
    • Wechsler, T.1    Newman, S.2    West, S.C.3
  • 138
    • 0035902459 scopus 로고    scopus 로고
    • Break-induced replication: a review and an example in budding yeast
    • Kraus E., Leung W.Y., Haber J.E. Break-induced replication: a review and an example in budding yeast. Proc Natl Acad Sci USA 2001, 98:8255-8262.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8255-8262
    • Kraus, E.1    Leung, W.Y.2    Haber, J.E.3
  • 139
    • 77956525242 scopus 로고    scopus 로고
    • HAATI survivors replace canonical telomeres with blocks of generic heterochromatin
    • Jain D., Hebden A.K., Nakamura T.M., Miller K.M., Cooper J.P. HAATI survivors replace canonical telomeres with blocks of generic heterochromatin. Nature 2010, 467:223-227.
    • (2010) Nature , vol.467 , pp. 223-227
    • Jain, D.1    Hebden, A.K.2    Nakamura, T.M.3    Miller, K.M.4    Cooper, J.P.5
  • 140
    • 58149398623 scopus 로고    scopus 로고
    • Translation of the Philadelphia chromosome into therapy for CML
    • Druker B.J. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008, 112:4808-4817.
    • (2008) Blood , vol.112 , pp. 4808-4817
    • Druker, B.J.1
  • 141
    • 79952395270 scopus 로고    scopus 로고
    • Cancer genomics: from discovery science to personalized medicine
    • Chin L., Andersen J.N., Futreal P.A. Cancer genomics: from discovery science to personalized medicine. Nat Med 2011, 17:297-303.
    • (2011) Nat Med , vol.17 , pp. 297-303
    • Chin, L.1    Andersen, J.N.2    Futreal, P.A.3
  • 142
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: oncogene and non-oncogene addiction
    • Luo J., Solimini N.L., Elledge S.J. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009, 136:823-837.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 144
    • 79959397953 scopus 로고    scopus 로고
    • Synthetic lethality: exploiting the addiction of cancer to DNA repair
    • Shaheen M., Allen C., Nickoloff J.A., Hromas R. Synthetic lethality: exploiting the addiction of cancer to DNA repair. Blood 2011, 117:6074-6082.
    • (2011) Blood , vol.117 , pp. 6074-6082
    • Shaheen, M.1    Allen, C.2    Nickoloff, J.A.3    Hromas, R.4
  • 145
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong P.C., Boss D.S., Yap T.A., Tutt A., Wu P., Mergui-Roelvink M., et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009, 361:123-134.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 146
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant H.E., Schultz N., Thomas H.D., Parker K.M., Flower D., Lopez E., et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005, 434:913-917.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3    Parker, K.M.4    Flower, D.5    Lopez, E.6
  • 147
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H., McCabe N., Lord C.J., Tutt A.N., Johnson D.A., Richardson T.B., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005, 434:917-921.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6
  • 148
  • 149
    • 77951720395 scopus 로고    scopus 로고
    • Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
    • Meindl A., Hellebrand H., Wiek C., Erven V., Wappenschmidt B., Niederacher D., et al. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet 2010, 42:410-414.
    • (2010) Nat Genet , vol.42 , pp. 410-414
    • Meindl, A.1    Hellebrand, H.2    Wiek, C.3    Erven, V.4    Wappenschmidt, B.5    Niederacher, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.