Inhibitors of DNA polymerase β: Activity and mechanism

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4331-4340

  Gao, Zhijie ^a   Maloney, David J ^a   Dedkova, Larisa M ^a   Hecht, Sidney M ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Antitumor agent potentiation; Enzyme DNA covalent complex; Inhibition mechanism; Natural products; Polymerase inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; BETULIC ACID; BLEOMYCIN; DNA DIRECTED DNA POLYMERASE BETA; EDGEWORIN; LYASE; OLEANOLIC ACID; STIGMASTEROL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHRYSOBALANACEAE; CONTROLLED STUDY; COUEPIA POLYANDRA; CYTOTOXICITY; DNA SYNTHESIS; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; EDGEWORTHIA GARDNERI; ENZYME INHIBITION; ENZYME MECHANISM; FRACTIONATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; THYMELAEACEAE;

BLEOMYCIN; CATALYSIS; CELL LINE, TUMOR; CELL SURVIVAL; COUMARINS; DNA; DNA POLYMERASE BETA; DNA REPAIR ENZYMES; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; SCHIFF BASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

COUEPIA; EDGEWORTHIA GARDNERI;

EID: 42149157403     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.071     Document Type: Article

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