Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

British Journal of Cancer

Volumn 104, Issue 4, 2011, Pages 653-663

  Mohammed, M Z ^a   Vyjayanti, V N ^b   Laughton, C A ^c   Dekker, L V ^c   Fischer, P M ^c   Wilson, D M ^b   Abbotts, R ^a   Shah, S ^a   Patel, P M ^a   Hickson, I D ^d   Madhusudan, S ^a  

^a Academic Unit of Oncology   (United Kingdom)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

DNA repair; glioma; human apurinic apyrimidinic endonuclease 1 (APE1); melanoma; small molecule inhibitors

Indexed keywords

1,3 BIS(1,3 BENZOTHIAZOL 2 YLTHIO)ACETONE; 3 (2 NAPHTHYL) 5 PHENYL 2,5 DIHYDROPYRAZOL 1 YL)CARBONYLMETHYL 5 NITROTHIOPHENE 2 CARBOXYLATE; 3 BENZOFURAN 2 YL 2 BENZOTHIAZOL 2 YL 3 OXO PROPANENITRILE; 5 FLUORO 1H INDOLE 2 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE INHIBITOR; DOXORUBICIN; ENZYME INHIBITOR; N (3 BENZOOXAZOL 2 YL 4 HYDROXY PHENYL) 2 (2 NAPHTHYLOXY)ACETAMIDE; N (4 FLUOROPHENYL) 2 [4 PHENYLSULFONYL 2 (4 TOLYL)OXAZOL 5 YL]SULFANYL ACETAMIDE; N [BENZO(1,3)DIOXOL 5 YLMETHYL] 4 [2 OXO 4 (THIAZOL 2 YLCARBAMOYLMETHYLSULFANYL) 9 THIA 3,5 DIAZABICYCLO(4.3.0) NONA 4,7,10 TRIEN 3 YL]BUTANAMID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; COMPUTER PROGRAM; CYTOTOXICITY; DRUG POTENTIATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; GLIOMA; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MELANOMA; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

BRAIN NEOPLASMS; CELL LINE, TUMOR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLIOMA; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INHIBITORY CONCENTRATION 50; MELANOMA; MODELS, BIOLOGICAL; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951675147     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6606058     Document Type: Article

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