The fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair

Science

Volumn 326, Issue 5960, 2009, Pages 1698-1701

  Knipscheer, Puck ^a   Räschle, Markus ^b   Smogorzewska, Agata ^c,d,g   Enoiu, Milica ^e   Ho, The Vinh ^f   Schärer, Orlando D ^e,f   Elledge, Stephen J ^c   Walter, Johannes C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f STONY BROOK UNIVERSITY   (United States)

^g ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FANCONI ANEMIA GROUP D2 PROTEIN; FANCONI ANEMIA PROTEIN;

AMINO ACID; ANEMIA; BIOCHEMISTRY; CANCER; CYTOLOGY; DNA; GENOMICS; MUTATION; PUBLIC HEALTH;

ARTICLE; CANCER SUSCEPTIBILITY; CELL CYCLE S PHASE; CELL FREE SYSTEM; DNA CROSS LINKING; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS; FANCONI ANEMIA; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UBIQUITINATION;

ANIMALS; CELL-FREE SYSTEM; CHROMATIN; DNA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; S PHASE; SIGNAL TRANSDUCTION; UBIQUITINATED PROTEINS; UBIQUITINATION; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 72949123930     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1182372     Document Type: Article

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21. This work was supported by NIH grant GM62267 and Leukemia and Lymphoma Society Award 1406-07 to J.C.W.; New York State of Science, Technology and Academic Research (NYSTAR) Faculty Development Award C040069 and Swiss Cancer League grant OCS-01413-08-2003 to O.D.S.; and a Dutch Cancer Society fellowship to P.K. A.S. was supported by T32CA09216 to the Pathology Department at the Massachusetts General Hospital and by the Burroughs Wellcome Fund. S.J.E. is an investigator of the Howard Hughes Medical Institute. We thank M. Hoatlin for the Xenopus FANCD2 cDNA, K. Cimprich for phospho-Rad1 antibody, and the Walter laboratory for feedback. M.R. thanks S. Jentsch and the Max Planck Institute for generous support. The Xenopus FANCI cDNA sequence was deposited to the National Center for Biotechnology Information, NIH, database (accession no. GU144566).