Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair

Cancer Research

Volumn 68, Issue 9, 2008, Pages 3169-3177

  Chen, Xi ^a   Zhong, Shijun ^b   Zhu, Xiao ^b   Dziegielewska, Barbara ^a   Ellenberger, Tom ^c   Wilson, Gerald M ^a   MacKerell Jr , Alexander D ^b   Tomkinson, Alan E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP);

ARTICLE; CANCER CELL; COMPLEX FORMATION; COMPUTER AIDED DESIGN; DNA REPAIR; DNA REPLICATION; DRUG DESIGN; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DOMAIN; BIOLOGICAL MODEL; CELL CULTURE; CELL STRAIN HCT116; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; EVALUATION; HELA CELL; METABOLISM; METHODOLOGY; PROTEIN BINDING; SYNTHESIS;

COMPUTER-AIDED DESIGN; DNA; DNA LIGASES; DNA REPAIR; DNA REPLICATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HCT116 CELLS; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN BINDING; TUMOR CELLS, CULTURED;

EID: 44849117230     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6636     Document Type: Article

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