FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair

Science

Volumn 329, Issue 5992, 2010, Pages 693-696

  Liu, Ting ^a   Ghosal, Gargi ^b   Yuan, Jingsong ^b   Chen, Junjie ^b   Huang, Jun ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FANCONI ANEMIA ASSOCIATED NUCLEASE 1; FANCONI ANEMIA GROUP C PROTEIN; FANCONI ANEMIA GROUP D2 PROTEIN; FANCONI ANEMIA PROTEIN; NUCLEASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANEMIA; DNA; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; MUTATION; PROTEIN;

ARTICLE; COMPLEX FORMATION; CROSS LINKING; DNA DAMAGE; DNA REPAIR; FANCONI ANEMIA; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HUMAN; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DOMAIN; UBIQUITINATION;

AMINO ACID SEQUENCE; CELL LINE; CELL NUCLEUS; DNA; DNA DAMAGE; DNA REPAIR; EXODEOXYRIBONUCLEASES; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; MITOMYCIN; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN BINDING; UBIQUITINATED PROTEINS; UBIQUITINATION; ZINC FINGERS;

EID: 77955290719     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1192656     Document Type: Article

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26. This work was supported in part by grants from Startup Fund (Life Sciences Institute, Zhejiang University to J.H.), the Fundamental Research Funds for the Central Universities, China (to J.H.), and the NIH (to J.C.). We thank L. Li, X. Shen, and Y. Zhang for reagents. J.H. would like to thank J.C. for his continuous support and mentoring. J.C. is a recipient of an Era of Hope Scholar award from the U.S. Department of Defense and is a member of M.D. Anderson Cancer Center.