Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

Oncogene

Volumn 28, Issue 24, 2009, Pages 2314-2323

  Walker, M ^a   Black, E J ^a   Oehler, V ^a   Gillespie, D A ^a,b   Scott, M T ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

ATR; Chk1; Kinase activity

Indexed keywords

ALANINE; CHECKPOINT KINASE 1;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; APHIDICOLIN; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CHICKENS; DNA DAMAGE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; G2 PHASE; IMMUNOPRECIPITATION; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; S PHASE; SERINE; TUMOR SUPPRESSOR PROTEINS;

EID: 67649253108     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.102     Document Type: Article

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