PolyADP-ribosylation and cancer

Cancer Science

Volumn 98, Issue 10, 2007, Pages 1528-1535

  Miwa, Masanao ^a   Masutani, Mitsuko ^b  

^a NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZAMIDE; 8 HYDROXY 2 METHYL 4(3H) QUINAZOLINONE; 8 OCTYLAMINO ADENOSINE DIPHOSPHATE (HYDROXYMETHYL) PYRROLIDINEDIOL; ADENOSINE DIPHOSPHATE (HYDROXYMETHYL) PYRROLIDINEDIOL; AG 014669; AG 14361; BENADROSTIN; BENZAMIDE; BLEOMYCIN; DIMETHYL SULFATE; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; MYRISTYL NICOTINATE; N BIS(3 PHENYL PROPYL) 9 OXO FLUORENE 2,7 DIAMIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NICOTINIC ACID; NICOTINIC ACID DERIVATIVE; NOBOTANIN B; PARGAMICIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLY(ADENOSINE DIPHOSPHATE RIBOSE) GLYCOSIDASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE) GLYCOSIDASE INHIBITOR; TANKYRASE; TANKYRASE 1; TEMOZOLOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANTINEOPLASTIC ACTIVITY; CANCER; CANCER PREVENTION; CARCINOGENESIS; CELL CYCLE REGULATION; CELL DEATH; CELL DIFFERENTIATION; CELL TRANSFORMATION; CHROMOSOMAL INSTABILITY; CLINICAL TRIAL; DNA METHYLATION; DNA REPAIR; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME INHIBITION; EXCISION REPAIR; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; HUMAN; MELANOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; CELL DEATH; GENOMIC INSTABILITY; HUMANS; NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES;

EID: 34548183836     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2007.00567.x     Document Type: Review

References (72)

1. Sugimura T. Poly (adenosine diphosphate ribose). Prog Nucl Acid Res Mol Biol 1973; 13: 127-51.
2. Masutani M, Nakagama H, Sugimura T. Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. Cell Mol Life Sci 2005; 62: 769-83.
3. Miwa M, Kanai M, Uchida M, Uchida K, Hanai S. Roles of poly(ADP-ribose) metabolism in the regulation of centrosome duplication and in the maintenance of neuronal integrity. In: Buerkle A, ed. Poly(ADP-Ribosyl)ation. Georgetown, Texas: Landes Bioscience, 2006: 51-60
4. Miwa M, Saikawa N, Yamaizumi Z, Nishimura S, Sugimura T. Structure of poly(adenosine diphosphate ribose): Identification of 2′-[1″-ribosyl-2″-(or 3″-) (1‴-ribosyl)] adenosine-5′,5″,5‴-tris (phosphate) as a branch linkage. Proc Natl Acad Sci USA 1979; 76: 595-9.
5. Althaus FR, Richter C. ADP-ribosylation of proteins. Enzymology and biological significance. Mol Biol Biochem Biophys 1987; 37: 1-237.
6. Hayashi K, Tanaka M, Shimada T, Miwa M, Sugimura T. Size and shape of poly(ADP-ribose): Examination by gel filtration, gel electrophoresis and electron microscopy. Biochem Biophys Res Commun 1983; 112: 102-7.
7. Schreiber V, Dantzer F, Ame JC, de Murcia G. Poly(ADP-ribose): Novel functions for an old molecule. Nat Rev Mol Cell Biol 2006; 7: 517-28.
8. Kanai M, Uchida M, Hanai S, Uematsu N, Uchida K, Miwa M. Poly(ADP-ribose) polymerase localizes to the centrosomes and chromosomes. Biochem Biophys Res Commun 2000; 278: 385-9.
9. Ohashi S, Kanai M, Hanai S et al. Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells. Biochem Biophys Res Commun 2003; 307: 915-21.
10. Morrison AR, Moss J, Stevens LA et al. ART2, A T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). J Biol Chem 2006; 81: 33-363-72.
11. Takamura-Enya T, Watanabe M, Totsuka Y et al. Mono (ADP-ribosyl)ation of 2′-deoxyguanosine residue in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterfly. Proc Natl Acad Sci USA 2001; 98: 12 414-19.
12. El-Khamisy SF, Masutani M, Suzuki H, Caldecott KW. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucl Acids Res 2003; 31: 5526-33.
13. de Murcia JM, Niedergang C, Trucco C et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA 1997; 94: 7303-7.
14. Shibata A, Kamada N, Masumura K et al. Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent. Oncogene 2005; 24: 1328-37.
15. Heale JT, Ball AR Jr, Schmiesing JA et al. Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair. Mol Cell 2006; 21: 837-48.
16. Malanga M, Althaus FR. Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and induces DNA strand break resealing. J Biol Chem 2004; 279: 5244-8.
17. von Kobbe C, Harrigan JA, May A et al. Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly (ADP-ribosyl) ation pathway after DNA damage. Mol Cell Biol 2003; 23: 8601-13.
18. Hochegger H, Dejsuphong D, Fukushima T et al. Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells. Embo J 2006; 25: 1305-14.
19. Bryant HE, Schultz N, Thomas HD et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005; 434: 913-17.
20. Farmer H, McCabe N, Lord CJ et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434: 917-21.
21. Bryant HE, Helleday T. Inhibition of poly(ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucl Acids Res 2006; 34: 1685-91.
22. Menissier de Murcia J, Ricoul M, Tartier L et al. Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. Embo J 2003; 22: 2255-63.
23. Oei SL, Ziegler M. ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose). J Biol Chem 2000; 275: 23 234-9.
24. Ame JC, de Murcia G. Regulation of PARG recruitment at DNA damage sites. Med Sci 2005; 11 (Suppl 1): 41.
25. Hassa PO, Haenni SS, Buerki C et al. Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem 2005; 280: 40 450-64.
26. Pavri R, Lewis B, Kim TK et al. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell 2005; 18: 83-96.
27. Idogawa M, Masutani M, Shitashige M et al. Ku70 and poly(ADP-Ribose) Polymerase-1 competitively regulate {beta}-catenin and T-cell factor-4-mediated gene transactivation: Possible linkage of DNA damage recognition and Wnt signaling. Cancer Res 2007; 67: 911-18.
28. Kim MY, Mauro S, Gevry N, Lis JT, Kraus WL. NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. Cell 2004; 119: 803-14.
29. Ju BG, Lunyak VV, Perissi V et al. A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science 2006; 312: 1798-802.
30. Tulin A, Spradling A. Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science 2003; 299: 560-2.
31. Zardo G, Caiafa P. The unmethylated state of CpG islands in mouse fibroblasts depends on the poly(ADP-ribosyl)ation process. J Biol Chem 1998; 273: 16 517-20.
32. Pleschke JM, Kleczkowska HE, Strohm M, Althaus FR. Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J Biol Chem 2000; 275: 40 974-80.
33. Yu W, Ginjala V, Pant V et al. Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet 2004; 36: 1105-10.
34. Karras GI, Kustatscher G, Buhecha HR et al. The macro domain is an ADP-ribose binding module. Embo J 2005; 24: 1911-20.
35. Shima H, Nakayasu M, Aonuma S, Sugimura T, Nagao M. Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly (ADP-ribose) polymerase or with dimethyl sulfoxide. Proc Natl Acad Sci USA 1989; 86: 7442-5.
36. Nozaki T, Masutani M, Watanabe M et al. Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells. Proc Natl Acad Sci USA 1999; 96: 13 345-50.
37. Nozaki T, Masutani M, Akagawa T, Sugimura T, Esumi H. Suppression of G1 arrest and enhancement of G2 arrest by inhibitors of poly(ADP-ribose) polymerase: Possible involvement of poly(ADP-ribosyl)ation in cell cycle arrest following gamma-irradiation. Jpn J Cancer Res 1994; 85: 1094-8.
38. Watanabe F, Fukazawa H, Masutani M et al. Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response. Biochem Biophys Res Commun 2004; 319: 596-602.
39. Yu SW, Wang H, Poitras MF et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002; 297: 259-63.
40. Masutani M, Suzuki H, Kamada N et al. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci USA 1999; 96: 2301-4.
41. Yamagami T, Miwa A, Takasawa S, Yamamoto H, Okamoto H. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res 1985; 45: 1845-9.
42. Cortes U, Tong WM, Coyle DL et al. Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol 2004; 24: 7163-78.
43. Masutani M, Gunji A, Ogino H et al. Functional analysis of poly (ADP-ribose) glycohydrolase: Hypersensitivity to DNA damaging agents and spontaneous development of renal lesions under Parg-deficiency. Med Sci 2005; 11 (Suppl 1): 22.
44. Koh DW, Dawson TM, Dawson VL. Mediation of cell death by poly (ADP-ribose) polymerase-1. Pharmacol Res 2005; 52: 5-14.
45. Andrabi SA, Kim NS, Yu SW et al. Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci USA 2006; 103: 18 308-13.
46. Hanai S, Kanai M, Ohashi S et al. Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster. Proc Natl Acad Sci USA 2004; 101: 82-6.
47. Kanai M, Tong WM, Sugihara E, Wang ZQ, Fukasawa K, Miwa M. Involvement of poly(ADP-Ribose) polymerase 1 and poly (ADP-Ribosyl)ation in regulation of centrosome function. Mol Cell Biol 2003; 23: 2451-62.
48. Kun E, Kirsten E, Milo GE, Kurian P, Kumari HL. Cell cycle-dependent intervention by benzamide of carcinogen-induced neoplastic transformation and in vitro poly(ADP-ribosyl)ation of nuclear proteins in human fibroblasts. Proc Natl Acad Sci USA 1983; 80: 7219-23.
49. Yu M, Schreek S, Cerni C et al. PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. Oncogene 2005; 24: 1982-93.
50. Tsutsumi M, Masutani M, Nozaki T et al. Increased susceptibility of poly (ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity. Carcinogenesis 2001; 22: 1-3.
51. Ogawa K, Masutani M, Kato K et al. Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. Cancer Lett 2006; 236: 32-8.
52. Gunji A, Uemura A, Tsutsumi M et al. Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. Cancer Lett 2006; 241: 87-92.
53. Tong WM, Ohgaki H, Huang H, Granier C, Kleihues P, Wang ZQ. Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice. Am J Pathol 2003; 162: 343-52.
54. Morrison C, Smith GC, Stingl L, Jackson SP, Wagner EF, Wang ZQ. Genetic interaction between PARP and DNA-PK in V (D) J recombination and tumorigenesis. Nat Genet 1997; 17: 479-82.
55. Tong WM, Cortes U, Hande MP et al. Synergistic role of Ku80 and poly (ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res 2002; 62: 6990-6.
56. Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R. Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am J Pathol 2003; 162: 1559-69.
57. Raval-Fernandes S, Kickhoefer VA, Kitchen C, Rome LH. Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. Cancer Res 2005; 65: 8846-52.
58. Bieche I, de Murcia G, Lidereau R. Poly(ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer. Clin Cancer Res 1996; 2: 1163-7.
59. Shiokawa M, Masutani M, Fujihara H et al. Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. Jpn J Clin Oncol 2005; 35: 97-102.
60. Lockett KL, Hall MC, Xu J et al. The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function. Cancer Res 2004; 64: 6344-8.
61. Hao B, Wang H, Zhou K et al. Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. Cancer Res 2004; 64: 4378-84.
62. Zhang X, Miao X, Liang G et al. Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Cancer Res 2005; 65: 722-6.
63. Sakiyama T, Kohno T, Mimaki S et al. Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk. Int J Cancer 2005; 114: 730-7.
64. Aguiar RC, Yakushijin Y, Kharbanda S, Salgia R, Fletcher JA, Shipp MA. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Blood 2000; 96: 4328-34.
65. Durkacz BW, Omidiji O, Gray DA, Shall S. (ADP-ribose)n participates in DNA excision repair. Nature 1980; 283: 593-6.
66. Kawamitsu H, Miwa M, Tanaka Y et al. Inhibitors of poly(adenosine diphosphate ribose) polymerase potentiate the antitumor activity of bleomycin against Ehrlich ascites carcinoma. J Pharmacobiodyn 1982; 5: 900-4.
67. Calabrese CR, Almassy R, Barton S et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. J Natl Cancer Inst 2004; 96: 56-67.
68. Gallmeier E, Kern SE. Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition. Cancer Biol Ther 2005; 4: 703-6.
69. Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T. Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell 2005; 7: 25-37.
70. Tentori L, Leonetti C, Scarsella M et al. Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide. Eur J Cancer 2005; 41: 2948-57.
71. Kirkland JB. Niacin and carcinogenesis. Nutr Cancer 2003; 46: 110-18.
72. Tashtoush BM, Qasem J, Williams JD, Dewald TP, Jacobson EL, Jacobson MK. Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography. J Pharm Biomed Anal 2007; 43: 893-9.