메뉴 건너뛰기




Volumn 104, Issue , 2016, Pages 39-79

P2X7 Receptor as a Therapeutic Target

Author keywords

ATP; Cancer; Inflammation; Ligands; Mood disorders; Neurodegeneration; Osteoporosis; P2X7; SNPs

Indexed keywords

BIOLOGICAL MARKER; PURINERGIC P2X RECEPTOR AGONIST; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; LIGAND; P2XR RECEPTOR, HUMAN;

EID: 84952690683     PISSN: 18761623     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.apcsb.2015.11.004     Document Type: Article
Times cited : (92)

References (221)
  • 3
    • 65649141604 scopus 로고    scopus 로고
    • Expression of the P2X7 receptor increases the Ca2 + content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis
    • E. Adinolfi, M.G. Callegari, M. Cirillo, P. Pinton, C. Giorgi, D. Cavagna, and et al. Expression of the P2X7 receptor increases the Ca2 + content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis The Journal of Biological Chemistry 284 2009 10120 10128
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 10120-10128
    • Adinolfi, E.1    Callegari, M.G.2    Cirillo, M.3    Pinton, P.4    Giorgi, C.5    Cavagna, D.6
  • 4
    • 21844450590 scopus 로고    scopus 로고
    • Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth
    • E. Adinolfi, M.G. Callegari, D. Ferrari, C. Bolognesi, M. Minelli, M.R. Wieckowski, and et al. Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth Molecular Biology of the Cell 16 2005 3260 3272
    • (2005) Molecular Biology of the Cell , vol.16 , pp. 3260-3272
    • Adinolfi, E.1    Callegari, M.G.2    Ferrari, D.3    Bolognesi, C.4    Minelli, M.5    Wieckowski, M.R.6
  • 8
    • 0037079543 scopus 로고    scopus 로고
    • P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia
    • E. Adinolfi, L. Melchiorri, S. Falzoni, P. Chiozzi, A. Morelli, A. Tieghi, and et al. P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia Blood 99 2002 706 708
    • (2002) Blood , vol.99 , pp. 706-708
    • Adinolfi, E.1    Melchiorri, L.2    Falzoni, S.3    Chiozzi, P.4    Morelli, A.5    Tieghi, A.6
  • 10
    • 77957303845 scopus 로고    scopus 로고
    • The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro
    • A. Agrawal, K.A. Buckley, K. Bowers, M. Furber, J.A. Gallagher, and A. Gartland The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro Purinergic Signal 6 2010 307 315
    • (2010) Purinergic Signal , vol.6 , pp. 307-315
    • Agrawal, A.1    Buckley, K.A.2    Bowers, K.3    Furber, M.4    Gallagher, J.A.5    Gartland, A.6
  • 11
    • 0142093204 scopus 로고    scopus 로고
    • Randomized clinical trial of adenosine 5'-triphosphate on tumor growth and survival in advanced lung cancer patients
    • H.J. Agteresch, S.A. Burgers, A. van der Gaast, J.H. Wilson, and P.C. Dagnelie Randomized clinical trial of adenosine 5'-triphosphate on tumor growth and survival in advanced lung cancer patients Anticancer Drugs 14 2003 639 644
    • (2003) Anticancer Drugs , vol.14 , pp. 639-644
    • Agteresch, H.J.1    Burgers, S.A.2    Van Der Gaast, A.3    Wilson, J.H.4    Dagnelie, P.C.5
  • 12
    • 33750615070 scopus 로고    scopus 로고
    • Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: A systematic review
    • Y. Alamanos, P.V. Voulgari, and A.A. Drosos Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: A systematic review Seminars in Arthritis and Rheumatism 36 2006 182 188
    • (2006) Seminars in Arthritis and Rheumatism , vol.36 , pp. 182-188
    • Alamanos, Y.1    Voulgari, P.V.2    Drosos, A.A.3
  • 14
    • 84885103040 scopus 로고    scopus 로고
    • Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain
    • L.A. Alves, R.J. Bezerra, R.X. Faria, L.G. Ferreira, and V. da Silva Frutuoso Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain Molecules 18 2013 10953 10972
    • (2013) Molecules , vol.18 , pp. 10953-10972
    • Alves, L.A.1    Bezerra, R.J.2    Faria, R.X.3    Ferreira, L.G.4    Da Silva Frutuoso, V.5
  • 15
    • 84905368055 scopus 로고    scopus 로고
    • Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis
    • E.P. Amaral, S.C. Ribeiro, V.R. Lanes, F.M. Almeida, M.R. de Andrade, C.C. Bomfim, and et al. Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis PLoS Pathogens 10 2014 e1004188
    • (2014) PLoS Pathogens , vol.10 , pp. e1004188
    • Amaral, E.P.1    Ribeiro, S.C.2    Lanes, V.R.3    Almeida, F.M.4    De Andrade, M.R.5    Bomfim, C.C.6
  • 16
    • 84943658021 scopus 로고    scopus 로고
    • The P2X7 receptor is a key modulator of the PI3K/GSK3beta/VEGF signaling network: Evidence in experimental neuroblastoma
    • F. Amoroso, M. Capece, A. Rotondo, D. Cangelosi, M. Ferracin, A. Franceschini, and et al. The P2X7 receptor is a key modulator of the PI3K/GSK3beta/VEGF signaling network: Evidence in experimental neuroblastoma Oncogene 34 2015 5240 5251
    • (2015) Oncogene , vol.34 , pp. 5240-5251
    • Amoroso, F.1    Capece, M.2    Rotondo, A.3    Cangelosi, D.4    Ferracin, M.5    Franceschini, A.6
  • 18
    • 84884709663 scopus 로고    scopus 로고
    • Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
    • S. Apolloni, S. Amadio, C. Montilli, C. Volonte, and N. D'Ambrosi Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis Human Molecular Genetics 22 2013 4102 4116
    • (2013) Human Molecular Genetics , vol.22 , pp. 4102-4116
    • Apolloni, S.1    Amadio, S.2    Montilli, C.3    Volonte, C.4    D'Ambrosi, N.5
  • 19
    • 84907217155 scopus 로고    scopus 로고
    • Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
    • S. Apolloni, S. Amadio, C. Parisi, A. Matteucci, R.L. Potenza, M. Armida, and et al. Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis Disease Models & Mechanisms 7 2014 1101 1109
    • (2014) Disease Models & Mechanisms , vol.7 , pp. 1101-1109
    • Apolloni, S.1    Amadio, S.2    Parisi, C.3    Matteucci, A.4    Potenza, R.L.5    Armida, M.6
  • 20
    • 84953364910 scopus 로고    scopus 로고
    • Clemastine confers neuroprotection and induces an anti-inflammatory phenotype in SOD1 mouse model of amyotrophic lateral sclerosis
    • [Epub ahead of print]
    • S. Apolloni, P. Fabbrizio, C. Parisi, S. Amadio, and C. Volonte Clemastine confers neuroprotection and induces an anti-inflammatory phenotype in SOD1 mouse model of amyotrophic lateral sclerosis Molecular Neurobiology 2014 1 14 10.1007/s12035-014-9019-8 [Epub ahead of print]
    • (2014) Molecular Neurobiology , pp. 1-14
    • Apolloni, S.1    Fabbrizio, P.2    Parisi, C.3    Amadio, S.4    Volonte, C.5
  • 21
    • 84877823786 scopus 로고    scopus 로고
    • The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis
    • S. Apolloni, C. Parisi, M.G. Pesaresi, S. Rossi, M.T. Carri, M. Cozzolino, and et al. The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis Journal of Immunology 190 2013 5187 5195
    • (2013) Journal of Immunology , vol.190 , pp. 5187-5195
    • Apolloni, S.1    Parisi, C.2    Pesaresi, M.G.3    Rossi, S.4    Carri, M.T.5    Cozzolino, M.6
  • 23
    • 33745047597 scopus 로고    scopus 로고
    • Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder
    • N. Barden, M. Harvey, B. Gagne, E. Shink, M. Tremblay, C. Raymond, and et al. Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 141B 2006 374 382
    • (2006) American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics , vol.141 B , pp. 374-382
    • Barden, N.1    Harvey, M.2    Gagne, B.3    Shink, E.4    Tremblay, M.5    Raymond, C.6
  • 25
    • 84908232996 scopus 로고    scopus 로고
    • The P2X7 receptor channel: Recent developments and the use of P2X7 antagonists in models of disease
    • R. Bartlett, L. Stokes, and R. Sluyter The P2X7 receptor channel: Recent developments and the use of P2X7 antagonists in models of disease Pharmacological Reviews 66 2014 638 675
    • (2014) Pharmacological Reviews , vol.66 , pp. 638-675
    • Bartlett, R.1    Stokes, L.2    Sluyter, R.3
  • 27
    • 77957778148 scopus 로고    scopus 로고
    • Randomized clinical trial on the effects of adenosine 5'-triphosphate infusions on quality of life, functional status, and fatigue in preterminal cancer patients
    • S. Beijer, P.S. Hupperets, B.E. van den Borne, N.E. Wijckmans, C. Spreeuwenberg, P.A. van den Brandt, and et al. Randomized clinical trial on the effects of adenosine 5'-triphosphate infusions on quality of life, functional status, and fatigue in preterminal cancer patients Journal of Pain and Symptom Management 40 2010 520 530
    • (2010) Journal of Pain and Symptom Management , vol.40 , pp. 520-530
    • Beijer, S.1    Hupperets, P.S.2    Van Den Borne, B.E.3    Wijckmans, N.E.4    Spreeuwenberg, C.5    Van Den Brandt, P.A.6
  • 29
    • 84888369402 scopus 로고    scopus 로고
    • Post-translational regulation of P2X receptor channels: Modulation by phospholipids
    • L.P. Bernier, A.R. Ase, and P. Seguela Post-translational regulation of P2X receptor channels: Modulation by phospholipids Frontiers in Cellular Neuroscience 7 2013 226
    • (2013) Frontiers in Cellular Neuroscience , vol.7 , pp. 226
    • Bernier, L.P.1    Ase, A.R.2    Seguela, P.3
  • 33
    • 0035046976 scopus 로고    scopus 로고
    • Extracellular nucleotide signaling: A mechanism for integrating local and systemic responses in the activation of bone remodeling
    • W.B. Bowler, K.A. Buckley, A. Gartland, R.A. Hipskind, G. Bilbe, and J.A. Gallagher Extracellular nucleotide signaling: A mechanism for integrating local and systemic responses in the activation of bone remodeling Bone 28 2001 507 512
    • (2001) Bone , vol.28 , pp. 507-512
    • Bowler, W.B.1    Buckley, K.A.2    Gartland, A.3    Hipskind, R.A.4    Bilbe, G.5    Gallagher, J.A.6
  • 36
    • 46449134214 scopus 로고    scopus 로고
    • Purinergic signalling and disorders of the central nervous system
    • G. Burnstock Purinergic signalling and disorders of the central nervous system Nature Reviews. Drug Discovery 7 2008 575 590
    • (2008) Nature Reviews. Drug Discovery , vol.7 , pp. 575-590
    • Burnstock, G.1
  • 38
    • 21244471404 scopus 로고    scopus 로고
    • A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes
    • G. Cabrini, S. Falzoni, S.L. Forchap, P. Pellegatti, A. Balboni, P. Agostini, and et al. A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes Journal of Immunology 175 2005 82 89
    • (2005) Journal of Immunology , vol.175 , pp. 82-89
    • Cabrini, G.1    Falzoni, S.2    Forchap, S.L.3    Pellegatti, P.4    Balboni, A.5    Agostini, P.6
  • 42
  • 45
  • 47
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • E.H. Choy, and G.S. Panayi Cytokine pathways and joint inflammation in rheumatoid arthritis The New England Journal of Medicine 344 2001 907 916
    • (2001) The New England Journal of Medicine , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 50
    • 33947199802 scopus 로고    scopus 로고
    • Changes in expression of P2X7 receptors in NOD mouse pancreas during the development of diabetes
    • R. Coutinho-Silva, T. Robson, P.E. Beales, and G. Burnstock Changes in expression of P2X7 receptors in NOD mouse pancreas during the development of diabetes Autoimmunity 40 2007 108 116
    • (2007) Autoimmunity , vol.40 , pp. 108-116
    • Coutinho-Silva, R.1    Robson, T.2    Beales, P.E.3    Burnstock, G.4
  • 51
    • 0141790831 scopus 로고    scopus 로고
    • Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation
    • R. Coutinho-Silva, L. Stahl, M.N. Raymond, T. Jungas, P. Verbeke, G. Burnstock, and et al. Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation Immunity 19 2003 403 412
    • (2003) Immunity , vol.19 , pp. 403-412
    • Coutinho-Silva, R.1    Stahl, L.2    Raymond, M.N.3    Jungas, T.4    Verbeke, P.5    Burnstock, G.6
  • 53
    • 70349694072 scopus 로고    scopus 로고
    • Release of adenosine and ATP during ischemia and epilepsy
    • N. Dale, and B.G. Frenguelli Release of adenosine and ATP during ischemia and epilepsy Current Neuropharmacology 7 2009 160 179
    • (2009) Current Neuropharmacology , vol.7 , pp. 160-179
    • Dale, N.1    Frenguelli, B.G.2
  • 55
    • 35748978219 scopus 로고    scopus 로고
    • Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice
    • T. Darville, L. Welter-Stahl, C. Cruz, A.A. Sater, C.W. Andrews Jr., and D.M. Ojcius Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice Journal of Immunology 179 2007 3707 3714
    • (2007) Journal of Immunology , vol.179 , pp. 3707-3714
    • Darville, T.1    Welter-Stahl, L.2    Cruz, C.3    Sater, A.A.4    Andrews, C.W.5    Ojcius, D.M.6
  • 57
    • 0142030089 scopus 로고    scopus 로고
    • Dehydroepiandrosterone potentiates native ionotropic ATP receptors containing the P2X2 subunit in rat sensory neurones
    • M. De Roo, J.L. Rodeau, and R. Schlichter Dehydroepiandrosterone potentiates native ionotropic ATP receptors containing the P2X2 subunit in rat sensory neurones The Journal of Physiology 552 2003 59 71
    • (2003) The Journal of Physiology , vol.552 , pp. 59-71
    • De Roo, M.1    Rodeau, J.L.2    Schlichter, R.3
  • 60
    • 84876350807 scopus 로고    scopus 로고
    • The therapeutic potential of modifying inflammasomes and NOD-like receptors
    • F. Di Virgilio The therapeutic potential of modifying inflammasomes and NOD-like receptors Pharmacological Reviews 65 2013 872 905
    • (2013) Pharmacological Reviews , vol.65 , pp. 872-905
    • Di Virgilio, F.1
  • 62
    • 67649383228 scopus 로고    scopus 로고
    • Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration
    • M. Diaz-Hernandez, M. Diez-Zaera, J. Sanchez-Nogueiro, R. Gomez-Villafuertes, J.M. Canals, J. Alberch, and et al. Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration The FASEB Journal 23 2009 1893 1906
    • (2009) The FASEB Journal , vol.23 , pp. 1893-1906
    • Diaz-Hernandez, M.1    Diez-Zaera, M.2    Sanchez-Nogueiro, J.3    Gomez-Villafuertes, R.4    Canals, J.M.5    Alberch, J.6
  • 63
    • 70350339068 scopus 로고    scopus 로고
    • Mammalian P2X7 receptor pharmacology: Comparison of recombinant mouse, rat and human P2X7 receptors
    • D.L. Donnelly-Roberts, M.T. Namovic, P. Han, and M.F. Jarvis Mammalian P2X7 receptor pharmacology: Comparison of recombinant mouse, rat and human P2X7 receptors British Journal of Pharmacology 157 2009 1203 1214
    • (2009) British Journal of Pharmacology , vol.157 , pp. 1203-1214
    • Donnelly-Roberts, D.L.1    Namovic, M.T.2    Han, P.3    Jarvis, M.F.4
  • 64
    • 58049118595 scopus 로고    scopus 로고
    • [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors
    • D.L. Donnelly-Roberts, M.T. Namovic, B. Surber, S.X. Vaidyanathan, A. Perez-Medrano, Y. Wang, and et al. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors Neuropharmacology 56 2009 223 229
    • (2009) Neuropharmacology , vol.56 , pp. 223-229
    • Donnelly-Roberts, D.L.1    Namovic, M.T.2    Surber, B.3    Vaidyanathan, S.X.4    Perez-Medrano, A.5    Wang, Y.6
  • 65
    • 60549098817 scopus 로고    scopus 로고
    • Orthosteric and allosteric binding sites of P2X receptors
    • R.J. Evans Orthosteric and allosteric binding sites of P2X receptors European Biophysics Journal 38 2009 319 327
    • (2009) European Biophysics Journal , vol.38 , pp. 319-327
    • Evans, R.J.1
  • 66
    • 77958610109 scopus 로고    scopus 로고
    • Structural interpretation of P2X receptor mutagenesis studies on drug action
    • R.J. Evans Structural interpretation of P2X receptor mutagenesis studies on drug action British Journal of Pharmacology 161 2010 961 971
    • (2010) British Journal of Pharmacology , vol.161 , pp. 961-971
    • Evans, R.J.1
  • 67
    • 0029088454 scopus 로고
    • Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors)
    • R.J. Evans, C. Lewis, G. Buell, S. Valera, R.A. North, and A. Surprenant Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors) Molecular Pharmacology 48 1995 178 183
    • (1995) Molecular Pharmacology , vol.48 , pp. 178-183
    • Evans, R.J.1    Lewis, C.2    Buell, G.3    Valera, S.4    North, R.A.5    Surprenant, A.6
  • 68
    • 0035884935 scopus 로고    scopus 로고
    • ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion
    • I.P. Fairbairn, C.B. Stober, D.S. Kumararatne, and D.A. Lammas ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion Journal of Immunology 167 2001 3300 3307
    • (2001) Journal of Immunology , vol.167 , pp. 3300-3307
    • Fairbairn, I.P.1    Stober, C.B.2    Kumararatne, D.S.3    Lammas, D.A.4
  • 72
    • 33745188916 scopus 로고    scopus 로고
    • A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization
    • Y.H. Feng, X. Li, L. Wang, L. Zhou, and G.I. Gorodeski A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization The Journal of Biological Chemistry 281 2006 17228 17237
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 17228-17237
    • Feng, Y.H.1    Li, X.2    Wang, L.3    Zhou, L.4    Gorodeski, G.I.5
  • 73
    • 84895769853 scopus 로고    scopus 로고
    • Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: A meta-analysis
    • W.P. Feng, B. Zhang, W. Li, and J. Liu Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: A meta-analysis PloS One 9 2014 e88575
    • (2014) PloS One , vol.9 , pp. e88575
    • Feng, W.P.1    Zhang, B.2    Li, W.3    Liu, J.4
  • 75
    • 40749094413 scopus 로고    scopus 로고
    • Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists
    • A.S. Florjancic, S. Peddi, A. Perez-Medrano, B. Li, M.T. Namovic, G. Grayson, and et al. Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists Bioorganic & Medicinal Chemistry Letters 18 2008 2089 2092
    • (2008) Bioorganic & Medicinal Chemistry Letters , vol.18 , pp. 2089-2092
    • Florjancic, A.S.1    Peddi, S.2    Perez-Medrano, A.3    Li, B.4    Namovic, M.T.5    Grayson, G.6
  • 79
    • 77449148016 scopus 로고    scopus 로고
    • Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation
    • S.A. Friedle, M.A. Curet, and J.J. Watters Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation Recent Patents on CNS Drug Discovery 5 2010 35 45
    • (2010) Recent Patents on CNS Drug Discovery , vol.5 , pp. 35-45
    • Friedle, S.A.1    Curet, M.A.2    Watters, J.J.3
  • 84
    • 84859900260 scopus 로고    scopus 로고
    • Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women
    • A. Gartland, K.K. Skarratt, L.J. Hocking, C. Parsons, L. Stokes, N.R. Jorgensen, and et al. Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women European Journal of Human Genetics 20 2012 559 564
    • (2012) European Journal of Human Genetics , vol.20 , pp. 559-564
    • Gartland, A.1    Skarratt, K.K.2    Hocking, L.J.3    Parsons, C.4    Stokes, L.5    Jorgensen, N.R.6
  • 87
    • 84903999475 scopus 로고    scopus 로고
    • Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells
    • A. Ghalali, F. Wiklund, H. Zheng, U. Stenius, and J. Hogberg Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells Carcinogenesis 35 2014 1547 1555
    • (2014) Carcinogenesis , vol.35 , pp. 1547-1555
    • Ghalali, A.1    Wiklund, F.2    Zheng, H.3    Stenius, U.4    Hogberg, J.5
  • 88
  • 89
    • 67650659532 scopus 로고    scopus 로고
    • Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival
    • R. Glas, N.S. Sauter, F.T. Schulthess, L. Shu, J. Oberholzer, and K. Maedler Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival Diabetologia 52 2009 1579 1588
    • (2009) Diabetologia , vol.52 , pp. 1579-1588
    • Glas, R.1    Sauter, N.S.2    Schulthess, F.T.3    Shu, L.4    Oberholzer, J.5    Maedler, K.6
  • 91
    • 84926436169 scopus 로고    scopus 로고
    • Purinergic P2X receptors: Structural and functional features depicted by X-ray and molecular modelling studies
    • L. Grimes, and M.T. Young Purinergic P2X receptors: Structural and functional features depicted by X-ray and molecular modelling studies Current Medicinal Chemistry 22 2015 783 798
    • (2015) Current Medicinal Chemistry , vol.22 , pp. 783-798
    • Grimes, L.1    Young, M.T.2
  • 92
    • 84857241763 scopus 로고    scopus 로고
    • P2X(7)-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells
    • M.W. Grol, I. Zelner, and S.J. Dixon P2X(7)-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells American Journal of Physiology. Endocrinology and Metabolism 302 2012 E561 E575
    • (2012) American Journal of Physiology. Endocrinology and Metabolism , vol.302 , pp. E561-E575
    • Grol, M.W.1    Zelner, I.2    Dixon, S.J.3
  • 93
    • 84943748673 scopus 로고    scopus 로고
    • A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis
    • B.J. Gu, J. Field, S. Dutertre, A. Ou, T.J. Kilpatrick, J. Lechner-Scott, and et al. A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis Human Molecular Genetics 24 2015 5644 5654
    • (2015) Human Molecular Genetics , vol.24 , pp. 5644-5654
    • Gu, B.J.1    Field, J.2    Dutertre, S.3    Ou, A.4    Kilpatrick, T.J.5    Lechner-Scott, J.6
  • 94
    • 78149416375 scopus 로고    scopus 로고
    • Association of XIAP and P2X7 receptor expression with lymph node metastasis in papillary thyroid carcinoma
    • L.Q. Gu, F.Y. Li, L. Zhao, Y. Liu, Q. Chu, X.X. Zang, and et al. Association of XIAP and P2X7 receptor expression with lymph node metastasis in papillary thyroid carcinoma Endocrine 38 2010 276 282
    • (2010) Endocrine , vol.38 , pp. 276-282
    • Gu, L.Q.1    Li, F.Y.2    Zhao, L.3    Liu, Y.4    Chu, Q.5    Zang, X.X.6
  • 98
  • 99
    • 84936891896 scopus 로고    scopus 로고
    • Inflammasomes: Mechanism of action, role in disease, and therapeutics
    • H. Guo, J.B. Callaway, and J.P. Ting Inflammasomes: Mechanism of action, role in disease, and therapeutics Nature Medicine 21 2015 677 687
    • (2015) Nature Medicine , vol.21 , pp. 677-687
    • Guo, H.1    Callaway, J.B.2    Ting, J.P.3
  • 100
    • 84863533721 scopus 로고    scopus 로고
    • Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice
    • R.R. Hansen, A. Nasser, S. Falk, S.B. Baldvinsson, P.H. Ohlsson, J.M. Bahl, and et al. Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice European Journal of Pharmacology 688 2012 27 34
    • (2012) European Journal of Pharmacology , vol.688 , pp. 27-34
    • Hansen, R.R.1    Nasser, A.2    Falk, S.3    Baldvinsson, S.B.4    Ohlsson, P.H.5    Bahl, J.M.6
  • 101
    • 84860785529 scopus 로고    scopus 로고
    • Molecular mechanism of ATP binding and ion channel activation in P2X receptors
    • M. Hattori, and E. Gouaux Molecular mechanism of ATP binding and ion channel activation in P2X receptors Nature 485 2012 207 212
    • (2012) Nature , vol.485 , pp. 207-212
    • Hattori, M.1    Gouaux, E.2
  • 103
    • 84926305271 scopus 로고    scopus 로고
    • Key sites for P2X receptor function and multimerization: Overview of mutagenesis studies on a structural basis
    • R. Hausmann, A. Kless, and G. Schmalzing Key sites for P2X receptor function and multimerization: Overview of mutagenesis studies on a structural basis Current Medicinal Chemistry 22 2015 799 818
    • (2015) Current Medicinal Chemistry , vol.22 , pp. 799-818
    • Hausmann, R.1    Kless, A.2    Schmalzing, G.3
  • 106
    • 84928699565 scopus 로고    scopus 로고
    • Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer
    • P. Hofman, J. Cherfils-Vicini, M. Bazin, M. Ilie, T. Juhel, X. Hebuterne, and et al. Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer Cancer Research 75 2015 835 845
    • (2015) Cancer Research , vol.75 , pp. 835-845
    • Hofman, P.1    Cherfils-Vicini, J.2    Bazin, M.3    Ilie, M.4    Juhel, T.5    Hebuterne, X.6
  • 107
    • 33751165071 scopus 로고    scopus 로고
    • A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat
    • P. Honore, D. Donnelly-Roberts, M.T. Namovic, G. Hsieh, C.Z. Zhu, J.P. Mikusa, and et al. A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat The Journal of Pharmacology and Experimental Therapeutics 319 2006 1376 1385
    • (2006) The Journal of Pharmacology and Experimental Therapeutics , vol.319 , pp. 1376-1385
    • Honore, P.1    Donnelly-Roberts, D.2    Namovic, M.T.3    Hsieh, G.4    Zhu, C.Z.5    Mikusa, J.P.6
  • 108
    • 67849099111 scopus 로고    scopus 로고
    • The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice
    • P. Honore, D. Donnelly-Roberts, M. Namovic, C. Zhong, C. Wade, P. Chandran, and et al. The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice Behavioural Brain Research 204 2009 77 81
    • (2009) Behavioural Brain Research , vol.204 , pp. 77-81
    • Honore, P.1    Donnelly-Roberts, D.2    Namovic, M.3    Zhong, C.4    Wade, C.5    Chandran, P.6
  • 110
    • 84880265647 scopus 로고    scopus 로고
    • Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors
    • B. Jelassi, M. Anchelin, J. Chamouton, M.L. Cayuela, L. Clarysse, J. Li, and et al. Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors Carcinogenesis 34 2013 1487 1496
    • (2013) Carcinogenesis , vol.34 , pp. 1487-1496
    • Jelassi, B.1    Anchelin, M.2    Chamouton, J.3    Cayuela, M.L.4    Clarysse, L.5    Li, J.6
  • 111
    • 79955579562 scopus 로고    scopus 로고
    • P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness
    • B. Jelassi, A. Chantome, F. Alcaraz-Perez, A. Baroja-Mazo, M.L. Cayuela, P. Pelegrin, and et al. P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness Oncogene 30 2011 2108 2122
    • (2011) Oncogene , vol.30 , pp. 2108-2122
    • Jelassi, B.1    Chantome, A.2    Alcaraz-Perez, F.3    Baroja-Mazo, A.4    Cayuela, M.L.5    Pelegrin, P.6
  • 112
    • 84883742562 scopus 로고    scopus 로고
    • Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079
    • A. Jimenez-Pacheco, G. Mesuret, A. Sanz-Rodriguez, K. Tanaka, C. Mooney, R. Conroy, and et al. Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079 Epilepsia 54 2013 1551 1561
    • (2013) Epilepsia , vol.54 , pp. 1551-1561
    • Jimenez-Pacheco, A.1    Mesuret, G.2    Sanz-Rodriguez, A.3    Tanaka, K.4    Mooney, C.5    Conroy, R.6
  • 113
    • 84911398051 scopus 로고    scopus 로고
    • P2X4 receptor in the dorsal horn partially contributes to brain-derived neurotrophic factor oversecretion and toll-like receptor-4 receptor activation associated with bone cancer pain
    • X.H. Jin, L.N. Wang, J.L. Zuo, J.P. Yang, and S.L. Liu P2X4 receptor in the dorsal horn partially contributes to brain-derived neurotrophic factor oversecretion and toll-like receptor-4 receptor activation associated with bone cancer pain Journal of Neuroscience Research 92 2014 1690 1702
    • (2014) Journal of Neuroscience Research , vol.92 , pp. 1690-1702
    • Jin, X.H.1    Wang, L.N.2    Zuo, J.L.3    Yang, J.P.4    Liu, S.L.5
  • 115
    • 84861196023 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures
    • N.R. Jorgensen, L.B. Husted, K.K. Skarratt, L. Stokes, C.L. Tofteng, T. Kvist, and et al. Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures European Journal of Human Genetics 20 2012 675 681
    • (2012) European Journal of Human Genetics , vol.20 , pp. 675-681
    • Jorgensen, N.R.1    Husted, L.B.2    Skarratt, K.K.3    Stokes, L.4    Tofteng, C.L.5    Kvist, T.6
  • 116
    • 77956389019 scopus 로고    scopus 로고
    • Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats
    • T.K. Kaan, P.K. Yip, S. Patel, M. Davies, F. Marchand, D.A. Cockayne, and et al. Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats Brain 133 2010 2549 2564
    • (2010) Brain , vol.133 , pp. 2549-2564
    • Kaan, T.K.1    Yip, P.K.2    Patel, S.3    Davies, M.4    Marchand, F.5    Cockayne, D.A.6
  • 117
    • 84861526394 scopus 로고    scopus 로고
    • Molecular and functional properties of P2X receptors - Recent progress and persisting challenges
    • K. Kaczmarek-Hajek, E. Lorinczi, R. Hausmann, and A. Nicke Molecular and functional properties of P2X receptors - Recent progress and persisting challenges Purinergic Signal 8 2012 375 417
    • (2012) Purinergic Signal , vol.8 , pp. 375-417
    • Kaczmarek-Hajek, K.1    Lorinczi, E.2    Hausmann, R.3    Nicke, A.4
  • 119
    • 0034139319 scopus 로고    scopus 로고
    • An update on the diagnosis of osteoporosis
    • J.A. Kanis An update on the diagnosis of osteoporosis Current Rheumatology Reports 2 2000 62 66
    • (2000) Current Rheumatology Reports , vol.2 , pp. 62-66
    • Kanis, J.A.1
  • 120
    • 67949117176 scopus 로고    scopus 로고
    • Crystal structure of the ATP-gated P2X(4) ion channel in the closed state
    • T. Kawate, J.C. Michel, W.T. Birdsong, and E. Gouaux Crystal structure of the ATP-gated P2X(4) ion channel in the closed state Nature 460 2009 592 598
    • (2009) Nature , vol.460 , pp. 592-598
    • Kawate, T.1    Michel, J.C.2    Birdsong, W.T.3    Gouaux, E.4
  • 121
    • 0037634326 scopus 로고    scopus 로고
    • Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
    • H.Z. Ke, H. Qi, A.F. Weidema, Q. Zhang, N. Panupinthu, D.T. Crawford, and et al. Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption Molecular Endocrinology 17 2003 1356 1367
    • (2003) Molecular Endocrinology , vol.17 , pp. 1356-1367
    • Ke, H.Z.1    Qi, H.2    Weidema, A.F.3    Zhang, Q.4    Panupinthu, N.5    Crawford, D.T.6
  • 122
    • 84940975762 scopus 로고    scopus 로고
    • P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus
    • J.Y. Kim, A.R. Ko, and J.E. Kim P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus Frontiers in Cellular Neuroscience 9 2015 352
    • (2015) Frontiers in Cellular Neuroscience , vol.9 , pp. 352
    • Kim, J.Y.1    Ko, A.R.2    Kim, J.E.3
  • 123
    • 0344324861 scopus 로고
    • Effect of convulsive activity upon the concentration of brain glucose, glycogen, lactate, and phosphates
    • J.R. Klein, and N.S. Olsen Effect of convulsive activity upon the concentration of brain glucose, glycogen, lactate, and phosphates The Journal of Biological Chemistry 167 1947 747 756
    • (1947) The Journal of Biological Chemistry , vol.167 , pp. 747-756
    • Klein, J.R.1    Olsen, N.S.2
  • 124
    • 84863192724 scopus 로고    scopus 로고
    • Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta
    • R.M. Koffie, T. Hashimoto, H.C. Tai, K.R. Kay, A. Serrano-Pozo, D. Joyner, and et al. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta Brain 135 2012 2155 2168
    • (2012) Brain , vol.135 , pp. 2155-2168
    • Koffie, R.M.1    Hashimoto, T.2    Tai, H.C.3    Kay, K.R.4    Serrano-Pozo, A.5    Joyner, D.6
  • 125
    • 84861700837 scopus 로고    scopus 로고
    • Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus
    • Q. Kong, K. Takahashi, D. Schulte, N. Stouffer, Y. Lin, and C.L. Lin Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus Neurobiology of Disease 47 2012 145 154
    • (2012) Neurobiology of Disease , vol.47 , pp. 145-154
    • Kong, Q.1    Takahashi, K.2    Schulte, D.3    Stouffer, N.4    Lin, Y.5    Lin, C.L.6
  • 127
    • 79251641533 scopus 로고    scopus 로고
    • Microglial P2X(7) receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
    • H.G. Lee, S.M. Won, B.J. Gwag, and Y.B. Lee Microglial P2X(7) receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease Experimental & Molecular Medicine 43 2011 7 14
    • (2011) Experimental & Molecular Medicine , vol.43 , pp. 7-14
    • Lee, H.G.1    Won, S.M.2    Gwag, B.J.3    Lee, Y.B.4
  • 128
    • 79955625073 scopus 로고    scopus 로고
    • Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions
    • L.Y. Lenertz, M.L. Gavala, Y. Zhu, and P.J. Bertics Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions Immunologic Research 50 2011 22 38
    • (2011) Immunologic Research , vol.50 , pp. 22-38
    • Lenertz, L.Y.1    Gavala, M.L.2    Zhu, Y.3    Bertics, P.J.4
  • 132
    • 67349241408 scopus 로고    scopus 로고
    • P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair
    • J. Li, R. Meyer, R.L. Duncan, and C.H. Turner P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair Calcified Tissue International 84 2009 405 412
    • (2009) Calcified Tissue International , vol.84 , pp. 405-412
    • Li, J.1    Meyer, R.2    Duncan, R.L.3    Turner, C.H.4
  • 133
    • 1642389166 scopus 로고    scopus 로고
    • More than the epidemiology of Alzheimer's disease: Contributions of the Canadian Study of Health and Aging
    • J. Lindsay, E. Sykes, I. McDowell, R. Verreault, and D. Laurin More than the epidemiology of Alzheimer's disease: Contributions of the Canadian Study of Health and Aging Canadian Journal of Psychiatry 49 2004 83 91
    • (2004) Canadian Journal of Psychiatry , vol.49 , pp. 83-91
    • Lindsay, J.1    Sykes, E.2    McDowell, I.3    Verreault, R.4    Laurin, D.5
  • 134
    • 40849111180 scopus 로고    scopus 로고
    • Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2 +)- and ATP-dependent in MC3T3-E1 osteoblasts
    • D. Liu, D.C. Genetos, Y. Shao, D.J. Geist, J. Li, H.Z. Ke, and et al. Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2 +)- and ATP-dependent in MC3T3-E1 osteoblasts Bone 42 2008 644 652
    • (2008) Bone , vol.42 , pp. 644-652
    • Liu, D.1    Genetos, D.C.2    Shao, Y.3    Geist, D.J.4    Li, J.5    Ke, H.Z.6
  • 136
    • 33747873833 scopus 로고    scopus 로고
    • P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder
    • S. Lucae, D. Salyakina, N. Barden, M. Harvey, B. Gagne, M. Labbe, and et al. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder Human Molecular Genetics 15 2006 2438 2445
    • (2006) Human Molecular Genetics , vol.15 , pp. 2438-2445
    • Lucae, S.1    Salyakina, D.2    Barden, N.3    Harvey, M.4    Gagne, B.5    Labbe, M.6
  • 138
    • 79958836059 scopus 로고    scopus 로고
    • Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: Implications for its therapeutic action
    • C. Marques-da-Silva, M.M. Chaves, N.G. Castro, R. Coutinho-Silva, and M.Z. Guimaraes Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: Implications for its therapeutic action British Journal of Pharmacology 163 2011 912 926
    • (2011) British Journal of Pharmacology , vol.163 , pp. 912-926
    • Marques-Da-Silva, C.1    Chaves, M.M.2    Castro, N.G.3    Coutinho-Silva, R.4    Guimaraes, M.Z.5
  • 139
    • 84863011694 scopus 로고    scopus 로고
    • Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: Re-evaluation of P2X7 knockouts
    • M. Masin, C. Young, K. Lim, S.J. Barnes, X.J. Xu, V. Marschall, and et al. Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: Re-evaluation of P2X7 knockouts British Journal of Pharmacology 165 2012 978 993
    • (2012) British Journal of Pharmacology , vol.165 , pp. 978-993
    • Masin, M.1    Young, C.2    Lim, K.3    Barnes, S.J.4    Xu, X.J.5    Marschall, V.6
  • 140
    • 34548398189 scopus 로고    scopus 로고
    • P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis
    • C. Matute, I. Torre, F. Perez-Cerda, A. Perez-Samartin, E. Alberdi, E. Etxebarria, and et al. P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis The Journal of Neuroscience 27 2007 9525 9533
    • (2007) The Journal of Neuroscience , vol.27 , pp. 9525-9533
    • Matute, C.1    Torre, I.2    Perez-Cerda, F.3    Perez-Samartin, A.4    Alberdi, E.5    Etxebarria, E.6
  • 141
    • 66249146391 scopus 로고    scopus 로고
    • Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders
    • A. McQuillin, N.J. Bass, K. Choudhury, V. Puri, M. Kosmin, J. Lawrence, and et al. Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders Molecular Psychiatry 14 2009 614 620
    • (2009) Molecular Psychiatry , vol.14 , pp. 614-620
    • McQuillin, A.1    Bass, N.J.2    Choudhury, K.3    Puri, V.4    Kosmin, M.5    Lawrence, J.6
  • 142
    • 77950345093 scopus 로고    scopus 로고
    • Inflammation 2010: New adventures of an old flame
    • R. Medzhitov Inflammation 2010: New adventures of an old flame Cell 140 2010 771 776
    • (2010) Cell , vol.140 , pp. 771-776
    • Medzhitov, R.1
  • 146
    • 70249093582 scopus 로고    scopus 로고
    • Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells
    • O. Mistafa, and U. Stenius Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells Biochemical Pharmacology 78 2009 1115 1126
    • (2009) Biochemical Pharmacology , vol.78 , pp. 1115-1126
    • Mistafa, O.1    Stenius, U.2
  • 147
    • 43049146243 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis co-existence with humans: Making an imprint on the macrophage P2X(7) receptor gene?
    • I. Mokrousov, N. Sapozhnikova, and O. Narvskaya Mycobacterium tuberculosis co-existence with humans: Making an imprint on the macrophage P2X(7) receptor gene? Journal of Medical Microbiology 57 2008 581 584
    • (2008) Journal of Medical Microbiology , vol.57 , pp. 581-584
    • Mokrousov, I.1    Sapozhnikova, N.2    Narvskaya, O.3
  • 149
    • 84926358328 scopus 로고    scopus 로고
    • Medicinal chemistry of P2X receptors: Allosteric modulators
    • C.E. Muller Medicinal chemistry of P2X receptors: Allosteric modulators Current Medicinal Chemistry 22 2015 929 941
    • (2015) Current Medicinal Chemistry , vol.22 , pp. 929-941
    • Muller, C.E.1
  • 151
    • 33745142545 scopus 로고    scopus 로고
    • Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists
    • D.W. Nelson, R.J. Gregg, M.E. Kort, A. Perez-Medrano, E.A. Voight, Y. Wang, and et al. Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists Journal of Medicinal Chemistry 49 2006 3659 3666
    • (2006) Journal of Medicinal Chemistry , vol.49 , pp. 3659-3666
    • Nelson, D.W.1    Gregg, R.J.2    Kort, M.E.3    Perez-Medrano, A.4    Voight, E.A.5    Wang, Y.6
  • 152
    • 70350012258 scopus 로고    scopus 로고
    • A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice
    • A. Nicke, Y.H. Kuan, M. Masin, J. Rettinger, B. Marquez-Klaka, O. Bender, and et al. A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice The Journal of Biological Chemistry 284 2009 25813 25822
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 25813-25822
    • Nicke, A.1    Kuan, Y.H.2    Masin, M.3    Rettinger, J.4    Marquez-Klaka, B.5    Bender, O.6
  • 155
    • 34250210564 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment
    • S.D. Ohlendorff, C.L. Tofteng, J.E. Jensen, S. Petersen, R. Civitelli, M. Fenger, and et al. Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment Pharmacogenetics and Genomics 17 2007 555 567
    • (2007) Pharmacogenetics and Genomics , vol.17 , pp. 555-567
    • Ohlendorff, S.D.1    Tofteng, C.L.2    Jensen, J.E.3    Petersen, S.4    Civitelli, R.5    Fenger, M.6
  • 157
    • 30644463628 scopus 로고    scopus 로고
    • The P2X7 receptor gene polymorphism 1513 A - >c has no effect on clinical prognostic markers and survival in multiple myeloma
    • S. Paneesha, J. Starczynski, C. Pepper, J. Delgado, L. Hooper, C. Fegan, and et al. The P2X7 receptor gene polymorphism 1513 A - >C has no effect on clinical prognostic markers and survival in multiple myeloma Leukemia & Lymphoma 47 2006 281 284
    • (2006) Leukemia & Lymphoma , vol.47 , pp. 281-284
    • Paneesha, S.1    Starczynski, J.2    Pepper, C.3    Delgado, J.4    Hooper, L.5    Fegan, C.6
  • 158
    • 44649092795 scopus 로고    scopus 로고
    • P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: A signaling axis promoting osteogenesis
    • N. Panupinthu, J.T. Rogers, L. Zhao, L.P. Solano-Flores, F. Possmayer, S.M. Sims, and et al. P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: A signaling axis promoting osteogenesis The Journal of Cell Biology 181 2008 859 871
    • (2008) The Journal of Cell Biology , vol.181 , pp. 859-871
    • Panupinthu, N.1    Rogers, J.T.2    Zhao, L.3    Solano-Flores, L.P.4    Possmayer, F.5    Sims, S.M.6
  • 159
    • 79954583662 scopus 로고    scopus 로고
    • P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration
    • P. Pellegatti, S. Falzoni, G. Donvito, I. Lemaire, and F. Di Virgilio P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration The FASEB Journal 25 2011 1264 1274
    • (2011) The FASEB Journal , vol.25 , pp. 1264-1274
    • Pellegatti, P.1    Falzoni, S.2    Donvito, G.3    Lemaire, I.4    Di Virgilio, F.5
  • 160
    • 66249113481 scopus 로고    scopus 로고
    • Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain
    • A. Perez-Medrano, D.L. Donnelly-Roberts, P. Honore, G.C. Hsieh, M.T. Namovic, S. Peddi, and et al. Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain Journal of Medicinal Chemistry 52 2009 3366 3376
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 3366-3376
    • Perez-Medrano, A.1    Donnelly-Roberts, D.L.2    Honore, P.3    Hsieh, G.C.4    Namovic, M.T.5    Peddi, S.6
  • 161
    • 79951704433 scopus 로고    scopus 로고
    • Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation in motor neuron disease
    • T. Philips, and W. Robberecht Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation in motor neuron disease Lancet Neurology 10 2011 253 263
    • (2011) Lancet Neurology , vol.10 , pp. 253-263
    • Philips, T.1    Robberecht, W.2
  • 162
    • 34247641287 scopus 로고    scopus 로고
    • P2X(7) purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability
    • R. Placido, G. Auricchio, S. Falzoni, L. Battistini, V. Colizzi, E. Brunetti, and et al. P2X(7) purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability Cellular Immunology 244 2006 10 18
    • (2006) Cellular Immunology , vol.244 , pp. 10-18
    • Placido, R.1    Auricchio, G.2    Falzoni, S.3    Battistini, L.4    Colizzi, V.5    Brunetti, E.6
  • 164
    • 84886509822 scopus 로고    scopus 로고
    • A role for tau at the synapse in Alzheimer's disease pathogenesis
    • A.M. Pooler, W. Noble, and D.P. Hanger A role for tau at the synapse in Alzheimer's disease pathogenesis Neuropharmacology 76 Pt. A 2014 1 8
    • (2014) Neuropharmacology , vol.76 , pp. 1-8
    • Pooler, A.M.1    Noble, W.2    Hanger, D.P.3
  • 165
    • 84863866578 scopus 로고    scopus 로고
    • The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis
    • L. Portales-Cervantes, P. Nino-Moreno, M. Salgado-Bustamante, M.H. Garcia-Hernandez, L. Baranda-Candido, E. Reynaga-Hernandez, and et al. The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis Cellular Immunology 276 2012 168 175
    • (2012) Cellular Immunology , vol.276 , pp. 168-175
    • Portales-Cervantes, L.1    Nino-Moreno, P.2    Salgado-Bustamante, M.3    Garcia-Hernandez, M.H.4    Baranda-Candido, L.5    Reynaga-Hernandez, E.6
  • 166
    • 84915756885 scopus 로고    scopus 로고
    • P2X7 mediates ATP-driven invasiveness in prostate cancer cells
    • Y. Qiu, W.H. Li, H.Q. Zhang, Y. Liu, X.X. Tian, and W.G. Fang P2X7 mediates ATP-driven invasiveness in prostate cancer cells PloS One 9 2014 e114371
    • (2014) PloS One , vol.9 , pp. e114371
    • Qiu, Y.1    Li, W.H.2    Zhang, H.Q.3    Liu, Y.4    Tian, X.X.5    Fang, W.G.6
  • 168
    • 78149373127 scopus 로고    scopus 로고
    • Targeting P2X(7) receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes
    • S. Ren, Y. Zhang, Y. Wang, Y. Lui, W. Wei, X. Huang, and et al. Targeting P2X(7) receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes Cell Biology International 34 2010 1205 1211
    • (2010) Cell Biology International , vol.34 , pp. 1205-1211
    • Ren, S.1    Zhang, Y.2    Wang, Y.3    Lui, Y.4    Wei, W.5    Huang, X.6
  • 169
    • 84862546166 scopus 로고    scopus 로고
    • Effects of nucleotide analogs at the P2X3 receptor and its mutants identify the agonist binding pouch
    • T. Riedel, S. Wiese, A. Leichsenring, and P. Illes Effects of nucleotide analogs at the P2X3 receptor and its mutants identify the agonist binding pouch Molecular Pharmacology 82 2012 80 89
    • (2012) Molecular Pharmacology , vol.82 , pp. 80-89
    • Riedel, T.1    Wiese, S.2    Leichsenring, A.3    Illes, P.4
  • 171
    • 77249098720 scopus 로고    scopus 로고
    • P2X7 gene polymorphisms and risk assessment for pulmonary tuberculosis in Asian Indians
    • V. Sambasivan, K.J. Murthy, R. Reddy, V. Vijayalakshimi, and Q. Hasan P2X7 gene polymorphisms and risk assessment for pulmonary tuberculosis in Asian Indians Disease Markers 28 2010 43 48
    • (2010) Disease Markers , vol.28 , pp. 43-48
    • Sambasivan, V.1    Murthy, K.J.2    Reddy, R.3    Vijayalakshimi, V.4    Hasan, Q.5
  • 174
    • 84921459193 scopus 로고    scopus 로고
    • Insights into the role of the unusual disulfide bond in copper-zinc superoxide dismutase
    • K. Sea, S.H. Sohn, A. Durazo, Y. Sheng, B.F. Shaw, X. Cao, and et al. Insights into the role of the unusual disulfide bond in copper-zinc superoxide dismutase The Journal of Biological Chemistry 290 2015 2405 2418
    • (2015) The Journal of Biological Chemistry , vol.290 , pp. 2405-2418
    • Sea, K.1    Sohn, S.H.2    Durazo, A.3    Sheng, Y.4    Shaw, B.F.5    Cao, X.6
  • 175
  • 177
    • 33644871635 scopus 로고    scopus 로고
    • A Thr357 to ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages
    • A.N. Shemon, R. Sluyter, S.L. Fernando, A.L. Clarke, L.P. Dao-Ung, K.K. Skarratt, and et al. A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages The Journal of Biological Chemistry 281 2006 2079 2086
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 2079-2086
    • Shemon, A.N.1    Sluyter, R.2    Fernando, S.L.3    Clarke, A.L.4    Dao-Ung, L.P.5    Skarratt, K.K.6
  • 178
    • 20244385275 scopus 로고    scopus 로고
    • Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region
    • E. Shink, M. Harvey, M. Tremblay, B. Gagne, P. Belleau, C. Raymond, and et al. Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 135B 2005 50 58
    • (2005) American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics , vol.135 B , pp. 50-58
    • Shink, E.1    Harvey, M.2    Tremblay, M.3    Gagne, B.4    Belleau, P.5    Raymond, C.6
  • 179
    • 33747190855 scopus 로고    scopus 로고
    • P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro
    • S.D. Skaper, L. Facci, A.A. Culbert, N.A. Evans, I. Chessell, J.B. Davis, and et al. P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro Glia 54 2006 234 242
    • (2006) Glia , vol.54 , pp. 234-242
    • Skaper, S.D.1    Facci, L.2    Culbert, A.A.3    Evans, N.A.4    Chessell, I.5    Davis, J.B.6
  • 180
    • 18144376312 scopus 로고    scopus 로고
    • A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population
    • K.K. Skarratt, S.J. Fuller, R. Sluyter, L.P. Dao-Ung, B.J. Gu, and J.S. Wiley A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population FEBS Letters 579 2005 2675 2678
    • (2005) FEBS Letters , vol.579 , pp. 2675-2678
    • Skarratt, K.K.1    Fuller, S.J.2    Sluyter, R.3    Dao-Ung, L.P.4    Gu, B.J.5    Wiley, J.S.6
  • 181
  • 182
    • 84945157887 scopus 로고    scopus 로고
    • Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients
    • A. Solini, V. Simeon, L. Derosa, P. Orlandi, C. Rossi, A. Fontana, and et al. Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients Oncotarget 6 2015 28743 28754
    • (2015) Oncotarget , vol.6 , pp. 28743-28754
    • Solini, A.1    Simeon, V.2    Derosa, L.3    Orlandi, P.4    Rossi, C.5    Fontana, A.6
  • 183
    • 33644543348 scopus 로고    scopus 로고
    • Prevalence and incidence studies of anxiety disorders: A systematic review of the literature
    • J.M. Somers, E.M. Goldner, P. Waraich, and L. Hsu Prevalence and incidence studies of anxiety disorders: A systematic review of the literature Canadian Journal of Psychiatry 51 2006 100 113
    • (2006) Canadian Journal of Psychiatry , vol.51 , pp. 100-113
    • Somers, J.M.1    Goldner, E.M.2    Waraich, P.3    Hsu, L.4
  • 184
    • 84930616412 scopus 로고    scopus 로고
    • Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats
    • N. Soni, P. Koushal, B.V. Reddy, R. Deshmukh, and P. Kumar Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats Epilepsy & Behavior 48 2015 4 14
    • (2015) Epilepsy & Behavior , vol.48 , pp. 4-14
    • Soni, N.1    Koushal, P.2    Reddy, B.V.3    Deshmukh, R.4    Kumar, P.5
  • 185
    • 84907899903 scopus 로고    scopus 로고
    • P2X7 receptor: An emerging target in central nervous system diseases
    • B. Sperlagh, and P. Illes P2X7 receptor: An emerging target in central nervous system diseases Trends in Pharmacological Sciences 35 2014 537 547
    • (2014) Trends in Pharmacological Sciences , vol.35 , pp. 537-547
    • Sperlagh, B.1    Illes, P.2
  • 188
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • L. Steinman Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system Cell 85 1996 299 302
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 189
    • 0029665112 scopus 로고    scopus 로고
    • The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
    • A. Surprenant, F. Rassendren, E. Kawashima, R.A. North, and G. Buell The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7) Science 272 1996 735 738
    • (1996) Science , vol.272 , pp. 735-738
    • Surprenant, A.1    Rassendren, F.2    Kawashima, E.3    North, R.A.4    Buell, G.5
  • 190
    • 79961174606 scopus 로고    scopus 로고
    • Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B
    • M. Tafani, L. Schito, L. Pellegrini, L. Villanova, G. Marfe, T. Anwar, and et al. Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B Carcinogenesis 32 2011 1167 1175
    • (2011) Carcinogenesis , vol.32 , pp. 1167-1175
    • Tafani, M.1    Schito, L.2    Pellegrini, L.3    Villanova, L.4    Marfe, G.5    Anwar, T.6
  • 191
    • 84895853570 scopus 로고    scopus 로고
    • Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells
    • E. Takai, M. Tsukimoto, H. Harada, and S. Kojima Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells Purinergic Signal 10 2014 487 497
    • (2014) Purinergic Signal , vol.10 , pp. 487-497
    • Takai, E.1    Tsukimoto, M.2    Harada, H.3    Kojima, S.4
  • 192
    • 84872255267 scopus 로고    scopus 로고
    • Autocrine regulation of TGF-beta1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells
    • E. Takai, M. Tsukimoto, H. Harada, K. Sawada, Y. Moriyama, and S. Kojima Autocrine regulation of TGF-beta1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells Journal of Cell Science 125 2012 5051 5060
    • (2012) Journal of Cell Science , vol.125 , pp. 5051-5060
    • Takai, E.1    Tsukimoto, M.2    Harada, H.3    Sawada, K.4    Moriyama, Y.5    Kojima, S.6
  • 193
    • 0037079306 scopus 로고    scopus 로고
    • Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia
    • U. Thunberg, G. Tobin, A. Johnson, O. Soderberg, L. Padyukov, M. Hultdin, and et al. Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia Lancet 360 2002 1935 1939
    • (2002) Lancet , vol.360 , pp. 1935-1939
    • Thunberg, U.1    Tobin, G.2    Johnson, A.3    Soderberg, O.4    Padyukov, L.5    Hultdin, M.6
  • 195
    • 84882722597 scopus 로고    scopus 로고
    • PKC-dependent ERK phosphorylation is essential for P2X7 receptor-mediated neuronal differentiation of neural progenitor cells
    • H.K. Tsao, P.H. Chiu, and S.H. Sun PKC-dependent ERK phosphorylation is essential for P2X7 receptor-mediated neuronal differentiation of neural progenitor cells Cell Death & Disease 4 2013 e751
    • (2013) Cell Death & Disease , vol.4 , pp. e751
    • Tsao, H.K.1    Chiu, P.H.2    Sun, S.H.3
  • 196
    • 84903127797 scopus 로고    scopus 로고
    • Gain and loss of function of P2X7 receptors: Mechanisms, pharmacology and relevance to diabetic neuropathic pain
    • D. Ursu, P. Ebert, E. Langron, C. Ruble, L. Munsie, W. Zou, and et al. Gain and loss of function of P2X7 receptors: Mechanisms, pharmacology and relevance to diabetic neuropathic pain Molecular Pain 10 2014 37
    • (2014) Molecular Pain , vol.10 , pp. 37
    • Ursu, D.1    Ebert, P.2    Langron, E.3    Ruble, C.4    Munsie, L.5    Zou, W.6
  • 199
    • 84876567309 scopus 로고    scopus 로고
    • Effect of the purinergic inhibitor oxidized ATP in a model of islet allograft rejection
    • A. Vergani, C. Fotino, F. D'Addio, S. Tezza, M. Podetta, F. Gatti, and et al. Effect of the purinergic inhibitor oxidized ATP in a model of islet allograft rejection Diabetes 62 2013 1665 1675
    • (2013) Diabetes , vol.62 , pp. 1665-1675
    • Vergani, A.1    Fotino, C.2    D'Addio, F.3    Tezza, S.4    Podetta, M.5    Gatti, F.6
  • 201
    • 0036340437 scopus 로고    scopus 로고
    • Evidence that ATP participates in the pathophysiology of pilocarpine-induced temporal lobe epilepsy: Fluorimetric, immunohistochemical, and Western blot studies
    • E.P. Vianna, A.T. Ferreira, M.G. Naffah-Mazzacoratti, E.R. Sanabria, M. Funke, E.A. Cavalheiro, and et al. Evidence that ATP participates in the pathophysiology of pilocarpine-induced temporal lobe epilepsy: Fluorimetric, immunohistochemical, and Western blot studies Epilepsia 43 Suppl. 5 2002 227 229
    • (2002) Epilepsia , vol.43 , pp. 227-229
    • Vianna, E.P.1    Ferreira, A.T.2    Naffah-Mazzacoratti, M.G.3    Sanabria, E.R.4    Funke, M.5    Cavalheiro, E.A.6
  • 202
    • 79952898989 scopus 로고    scopus 로고
    • P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT
    • M. Viikki, O. Kampman, S. Anttila, A. Illi, E. Setala-Soikkeli, M. Huuhka, and et al. P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT Neuroscience Letters 493 2011 127 130
    • (2011) Neuroscience Letters , vol.493 , pp. 127-130
    • Viikki, M.1    Kampman, O.2    Anttila, S.3    Illi, A.4    Setala-Soikkeli, E.5    Huuhka, M.6
  • 205
    • 4043079197 scopus 로고    scopus 로고
    • P2X7 receptor inhibition improves recovery after spinal cord injury
    • X. Wang, G. Arcuino, T. Takano, J. Lin, W.G. Peng, P. Wan, and et al. P2X7 receptor inhibition improves recovery after spinal cord injury Nature Medicine 10 2004 821 827
    • (2004) Nature Medicine , vol.10 , pp. 821-827
    • Wang, X.1    Arcuino, G.2    Takano, T.3    Lin, J.4    Peng, W.G.5    Wan, P.6
  • 206
    • 79959865000 scopus 로고    scopus 로고
    • Lack of association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis
    • X. Wang, H. Xiao, H. Lan, C. Mao, and Q. Chen Lack of association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis Respirology 16 2011 790 795
    • (2011) Respirology , vol.16 , pp. 790-795
    • Wang, X.1    Xiao, H.2    Lan, H.3    Mao, C.4    Chen, Q.5
  • 208
    • 84876470724 scopus 로고    scopus 로고
    • Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients
    • A. Wesselius, M.J. Bours, Z. Henriksen, S. Syberg, S. Petersen, P. Schwarz, and et al. Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients Osteoporosis International 24 2013 1235 1246
    • (2013) Osteoporosis International , vol.24 , pp. 1235-1246
    • Wesselius, A.1    Bours, M.J.2    Henriksen, Z.3    Syberg, S.4    Petersen, S.5    Schwarz, P.6
  • 210
    • 0037196958 scopus 로고    scopus 로고
    • A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: A molecular study
    • J.S. Wiley, L.P. Dao-Ung, B.J. Gu, R. Sluyter, A.N. Shemon, C. Li, and et al. A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: A molecular study Lancet 359 2002 1114 1119
    • (2002) Lancet , vol.359 , pp. 1114-1119
    • Wiley, J.S.1    Dao-Ung, L.P.2    Gu, B.J.3    Sluyter, R.4    Shemon, A.N.5    Li, C.6
  • 211
    • 0037931836 scopus 로고    scopus 로고
    • An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor
    • J.S. Wiley, L.P. Dao-Ung, C. Li, A.N. Shemon, B.J. Gu, M.L. Smart, and et al. An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor The Journal of Biological Chemistry 278 2003 17108 17113
    • (2003) The Journal of Biological Chemistry , vol.278 , pp. 17108-17113
    • Wiley, J.S.1    Dao-Ung, L.P.2    Li, C.3    Shemon, A.N.4    Gu, B.J.5    Smart, M.L.6
  • 212
    • 79953023121 scopus 로고    scopus 로고
    • Molecular determinants of potent P2X2 antagonism identified by functional analysis, mutagenesis, and homology docking
    • C. Wolf, C. Rosefort, G. Fallah, M.U. Kassack, A. Hamacher, M. Bodnar, and et al. Molecular determinants of potent P2X2 antagonism identified by functional analysis, mutagenesis, and homology docking Molecular Pharmacology 79 2011 649 661
    • (2011) Molecular Pharmacology , vol.79 , pp. 649-661
    • Wolf, C.1    Rosefort, C.2    Fallah, G.3    Kassack, M.U.4    Hamacher, A.5    Bodnar, M.6
  • 213
    • 84946475966 scopus 로고    scopus 로고
    • P2X receptor expression in peripheral blood monocytes is correlated with plasma C-reactive protein and cytokine levels in patients with type 2 diabetes mellitus: A preliminary report
    • H. Wu, Y. Nie, H. Xiong, S. Liu, G. Li, A. Huang, and et al. P2X receptor expression in peripheral blood monocytes is correlated with plasma C-reactive protein and cytokine levels in patients with type 2 diabetes mellitus: A preliminary report Inflammation 38 2015 2076 2081
    • (2015) Inflammation , vol.38 , pp. 2076-2081
    • Wu, H.1    Nie, Y.2    Xiong, H.3    Liu, S.4    Li, G.5    Huang, A.6
  • 214
    • 84897506540 scopus 로고    scopus 로고
    • The effect of P2X7 receptor 1513 polymorphism on susceptibility to tuberculosis: A meta-analysis
    • G. Wu, M. Zhao, X. Gu, Y. Yao, H. Liu, and Y. Song The effect of P2X7 receptor 1513 polymorphism on susceptibility to tuberculosis: A meta-analysis Infection, Genetics and Evolution 24 2014 82 91
    • (2014) Infection, Genetics and Evolution , vol.24 , pp. 82-91
    • Wu, G.1    Zhao, M.2    Gu, X.3    Yao, Y.4    Liu, H.5    Song, Y.6
  • 215
    • 84930015180 scopus 로고    scopus 로고
    • P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway
    • J. Xia, X. Yu, L. Tang, G. Li, and T. He P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway Oncology Reports 34 2015 103 110
    • (2015) Oncology Reports , vol.34 , pp. 103-110
    • Xia, J.1    Yu, X.2    Tang, L.3    Li, G.4    He, T.5
  • 217
    • 84929664334 scopus 로고    scopus 로고
    • Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18
    • Y. Yang, H. Li, T.T. Li, H. Luo, X.Y. Gu, N. Lu, and et al. Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18 The Journal of Neuroscience 35 2015 7950 7963
    • (2015) The Journal of Neuroscience , vol.35 , pp. 7950-7963
    • Yang, Y.1    Li, H.2    Li, T.T.3    Luo, H.4    Gu, X.Y.5    Lu, N.6
  • 219
    • 33645224970 scopus 로고    scopus 로고
    • COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    • Y. Yiangou, P. Facer, P. Durrenberger, I.P. Chessell, A. Naylor, C. Bountra, and et al. COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord BMC Neurology 6 2006 12
    • (2006) BMC Neurology , vol.6 , pp. 12
    • Yiangou, Y.1    Facer, P.2    Durrenberger, P.3    Chessell, I.P.4    Naylor, A.5    Bountra, C.6
  • 220
    • 84905455228 scopus 로고    scopus 로고
    • Targeting cancer-derived adenosine: New therapeutic approaches
    • A. Young, D. Mittal, J. Stagg, and M.J. Smyth Targeting cancer-derived adenosine: New therapeutic approaches Cancer Discovery 4 2014 879 888
    • (2014) Cancer Discovery , vol.4 , pp. 879-888
    • Young, A.1    Mittal, D.2    Stagg, J.3    Smyth, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.