Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis

DMM Disease Models and Mechanisms

Volumn 7, Issue 9, 2014, Pages 1101-1109

  Apolloni, Savina ^a,b   Amadio, Susanna ^b   Parisi, Chiara ^a   Matteucci, Alessandra ^c   Potenza, Rosa L ^c   Armida, Monica ^c   Popoli, Patrizia ^c   D'Ambrosi, Nadia ^a,d   Volonté, Cinzia ^a,b  

^a CNR   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

ALS; Brilliant Blue G; Microglia; Motor neuron; P2X7

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRILLIANT BLUE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; PURINERGIC P2X7 RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; BIOLOGICAL MARKER; COOMASSIE BRILLIANT BLUE; COPPER ZINC SUPEROXIDE DISMUTASE; FUCHSINE; PRIMER DNA; PURINERGIC P2X RECEPTOR ANTAGONIST; SUPEROXIDE DISMUTASE;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG DOSE INCREASE; FEMALE; GENERAL CONDITION IMPROVEMENT; GLIOSIS; IMMUNOMODULATION; LUMBAR SPINAL CORD; MALE; MOTONEURON; MOTOR PERFORMANCE; MOUSE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; RECEPTOR BLOCKING; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENETICS; INFLAMMATION; METABOLISM; MICROGLIA; MUTANT MOUSE STRAIN; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION; SPINAL CORD; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BASE SEQUENCE; BIOLOGICAL MARKERS; DNA PRIMERS; FEMALE; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MICROGLIA; MOTOR NEURONS; POLYMERASE CHAIN REACTION; PURINERGIC P2X RECEPTOR ANTAGONISTS; ROSANILINE DYES; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 84907217155     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.017038     Document Type: Article

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