Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18

Journal of Neuroscience

Volumn 35, Issue 20, 2015, Pages 7950-7963

  Yang, Yan ^a   Li, Hui ^a   Li, Ting Ting ^a   Luo, Hao ^a   Gu, Xi Yao ^a   Lü, Ning ^a   Ji, Ru Rong ^b   Zhang, Yu Qiu ^a  

^a FUDAN UNIVERSITY   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bone cancer pain; Female rats; IL 18; Microglia; Neuron glial interaction; P2X7 receptor

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL] CYCLOHEXANOL; ADENOSINE TRIPHOSPHATE; BRILLIANT BLUE; BRILLIANT BLUE G; CD11B ANTIGEN; DACTINOMYCIN; DNA NUCLEOTIDYLEXOTRANSFERASE; FLUOROCITRIC ACID; INTERLEUKIN 18; MINOCYCLINE; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BEHAVIOR ASSESSMENT; BONE CANCER; CANCER PAIN; CELL ACTIVATION; CONTROLLED STUDY; DNA FRAGMENTATION; FEMALE; HYPERACTIVITY; HYPERALGESIA; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; MICROGLIA; NEUROPATHIC PAIN; NEUROTOXICITY; NOCICEPTION; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; RAT; SPINE; SYNAPTIC TRANSMISSION; TUMOR CELL INOCULATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BONE TUMOR; CEREBROSPINAL FLUID; COMPLICATION; EXCITATORY POSTSYNAPTIC POTENTIAL; GENETICS; METABOLISM; MINIATURE ENDPLATE POTENTIAL; NEURALGIA; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTERIOR HORN CELL; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; BONE NEOPLASMS; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; INTERLEUKIN-18; MICROGLIA; MINIATURE POSTSYNAPTIC POTENTIALS; MINOCYCLINE; NEURALGIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POSTERIOR HORN CELLS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2X7;

EID: 84929664334     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5250-14.2015     Document Type: Article

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