Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 3848-3851

  Betschmann, Patrick ^a   Bettencourt, Brian ^a   Donnelly Roberts, Diana ^a   Friedman, Michael ^a   George, Jonathan ^a   Hirst, Gavin ^a   Josephsohn, Nathan ^a   Konopacki, Donald ^a   Li, Biqin ^a   Maull, John ^a   Morytko, Michael J ^a   Moore, Nigel StJohn ^a   Namovic, Marian ^a   Rafferty, Paul ^a   Salmeron Garcia, Jose Andres ^a   Tarcsa, Edit ^a   Wang, Lu ^a   Woller, Kevin ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Antagonists; Cyanoguanidine; P2X7; Piperazine

Indexed keywords

INTERLEUKIN 1BETA; PIPERAZINE DERIVATIVE; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CYTOKINE RELEASE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GUANIDINES; HUMANS; INHIBITORY CONCENTRATION 50; INTERLEUKIN-1BETA; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PIPERAZINES; RATS; RECEPTORS, PURINERGIC P2; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 47149090522     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.055     Document Type: Article

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