Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

Brain

Volumn 133, Issue 9, 2010, Pages 2549-2564

  Kaan, Timothy K Y ^a   Yip, Ping K ^a   Patel, Sital ^b   Davies, Meirion ^a   Marchand, Fabien ^a,e   Cockayne, Debra A ^c,f   Nunn, Philip A ^c,f   Dickenson, Anthony H ^b   Ford, Anthony P D W ^d   Zhong, Yu ^c,g   Malcangio, Marzia ^a   McMahon, Stephen B ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Inflammatory Disease Biology Group Roche Palo Alto   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e INSERM   (France)

^f Hoffmann La Roche   (United States)

^g Non Clinical Safety   (United States)

Author keywords

cancer pain; dorsal horn; dorsal root ganglion; extracellular signal regulated kinases; P2X3

Indexed keywords

ADENOSINE TRIPHOSPHATE; AF 353; ANALGESIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; AMIDINE; CALCITONIN GENE RELATED PEPTIDE; DIAMIDINO COMPOUND 253/50; P2RX2 PROTEIN, RAT; P2RX3 PROTEIN, RAT; PURINERGIC P2 RECEPTOR; PURINERGIC P2 RECEPTOR ANTAGONIST; PYRIMIDINE DERIVATIVE; RO-4 COMPOUND;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE CANCER; BONE CANCER PAIN; CANCER CELL CULTURE; CANCER PAIN; CARCINOMA CELL; COCULTURE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROPHYSIOLOGY; ENZYME PHOSPHORYLATION; IN VIVO STUDY; NERVE EXCITABILITY; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL GANGLION; THERMAL STIMULATION; ANIMAL; BONE TUMOR; CARCINOMA; CELL CULTURE; COMPLICATION; CYTOLOGY; DIAGNOSTIC USE; DISEASE MODEL; DRUG EFFECTS; HYPERALGESIA; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; ORAL DRUG ADMINISTRATION; PAIN; PAIN MEASUREMENT; PATHOLOGY; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY; RADIOGRAPHY; SENSORY NERVE CELL; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ADMINISTRATION, ORAL; AMIDINES; ANIMALS; BONE NEOPLASMS; CALCITONIN GENE-RELATED PEPTIDE; CARCINOMA; CELLS, CULTURED; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GANGLIA, SPINAL; HYPERALGESIA; PAIN; PAIN MEASUREMENT; PURINERGIC P2 RECEPTOR ANTAGONISTS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X2; RECEPTORS, PURINERGIC P2X3; SENSORY RECEPTOR CELLS; X-RAY MICROTOMOGRAPHY;

EID: 77956389019     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq194     Document Type: Article

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